www.genenetwork.org (one of the first web sites in biomedical research, established Jan 1994)

www.nervenet.org, www.mbl.org

www.complextrait.org

DEGREES Ph.D. (1983) Physiology, University of California, Davis

B.A. (1975) Psychobiology, University of California, Santa Cruz

INTERESTS • Systems genetics, complex trait analysis, and functional genomics

• Control of gene expression

• Genetics of CNS diseases and addiction

• Visual system structure, function, development

• Advanced methods in collaborative research, data sharing, web services

PROFESSIONAL EXPERIENCE

2009–present UT-Oak Ridge National Laboratory Governor’s Chair in Computational Genomics

2001–2009 William and Dorothy Dunavant Chair of Excellence in Developmental Genetics: Department of Pediatrics (secondary appointment), University of Tennessee Health Science Center (UTHSC)

2008–present Director: UT Center for Integrative and Translational Genomics (CITG)

2008–present Chief Scientific Officer: Varigenix Inc., Memphis TN

2000–2007 Codirector/Director: Center of Genomics and Bioinformatics, UTHSC

1997–present Professor: Department of Anatomy and Neurobiology and Center for Neuroscience, UTHSC (primary)

2001–present Member: Feinstone Center for Genomic Research, University of Memphis

1992–1997 Associate Professor: Department of Anatomy and Neurobiology and Center for Neuroscience, UTHSC

1989–1992 Assistant Professor: Department of Anatomy and Neurobiology and Center for Neuroscience, UTHSC

1986–1989 Assistant Professor: Yale University School of Medicine, Section of Neuroanatomy

1985–1986 Associate Research Scientist: Yale University School of Medicine, Section of Neuroanatomy (P. Rakic, mentor)

1984–1989 Instructor: Neuroanatomy laboratory, Yale University School of Medicine, Section of Neuroanatomy

1983–1985 Postdoctoral fellow: Yale University School of Medicine, Section of Neuroanatomy (P. Rakic, mentor)

1982–1983 Assistant Research Physiologist: University of California, Davis

1982 Instructor: University of California, Davis

1979–1982 National Institutes of Health Trainee: University of California, Davis (L.M. Chalupa, thesis advisor)

1978–1981 Teaching Assistant and Teaching Associate: Animal Physiology and Psychology, University of California, Davis

Professional SOCIETIES

Society for Neuroscience (Chair, Neuroinformatics Committee, 2003-2008)

Complex Trait Consortium (founder and director, 2001–2008)

Research Society on Alcoholism (member)

International Society for Computational Biology (member 2009)

American Society for Human Genetics (member)

Association for Research in Vision and Ophthalmology (member)

International Behavioural and Neural Genetics Society (member, president 2005)

International Mammalian Genome Society (member),

Behavioural Neurogenetics Initiative (ex-member)

IEEE (ex-member)

Grants and Fellowships

2001–present Principal Investigator: INIA: Robust Systems Genetics of Alcohol and Stress Effects on CNS, National Institutes of Health U01AA13499. TDC ~$1.68 M over last 5 years (02.05.02–01.31.17)

2007–present Principal Investigator: INIA: Bioinformatics Core, National Institutes of Health U01AA0016662. TDC ~$750K over last 5 years (02.05.12–01.31.17)

2007–2012 Principal Investigator: Systems Genetics of the HPA, National Institutes of Health U01AA017590. TDC ~$875K over 5 years (07.01.07–06.30.12)

2012–present Coinvestigator: Integrated Approach to Understanding Host-Pathogen Interactions (RFP NIH NIAID DMID-AI2010100) 5 years at 5% effort (in negotiation, Gerald Byrne UTHSC PI) funding through 1/31/2019

2011–present Coinvestigator: BXD Aging Colony. This is a collaboration between RWW and Prof Johan Auwerx (EPFL Lausanne) to maintain a colony for joint research ($50,000/yr for 2 years, administered through CITG UTHSC

2008–present Director: State of Tennessee funds for the UT Institute for Integrative and Translational Genomics. TDC ~$1M (recurring) in 2008 budget year to UTHSC

2011–present Memphis Research Consortium organizing member, State of Tennessee,, ~$6 million, non-recurring for Genetics and Epidemiology of Pediatric Obesity

2010–present European FP7: Human Brain Project Networks of Excellence coinvestigator with Seth Grant and Henry Markram (funded travel to collaborate on full application). RWW is Work Package leader on pending full application (April 2012 submission)

2011–2013 Genetics of Stroke. 1R21NS066166 (PI: Nowak T) NINDS, Role: consultant, collaborator (unfunded)

2009-2011 Coinvestigator: Neuron-Specific Candidate Gene Expression and Adolescent Vulnerability to Smoking. 1RC2DA028962 (PI: Sharp B) 09.25.09–9.26.11; 0.50 calendar; NIDA $1,441,300 Role: coinvestigator

2007–2012 Coinvestigator: Modulators of Retinal Injury, National Institutes of Health R01 EY017841. TDC ~$1.0 over 5 years (10.01.07–9.31.11)

2005 – 2010 Coinvestigator: Dispersion Patterns for Retinal Neuroblasts, National Institutes of Health R01 EY0110871. TDC ~$1.0 over 5 years (07.01.05–06.30.10)

2008–2010 Lead contract with Eli Lilly and Co, Genes that Influence Diabetic Nephropathy. (DOE NFE-08-01254, $135K subcontract to UT-Battelle, LLC) (R07-3003-263)

2005–present Coinvestigator, Mouse Biomedical Informatics Research Network (BIRN), National Institutes of Health R24 RR021760. National Center for Research Resources, TDC ~$1.0 M over 5 years (04.01.05–03.31.09)

2006–2008 Principal Investigator: Huntingtin Transcriptome Analysis, High Q Foundation, $466,800 (02-01-06 to 01-31-08)

2004–present Coinvestigator: Integrative Genetics of Cancer Susceptibility, NCI 1U01CA105417. TDC $600,000 over 5 years (04.01.04–03.31.2009, with DW Threadgill)

2000–present Principal Investigator: Informatics Center for Mouse Neurogenetics, National Institutes of Health and National Science Foundation, Human Brain Project 2P20-DA21131, 1P20-MH62009, and IBN-0003982. TDC ~$5.4 M over 5 years (9.28.00–6.30.10, 32%)

2007–2010 Associated partner: German Network for Systems Genetics (GeNeSys). Helmholtz Centre for Infection Research. No funds

2010–present Associated partner of EU COST program: SYSGENET led by Prof Klaus Schughart (no funds)

2007–2011 Coinvestigator, subcontract: Gene Array Technology Center for Alcohol Research (the Rodent Gene Array Program) with Boris Tabakoff, University of Colorado Medical Center (08.01.07-07-31-11)

2005–2007 Coinvestigator: Development of Advanced Tools for Diagnosis and Triaging of Individuals Exposed to Select Pathogens, DOD/US W81XHW-05-01-0227

2005–2010 Coinvestigator: Dispersion Patterns for Retinal Neuroblasts, NEI R01EY011087-07A1. (B Reese, PI; RW Williams, coinvestigator)

2001–2006 Principal Investigator: INIA: Genotyping Core, National Institutes of Health 1U24AA13513. TDC ~$600,000 over 5 years (01.01.02–12.30.06)

2004–2007 Consultant: Conti Center, John Csernanski PI, Jim Cheverud, PI Project 5. Genetics of Schizophrenia-Related Traits in Mice, Washington University

2007–present Consultant: Consortium for Neuropsychiatric Phenomics–Coordinating Center (R Bilder PI, UCLA)

2004–2007 External Advisory Board: P20 Exploratory Transdisciplinary Imaging Genetics Center and Function BIRN (Steve Potkin, PI, University of California, Irvine)

2000–2004 Principal Investigator: Genetic and Epigenetic Control of Eye Growth National Institutes of Health R01 EY12991. TDC $200,00 year 1, $800,000 all years (9.1.00–7.31.04, 30%)

1999–2002 Principal Investigator: Biometric and Functional Studies of the Eye and Retina, National Institutes of Health R01 EY13070. TDC $150,000 year 1, $444,381 all years (12.01.99–11.30.02, 25%)

2001 Principal Investigator: High Resolution QTL Mapping in Mice. NIHLB Mammalian Genotyping Service (7.1.01). Grant funded 350,000 genotypes.

2001 Collaborator: Sleep Patterns During Infectious Disease, NIH NL70522. TDC $225,00 year 1, $1.11M all years (9.19.01–7.31.05; Linda Toth, PI; no funded effort)

2000–2005 Eye Domain Coinvestigator: Targeted Mutagenesis of the Mouse Genome and Neural Phenotypes, NIH U01-MH61971. TDC, $2,664,000/year (D Goldowitz PI, RW Williams co-PI; funding from 7.1.00–6.30.05, RW 5%)

2000 Principal Investigator: An Advanced Intercross for Mapping Multigenic Morphometric Traits in Mice: A Community QTL Mapping Resource, NIHLB Mammalian Genotyping Service. (1.1.00) Grant funded ~190,000 genotypes.

1996–2000 Principal Investigator: Genetic Control of Neuron Populations, NIH R01 NS35485. TDC ~$733,000 all years (07.1.96 to 07.31.00, 20%)

1987–2000 Principal Investigator: Growth of Optic Nerve Fibers, NIH R01 EY06627-10. TDC, $437,500 (12.1.95 to 05.30.00)

1991–1994 Principal Investigator: Development and Clonal Structure of the Mammalian Retina, NIH R01 EY 08868–03. TDC $260,518

1992–1996 Coinvestigator: Genetic Basis of Retinal Development, NIH R01 EY09586-03 (Dan Goldowitz, PI). TDC $505,991 (4.1.92 to 3.31.96)

Awards Loren D. Carlson Prize in Physiology, 1982–83

Fellow Award, Winter Conference on Brain Research, 1987

Excellence in Teaching Award, University of Tennessee, 1995

Distinguished Scientist Award, 2007, International Behavioural and Neural Genetics Society

Distinguished Mentor Award, 2011, by the UT Postdoctoral Research Association

Michael Gale Lecture: International Plant & Animal Genome Conference 2012

Patents Tissue Analyzer: Inventors Robert W. Williams, Pasko Rakic, U.S. Patent 4,932,044; filed November 4, 1988; issued June 5, 1990. See http://www.patents.ibm.com/claims?patent_number=4932044

Method for ultra-high resolution mapping of genes and determination of genetic networks among genes underlying phenotypic traits: Inventors David W. Threadgill (Chapel Hill NC) and Robert W. Williams (Memphis TN), U.S. Patent Application (EP 1543930) filed December 1, 2000.

Method for determining sensitivity to environmental toxins and susceptibility to Parkinson’s disease. Inventors: Richard Smeyne (Memphis TN) and Robert W. Williams (Memphis TN). U.S. Patent Application (EP Patent 1543930).

Invention Disclosure: P2P-R cooperates with the MAD2, BUB3 and p55CDC/cdc20 mitotic checkpoint-associated proteins. Inventors: Dr. Robert E. Scott and Robert W. Williams, Memphis TN

Symposia, Conferences, CONSORTIA

2012 Coorganizer with Martien Kas: International Neuroinformatics Coordinating Facility: Genetics Models of Psychiatric and Neurological Disease

Participant: Summer School “Neurogenetics. Unraveling behavior and brain mechanisms using modern technologies” Aug 20-25 http://school4.neurobiotech.ru/en/main_en Zvenigorod, Russia

2010 Coorganizer: Mouse Genetics 2011, Washington DC, June 22-26

Course Instructor: Aug 14-16: GeNeSys program Helmholtz Foundation, Braunschweig Germany

2009 Coorganizer: 1^st world-wide BXD scientific meeting (The BXD World), Braunschweig, (with Dr. Klaus Schughart). Nov 30 – Dec 1

Chair: INCF Digital Atlasing Taskforce meeting, Pilzen, Czech Republic (Sept 6, and 7)

2008* Organizer, International Neuroinformatics Congress, Stockholm, Workshop on Neurogenomics Meets Bioinformatics Meets Neuroinformatics (Sept 27-28)

Chair: SfN Task Force on Metadata and Linkage (with Jack Van Horn and David Van Essen). A follow-up to the PubMed Plus leadership conference

Lead organizer and chiar of Oversight Committee: INCF Workshop on Mouse and Rat Brain Atlasing Systems. March 5, UCLA

Organizer: UT-ORNL-UKY Bioinformatics Summit. Mar 28-30, Lake Barkley, KY

2007* Lead organizer: Consortium for Integrative and Translational Genomics, first meeting at the Oak Ridge National Laboratory, Sept 27-28

Neurogenetics Terminology workshop leader: Neuroscience Informatics Framework sponsored workshop held at the SfN 2007 meeting. Jointly organized with Daniel Gardner

Lead organizer: PubMed Plus leadership conference, sponsored by the SfN, David Van Essen (President), St. Louis, June 14–16

Lead organizer: International Neuroscience Coordinating Facility Workshop on Mouse and Rat Brain Atlasing Systems. Feb 13–14, Karolinska Institute, Stockholm

2006* Multistrain Mouse Testing Strategy Advisory Working Group, NIEHS, Research Triangle Park, July 21 (with John Pritchard)

Databasing the Brain, European Union workshop, Oslo, Norway, June 25–27

Symposium honoring Dr. Lorraine Flaherty, Genomics Institute, Wadsworth Center, Albany Medical College, Albany, New York, June 19

Neurofederatie Keynote Lecture, Endo-Neuro-Psychopharmacology (ENP) annual meeting, Amsterdam, June 7

Genes Meet Behavior, a joint symposium of the International Behavioral

Neuroscience Society and International Behavioural and Neural Genetics Society, Whistler, Canada, May 24

* Gordon Research Conference on Genes and Behavior, Ventura, California, Feb 11–17

* Blueprint LINC team member, NIH, Bethesda, March 30–31

2005* Human Brain Project Special Interest Social, presentation, SfN annual meeting, Washington, Nov 14

German Genetics Society, Genetics of Infection, symposium presentation, Braunschweig, Germany, Sept 22

Opening lecture, 4th Annual Complex Trait Consortium (CTC) meeting, Groningen, Netherlands, June 27

Mouse Models of Human Cancers Consortium Glioblastoma Meeting, St. Louis, June 16–18

International Behavioural and Neural Genetics Society annual meeting, Sitges, Spain, June 9–13

GENSAT Gene Selection Advisory Meeting, Bethesda, June 7

High Q Foundation Meeting on Microarrays and Discovery of Therapeutic Targets for Huntington’s Disease, New York, May 19

