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EXPERIMENTAL PLAN |
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Principal Investigator/Program Director Williams, Robert W. |
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Time course of developmentExperience with development of the Map Manager programs has taught some important lessons about development of this type of software. The most important is that development of an easy-to-use interface requires multiple cycles of development, user feedback, and modification. This process takes longer than it seems it should. With that in mind, we plan on the following time course for developing and testing services that will be made available to the scientific community. Year 01: Basic descriptive statistics and heritability measures for traits. Single-locus association and fast interval mapping for curated data sets from recombinant inbred lines. Fast empirical significance thresholds and/or permutation tests for single-locus association and fast interval mapping. Documentation and tutorials for these functions. Year 02: Single locus association and standard interval mapping for the G10 advanced intercross. Graphic display of interval mapping results. Fast empirical significance thresholds and/or permutation tests for standard interval mapping. Data export in formats for other mapping software. Documentation and tutorials for these functions. Year 03: Composite interval mapping for all curated data sets and empirical significance thresholds for these. Correlation of submitted traits among each other and with traits stored in the NTB. Documentation and tutorials for these functions. Year 04: Detection and analysis of epistatic interactions between QTLs. Analysis of crosses in which both trait values and marker genotypes are submitted by the user. Documentation and tutorials for these functions. Year 05: Bootstrap methods for confidence intervals on QTL location. Weighted regression and nonparametric regression methods. Documentation and tutorials for these functions.
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