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Author Archive Quantitative Neurogenetics & QTL Mapping Genetics of Myopia Control of Neuron Number and Stereology Growth Cones and Dying Axons Retina Development and Visual System Mutants Grant Application U.S. Patent Abstracts Need Help? Help with Publications Help with Nervenet Contact Us

Publications on the Web This is an annotated list of papers, reviews, grants, and abstracts by R. W. Williams and colleagues. List of Contents Quantitative Neurogenetics & QTL Mapping An example of a hippocampus used for gene mapping. This dissection is from the left hemisphere. Five cross-sections illustrate internal structure. For more details on this work and information on QTLs that control hippocampal size and structure, see the article Genetic Control of Neuron Number below. Genes associated with basolateral amygdala morphology are involved in neuronal development. [Nature Neuroscience Getaway] Elissa Chesler Reviewer Response [Mapping comparision plot, heritability expression and compare colocalization. [zip version] GenomeMixer: a complex genetic cross simulator. [pdf version] Seeing the Unseen: Microarray-Based Gene Expression Profiling in Vision. [pdf version] A new set of BXD recombinant inbred lines from advanced intercross population in mice. [pdf version] Genetic Correlates of Gene Expression in Recombinant Inbred Strains: A Relational Model System to Explore Neurobehavioral Phenotypes Genetic Structure of Recombinant Inbred Mice Strength in Numbers: Chasing the Engram Using Microarrays QTL analysis and genome-wide mutagenesis in mice: Complementary genetic approaches to the dissection of complex traits Short Course Tutorial in Quantitative Neurogenetics Mapping Genes that Modulate Mouse Brain Development: A Quantitative Genetic Approach Genetic Control of Neuron Number. By Richelle Cutler Strom Genetic Architecture of the Mouse Hippocampus Neurogenetic Analysis of the Olfactory Bulbs in Mice Biometric and QTL Analysis of the Cerebellum Complex Trait Analysis of the Mouse Striatum Combining Mutagensis and QTL Analysis: The Consomic Mutagenesis Screen Genetic Dissection of Retinal Development An Analysis of Variation in Retinal Ganglion Cell Number in Mice A Major QTL on Chr 11 Controls Variation in Ganglion Cell Number Cell Production and Cell Death in the Generation of Variation in Neuron Number List of Contents Genetics of Myopia The Eye1 locus. Linkage between variation in eye weight and proximal Chr 5. The x-axis represents the entire genetic length of Chr 5—from the proximal end (left) near marker D5Mit346 to the distal end of the chromosome at approximately 60 cM (far right). The y-axis represents the strength of linkage assessed using the likelihood ratio statistic (LRS) computed at 1 cM intervals using an interval mapping procedure without any adjustment for secondary QTLs using data for the 26 BXD strains. Eye1 and Eye2: Quantitative trait loci that modulate eye size, lens weight, and retinal area Mouse Models for the Analysis of Myopia: Variation in Eye and Lens Size of Adult Mice Modulation of Retinal Cell Populations and Eye Size in Retinoic Acid Receptor knockout Mice List of Contents Control of Neuron Number and Stereology Two theoretical curves that illustrate the expected number of sg/sg genotype Purkinje cells (PC) in sg/sg by +/+ chimeras, assuming two different modes of gene action (see Herrup & Mullen 1981 for the assumptions and calculations on which these curves are based). The Control of Neuron Number Direct Three-Dimensional Counting The Annotated Abercrombie Brain Volume Estimation from Serial Sections Rapid Evolution of the Cat Visual System Neuron Number in Fetal Monkey LGN List of Contents Growth Cones and Dying Axons This monster took the better part of three years to complete. The web edition has been updated with new figures (including color-tinted electron micrographs). If you would like to see high-resolution images of growth cones and dying axons, this is a great source. The paper was published in The Journal of Comparative Neurology in 1986 by R. W. Williams, Michael Bastiani, Barry Lia, and Leo Chalupa. We show that about 80% of all retinal ganglion cells die early in development in domestic cats. The paper has a fairly long discussion on the developmental significance (and insignificance) of neuron death. Growth Cones, Dying Axons, and Developmental Fluctuation in the Fiber Population of the Cat's Optic Nerve Dispersion of Growing Axons within the Optic Nerve of the Embryonic Monkey Growth Cone Distribution Patterns in the Optic Nerve of Fetal Monkeys: Implications for Mechanisms of Axon Guidance List of Contents Retinal Developmental and Visual System Mutants The distribution of retinal ganglion cells in the cat's retina. Colors are used to indicate cell packing density. The area centralis (dark blue region) contains as many as 8,600 cells/mm2. Cell densities are particularly high along the hroizontal axes from the temporal periphery (right) to the nasal periphery (left). If you select the image you may view an enlarged version with overlaid cell counts per 0.058 µm2 (multiply by 17.24 to obtain cell densities per mm2). Prenatal Development of Retinal Projections to the Superior Colliculus in the Cat Binocular Interaction and Ganglion Cell Death Prenatal Development and Reorganization of the Cat's Visual System Target Recognition and Visual Maps in the Thalamus of Achiasmatic Dogs Analysis of the Retinas and Optic Nerves of Achiasmatic Belgian Sheepdogs Asymmetric Connections, Duplicate Layers, and a Vertically Inverted Map in the Primary Visual System Structure of Clonal and Polyclonal Cell Arrays in Chimeric Mouse Retina Lineage vs. Environment in Embryonic Retina Clonal Architecture of the Mouse Retina Extrinsic Modulation of Retinal Ganglion Cell Projections The Human Retina has a Cone-Enriched Rim Mapping the Bst Mutation on Mouse Chr 16 List of Contents Grant Applications The full text of a 1995 NSF grant submission that outlines our research objectives and methods. The focus is on mapping quantitative trait loci that affect CNS development. The full text of a project now funded by the Human Brain Project to continue the development of the Informatics Center for Mouse Neurogenetics (funding from 2000 to 2004). An NSF grant application Informatics Center for Mouse Neurogenetics: An NIH P20 grant application (PDF FORMAT) Informatics Center for Mouse Neurogenetics: An NIH P20 grant application (HTML FORMAT) List of Contents A 1990 U.S. Patent A patent for a system to accurately count numbers of cells or particles in a section or sample of tissue. A 1990 Patent for Cell Counting List of Contents Most Recent Abstracts   2000 Williams RW, Lu L, Airey DC, Kulkarni K, Manly KF, Zhou G, Threadgill DW (2000) RIX mapping: A demonstration using CXB RIX hybrids to map QTLs modulating eye size in mice. Int Mouse Genome Conf 14: XX.   2000 Williams RW, Lu L, Airey DC, Kulkarni K, Manly KF, Zhou G, Threadgill DW (2000) RIX mapping: A demonstration using CXB RIX hybrids to map QTLs modulating eye size in mice. Rosen GD, Williams AG, Capra JA, Connolly MT, Cruz B, Lu L, Airey DC, Kulkarni K, Williams RW (2000) The Mouse Brain Library @ www.mbl.org. Int Mouse Genome Conf 14: XX   2001 Lu L, Airey DC, Williams RW (2001) Genetic architecture of the mouse hippocampus: Identification of gene loci with regional effects. 31st Annual Neuroscience meeting:XX

Short Course Tutorial Neuroscience Meets Quantitative Genetics: Using Morphometric Data to Map Genes that Modulate CNS Architecture Updated August 2000 with new figures and text on RIX mapping.   Learn More More Publications Related Sites Complextrait.org