2nd Annual Experimental Neurogenetics of the Mouse workshop, faculty member, Memphis, May 16–24

Plenary lecture, Data Sharing in the Age of Discovery Science, Human Brain Project, NIH, Natcher Center, April 25

Collaborative Cross Organizing Committee meeting, ORNL, March 24–25

Gordon Research Conference on Quantitative Genetics and Genomics, Ventura, California, Feb 19–24

Mouse Models of Human Cancers Consortium Committee Meeting, Vanderbilt, Jan 19–21

1st International Imaging Genetics Conference, UC Irvine, Jan 17

2004 NIEHS Toxicogenomics Research Consortium meeting, Chapel Hill, Dec 6–8

Mouse Resources Roundtable Conference, The Jackson Laboratory, Nov 19–21

Biomedical Informatics Research Network (BIRN) Symposium speaker, Boston, Oct 13

Co-organizer, 3rd Annual Complex Trait Consortium meeting, Bar Harbor, July 6–9

Organizer, 10th International Summer School on Behavioral Neurogenetics, Memphis, August 8–15

2003 Lecturer, NIDA Addiction Studies Workshop for Journalists, Tucson, Dec 8

Mouse Atlas Workshop, NIMH Office of Neuroinformatics, Nov 18

American Society of Human Genetics symposium speaker, Los Angeles, Nov 5

Oregon Health Science symposium, Portland, Oct 9

Keynote, 9th International Summer School on Behavioral Neurogenetics, Aug 6–9, Toulouse, France

Joint Statistics Meeting symposium speaker, San Francisco, Aug 4–6

Mouse Initiatives V: Genomics of Complex System in Biomedical Research, July 31–Aug 2, www.jax.org/courses/mi5_03.html

Behavior Genetics Association Symposium, Chicago, June 27

2002 National Cancer Institute: Mouse Models of Human Cancers Consortium Roundtable, Newport Beach, Dec 11–13

Host and organizer, 1st Complex Trait Consortium Meeting, Memphis, May 2–4

Spring Brain Conference Plenary Session organizer: Identifying Genes Controlling Brain Structure and Behavior Using Complex Trait Analysis, Sedona, March 12–15

Chair, Bioinformatics 2002, Society for Neuroscience Short Course, Orlando, Nov 2

Instructor, 8th International Summer School on Behavioral Neurogenetics, Worcester, Aug 5–9

2001 Chair, International Complex Trait Consortium, Edinburgh, Scotland, Oct. 23

Sponsor and organizing committee, 4th Annual Meeting, International Behavioral and Neural Genetics Society, San Diego, Nov. 8–9

Workshop presentation, South-East Regional Meeting of the Society of Developmental Biology, Montreat NC, May 24

Invited speaker, Neuroinformatics Faces Functional Genomics symposium: Tools for Collaborative Analysis of Complex Neurodevelopmental and Behavioral Traits, Natcher Building, Bethesda, May 22

2000 NIAAA-sponsored QTL meeting, invited speaker, Washington, Dec 1 (organized by Robert Karp)

Human Brain Project: Neuroinformatics Satellite Symposium, invited participant, New Orleans, Nov 4 (presentation by GD Rosen)

1999 Co-organizer, Symposium on QTL Mapping, Behavior Genetics Association, Vancouver, July 1

Co-organizer and sponsor, Molecular Biology/Molecular Genetics of the Visual System, Center for Vision Research, Memphis, Mar 26

Gordon Research Conference in Quantitative Genetics, Ventura, Feb 14–19

1998 Lecturer, Short Course in Quantitative Neuroanatomy, Society for Neuroscience

Chair, American Association of Anatomists, Experimental Biology 98: Symposium on Quantitative Neurobiology and the Human Brain Project

Presentation, Chautauqua Short Course for college teachers in neuroscience

1997 Chair, American Association of Anatomists, Experimental Biology 97: Mini-symposium on Quantitative Neurobiology

1996–2000 Chair, Mouse Chromosome 7 Committee, International Mammalian Genome Society

1994–1996 Co-chair, Mouse Chromosome 7 Committee, International Mammalian Genome Society

1996 Co-organizer, Symposium on Cortical Development, Center for Neuroscience, University of Tennessee, Memphis, June

1991 Participant, The Jackson Laboratory, Short Course in Medical and Experimental Mammalian Genetics, Aug

1989 Organizer, Winter Brain Conference Workshop, Different Strategies of Brain Development, Jan (co-organizer Karl Herrup)

1985 Participant, Gordon Research Conference, Central Nervous System, Tilton School, New Hampshire, June

1983 Participant, Molecular Bases of Neuronal Development, Neuroscience Institute, Salk, La Jolla, Oct

1981 Participant, NATO Advanced Studies Institute, Formation of Neuronal Connections, Varenna, Italy, May

Visiting Scientist

2011 Sabbatical host to Dr. Klaus Schughart (HZI, Braunschweig, Germany) from Feb to May

2011 Host to Dr. Grant Morahan (U Western Australia) June

2007–2009 Visiting Professor, University of Utrecht (Prestige MSc Neuroscience Program hosted by Martien Kas)

2006 University of California, San Diego, March (Dr. Mark Ellisman)

2000–2002 Advisory Professor, Fudan University, Shanghai, China

2000–present Collaborator, with Profs. Tan and Gu, Nantong Medical College, Nantong, China

1997 Harvard University, Beth Israel Hospital, June (Dr. Glenn Rosen)

1996 California Institute of Technology, Aug (Drs. John Allman and Scott Fraser)

1993 The Jackson Laboratory, July (Dr. Muriel Davisson)

Scientific Boards

2008–present Chairman of the Board and Chief Scientific Officer, Varigenix, Inc., Memphis TN (a biotech startup with licenses from UTHSC and JAX to commercialize BXD strains of mice)

2009–present NIAAA Alcohol Research & Health Advisory Board Member, Editor of special issue on Genetics of Alcoholism (2012)

2007–present Chair: Oversight Committee of the INCF Digital Brain Atlasing Program

2006–2007 Scientific Advisory Board, Institute Clinique de la Souris, Strasbourg, France (Prof. Johan Auwerx)

2007–present Scientific Advisory Board, Conte Center: Genes Controlling Assembly and Function of Serotonin Systems, Randy Blakely and colleagues, Vanderbilt University

2002–2008 NIAAA INIA-Stress Scientific Advisory Board

2006–present Scientific Advisory Board, National Center for Microscopy and Imaging Research (NCMIR), UCSD, Mark Ellisman and colleagues

2006–2008 US Representative and Advisory Board member, International Neuroinformatics Coordinating Facility (INCF), Stockholm, Sweden

2004–2009 Scientific Advisory Board, Portland Alcohol Research Center, VAM (PARC) Portland

2004–2007 External Advisory Board, Exploratory Transdisciplinary Imaging Genetics Center (Steven Potkin, PI, UCI)

2001–2007 Genome Explorations Inc., Memphis

Invited Seminars, Workshops, and Lectures (Incomplete)

2012

Member: INCF Atlasing Workshop, Stockholm, Dec 13-14,

Plenary speaker: Swiss Laboratory Animal Sciences Association, Nov 19-20, Zurich

Speaker: University of Texas San Antonio, Oct 22

Speaker: Pigment Society, Deer Valley Utah, Sept 20

Speaker: Bioinformatics and Systems Biology: Short course, Patras Greece, July 3

Plenary speaker: Complex Trait Community 11th annual meeting; Multiscalar Analysis & Integration of Phenotypes: Power, Precision, and Priors, Paris, Jun 15

Speaker INCF Canadian Neuroinformatics, Atlases, Genomes, and Genetics: An International Tool Set to Help Understand Brain Function: Vancouver Canada, May 24

Speaker The Urban Child Institute lecture: March 22

Speaker University of Memphis: Bioinformatics seminar series: March 2

Speaker UT Board of Trustees Research presentation: Feb 28

Plenary speaker (Michael Gale Lecture) at the International Plant & Animal Genome Conference (San Diego, CA): Systems Genetics: Tools and Techniques to Link Genomes and Phenomes, Jan 16

2011

Speaker: Systems Genetics and Systems Neuroscience, University of Tennessee Health Science Center, Anatomy and Neurobiology, Nov 1

Presentation on GeneNetwork: Seth Grant and colleagues: Sanger Institute, UK, Oct 17

Speaker: Next-Generation sequencing technologies: Medical sequencing approaches for complex disorders. NIAAA Symposium, Sept 10, Washington DC

Speaker: Max-Planck Institute, Gottingen, Germany, July 4: Systems level neurogenetics using isogenic populations of immortal mice: a new collaborative landscape

Speaker: Systems Biology Summit, Richmond VA, June 16, Genetic Control of Gene Networks in Complex Traits

Speaker: BSEC Knoxville TN March 17

Speaker: Grand Rounds, University of Florida, Tallahassee, Feb 17

Instructor: University of Memphis, Bioinformatics Seminar, Feb 4

Speaker: Robust Systems Genetics for Physiologist. Department of Physiology, UTHSC, Jan 6

2010

Speaker: Sysgenet presentation on Mouse Reference Populations: Brussels, Belgium, Dec 6

Speaker: ASHG NIAAA meeting: Tightening the Genotype-Phenotype Gap. Title: Functional Analysis of Candidate Genes for Alcoholism in Humans, An introduction to reverse complex trait analysis using rodent reference populations, Washington, Nov 2

Speaker: Mouse Development, Genetics & Genomics, Cold Spring Harbor Laboratory, Oct 26-30

Speaker: The Genomics of Common Diseases 2010, Baylor, Oct 6-9

Speaker: Japan Node Neuroinformatics: Title: Massive Image Collections and Pivot: Sept 2

Workshop organizer: GeneNetwork workshop: Braunschweig, Germany, Aug 16-18

Plenary speaker: BSEC IEEE Symposium: Neuroinformatics: Building an integrative framework to study brain function, injury and regeneration. Oak Ridge, May 25

Speaker: Mouse models for human diseases (CASIMIR--European Commission meeting), London, May 19, London

Speaker: A whole genome sequence for DBA/2J and its use in reverse complex trait analysis. IBANGS Halifax, May 16

Speaker: Next-generation Sequencing and Its Impact on Bioinformatics. University of Memphis, Bioinformatics Program seminar, Feb 26

Speaker: Analysis of Complex Biological Networks using On-Line Resources. University of Memphis, Biology Program Seminar Series, Feb 25

Speaker: Systems genetics of transcription in brain: Analysis of covariance, causality, and addiction using the GeneNetwork platform. Gallo Center, UCSF, Nashville, Feb 17

Speaker: Systems genetics of gene transcription and disease susceptibility: What Genetic Reference Populations and online databases can do for your research program. University of Cincinnati, Jan 22

2009

Workshop: INCF Workshop on Animal Models in Genetics (Stockholm, Dec 13,14)

Workshop and speaker: BXD World meeting, Braunschweig, Nov 30-Dec2

Speaker: It’s the Network Stupid! Serotonin Symposium, Vanderbilt University, Nashville, Nov 11

Organizer and speaker: Workshop: Jump-Starting Genomics in Your Research Program. UTHSC, Nov 4 and Nov 10

Speaker: Genetics of Aging: Bandera Conference. UT San Antonio, Nathan Shock Center, Bandera, Oct 16

Speaker: Genetics of Neurodevelopmental Disorders: Use of New Mouse Models for High-Efficiency Translational Research. Children’s Foundation Research Center seminar, Le Bonheur Hospital, Memphis, Sep 21

Presenter: Genetics of Nicotine Addiction, Lung Cancer, and COPD. GeneNetwork: a web resource to study gene function and to evaluate candidate genes from GWAS studies. 1 hr. web seminar (hosted by J. Pollack), July 27

Speaker: International Society for Computational Biology, ISMB/ECCB, Highlights Special Session on eQTL, Stockholm, Sweden, Jun 28

Speaker: ICNF, Presentation on the Digital Brain Atlasing Program, Karolinska, Sweden, May 7

Speaker: EPFL, Lausanne, Switzerland, May 1

Speaker: International Waldenstrom’s Macroglobulinemia Foundation meeting, Memphis, April 20

Speaker: Buck Institute for Age Research, Novato, CA, Apr 20

Seminar: UTHSC Molecular Sciences: A practical guide to host genetics of infectious disease using mouse reference populations, Apr 13.

Seminar and workshop: University of Nebraska, Lincoln, Dept of Animal Science, Mar 30 - 31

Speaker and consultant: UCLA, Symposium on ultra high throughput biology, Feb 19 - 20

Two lectures and workshop: University of Utrecht, Rudolf Magnus Institute, Jan 5 - 9

2008

Speaker: Departments of Psychiatry and Neurology, VCU, Richmond, Dec 2

Speaker: NIDA Workforce Development, Philadelphia, Nov 16

Speaker: Departments of Pharmacology, University of Colorado, Denver, Richmond, Nov 3

Speaker: GeneSys Inaugural Meeting, Systems genetics of brain function and disease using the GeneNetwork platform, Edinburg, Oct 1-3

Presentation: CHDI, High Q Foundation, New York and Princeton Aug 18-19

Speaker: GeNeSys 2^nd Annual Meeting, Dresden Germany, Oct 24-25

Speaker and participant: Gordon Research Conference, Oxford UK, Aug 11-15

Participant: French-American Workshop on Multi-scale Modeling in Neuroscience, Bordeaux, June 8-10

Speaker: Eli Lilly and Co, May 22

Moderator: Genes, Brain, and Behavior: Symposium on Methodological considerations in the genetical genomics of complex traits, Portland OR, May 7

Speaker: Seminar, Northwestern University, Chicago, Apr 14

Speaker: Seminar and 1 day workshop leader, Dalhousie University, Department of Psychology. Halifax, Canada, Apr 4–5

Speaker: Understanding the Brain through Informatics, INCF @ Karolinska (The Neuroinformatics of Gene Expression: Collaborative Web Classes and Labs), Washington DC, Mar 7

Speaker: Université de Lausanne, UNIL-EPFL mini-symposium on mouse resources to map complex traits (Collaborative Web Software Systems for Integrative Genomics), Lausanne, Switzerland, Feb 26

Speaker: University of Iowa, Department of Human Genetics seminar series, Cedar Rapids, Feb 19

Speaker: University of Alabama, Birmingham, Department of Molecular Biology seminar series (Genetics of Gene Expression in Brain and Kidney: Problems and Prospects) Feb 15

Speaker: Mouse Models of Human Cancers Consortium Steering Committee satellite conference on the Collaborative Cross, Washington DC, Jan 7

