RESEARCH PLAN

Principal Investigator/Program Director Williams,Robert W.

• Aim1. Construction of mouse 3D brain atlases and navigation software.
• Aim2. Affined mapping into standard coordinates.
• Aim3. Segmentation of the MBL and extraction of quantitative traits.
• Problems and Issues Addressed in the Project.
• Status of current research efforts.
• Limitations of existing approaches.
• Relationship of project to objectives of the Human Brain Project.
• Integrative relationship between brain research and informatics components of the project.
• Novelty of the Informatics component.

EXPERIMENTAL PLAN

• New methods and their advantages    Aim 1: Construction of mouse 3D brain atlases and navigation software.
• Aim 2: Affined mapping into the MBL standard coordinate system.
• Aim 3: Segmentation of the MBL and extraction of quantitative traits.
• Assessment of feasibility  Aim 1: Contruction of mouse 3D brain atlases and navigation software.
• Potential pitfalls and potential solutions  Aim 1: Construction of mouse 3D brain atlases and navigation software.
• Aim 2: Linear alignment of MBL into the standard coordinate system.
• Aim 3: Segmentation of the MBL and extraction of quantitative traits.
• Means of assessing success with respect to Phase II objectives.
• Legacy data and other collections.
• Assessing success.
• Relevance of project 3 to the whole program.