2007

Speaker: 11st Annual Meeting of GeneSys, Dresden, Germany, Dec 4–5

Co-organizer, New Directions in Data Mining: Synergies between Databases and Online Journal Publications, Society for Neuroscience workshop, San Diego, Nov 7

Speaker: California Nanosystems Institute, UCLA, Sept 18

Speaker: Riken Brain Science Institute, Tokyo, Japan, Sept 13

Speaker: Neuro2007 Special Session on International Collaborations in Neuroinformatics (Large Scale Analysis of Gene Expression in the CNS: A Rapidly Expanding Collaborative Landscape), Yokohama, Japan, Sept 10

Keynote speaker: 2nd Annual Department of Genetics Retreat, University of Alabama, Birmingham, Sept 6

Participant: International Neuroscience Coordinating Facility Workshop on Portals in Neuroinformatics, Karolinska Institute, Stockholm, Sweden, Sept 3–4

Seminar: Institute for Systems Biology, Seattle, July 31

Seminar: Allen Institute for Brain Science, Seattle, July 30

Workshop: High Q Foundation, New York, July 17–18

Seminar: Vanderbilt University, Nashville, July 2

Organizer: SfN PubMed Plus Leadership Conference, Washington University, St. Louis, June 17–19

NIDA Workshop, Addiction, Microarrays, and Gene Discovery, May 30-June 1

Seminar: University of Wageningen, Netherlands, May 24

Distinguished Investigator award presentation: IBANGS, Doorwerth, Netherlands, May 23

Seminar: Genetics of Gene Expression in the Mouse Eye, GSF, Seminars on Genome Research, Institute for the Environment and Health, Munich, Germany, May 15

Keynote lecture: 5th Annual Dean’s Symposium, UTHSC College of Medicine, (Personalized, Predictive and Preventive Health Care: How the Mouse Will Make It Happen), April 13

Co-organizer: UT-UK-ORNL Bioinformatics Summit, Paris Landing, TN, April 13–15

Karolinska Institute, keynote seminar, Feb 15

Organizer: 1st International Neuroscience Coordinating Facility Workshop on Mouse and Rat Brain Digital Atlasing Systems, Karolinska Institute, Stockholm, Sweden, Feb 13–14

Scripps Florida, seminar series presentation, Jupiter, Florida, Jan 9

2006

Panelist: Society for Scholarly Publishing: Washington DC, Nov 13

Workshop presentation: Application of Pharmacogenomics to Drug Development and Therapy, 14th ISSX Meeting, Puerto Rico, Short Course presentation, Oct 22

Speaker: IIIe cycle, Lausanne Genome Day, Lausanne, Switzerland, Oct 4–5

Speaker: Unveiling Genome-Wide DNA Variation in 15 Diverse Mouse Strains: NIEHS, Sept 26

Speaker: West Virginia University Eye Institute, seminar, Sept 20

Instructor: Route 28 Meeting Adult Neurogenesis Course, Fraueninsel, Germany, Sept 2–8

Instructor: Plant Genome Short Course, Boston, Aug 1–3

Speaker: Eli Lilly Integrative Biology Research Group, Lectures, Indianapolis, June 12–13

Speaker: Workshop on Systems Genetics, University of Utrecht, Netherlands, June 6

Speaker: ARVO mini symposium, Ft. Lauderdale, May 3

Speaker: UT-UK-ORNL Bioinformatics Summit, Lake Barkley KY, April 22

Speaker: Society for Neuroscience Chapter lecture, University of Mississippi Medical Center, April 11

Speaker: SERCEB Infectious Disease Meeting, New York City, March 26–28

Speaker: Cold Spring Harbor, Systems Biology lecture, March 25

Speaker: Illumina Corp, La Jolla, March 15

Speaker: Cold Spring Harbor Laboratory, weekly seminar, Feb 24

Speaker: UCSB Engineering, seminar in imaging and genetics, Santa Barbara, Feb 14

2005

University of Texas at Austin, Department of Neurobiology, Nov 28

University of Colorado, Boulder, Institute for Behavior Genetics, Oct 14

Oxford University, Wellcome Trust, July 1

Lecture, Universidad Autonoma de Barcelona, Spain, June 8

SERCEB Annual Meeting seminar, Chapel Hill, May 5

NIEHS Seminar: Systems Genetics, Research Triangle Park, May 2

VA MC Memphis Seminar, March 11

UTHSC Pathogenesis Center Chalk talk, March 2

NIDA, Molecular Anatomy: Synergy by Informatics 2, Feb 15

UTHSC Department of Pharmacology, Genetic Modulation of Transcripts, Cells, and Behavior: Or, How I learned to stop worrying and love complexity, Feb 9

St. Jude Children’s Hospital Danny Thomas Lecture Series: Genetic Variation in Transcriptional Activity, Jan 7

2004

Vanderbilt University: Seminar in Integrative Genomics, Nov 30

Department of Neuroscience, Vrije Universiteit, Amsterdam, Aug 27

Groningen Universiteit, Department of Stem Cell Biology, Aug 26

Route 28 Conference, Fraueninsel, Germany, Aug 23

Czech National Academy of Science, Prague, Aug 20

IGBMC Illkirch, France, Aug 18

Tübingen Neurocolloquium, Germany, May 27

GBF Braunschweig, Germany, May 25

Max-Delbrück-Centrum, Berlin-Buch, Germany, May 24

University of Kentucky, Lexington, April

MGH/MIT Harvard, Feb 25

2003

Yale University, Department of Genetics, Dec 16

University of Chicago, Committee on Genetics, Dec 2

Department of Neuroscience, Vanderbilt University, Nashville, Oct 22

Nathan Kline Institute, New York, Oct 17

Special lecture: 9^th international summer school on behavioral neurogenetics, Toulouse, Aug 5

Mouse Initiatives V meeting, Jackson Laboratory, Aug 1

Purdue University, June 19

Human Brain Project, Bethesda, Natcher Center, http://videocast.nih.gov/ram/brain051203.ram May 12

Pennsylvania State University, Genomics Spring Fever: Complex Genetics of Brain and Behavior, May 2, 3

Wadsworth Center, Albany, New York, Feb 2003

St Jude Children’s Research Hospital: Dissecting Transcriptional Networks (Affymetrix Memphis User Group Meeting), Feb 6

University of Toronto, Mt. Sinai Hospital, Feb 4

2002

Wake Forest University, Drug Addiction Workshop for Journalists, Tucson, Dec

Department of Physiology, University of California, Davis, Dec

University of Memphis, Sept 13

Wilmer Eye Institute, Johns Hopkins University, The Complex Genetics of Eye and Brain Development: Gene Network Analysis Using Microarrays, Aug 29

University of Tübingen, Neurobiology of Vision, Germany, July 9–10

King’s College, London, July 7

University of Alabama, Section of Statistical Genetics, June 17

New England College of Optometry, Boston, Apr 25

Southern Illinois University, School of Medicine, Mar 15

University of Tennessee Health Science Center, Grand Rounds in Pediatrics, Mar 13

Neuroinformatics, 35th Annual Winter Conference on Brain Research, Jan 27

2001

New Mouse Behavioral Phenotyping Assays: Half Moon Bay CA, Dec

Society for Developmental Biology, Southeast Regional Meeting, Workshop presentation, May

Human Brain Project Conference, NIH, Natcher Center, May

Cornell University, Departments of Psychology and Neuroscience, Apr

Stanford University, Apr 12

University of Alabama, Birmingham, Department of Medicine, Mar 21

MCP-Hahneman, Department of Neuroscience, Mar 14

UCLA, Neuroscience Grand Rounds, Feb 7

2000

Shanghai Medical University (Fudan), Department of Histology and Embryology, Nov

Beijing Medical University, Department of Histology and Embryology, Nov

Nantong Medical College, Neuroscience Institute, Nov

University of North Carolina, Chapel Hill, Department of Genetics, Oct 23

University of Tennessee, Biomedical Engineering Joint Program, Sept 14

Cold Spring Harbor, Banbury Center, August 28

UCSB Neuroscience Research Institute, Quantitative Genetics of CNS Development: View from the Trailhead, Santa Barbara, May 26

State University of New York at Buffalo, Roswell Park Cancer Institute, May 8

1999 and earlier

Drexel University, Department of Biomedical Engineering, Nov 2, 1999

University of Michigan, Department of Genetics, Oct 5, 1999

Vanderbilt University, Vision Research Center: The genetics of brain evolution, Nashville, May 7, 1999

UCSB Neuroscience Research Institute, Santa Barbara, Feb 16, 1999

Case Western Reserve University, Department of Neurosciences, Cleveland, Jan 21, 1999

VA Medical Center, New Power of Forward Genetics: Analysis of Polygenic Traits that Control Disease and Development, Memphis, Nov 20, 1998

Case Western Reserve University, Depts. of Ophthalmology and Genetics, Cleveland, Nov 18, 1998

Yale University, Department of Neuroanatomy, New Haven, July 1998

University of Southern California, Department of Anatomy & Neurobiology, June 1998

UCSD Department of Neuroscience, San Diego, June 1998

Pasteur Institute, Paris, France, Oct 1997

Mount Sinai Medical School, Department of Neuroscience, New York, NY, June 1997

Harvard University, Beth Israel Deaconess, Department of Neurology, June 1997

California Institute of Technology, Pasadena, Nov. 1995

Conference on Brain Evolution, Ithaca, New York, June 1995

National Cancer Institute (Steve O'Brien), Frederick, Maryland, June 9, 1995

The Jackson Lab Bioinformatics Group, Bar Harbor Maine, July 1993

25th Annual Meeting of the Biomedical Engineering Society, Memphis, Oct 24, 1993

University of Utah, Department of Biology, Salt Lake City, Jan. 1989

Winter Conference for Brain Research, Snowbird, Utah, Jan. 1989

University of Texas, Houston, Department of Neurobiology and Anatomy, Dec 1988

SUNY, Stony Brook, Department of Neurobiology, Oct 1988

Winter Conference for Brain Research, Vail, Colorado, Jan 1987

Conference on the Development of the Vertebrate Retina, Ithaca, New York, June 1987

New York University, Department of Physiology and Neuroscience, New York, Oct 1986

University of Rochester, Center for Visual Sciences, Rochester, New York, Apr 1986

Rush-Presbyterian-St. Luke's Medical Center, Chicago, Nov 1986

University of California, Davis, Department of Psychology, June 1985

Stanford University, Department of Neurobiology, June 1985

SUNY Department of Biological Sciences, Albany, New York, Jan 1984

REVIEWER FOR

Anatomy and Embryology, Behavior Genetics, Brain Behavior and Evolution, Behavioral Brain Sciences, Cerebral Cortex, Current Biology, Developmental Biology, European Journal of Neuroscience, Experimental Eye Research, Gene Expression Patterns, Genesis, Genomics, Investigative Ophthalmology and Vision Science, Journal of Comparative Neurology, Journal of Heredity, Journal of Neurobiology, Journal of Neurochemistry, Journal of Neurophysiology, Journal of Neuroscience, Journal of Neuroscience Methods, Molecular Vision, Nature Genetics, Neuroscience, Optometry and Vision Research, Proceedings of the National Academy of Science, Science, Visual Neuroscience, Vision Research

EDITORIAL BOARDS/COMMITEES

2008–present Editor-in-Chief: Frontiers in Neurogenomics

2012–2016 Editorial board: Mammalian Genome

20010–2011 Editor: Special Issue on the Genetics and Alcoholism: Alcohol Research Current Reviews

2007–2010 Editorial advisory board: Alcohol Research & Health (NIAAA)

2007–present Associate editor: Frontiers in Neuroinformatics (CRC Press)

2005–2008 Member: Executive Committee of the Collaborative Cross

2006–2008 NeuroCommons Working Group (Science Commons, Creative Commons); chaired by John Wilbanks

2006–2008 US Representative and member of the Executive Committee of the International Neuroinformatics Coordinating Facility (INCF, Stockholm)

2006–2008 Advisory board member of the NIH Blueprint Neuroinformatic Framework group (PI Dan Gardner)

2004–2005 President: International Behavioural and Neural Genetics Society (executive committee from 2003–2006)

2004–2010 Chair (2004-2008) and member: Neuroinformatics Committee, Society for Neuroscience

2004–2005 Member: International Mouse Resource Centers Roundtable

2004–2009 Elected Member: International Committee on Standardized Genetic Nomenclature for Mice

2003–2005 Member: Committee on Animals in Research, Society for Neuroscience

2004–2005 Member: Science Educator Award Selection Committee, SfN

2006–present Journal of Biomedical Discovery and Collaboration (www.j-biomed-discovery.com)

2005-present Alcohol: editorial board member

2002–present Genes, Brain & Behavior: editorial board member

2002–present Neuroinformatics: editorial board member

2002 Gene Expression Patterns: board member

2001–present BioMed Central Neuroscience: core reviewer board member www.biomedcentral.com/info/biologyeditorial.asp

2001–present Behavior Genetics: editorial board member

2000 Behavior Genetics: guest editor

1995–present Molecular Vision: board member

1993–present European Journal of Anatomy: board member

GRANT PROPOSAL REVIEWS

2011-2012 Member, NIDA P30 Centers of Excellence review panel ZDA1 EXL-T (03) 1

2008–2010 Chair, Molecular Neurogenetics (MNG) Study Section

2009 Review for NWO: Netherlands Organisation for Scientific Research (TOP-Chemistry in relation to biological and medical sciences 2008)

2007* Chair, MDCN-K(51) Special Emphasis Panel, NIH IRG: Neuroinformatics and Neuroimaging, July 18–19

2007* Special Emphasis, NIH IRG: Conte Center: ZMH1-ERB-S-03, Feb 26

2006* Review Member, NIH IRG: Neuroinformatics and Neuroimaging: ZRG1 MDCN-K51 S, June 21

2005* ZRG1 MDCN-K (92), Neurogenetics

2004* Chair NIH ZRG1 IDM-K (04) Genetics of Viral Pathogenesis, Mar 15

2004–2005* Chair and member NIH MDCN-G (55) Human Brain Project

2004* American Institute of Biological Sciences: Disease Prevention & Epidemiology review panel, USAMRMC

2003* MRC Program Review, July 2003

2002* BISTI SS-E(51) and Human Brain Project SS-E(95), Oct 22–25

2002* MCDN Special Review panel ZRG1 SSS-P 09 S, Sept 6

2002* NEI Special Review panel ZEY1 VSN 06 R, Aug

2002* Science Foundation Ireland reviewer, July

2002* NIH Mammalian Genetics IRG, June 2002

2002–2004* Mammalian Genotyping Advisory Panel, Apr 2002, 2003, 2004

2002* NIH Special Review, Feb 8

2001* NIH Innovations in Biomedical Science Tech ZRG1 SSS-7 21B, Nov 6

2001* NIH BISTI Panel Reviewer ZRG1 SSS-E01, July 1, Nov

2001* NIH CSR Reviewer ZRG1FCN-3 01 BISTI, July 19

2001* NIH Special Emphasis Panel ZRG1 SSS-R (02), July 2

2001* NIEHS Review Panel (Inbred Rodents) ES-01-05, June 29

2001* Medical Research Council (UK) Strategic Grants Reviewer

2000* Fonds voor Weterschappelijk Onderzoek - Vlaanderen (Belgian NIH)

2000* NIH VISB Study Section Ad Hoc Member, June

2000* NIMH Special Emphasis Panel Reviewer (Gene Array RFA MH-00-002, July

2000* UT System-wide Advisory Panel: Biotechnology and Biological Sciences Review, July

1999* NIH VISC Study Section Ad Hoc Member, Feb

1999* NIMH Center Grant Reviewer

1999* NIMH Special Emphasis Panel Reviewer ZMH1 BRB-I

1998* Department of Veterans Affairs: Merit Review Consultant

1995* Consultant to NIH VIS-B Study Section

Teaching

2011-2012 UTHSC Pathology residents lecture

2010 GeNeSys workshop on systems genetics. HZI Braunschweig, Germany (14 student participants): 16 contact hours. Aug 16–18.

2008–present UTHSC, Behavioral Neuroscience (ANAT 821), graduate student seminar in neurogenetics

2007–present UTHSC, Bioinformatics Special Topics Course (Biochem 920), graduate student seminar in genomics

2011–present UTHSC, Next Generation Sequence User’s Group: monthly 3 hour informal training and seminar series on genomics (sponsored by the CITG and RW Williams)

2007–present University of Memphis, Research Seminars in Bioinformatics (BINF 7980). Four 90-minute lectures (Feb and March)

2006* The Jackson Laboratory: Short Course in Vision Research

NSF Plant Microarray Short Course, instructor, Boston, Aug 1–3

Third Annual Experimental Neurogenetics of the Mouse workshop, Memphis, May 16–24

Cold Spring Harbor, Systems Biology Short Course, March 23

2004–2006 Faculty, Annual Experimental Neurogenetics of the Mouse Workshop, 15–20 students/year (8-day short course at UTHSC and the University of Memphis)

2005 Course director: NIEHS Short Course on Systems Genetics (offered twice) at NIEHS main campus, Sept 7–8

2005–present NS 825: Graduate School, Developmental and Molecular Neurobiology lecturer (fall)

2005–present NS212: School of Medicine, Neuroscience lecturer (fall)

2005* Society for Neuroscience, Meet the Expert Series leader, Microarray analysis, SfN annual meeting, Washington, Nov 12

Memphis City Schools Middle/Secondary Science In-Service Session 15: The Human Genome, August 11 (2 sessions)

2001–present Course member and co-director: International Summer School in Behavioral Neurogenetics (Behavioral Neurogenetics Initiative). Annual course (one week, 15 to 30 grad and postdoctoral students/year)

2001–2003 Course co-director: Neuroscience Seminar Series (NS8): a graduate level course, 15–20 contact hours, ~15 students/year.

1992–2003 Course director: Morphological Neuroscience (NS822): a graduate level course, ~40 contact hours, ~ 8 students/year.

2003–2004 Lecturer: Comparative Medicine CM712, UTHSC: Mouse Genetics (graduate level)

2003–present Lecturer: Bioinformatics, University of Memphis (graduate level)

2000–2002 Lecturer and Lab: Medical Neuroanatomy (M): ~20 contact hours, Lectures in CNS development. 150 students/year.

2002–2003 Short Course director: Society of Neuroscience, Bioinformatics

2003 Course co-director: Memphis Microarray Short Course, June 4–12

2002* Lecturer: NIDA Addiction Studies Workshop for Journalists, Tucson, Dec 8

2002* Short Course director: UAB Birmingham: Design and Analysis of Recombinant Inbred Strain Experiments, all day course, June 18

1998* Course Lecturer: Short Course in Quantitative Neuroanatomy, Society for Neuroscience, Los Angeles

1994–1996* Course director: Seminars in Neuroscience (NS821): Graduate level. 40 contact hours, 10 to 15 students per year

1995* SGAEC Excellence in Teaching Award, University of Tennessee (for NS822)

1995* Short Course in Genetic Testing: Memphis city schools service training for science high school teachers. 15 high school science teachers.

1994–1995* Human and Mouse Genetics: City Labs program for high school science teachers. 10 to 12 high school science teachers.

1990–1996* Medical Embryology, University of Tennessee, 8 lectures on development of cardiovascular, urogenital, and gastrointestinal systems. 8 lecture hours, ~120 first-year medical students.

1983–1989* Neuroscience-Neuroanatomy laboratory instructor, Yale University. Team-taught first-year medical students, roughly 20 contact hours, 25 students per lab.

1982* Course Director: Sensory Psychology, University of California, Davis. 25 junior and senior psychology majors.

Administrative

2001 – 2011 Founding Director: Complex Trait Community

2010 – 2012 Memphis Research Consortium: Task force member

2007 – present Scientific Director: Center for Integrative and Translational Genomics, UTHSC

2000 – 2008 Director (2007-2008) and codirector: UT Center of Excellence in Genomics and Bioinformatics

2011–2012 Member: Search Committee: Statistical Genetics, UTHSC Preventive Med

2010 – 2011 Member: Search Committee; Executive Dean of UTHSC

2010 – 2011 Member: Search Committee; Vice Chancellor for Research. UTHSC

2003 – 2009 Member: Health Science Center Information Technology Committee

2004 – present Member: Biomedical Informatics Research Network (Mouse BIRN)

2001 – present The Center for Vision Research, UTHSC

2005 – 2006 Member: Search Committee; Executive Dean of UT Medical Colleges

2002 University of Tennessee Research Foundation Task Force Subcommittee (T. Ballard, chair)

2001 – 2002 Section Coordinator for the Visual and Auditory Systems research section, Center for Neuroscience, UTHSC

2002 – 2004 Member: Computing and Telecommunications Committee of the UTHSC Faculty Senate (C. Russell, chair). Chair: Research Computing subcommittee, UTHSC

1999 – present Tennessee Mouse Genome Consortium, Scientific Steering Committee

1999 – 2001 Member: Promotion and Tenure Committee, Department of Anatomy and Neurobiology, UTHSC

1999 – present Scientific Advisory Board: Tennessee Mouse Genome Consortium

1998 Chair: Promotion and Tenure Committee, Department of Anatomy and Neurobiology, UTHSC

1998 – present Member: Department of Anatomy and Neurobiology Space and Research Committee, UTHSC

1997 – present Member: Department of Anatomy and Neurobiology Advisory Council, UTHSC

1997 – present Member: Graduate Health Sciences Electronic Thesis and Dissertation Advisory Committee, UTHSC

1997 – 1999 Member: Center for Neuroscience: Graduate Student Recruitment Committee, UTHSC

1990 – 1997 Member: University of Tennessee, Graduate Health Science School, Policy Subcommittee

1995 – 1997 Member: University of Tennessee, Graduate Health Science School, Graduate Studies Council

1990 – 1994 Member, University of Tennessee library committee member

1990 – 1996 Member: Department of Anatomy and Neurobiology: Graduate student admissions and policy committee

Graduate Students, Postdoctoral Fellows, ADVISEEs

Nourtan Abdeltawab Ph.D. in 2010 (Molecular Biology with Malak Kotb)

Adrienne Adler 2011-2012: Now M.D. Ph.D. student at Wake Forest University

Vida Abedi MS. In 2011 Engineering (with Mohammed Yeasin, U of Memphis)

Megan Mulligan, Ph.D. Postdoctoral fellow (May 2009 – present)

Khyobeni Mozhui Ph.D. in 2009 (Now a postdoctoral fellow with RWW)

Vida Abedi M.S., April 2011, Department of Electrical Engineering, U Memphis

Daniel Ciobanu, Ph.D. Postdoctoral fellow with RWW from 2007–Jan 2009. Now Assistant Professor, University of Nebraska, Lincoln

Collin Hovinga, Pharm.D. K12 CTSI-sponsored research mentor. Collin is Director of Research at PSS/Dell Children’s Hospital, Austin TX(2011-present)

Jasgit (Jesse) C. Sachdev M.D. K12 CTSI-sponsored research mentor. Jesse is an assistant professor in the Department of Medicine at UTHSC (2008-2010)

John A. Capra, Ph.D. Undergraduate bioinformatics summer student. Ph.D. Princeton 2008, Now postdoctoral fellow, Gladstone UCSF

Manjunatha N. Jagalur Ph.D. candidate, computer science. Primary mentor is Dr. David Kulp at University of Massachusetts, Amherst. My role is as a joint Ph.D. advisor.

Richelle C. Strom Ph.D. in 1999, University of Tennessee. Postdoctoral Fellow with Prof. Ruben Adler, Johns Hopkins University

Dennis S. Rice Ph.D. in 1996, University of Tennessee. Director of Ophthalmology at Lexicon Pharmaceuticals, The Woodlands, TX

Dale Hogan, Ph.D. NRSA NEI Postdoctoral fellow, 1992–1996; Research Associate with Mark Opp, Department of Psychiatry and Behavior, University of Texas Medical Branch, Galveston

Guomin Zhou, M.D., Ph.D. Research fellow, 1997–1999; Chairman and Professor of Histology and Embryology, Fudan University, Shanghai, China

Lu Lu, M.D. Research fellow, 1999–2001; Associate Professor, UTHSC; Professor in Histology and Embryology, Medical University of Nantong, China

David C. Airey, Ph.D. NRSA, NEI Postdoctoral fellow, April 1999–July 2001; Assistant Professor, Vanderbilt University

Elissa J. Chesler, Ph.D. Research fellow, July 2002–2005; Assistant Professor, The Jackson Laboratory

Jeremy Peirce, Ph.D. Research fellow, June 2003–2006; staff scientist at Illumina Inc. Author of Attention-Deficit/Hyperactivity Disorder (2008) by Chelsea House Publishers

Anand Kulkarni, M.D. Research fellow, Nov 1999–Nov 2000; pathologist, UTHSC

Siming Shou, Ph.D. Postdoctoral fellow, September 2001–2002

E. Gilissen, Ph.D. Postdoctoral fellow (1996–1997, with John Allman at Caltech); faculty Ph.D. of paleontology, University of the Witwassersrand, South Africa

Kathryn Ryder M.D. Dissertation, Yale University School of Medicine, 1987; associate professor, Department of Medicine, UTHSC

Michael Borodkin M.D. dissertation, Yale University School of Medicine, 1989

Ph.D. and M.S. Committees (Mentored by RWW unless noted)

Sumana Chintalapudi Ph.D. candidate, UTHSC (mentored by Monica Jablonski)

Neha Mehta Ph.D. candidate, Northwestern University, 2012–present (mentored by E. Redei)

Ashutosh Pandey Ph.D. candidate, UTHSC (2011–present)

Felecia D. Emery Ph.D. candidate, UTHSC (2011–present, mentored by Mark Miller)

Suresh Kannan Ph.D. candidate, Univ Dresden, 2012–present (mentored by G. Kempermann)

Khyobeni Mozhui Ph.D. in Neuroscience, UTHSC, May 2009

Rick Laughlin Ph.D. candidate, UCLA 2008

Nourtan Adeltawab Ph.D. candidate, UTHSC 2008

C. J. Jeon Ph.D. in Neuroscience, UTHSC 1992

Angela R. Howe Ph.D. in Neuroscience, UTHSC 1994

Vandana Menon Ph.D. in Physiology, UTHSC 1996

Qing Tang Ph.D. in Anatomy and Neurobiology, UTHSC June 1996

Loren Martin Ph.D. in Anatomy and Neurobiology, UTHSC Nov 2000

Toya H. Kimble Ph.D. in Anatomy and Neurobiology, UTHSC Jan 2003

Félix Vázquez-Chona Ph.D. in Anatomy and Neurobiology, UTHSC 2006

Kathryn Ryder, M.D. M.S. in Epidemiology, UTHSC 2002

A. Iannaccone, M.D. M.S. in Epidemiology, UTHSC 2002

ORIGINAL PAPERS

A substantial number of these papers are available online at www.nervenet.org.

1. Williams RW, Chalupa LM (1982) Prenatal development of retinocollicular projections in the cat: An anterograde tracer transport study. Journal of Neuroscience 2:604–622 Revised and updated text at <http://nervenet.org/papers/SC1982.html>.

2. Stone, J, Rapaport DH, Williams RW, Chalupa LM (1982) Uniformity of cell distribution in the ganglion cell layer of prenatal cat retina: Implications for mechanisms of retinal development. Developmental Brain Research 2: 231–242

3. Williams RW, Bastiani MJ, Chalupa LM (1983) Loss of axons in the cat optic nerve following fetal unilateral enucleation: An electron microscopic analysis. Journal of Neuroscience 3: 133–144

4. Williams RW, Chalupa LM (1983) An analysis of axon caliber within the optic nerve of the cat: Evidence of size groupings and regional organization. Journal of Neuroscience 3: 1554–1564

5. Williams RW, Chalupa LM (1983) Development of the retinal pathway to the pretectum of the cat. Neuroscience 10: 1249–1267

6. Chalupa LM, Williams RW, Hughes MJ (1983) Visual properties of neurons in the tectorecipient zone of the cat’s lateral posterior-pulvinar complex: A comparison with the superior colliculus. Journal of Neuroscience 3: 2587–2596

7. Chalupa, LM, Williams RW (1984) Organization of the cat’s lateral geniculate nucleus following interruption of prenatal binocular competition. Human Neurobiology 3: 103–107

8. Chalupa LM, Williams RW, Henderson Z (1984) Binocular interaction in the fetal cat regulates the size of the ganglion cell population. Neuroscience 12: 1139–1146 <nervenet.org/papers/SC1982.html>

9. Williams RW, Rakic P (1985) Dispersion of growing axons within the optic nerve of the embryonic monkey. Proceedings of the National Academy of Science USA 82: 3906–3910 <nervenet.org/papers/dispersion85.html>

10. Williams RW, Crabtree, JW, Chalupa LM, Spear PD, Kornguth SE (1985) Selectivity of antibody-mediated destruction of retinal ganglion cell axons. Brain Research 336: 57–66

11. Williams RW, Bastiani MJ, Lia B, Chalupa LM (1986) Growth cones, dying axons, and developmental fluctuations in the fiber population of the cat’s optic nerve. Journal of Comparative Neurology 246: 32–69 <nervenet.org/papers/Cat86.html>.

12. Lia B, Williams RW, Chalupa LM (1986) Does axonal branching contribute to the overproduction of optic nerve fibers during early development of the cat’s visual system. Developmental Brain Research 25:296–301

13. Lia B, Williams RW, Chalupa LM (1987) Formation of retinal ganglion cell topography during prenatal development. Science 236:848–851

14. Williams RW, Rakic P (1988) Elimination of neurons from the lateral geniculate nucleus of rhesus monkeys during development. Journal of Comparative Neurology 272:424–436 <nervenet.org/papers/RHESUS_LGN.html>

15. Williams RW, Rakic P (1988) Three-dimensional counting: An accurate and direct method to estimate cell numbers in sectioned material. Journal of Comparative Neurology 278:344–352 <nervenet.org/papers/3DCounting.html>

16. Wikler KC, Williams RW, Rakic P (1990) Photoreceptor mosaic: Number and distribution of rods and cones in the rhesus monkey retina. Journal of Comparative Neurology:297:499–508

17. Williams RW, Borodkin M, Rakic P (1991) Growth cone distribution patterns in the optic nerve of fetal monkeys: Implications for mechanisms of axonal guidance. Journal of Neuroscience 11: 1081–1094 <nervenet.org/papers/GC91.html>

18. Rakic, P., Suñer I, Williams RW (1991) A novel cytoarchitectonic area induced experimentally within the primate visual cortex. Proceedings of the National Academy of Science USA 88: 2083–2087

19. Williams RW (1991) The human retina has a cone-enriched rim. Visual Neuroscience 6:403–406

20. Williams RW, Goldowitz D (1992) Structure of clonal and polyclonal cell arrays in chimeric mouse retina. Proceedings of the National Academy of Science USA 89: 1184–1188 (PMC48413)

21. Williams RW, Cavada C, Reinoso-Suárez F (1993) Rapid evolution of the visual system: A cellular assay of the retina and dorsal lateral geniculate nucleus of the Spanish wildcat and the domestic cat. Journal of Neuroscience 13:208–228 <nervenet.org /papers/wildcat.html>

22. Williams RW, Hogan D, Garraghty PE (1994) Target recognition and visual maps in the thalamus of achiasmatic mutant dogs. Nature 367:637–639; and see New and Views article by R.W. Guillery, Nature 367:597–598 <nervenet.org/papers/DOGLGNNature.html>

23. Williams RW (1994) The Portable Dictionary of the Mouse Genome: A personal database for gene mapping and molecular biology. Mammalian Genome 5:372-375. See <nervenet.org/main/dictionary.html>. This short paper’s main claim to fame is that it is the earliest publication in PubMed to list a web site URL (“http://”) in the abstract.

24. Brilliant MB, Williams RW, Conti C, Angel J, Holdener BC (1994) Mouse chromosome 7. Mammalian Genome 5: S104–S123

25. Dell'Osso LF, Williams RW (1995) Ocular motor abnormalities in achiasmatic mutant Belgian sheepdogs: Unyoked eye movements in a mammal. Vision Research: 35:109–116

26. Scheetz AJ, Williams RW, Dubin MW (1995) Severity of ganglion cell death during early postnatal development is modulated by neuronal activity and binocular competition. Visual Neuroscience 12:605–610

27. Hogan D, Williams RW (1995) Analysis of the retinas and optic nerves of achiasmatic Belgian sheepdogs. Journal of Comparative Neurology: 352:367–380

28. Rice DS, Williams RW, Goldowitz D (1995) Genetic control of retinal projections in inbred strains of albino mice. Journal of Comparative Neurology 354: 459–469

29. Rice DS, Williams RW, Harris B, Bailey PW, Davisson MT, Goldowitz D (1995) Mapping the Bst mutation on mouse Chromosome 16: A model for human optic atrophy. Mammalian Genome 6:546–548 <nervenet.org/papers/Bst2.html>

30. Hogan D, Garraghty PE, Williams RW (1996) Lamination and visual topography in the lateral geniculate nucleus of normal and achiasmatic dogs. European Journal of Anatomy 1:3–11

31. Ezer AD, Williams RW, Goldowitz D (1996) Arbitrary primer PCR of dog DNA with estimates of average heterozygosity. Journal of Heredity 87:450–455

32. Goldowitz D, Rice DS, Williams RW (1996) Clonal architecture of the mouse retina. Progress in Brain Research 108: 2–15

33. Brilliant MH, Williams RW, Holdener BC, Angel JM (1996) Mouse chromosome 7. Mammalian Genome 6: S135–S150

34. Hamvas R, Trachtulec Z, Forejt J, Williams RW, Artzt K, Fischer-Lindahl K., Silver LM (1996) Mouse chromosome 17. Mammalian Genome 6: S281–S299

35. Williams RW, Strom RC, Rice DS, Goldowitz D (1996) Genetic and environmental control of retinal ganglion cell number in mice. Journal of Neuroscience 16: 7193–7205 <www.jneurosci.org/cgi/content/full/16/22/7193>

36. Rice DS, Tang Q, Williams RW, Harris B, Davisson MT, Goldowitz D (1997) Retinal ganglion cell loss and misdirect axon growth associated with fissure defects in Bst mutant mice. Investigative Ophthalmology and Visual Science 38:2112–2124

37. Williams RW, Strom RC, Goldowitz D (1998) Natural variation in neuron number in mice is linked to a major quantitative trait locus on Chr 11. Journal of Neuroscience 18:138–146 <www.jneurosci.org/cgi/content/abstract/18/1/138>

38. Williams RW, Holdener BC, Angel JM, Oakey R, Hunter K (1998) Mouse chromosome 7. Mammalian Genome 8:S136–159. <www.informatics.jax.org/bin/ccr/index?year=1998>

39. Strom, RC, Williams RW (1998) Cell production and cell death in the generation of normal variation in neuron number. Journal of Neuroscience 18:9948–9953 <www.jneurosci.org/cgi/content/abstract/18/23/9948>

40. Dell'Osso, LF Williams RW, Jacobs JB, Erchul DM (1998) The congenital and see-saw nystagmus in the prototypical achiasma of canines: comparison to the human achiasmatic prototype. Vision Research 38:1629–1641

41. Zhou G, Williams RW (1999) Eye1 and Eye2: Gene loci that modulate eye size, lens weight, and retinal area in mouse. Investigative Ophthalmology and Visual Science 40:817–825 <nervenet.org/papers/Eye1.html>

42. Williams RW (1999) A targeted screen to detect recessive mutations that have quantitative effects. Mammalian Genome 10:734–738 <nervenet.org/papers/consomic.html>

43. Zhou G, Williams RW (1999) Mouse models for the analysis of myopia: an analysis of variation in eye size of adult mice. Optometry and Vision Science: 76:408–418 <nervenet.org/papers/OVSMyopia.html>.

44. Williams RW, Angel JM, Holdener BC, Oakey R, Hunter K (1999) Mouse chromosome 7. Mammalian Genome 10:947 <www.informatics.jax.org/bin/ccr/index?year=1999>

45. Dell'Osso LF, Hertle RW, Williams RW, Jacobs JB (1999) A new surgery for congenital nystagmus: effects of tenotomy on an achiasmatic canine and the role of extraocular proprioception. J Amer Acad Ped Ophthal Soc, 3:166–182

46. Toth LA, Williams RW (1999) Circadian patterns of locomotor activity in CXB recombinant inbred mice. Behavior Genetics 29:319–328

47. Toth LA, Williams RW (1999) Strain-related differences in slow wave sleep and rapid-eye-movement sleep in C57BL/6J and BALB/c mice. Behavior Genetics 29:329–337

48. Toth LA, Williams RW (1999) Circadian patterns of slow wave sleep in influenza-infected C57BL/6 and BALB/c mice: A genetic analysis using CXB recombinant inbred strains. Behavior Genetics 29:339–348

49. Rice DS, Goldowitz D, Williams RW, Hamre K, Johnson PT, Tan SS, Reese BE (1999) Extrinsic modulation of retinal ganglion cell projections: analysis of the albino mutation in pigmentation mosaic mice. Developmental Biology 216:41–56 <www.idealibrary.com/links/artid/dbio.1999.9467>

50. Hogan D, Garraghty PE, Williams RW (1999) Asymmetric connections, duplicate layers, and reversed maps in the primary visual system. Journal of Neuroscience 19: RC38:1–6 <www.jneurosci.org/cgi/content/full/3657>

51. Kimble TDH, Williams RW (1999) Structure of the cone photoreceptor mosaic in the retinal periphery of adult humans: Analysis as a function of age, sex, and hemifield. Anatomy and Embryology, 201:305–316

52 Dell'Osso LF, Hogan D, Jacobs JB, Williams RW (1999) Eye movements in canine hemichiasma: Does human hemichiasma exist? Neuro-ophthalmology 22:47–58

53. Angel JM, Williams RW (2000) Mouse chromosome 7. Mammalian Genome 11: 948–949

54. Williams RW, Lu L, Kulkarni A, Zhou G, Airey DC (2001) Genetic dissection of the olfactory bulbs of mice: QTLs on chromosomes 4, 6, 11, and 17 modulate bulb size. Behavior Genetics, 31:61–77 <nervenet.org/papers/OB/OB2000.html>

55. Cook MN, Williams RW, Flaherty L (2001) Anxiety-related behaviors in the elevated zero maze are affected by genetic factors and retinal degeneration. Behavioral Neuroscience, 115:468–476

56. Lu L, Airey DC, Williams RW (2001) Complex trait analysis of the mouse hippocampus: Mapping and biometric analysis of two novel gene loci that modulate hippocampal size. Journal of Neuroscience, 21:3503–3514 <nervenet.org/papers/hipp1.html>

57. Rosen GD, Williams RW (2001) Complex trait analysis of the mouse striatum: Independent QTLs modulate volume and neuron number. Biomed Central Neuroscience 2:5 (PMC31432)

58. Airey DC, Lu L, Williams RW (2001). Genetic control of the mouse cerebellum: identification of quantitative trait loci modulating size and architecture. Journal of Neuroscience, 21:5099–5109 <nervenet.org/papers/cerebellum2000.html>

59. Hardy CL, Lu L, Nguyen P, Woodland DL, Williams RW, Blackman MA (2001) Identification of quantitative trait loci controlling activation of TRBV4 CD8+ T cells during murine g-herpes virus-induced infectious mononucleosis Immunogenetics, 53: 395–400

60. Williams RW, Gu J, Qi S, Lu L (2001) The genetic structure of recombinant inbred mice: High-resolution consensus maps for complex trait analysis. Genome Biology 2:46.1–46.18 <http://genomebiology.com/2001/2/11/research/0046/> (PMC59991)

61. Zhou G, Strom RC, Giguere V, Williams RW (2001) Modulation of retinal cell populations and eye size in retinoic acid receptor knockout mice. Molecular Vision, 7, <www.molvis.org/molvis/v7/a36/>

62. Hsu, HC, Mountz JD, Williams RW, Shelton BJ, Yang P, Matsuki Y, Xu X, Zhang HG, Geiger H, van Zant G (2002) Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11. Mech Ageing Dev,123:1145–1158

63. Geisert Jr EE, Williams RW, Geisert G, Maecker HT, Deng J, Levy S (2002) Increased brain size and glial cell number in CD81-null mice. Journal of Comparative Neurology, 453:22–32

64. Airey DW, Lu L, Shou S, Williams RW (2002) Genetic sources of individual differences in cerebellum. The Cerebellum 1:233–240

65. Hitzemann R, Hitzemann B, Rivera S, Gatley J, Thanos P, Lu L, Shou S, Williams RW (2002) Dopamine D2 receptor binding, Drd2 expression and the number of dopamine neurons in the BXD recombinant inbred series: genetic relationships to alcohol and other drug associated phenotypes. Alcoholism: Clinical and Experimental Research 27:1–11

66. Grizzle WE, Mountz JD, Yang PA, Xu X, Sun S, Van Zant GE, Williams RW, Hsu HC, Zhang HG (2002) BXD recombinant inbred mice represent a novel T-cell mediated immune response tumor model. International Journal of Cancer 101:270–279

67. Cook R, Lu L, Gu J, Williams RW, Smeyne RJ (2003) Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. Molecular Brain Research 110:279–288

68. Hsu HC, Zhang HG, Li L, Yi N, Yang PA, Wu Q, Zhou J, Sun S, Xu X, Yang X, Lu L, Van Zant G, Williams RW, Allison DB, Mountz JD (2003) Age-related thymic involution in C57BL/6J X DBA/2J recombinant inbred mice maps to mouse chromosome 9. Genes and Immunity 4:402–410

69. Hitzemann R, Malmanger B, Reed C, Lawler M, Hitzemann B, Coulombe S, Buck K, Rademacher B, Walter N, Polyakov Y, Sikela J, Williams RW, Flint J, Talbot C (2003) A strategy for integration of QTL, gene expression, and sequence analyses. Mammalian Genome 14: 733–747

70. Schaeffel F, Burkhardt E, Howland HC, Williams RW (2004) Measurement of refractive state and deprivation myopia in two strains of mice. Optometry and Vision Science , 81:99–110

71. Peirce J, Chesler EJ, Williams RW, Lu L (2003) Genetic architecture of the mouse hippocampus: Identification of gene loci with regional effects. Genes, Brain and Behavior 2:238–252

72. Wang J, Williams RW, Manly KF (2003) WebQTL: Web-based complex trait analysis. Neuroinformatics 1:299–308

73. Pollock GS, Robichon R, Boyd KA, Kerkel KA, Kramer M, Lyles J, Ambalavanar R, Khan A, Kaplan DR, Williams RW, Frost DO (2003) TRKB receptor signaling regulates dynamics of developmental retinal ganglion cell death but not final number. Journal of Neuroscience 23: 10137–10145

74. Rosen GD, La Porte NT, Diechtiareff B, Pung, CJ, Nissanov J, Gustafson C, Bertrand L, Gefen S, Fan Y, Tretiak OJ, Manly KF, Parks MR, Williams AG, Connolly MT, Capra JA, Williams RW (2003) Informatics center for mouse genomics: the dissection of complex traits of the nervous system. Neuroinformatics, 1:327–342

75. Chesler EJ, Wang J, Lu L, Qu Y, Manly KF, Williams RW (2003) Genetic correlates of gene expression in recombinant inbred strains: a relational model system to explore neurobehavioral phenotypes. Neuroinformatics 1: 343–357

76. Seecharan DJ, Kulkarni AL, Lu L, Rosen GD, Williams RW (2003) Genetic control of interconnected neuronal populations in the mouse primary visual system. Journal of Neuroscience 23:11178–11188

77. Williams AG, Williams RW (2004) GenomeMixer: A complex genetic cross simulator. Bioinformatics 20:2488–2490

78. Peirce J, Lu L, Gu J, Silver LM, Williams RW (2004) A new set of BXD recombinant inbred lines from advanced intercross populations in mice. BMC Genetics 5:7 (PMC420238)

79. Williams RW, Bennett B, Lu L, Gu J, DeFries JC, Carosone-Link P, Rikke B, Belknap JK, Johnson TE (2004) Genetic structure of the LXS panel of recombinant inbred mouse strains. Mammalian Genome 15:637–647

80. Schauwecker PE, Williams RW, Santos JB (2004) Genetic control of seizure-induced cell death susceptibility in mice. Journal of Comparative Neurology 477:96–107

81. Ponomarev I, Schafer GL, Blednov YA, Williams RW, Iyer VR, Harris A (2004) Convergent analysis of cDNA and short oligomer microarrays, mouse null mutant, and bioinformatics resources to study complex traits. Genes, Brains and Behavior 3:360–368

82. Tan XL, Zhou Y, Cai KF, Shao YX, Zhu SX, Lu L, Williams RW, Gu XS (2004) Identification of QTLs for weight and cross-sectional area on cervical enlargement of spinal cord in mice. Yi Chuan Xue Bao 31:801–806

83. Jablonski MM, Lu L, Wang, XF, Chesler EJ, Carps E, Qi S. Gu J, Williams RW (2004) The ldis1 lens mutation in RIIIS/J mice maps to chromosome 8 near cadherin 1. Molecular Vision 10:577–587

84. Simon P, Schott K, Williams RW, Schaeffel F (2004) Post-translational regulation of the immediate early gene EGR1 by light in the mouse retina. European Journal of Neuroscience 20:3371–3377

85. Scott RE, White-Grindley E, Ruley HE, Chesler EJ, Williams RW (2005) P2P-R expression is genetically coregulated with components of the translation machinery with PUM2, a translational repressor that associates with the P2P-R mRNA. Journal of Cellular Physiology 204:99–105

86. Baldwin NE, Chesler EJ, Kirov S, Langston MA, Snoddy JR, Williams RW, Zhang B (2005) Computational, integrative and comparative methods for the elucidation of genetic co-expression networks. Journal of Biomedicine and Biotechnology 2:172–180 (PMC1184052)

87. Mountz JD, Yang PA, Wu Q, Zhou J, Tousson A, Fitgerald A, Allen J, Wang X, Cartner S, Grizzle WE, Yi N, Lu L, Williams RW, and Hsu H-C (2005) Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in BXD2 recombinant inbred strain of mice. Scandinavian Journal of Immunology 61:128–138

88. Chesler EJ, Lu L, Shou S, Qu Y, Gu J, Wang J, Hsu HC, Mountz JD, Baldwin N, Langston MA, Threadgill DW, Manly KF, Williams RW (2005) Genetic dissection of gene expression reveals polygenic networks modulating brain structure and function. Nature Genetics 37:233–242

89. Bystrykh L, Weersing E, Dontje B, Sutton S, Pletcher MT, Wiltshire T, Su AI, Vellenga E, Wang J, Manly KF, Lu L, Chesler EJ, Alberts R, Jansen RC, Williams RW, Cooke M, de Haan G (2005) Uncovering regulatory pathways affecting hematopoietic stem cell function using “genetical genomics” Nature Genetics 37:225–232

90. Kerns RT, Ravindranathan A, Hassan S, Cage MP, York T, Williams RW, Miles MF (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. Journal of Neuroscience 25:2255–2265

91. Carlborg Ö, De Koning D-J, Chesler EJ, Manly KM, Williams RW, Haley CS (2005) Methodological aspects of the genetic dissection of gene expression. Bioinformatics 21:2383–2393

92. Manly KF, Wang J, Williams RW (2005) Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression. Genome Biology 6:R27.1-27.10 (PMC1088946)

93. Zou F, Gelfond JA, Airey DC, Lu L, Manly KF, Williams RW, Threadgill DW (2005) Quantitative trait locus analysis using recombinant inbred intercrosses (RIX): theoretical and empirical considerations. Genetics 170:1299–1311 (PMC1451174)

94. Tsaih, SW, Lu L, Airey DC, Williams RW, Churchill GA (2005) Quantitative trait mapping in a diallel cross of recombinant inbred lines. Mammalian Genome 16:344–355

95. Li HQ, Lu L, Manly KF, Wang J, Zhou M, Williams RW, Cui Y (2005) Inferring gene transcriptional modulatory relations: a genetical genomics approach. Human Molecular Genetics 14:119–1125

96. Jablonski MM, Wang, XF, Lu L, Miller DR, Rinchik EM, Williams RW, Goldowitz, D (2005) The Tennessee Mouse Genome Consortium: identification of novel ocular mutants. Visual Neuroscience 22:595–604

97. Jablonski MM, Dalke C, Wang XF, Lu L, Manly K, Pretsch W, Pardue M, Rinchik, Williams RW, Goldowitz D, Graw J (2005) An ENU-induced mutation in Rs1h causes disruption of retinal structure and function. Molecular Vision 11:596–581

98. Vazquez-Chona FR, Khan AN, Chan CK, Moore AN, Dash PK, Rosario Hernandez R, Lu L, Chesler EJ, Manly KF, Williams RW, Geisert Jr EE (2005) Genetic networks controlling retinal injury. Molecular Vision 11:958–970 (PMC2814057)

99. Li CX, Wei X, Lu L, Peirce JL, Williams RW, Waters RS (2005) Genetic analysis of barrel field size in the first somatosensory area (SI) in inbred and recombinant inbred strains of mice. Somatosensory and Motor Research 22:141–150

2006

100. Kempermann G, Chesler EJ, Lu L, Williams RW, Gage FH (2006) Natural variation and genetic covariance in adult hippocampal neurogenesis. Proceedings of the National Academy of Science USA 103:780–785 (PMC1325968)

101. Lan H, Chen M, Byers JE, Yandell BS, Stapleton DS, Mata CM, Mui TK, Flowers MT, Schueler KL, Manly KF, Williams RW, Kendziorski, CM, Attie AD (2006) Combined expression trait correlations and expression quantitative trait locus mapping. PLoS Genetics 2:51–61 (PMC1331977)

102. Li H, Chen H, Bao L, Manly KF, Chesler EJ, Lu L, Wang J, Zhou M, Williams RW, Cui Y (2006) Integrative genetic analysis of transcription modules: towards filling the gap between genetic loci and inherited traits. Human Molecular Genetics 15:481–492

103. Martin M, Dong H, Vallera D, Lee D, Lu L, Williams RW, Rosen GD, Cheverud J, Csernansky J (2006) Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice. Genes, Brain and Behavior 5:614–623

104. Bao L, Wei L, Peirce JL, Homayouni R, Li H, Zhou M, Chen H, Lu L, Williams RW, Pfeffer LM, Goldowitz D, Cui Y (2006) Combining gene expression QTL mapping and phenotype spectrum analysis to uncover gene regulatory relations. Mammalian Genome 17:575–583

105. Radcliffe RA, Lee MJ, Williams RW (2006) Prediction of cis-QTLs in a pair of inbred mouse strains with the use of expression and haplotype data from public databases. Mammalian Genome 17:643–642

106. Peirce JL, Lu L, Li H, Wang J, Manly KF, Hitzemann RJ, Belknap JK, Rosen GD, Goodwin S, Sutter TR, Williams RW (2006) How replicable are mRNA expression QTLs. Mammalian Genome 17:643–642

107. Aliesky HA, Pichurin PN, Chen CR, Williams RW, Rapoport B, McLachlan SM (2006) Probing the genetic basis for thyrotropin receptor antibodies and hyperthyroidism in immunized CXB recombinant inbred mice. Endocrinology 147:2789–2800

108. Shifman S, Bell JT, Copley RR, Taylor M, Williams RW, Mott R, Flint J (2006) A high resolution single nucleotide polymorphism genetic map of the mouse genome. PLoS Biology 4:2227–2237 (PMC1635748)

2007

109. Aziz, R, Kanal R, Abdeltawab NF, Rowe SL, Su Y, Carrigan D, Nooh MM, Attia RR, Brannen C, Gardner LA, Lu L, Williams RW, Kotb M (2007) Susceptibility to severe streptococcal sepsis: a mouse reference population to study genetic and environmental factors. Gene and Immunity 8:404–415 (PMID: 17525705)

110. Bao L, Peirce JL, Lu L, Zhou M, Li H, Goldowitz D, Williams RW, Cui Y (2007) An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes. Human Molecular Genetics 16:1381–1390

111. Bao L, Zhou M, Wu L, Lu L, Goldowitz D, Williams RW, Cui Y (2007) PolymiRTS database: linking polymorphisms in microRNA target sites with complex traits. Nucleic Acids Res (database issue): D51–54 (PMC1669716)

112. Bhave SV, Hornbaker C, Phang TL, Saba L, Lapadat R, Kechris K, Gaydos J, McGoldrick D, Dolbey A, Leach S, Soriano B, Ellington A, Ellington E, Jones K, Mangion J, Belknap JK, Williams RW, Hunter LE, Hoffman PL, Tabakoff B (2007) The PhenoGen Informatics website: tools for the analysis of complex traits. BMC Genetics 8:59 (PMC2034588)

113. Bug W, Wong WW, Gustafson C, Johnson GA, Martone ME, Price DL, Rosen GD, Williams RW, Zaslavsky I, Nissanov J (2007) Brain atlasing tool interoperation: NeuroTerrain-Smart Atlas synergistic visualization and analysis environment. Neural Engineering, 2007 3^rd International IEEE/EMBS Conference, ISBN: 1-4244-0792-3

114. Dong H, Martin M, Colvin J, Ali Z, Wang L, Lu L, Williams RW, Rosen GD, Csernansky JG, Cheverud JM (2007) Quantitative trait loci linked to thalamic and cortical gray matter volumes in BXD recombinant inbred mice: implications for the genetics of schizophrenia. Heredity 99:62–69

115. Gatti D, Maki A, Chesler EJ, Kosyk O, Kirova R, Lu L, Manly KF, Qu Y, Williams RW, Perkins A, Langston ME, Threadgill DW, Rusyn I (2007) Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology 46:548–557

116. Miyairi I, Tatireddigari A, Mahdi OS, Belland RJ, Lu L, Williams RW, Byrne GI (2007) The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia sus psittaci infection. Journal of Immunology 179:1814–1824 (free article)

117. Mozhui K, Hamre KM, Holmes A, Lu L, Williams RW (2007) Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Behavior Genetics 37:223–243 (featured article in Nature Neuroscience Gateway: http://www.neuroscience-gateway.org/2007/070215/full/aba1717.shtml)

118. Peirce JL, Broman KW, Lu L, Williams RW (2007) A simple method for combining genetic mapping data from multiple crosses and experimental designs. PLoS One 2:e1036 (PMC2001185)

119. Vázquez-Chona F, Lu L, Williams RW, Geisert EE (2007) Genetic influences on retinal gene expression and wound healing. Gene Regulation and Systems Biology 1:327-348

120. Yang J, Zhu J, Williams RW (2007) Mapping the genetic architecture of complex traits in experimental populations. Bioinformatics 23:1527–1536 (free article)

2008

121. Abdeltawab NF, Aziz RK, Kansal R, Rowe SL, Su Y, Gardner L, Brannen C, Nooh MM, Attia RR, Abdelsamed HA, Taylor WL, Williams RW, Kotb M (2008) An unbiased systems genetics approach to mapping genetic loci modulating susceptibility to severe streptococcal sepsis. PLoS Pathogens 4:e1000042 (PMC2277464)

122. Chesler EJ, Miller DR, Branstetter L, Galloway L, Jackson B, Philip Vm, Voy B, Culiat CT, Threadgill DW, Williams RW, Churchill GA, Johnson DK, Manly KF (2008) The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics. Mammalian Genome 19:382-389 (PMC2745091)

123. Crawford, NPS, Walker RC, Officewala JS, Lukes L, Williams RW, Hunter KW (2008) The diasporin pathway: a tumor progression-related network that predicts breast cancer survival. Clinical and Experimental Metastasis 25:357-369 ()

124. Danciger M, Ogando D, Yang H, Matthes MT, Yu H, Ahern K, Yasumura D, Williams RW, LaVail MM (2008) Genetic modifiers of retinal degeneration in the rd3 mouse. Investigative Ophthalmology and Visual Science 49:2863-2869 (PMC2574750)

125. Druka A, Potokina E, Luo Z, Bonar N, Druka I, Zhang, L, Marshall DF, Steffenson BJ, Close TJ, Wise RP, Kleinhofs A, Williams RW, Kearsey MJ, Waugh R (2008) Exploiting regulatory variation to identify genes and loci underlying quantitative resistance to the wheat stem rust pathogen Puccinia graminis f. sp. tritici in barley. Theoretical and Applied Genetics 117:261-272

126. Druka A, Druka I, Centeno AG, Li H, Sun Z, Thomas WTB, Bonar N, Steffenson BJ, Ullrich SE, Kleinhofs A, Wise RP, Close TJ, Potokina E, Luo Z, Wagner C, Schweizer GF, Marshall DF, Kearsey MJ, Williams RW, Waugh R (2008) Towards systems genetic analyses in barley: Integration of phenotypic, expression and genotype data into GeneNetwork. Manuscript. BMC Genetics 9:73 (PMC2630324)

127. Gardner D, Akil H, Ascoli AG, Bowden DM, Bug W, Donohue DE, Goldberg DH, Grafstein B, Grethe JS, Gupta A, Halavi M, Kennedy DN, Marenco L, Marton ME, Miller P, Muller HM, Robert A, Shepherd GM, Sternberg PW, Van Essen DC, Williams RW (2008) The Neuroscience Information Framework: a data and knowledge environment for neuroscience. Neuroinformatics 6:149-160 (PMC2661130)

128. Hsu H-C, Yang PA, Wu Q, Myers R, Wang J, Guentert T, Chen J, Yi J, Tousson A, Stanus AL, Le TVL, Lorenz RG, Xu H, Kolls HK, Carter RH, Chaplin DD, Williams RW, Mountz JD (2008) Interleukin 17–producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nature Immunology 9:166–175

129. Jan TA, Lu L, Li CX, Williams RW, Waters RS (2008) Genetic analysis of posterior medial barrel subfield (PMBSF) size in somatosensory cortex (SI) in recombinant inbred strains of mice. BMC Neuroscience 9:3 (PMC2254631)

130. Lu L, Wei L, Peirce JL, Wang X, Zhou J, Homayouni R, Williams RW, Airey DC (2008) Using gene expression databases for classical trait QTL candidate gene discovery in the BXD recombinant inbred genetic reference population: mouse forebrain weight. BMC Neuroscience 9:444 (PMC2570693)

131. McLachlan SM, Aliesky H. Pichurin PN, Chen CR, Williams RW, Rapoport B (2008) Shared and unique susceptibility genes for Graves’ disease induced by thyrotropin receptor adenovirus immunization in BXH and CXB recombinant inbred mice. Endocrinology 149:2001-2009 (PMC2276708)

132. Mozhui K, Ciobanu DC, Schikorski T, Wang X, Lu L, Williams RW (2008) Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression. PLoS Genetics 4:e1000260 (PMC2577893)

133. Mulligan MK, Ponomarev I, Boehm SL, Owen JA, Levin PS, Berman AE, Blednov YA, Crabbe JC, Williams RW, Miles MF, Bergeson SE (2008) Alcohol trait and transcriptional genomic analysis of C57BL/6J substrain. Genes, Brain & Behavior 7:677-689

134. Pardue MT, Faulkner AE, Fernandes A, Yin H, Schaeffel F, Williams RW, Pozdeyev N, Iuvone PM (2008) High susceptibility to experimental myopia in a mouse model with a retinal on pathway defect. Investigative Ophthalmology and Visual Science 49:706-712 (PMC2752325)

135. Peirce JL, Broman KW, Lu L, Chesler EJ, Zhou G, Airey DC, Birmingham AE, Williams RW (2008) Genome reshuffling for advanced intercross permutation (GRAIP): A permutation method for quantitative advanced intercross population analysis. PLoS One 3:e1977 (PMC2295257)

136. Reiner DJ, Jan TA, Boughter JD, Li CX, Lu L, Williams RW, Waters RS (2008) Genetic analysis of tongue size and taste papillae number and size in recombinant inbred strains of mice. Chemical Senses 33:693-707 (PMC2565774)

137. Yang RJ, Mozhui K, Karlsson RM, Cameron HA, Williams RW, Holmes A (2008) Variation in mouse basolateral amygdala volume is associated with differences in stress reactivity and fear learning. Neuropsychopharmacology 33:2595-2604 (free article)

2009

138. Badea A, Johnson GA, Williams RW (2009) Genetic dissection of the mouse brain using high-field magnetic resonance microscopy. Neuroimaging 45:1067-79 (PMC2667384)

139. Boon ACM, deBeauchamp J, Hollmann A, Luke J, Kotb M, Rowe S, Finkelstein D, Neale G, Lu L, Williams RW, Webby RJ (2009) Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. Journal of Virology 83:10417-10426 (PMC2753106)

140. Brigman JL, Mathur P, Lu L, Williams RW, Holmes A (2009) Genetic relationship between anxiety- and fear-related behaviors in BXD recombinant inbred mice. Behavioral Pharmacology 20:204-209 (PMC2701299)

141. Davies MN, Lawn S, Whatley S, Fernandes C, Williams RW, Schalkwyk LC (2009) Is blood a reasonable surrogate for brain in gene expression studies? Frontiers in Neuroscience 3:54 (PMC2858613)

142. Gaglani SM, Lu L, Williams RW, Rosen GD (2009) The genetic control of neocortex volume and covariation with patterns of gene expression in mice. BMC Neuroscience 10:44 (PMC2685397)

143. Geisert EE Jr, Lu L, Freeman-Anderson NE, Templeton JP, Nassr M, Wang X, Gu W, Jiao Y, Williams RW (2009) Gene expression in the mouse eye: an on-line resource for genetics using 103 strains of mice. Molecular Vision 15:1730-1763 (PMC2736153)

144. Koutnikova H, Markku L, Lu L, Combe R, Paananen J, Kuulasmaa T, Kuusisto J, Häring H, Hansen T, Pedersen,O, Smith U, Hanefel M, Williams RW, Auwerx J (2009) Identification of UBP1 as a critical blood pressure determinant. PLoS Genetics 5:e1000591 (PMC2715105)

145. Overall RW, Kempermann G, Peirce J, Lu L, Goldowitz D, Gage FH, Goodwin S, Smit G, Airey DC, Rosen GD, Schalkwyk LC, Sutter TR, Nowakowski R, Whatley S, Williams RW (2009) Systems genetics of the hippocampal transcriptome in 99 mouse strains. Frontiers in Neuroscience 3:55 (PMC2858614)

146. Rosen GL, Pung C, Owens C, Caplow J, Kim H, Lu L, Williams RW (2009) Genetic modulation of striatal volume in BXD recombinant inbred mice. Genes, Brain & Behavior 8:296-308 (PMC2706028)

147. Templeton JP, Nassr M, Vazques-Chona, Freeman-Anderson NE, Orr WE, Williams RW, Geisert EE (2009) Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush. BMC Neuroscience 10:90 (PMC2727955)

148. Whitney IE, Raven M, Ciobanu DC, Williams RW, Reese BE (2009) Multiple genes on chromosome 7 regulate dopaminergic amacrine cell number in the mouse retina. Investigative Ophthalmology and Visual Science 50:1996-2003 (PMC2672967)

2010

149. Ciobanu DC, Lu L, Mozhui K, Wang X, Morris JA, Taylor WL, Dietz K, Simon P, Williams RW (2010) Detection, validation, and downstream analysis of allelic variation in gene expression. Genetics 184:119-128 (PMC2802080)

150. Hoffman P, Bennett B, Saba L, Bhave S, Carosone-Link P, Hornbaker C, Kechris K, Williams RW, Tabakoff B (2010) Using the Phenogen website for ‘in silico’ analysis of morphine-induced analgesia: identifying candidate genes. Addiction Biology Nov 4. doi: 10.1111/j.1369-1600.2010.00254.x. PMID: 21054686

151. Li, Z., Mulligan MK, Wang X, Miles MF. Lu L, Williams RW (2010) A mutation in Comt generates mRNA isoforms and causes widespread expression and behavioral differences among inbred mice. PLoS One 5:e12181

152. Lionikas A, Carlborg O, Lu L, Peirce JL, Williams RW, Yu F, Vogler GP, McClearn GE, Blizard DA (2010) Genomic analysis of variation in hindlimb musculature of mice from the C57BL/6J and DBA/2J lineage, Journal of Heredity 101:360-367 (PMC2855676)

153. Mozhui K, Karlsson RM, Kash TL, Ihne J, Norcross M, Patel S, Farrell MR, Hill EE, Martin KP, Camp M, Fitzgerald P, Ciobanu DC, Sprengel R, Mishina M, Wellman CL, Winder DG, Williams RW, Holmes A (2010) Genetically-driven variation in behavioral responses to stress is associated with divergent glutamate plasticity. Journal of Neuroscience 30:5357-5367 (PMC2866495)

154. Mulligan MK, Rogers Jr. GL. Lu L, Langston MA. Williams RW (2010) Genetic analysis of BDNF expression cliques and adult neurogenesis in the hippocampus. 2010 Annual ORNL Biomedical Science & Engineering Conference. May 25-26, 2010 Oak Ridge, TN. IEEE Catalog Number: CFP1047G-ART

155. Peidis P Giannakouros T, Burow ME, Williams RW, Scott RE (2010) Systems genetics analyses predict a transcription role for P2P-R: molecular confirmation that P2P-R is a transcriptional co-represssor. BMC Systems Biology 4:14 (PMC2843647)

156. Poon A, Li Z, Wolfe GW, Lu L, Williams RW, Hayes NL, Nowakowski RS, Goldowitz D (2010) Identification of a Chr 11 quantitative trait locus that modulates proliferation in the rostral migratory stream of the adult mouse brain. European J Neuroscience 32:523-37

157. Rapoport B, Williams RW Chen CR, McLachlan SM (2009) Evidence from recombinant inbred CXB and BXH mice that immunoglobulin heavy chain variable region genes contribution to induction of thyroid stimulating antibodies. Genes and Immunity 11:254-263 (PMID: 20407472)

158. Reinius B, Shi C, Hengshuo L, Sandhu KS, Radomska KJ, Rosen GD, Lu L, Kullander K, Williams RW, Rosen GD, Jazin E (2010) Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse. BMC Genomics 11:614 PMC3091755

159. Ziebarth JD, Cook MN, Li B, Williams RW, Lu L, Cui Y (2010) Systems genetics analysis of molecular pathways underlying ethanol-induced behavioral phenotypes. 2010 Annual ORNL Biomedical Science & Engineering Conference. May 25-26, 2010 Oak Ridge, TN. IEEE Catalog Number: CFP1047G-ART DOI 10.1109/BSEC.2010.5510821

2011

160. Alberts R, Chen H, Pommerenke C, Smit AB, Spijker S, Williams RW, Geffers R, Bruder D, Schughart K (2011) Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease. BMC Genomics 12:610

161. Chen H, Liu Z, Gong S, Wu X, Taylor WL, Williams RW, Matta SG, Sharp BM (2011) Genome-wide gene expression profiling of nucleus accumbens neurons projecting to ventral pallidum using both microarray and transcriptome sequencing. Frontiers in Neuroscience 5:98 PMID: 21886604

162. Gatti DM, Lu L, Williams RW, Sun W, Wright FA, Threadgill DW, Rusyn I (2011) MicroRNA expression in the livers of inbred mice. Mutation Research in press

163. Freeman NE, Templeton JP, Orr WE, Lu L, Williams RW, Geisert EE (2011) Genetic networks in the mouse retina: Growth Associated Protein 43 and Phosphate Tensin Homology network. Molecular Vision 17:1355-1372 PMC3108897

164. Furlotte N, Xu L, Williams RW, Homayouni R (2011) Literature-based evaluation of microarray normalization procedures. IEEE Bioinformatics and Biomedicine Conference, 608-611. DOI 10.1109/BIBM.2011.114

165. Jablonski MM, Freeman NE, Orr WE, Templeton JP, Lu L, Williams RW, Geisert EE (2011) Genetic pathways regulating glutamate levels in retinal Müller cells. Neurochem Res 36:594-603 (PMID: 20882406)

166. Krebs J, Römer D, Overall RW, Fabel K. Babu H, Brandt M, Williams RW, Jessberger S, Kempermann G (2011) Adult hippocampal neurogenesis and plasticity in the infrapyramidal bundle of the mossy fiber projection: II. Genetic covariance and identification of Nos1 as a linking candidate gene. Frontiers in Neuroscience 5:106 PMID: 21960957

167. Laughlin RE, Grant TL, Williams RW, Jentsch JD (2011) Genetic dissection of behavioral flexibility: reversal learning in mice. Biological Psychiatry 69:1109-1116 PMID: 21392734

168. Lu, H, Wang X, Pullen M, Guan H, Chen H, Sahu S, Zhang B, Chen H, Williams RW, Geisert EE, Lu L, Jablonski MM (2011) Genetic dissection of the Gpnmb network in the eye. Invest Ophthalmol Vis Sci 52:4132-4142 PMID: 21398278

169. Lu H., Li L, Watson ER, Williams RW, Geisert EE, Jablonski MM, Lu L (2011) Complex interactions of Tyrp1 in the eye. Molecular Vision 17:2455-2468 PMID: 21976956

170. McLachlan SM, Lu L, Aliesky HA, Williams RW, Rapoport B (2011) Distinct genetic signatures for variability in total and free serum tyroxine levels in four sets of recombinant inbred mice. Endocrinology 152:1172-1179 PMID: 21209025

171. McLachlan SM, Aliesky HA, Chen CR, Williams RW; Rapoport B (2011) Exceptional hyperthyroidism and a role for both major histocompatiblity class I and class II genes in a murine model of Graves' disease. PLoS One 6: e21378 PMC3124500

172. Mozhui K, Wang X, Chen J, Mulligan MK, Li Z, Ingles J, Chen X, Lu L, Williams RW (2011) Genetic regulation of Nrxn1 expression: an integrative cross-species analysis of schizophrenia candidate genes. Translational Psychiatry 1: e25

173. Poot M, Badea A, Williams RW, Kas MJ (2011) Identifying human disease genes through cross-species gene mapping of evolutionarily conserved processes. PLoS One i6:e18612 PMC3087714

174. Porcu P, O’Buckley Tk, Song SC, Harenza JL, Lu L, Wang X, Williams RW, Miles MF, Morrow AL (2011) Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: identification of QTLs and downstream gene regulation. PLoS One 6:e18405 PMC3072994

175. Römer B, Krebs J, Overall RW, Fabel K, Babu H, Overstreet-Wadiche L, Brandt MD, Williams RW, Jessberger S, Kempermann G (2011) Adult hippocampal neurogenesis and plasticity in the infrapyramidal bundle of the mossy fiber projection: I. Co-regulation by activity. Frontiers in Neuroscience 5:107 PMID: 21991243

176. Whitney IE, Raven MA, Lu L, Williams RW, Reese BE (2011) A QTL on chromosome 10 modulates cone photoreceptor number in the mouse retina. Invest Ophthalmol Vis Sci 52:3228-3236 PMID: 21330668

177. Whitney IE, Raven MA, Ciobanu DC, Poché RA, Ding Q, Elshatory Y, Gan L, Williams RW, Reese BE (2011) Genetic modulation of horizontal cell number in the mouse retina. Proceedings of the National Academy of Sciences 108:9697-9702

178. Yan L, Zhou X, Lu L, Centeno A, Kuan L, Hawrylycz M, Larimer M, Rosen GD, Williams RW (2011) Global exploratory analysis of massive neuroimaging collections using Microsoft Silverlight PivotViewer. ORNL Biomedical Science & Engineering Conference 1-4. IEEE DOI 10.1109/BSEC.2011.5872323

2012

179. Alberts R, Lu L, Williams RW, Schughart K (2012) Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures. Respiratory Research 12:61 PMID: 21535883

180. Andreux PA, Williams EG, Koutnikova H, Houtkooper RH, Champy MF, Schoonjans K, Williams RW, Auwerx J (2012) Systems genetics of metabolism — the use of the BXD reference panel for multiscalar integration. Cell in press

181. Boughter Jr JD, St. John SJ, Tokita K, Lu L, Heck D, Williams RW (2012) A QTL on chromosome 1 contributes to rhythmic oromotor movement in mice. PLoS One 7:e38169

182. Brunschwig H, Levi L, Ben-David E, Williams RW, Yakir B, Shifman S (2012) Fine-scale map of recombination rates and hotspots in the mouse genome. Genetics 191:757-764

183. Cao Y, Zhang J, Jiao Y, Yan J, Jiao F, Liu XY, Williams RW, Hasty K, Stuart J, Gu W (2012) Genomic dissection and prioritizing of candidate genes of QTL for regulating spontaneous arthritis on chromosome 1 in mice deficient for interleukin-1 receptor antagonist. Journal of Genetics in press

184. Cao Y, Jiao Y, Wang L, Huang Y, Postlethwaite A, Stuart J, Kang A, Williams RW, Gu W (2012) Anakinra as an interleukin 1 receptor antagonist, complicated genetics and molecular impacts- from the point of view of mouse genomics. Int Immunopharmacol in press PMID: 22425556

185. Collaborative Cross Consortium (2012) The genome architecture of the Collaborative Cross mouse genetic reference population. Genetics 190:389-401 PMC: 22345608

186. Jellen LC, Unger EL, Lu L, Williams RW, Rousseau S, Wang X, Earley CJ, Allen RP, Miles MF, Jones BC (2012) Systems genetic analysis of the effects of iron deficiency in mouse brain. Neurogenetics in press PMID: 22457016

187. Jiao Y, Lu L, Williams RW, Smeyne RJ (2012) Genetic dissection of strain dependent paraquat-induced neurodegeneration in the substantia nigra pars compacta. PLoS One 7(1): e29447 PMID: 22291891

188. Hager R, Lu L, Rosen GD, Williams RW (2012) Genetic architecture supports mosaic brain evoluation and independent brain-body size regulation. Nature Communications in press

189. McKnite AM, Perez-Munoz, PE, Lu L, Williams EG, Brewer S, Andreux P, Bastiaansen JWM, Wang X, Kachman SD, Auwerx J, Williams RW, Benson AK, Peterson DA, Ciobanu DC (2012) Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits. PLoS One 7: e39191 PMID: 22723961

190. Miyairi I, Ziebarth J, Laxton JD, Wang X, van Rooijen N, Williams RW, Lu L, Byrne GI, Cui Y (2012) Prediction and validation of causal pathways of Chlamydia disease susceptibility. PLoS One 7:e33781 PMID: 22438999

191. Mozhui K, Lu L, Armstrong WE, Williams RW (2012) Sex-specific modulation of gene expression networks in murine hypothalamus. Frontiers in Neuroscience 6:63

192. Mulligan MK, Wang X, Adler AL, Mozhui K, Lu L, Williams RW (2012) Complex control of GABA(A) receptor subunit mRNA expression: Variation, covariation, and genetic regulation. PLoS One 7:e34586 PMID: 22506031

193. Rosen GD, Azoulay N, Griffin E, Newbury A, Koganti L, Fujisaki N, Takahashi E, Grant E, Truong D, Fitch R, Lu L, Williams RW (2012) Bilateral subcortical heterotopia with partial callosal agenesis in a mouse mutant. Cerebral Cortex in press PMID: 22455839

194. Wang X, Mozhui K, Li Z, Mulligan MK, Ingels JF, Zhou X, Hori R, Chen H, Cook MN, Williams RW, Lu L (2012) A promoter polymorphism in the Per3 gene is associated with alcohol and stress response. Translational Psychiatry 2:e73

195. Wolen AR, Phillips CA, Langston MA, Vorster PJ, Bruce NA, York TP, Williams RW, Miles MF (2011) Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: Functional and mechanistic implications. PLoS One 7:e33575

196. Ziebarth J, Cook MN, Wang X, Williams RW, Lu L, Cui Y (2012) Treatment- and population-dependent activity patterns of behavioral and expression QTLs. PLoS One 7(2):e31805 PMID: 22359631

197. Jiao Y, Jin X, Yan J, Stuart J, Gibson G, Lu L, Williams RW, Wang YJ, Gu W (2012) Differential gene expression between wild-type and Gulo deficient mice supplied with vitamin C. Genetics and Molecular Biology in submission

198. Reinius B, Johansson MJ, Randomska KJ, Morrow EH, Pandey GK, Kanduri C, Williams RW, Jazin E (2011) Abundance of female-biased and paucity of male-biased somatically expressed genes on the mouse X-chromosome. In submission

199. Houtkooper RH, Mouchiroud L, Katsyuba E, Ryu D, Moullan N, Knott G, Williams RW, Auwerx J (2012) Mitochondrial ribosomal proteins identify UPRmt as an overarching longevity mechanism. Nature In revision (July 24, 2012)

200. Detti L, Martin DC, Williams RW, Schlabritz-Loutsevich N, Williams LJ, Uhlmann RA (2012) Somatic, uterine and ovarian development in pre-pubertal mice treated with cyclophosphmice. Cancer Biology & Therapy

201. Jones BC, Miller DB, O’Callaghan JP, Lu L, Unger EL, Alam G, Williams RW (2012) Genetic and strain variation in MPTP neurotoxicity. In submission July 2012 (Neurogenetics)

Legend: Illustration of the embryonic mammalian visual system in the style of da Vinci (by RWW1985)

REVIEWS, LETTERS, BOOK CHAPTERS

1. Chalupa LM, Williams RW (1984) Prenatal development and reorganization in the visual system of the cat. In Development of Visual Pathways in Mammals. Stone J, Dreher B, Rapaport DH (eds) Alan R Liss Inc, New York, pp 89–102. Full text <nervenet.org/papers/CatRev84.html>

2. Chalupa LM, Williams RW (1985) Formation of retinal projections in the cat. In Advances in Neuronal and Behavioral Development. vol 1 (Aslin RN, ed): Norwood, New Jersey: Ablex Publishing, pp 1–32

3. Williams RW, Herrup K (1988) The control of neuron number. Annual Review of Neuroscience 11:423–453 <nervenet.org/papers/NUMBER_REV_1988.html>.

4. Williams RW. Goldowitz D (1992) Lineage versus environment in embryonic retina: A revisionist perspective. Trends in Neuroscience 15:368–373

5. Williams RW, Goldowitz D (1993) Lineage versus environment in embryonic retina: Letters to the editor. Trends in Neuroscience 16:96–98 <nervenet.org/papers/TINS_1992.html>

6. Williams RW (1990) The primary visual system does not care about Previc’s near-far dichotomy. Why not? Behavioral and Brain Sciences: 13:557

7. Williams RW (1992) A very rare congenital eye movement disorder in Belgian sheepdogs. National Belgian Newsletter 44:75

8. Williams RW, Strom RC, Zhou G, Yan Z (1998) Genetic dissection of retinal development. Seminars in Cell and Developmental Biology 9:249–255 <nervenet.org/papers/retinarev98.html>

9. Williams RW (1998) Neuroscience meets quantitative genetics: Using morphometric data to map genes that modulate CNS architecture. Short Course in Quantitative Neuroanatomy (Morrison J, and Hof P, eds) pp 66-78 <nervenet.org/papers/ShortCourse98.html>

10. Toth LA, Williams RW (1998). Genetic analysis of complex quantitative traits using inbred mice. Sleep Research Society Bulletin 4:50–56

11. Williams RW (2000). Mapping genes that modulate mouse brain development: a quantitative genetic approach. In: Mouse brain development (Goffinet AF, Rakic P, eds). Springer, New York, pp 21–49 <nervenet.org/papers/brainrev99.html>

12. Belknap JK, Crabbe JC, Phillips TJ, Hitzemann R, Buck KJ, Williams RW (2001) Quantitative trait loci and genome-wide mutagenesis: two phenotype-driven approaches to the dissection of complex murine traits. Behavior Genetics 31:5–15

13. Mountz JD, van Zant G, Zhang H, Grizzle WE, Ahmed R, Williams RW, Hsu HC (2001) Genetic dissection of age-related changes in immune function in mice. Scandinavian Journal of Immunology 54:10–20

14. Airey DC, Williams RW. (2002) Quantitative genetic perspectives. Commentary to Finlay BL, Darlington RB, and Nicastro N (2002) Developmental structure in brain evolution. Behavioral and Brain Sciences 24:279–280

15. Hunter K, Williams RW (2002) Quantitative trait locus analysis in cancer research. ILAR J 43:80–88

16. Threadgill, Hunter K, Williams RW (2002) Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort. Mammalian Genome 13:175–178

17. WilliamsRW, Dubnau J, EnochMA, FlahertyL, SluyterF, Gannon KS, Maxson SC, RiedlCAL, Williams KD, HolmesA, BolivarVJ, Crusio WE (2002) Hot topics in behavioral and neural genetics. Gene, Brain and Behavior 1:1–10

18. Williams RW, Glueck SB (2002) New views of gene expression in the brain: Focus on “Gene expression tomography.” Physiological Genomics 8:79

19. Williams RW (2002) Everyday bioinformatics: map, microarrays and beyond. Bioinformatics 2002, a Society for Neuroscience Short Course (Williams RW, Goldowitz D, eds), Society for Neuroscience, pp. 1–10

20. Dell’Osso LF, Williams RW, Jacobs JB, Hertle RW, FitzGibbon EJ, Thompson MA, Yang D (2002) Novel surgery for nystagmus: initial trial results. Research to Prevent Blindness 16: 56–57

21. Williams RW, Flaherty L, Threadgill DW (2003) The math of making mutant mice. Genes, Brain and Behavior 2:191–200

22. Williams RW, Moody SA (2003) Developmental and genetic control of cell number in the retina. In: The Visual Neurosciences, eds. Chalupa LM , Werner JS. MIT Press. pp 65–78

23. Williams RW, Broman KW, Cheverud JM, Churchill GA, Hitzemann RW, Hunter K, Mountz JD, Pomp P, Reeves RH, Schalkwyk LC, Threadgill DW (2002) A collaborative cross for high-precision complex trait analysis. 1^st Workshop Report of the Complex Trait Consortium: Sept 2002. http://www.complextrait.org/Workshop1.pdf

24. von Bartheld CS, Williams RW (2003) Measurement of differential shrinkage or compression in the z-axis of tissue sections. Current Protocols in Neuroscience Unit 11.11–1.11.29 Suppl 24

25. von Bartheld CS, Williams RW (2003) Calibration of counting methods by a limited and simple 3-D reconstruction of serial sections. Current Protocols in Neuroscience Unit 11.11–1.11.29 Suppl 24

26. Williams RW, von Bartheld CS, Rosen GD (2003) Counting cells in sectioned material—3D counting, the optical disector, and Abercrombie’s two-section comparison method. Current Protocols in Neuroscience Unit 1.11.1–1.11.29 Suppl 24

27. Rosen GD, Williams RW (2003) Celloidin embedding and cresyl violet staining. Current Protocols in Neuroscience Unit 11.11–1.11.29 Suppl 24

28. Rosen GD, Williams RW (2003) Estimation of regional volume from serial sections using point counting and Cavalieri’s rule. Current Protocols in Neuroscience Unit 1.11

29. Williams RW, Rosen GD (2003) Providing researchers access to tissue banks. American Laboratory

30. Gardner D, Toga AW, Ascoli GA, Beatty J, Brinkley AF, Dale AM, Fox PT, Gardner EP, George JS, Goddard N, Harris KM, Herskovits EH, Hines M, Jacobs GA, Jacobs RE, Jones EG, Kennedy DN, Kimberg DY, Mazziotta JC, Miller P, Mori S, Mountain DC, Reiss AL, Rosen GD, Rottenberg DA, Shepherd GM, Smalheiser NR, Smith KP, Strachan T, Van Essen DC, Williams RW, Song STC (2003) Toward effective and rewarding data sharing. Neuroinformatics, 1:288–295

31. Schaeffel F, Simon P, Feldkaemper M, Ohngemach S, Williams RW (2003) Molecular biology of myopia. Clinical and Experimental Optometry, 86: 295–307

32. The Complex Trait Consortium: Flaherty L, Abiola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett BB, Blankenhorn EP, Blizard DA., Bolivar V, Brockmann GA, Buck KJ, Bureau J-F, Casley, WL, Chesler EJ, Cheverud JM, Churchill GA, Cook M, Crabbe JC, Crusio WE, Darvasi A, de Haan G, Demant P, Doerge RW, Elliott RW, Farber CR, Flint J, Gershenfeld H, Gibson JP, Gu W, Himmelbauer H, Hitzemann R, Hsu H-C, Hunter K, Iraqi F, Jansen RC, Johnson TE, Jones BC, Kempermann G, Lammert F, Lu L, Manly KF, Matthews DB, Medrano JF, Mehrabian M, Mittleman G, Mock BA, Mogil JS, Montagutelli, X, Morahan G, Mountz JD, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Paigen B, Palmer AA, Peirce JL., Pomp D, Rosemann M, Rosen GD, Schalkwyk LC, Seltzer Z, Settle S, Shimomura K, Shou S, SikelaJM, SiracusaLD, Spearow JL, TeuscherC, Threadgill DW, Toth LA, ToyeAA., Vadasz C, Van Zant G, Wakeland E, Williams RW, ZhangH-G, Zou F (2003) The nature and identification of quantitative trait loci: a community’s view. Nature Genetics Reviews 4: 911–916 (PMC2063446)

33. Nissanov J, Williams RW (2003) Mouse neuroinformatic public resources. An invitation to end-users. Neuroinformatics 1:297–298

34. Williams RW (2003) A neuroscientist’s guide to genomic resources. In: The Bioinformatics of Brains: From genes and proteins to behavior (Williams RW, ed) pp. 1–8. Washington, DC: Society for Neuroscience

35. Williams RW (2003) WebQTL: a tour of transcriptional networks. In: The Bioinformatics of Brains: From genes and proteins to behavior (Williams RW, ed) pp. 51–59. Washington, DC: Society for Neuroscience

36. Williams RW (2003) Managing your lab data flux: getting beyond Excel (Williams RW, ed) pp. 83–92. Washington, DC: Society for Neuroscience

37. Zareparsi S, Hero A, Zack DJ, Williams RW, Swaroop A (2004) Seeing the unseen: microarray-based gene expression profiling in vision. Investigative Ophthalmology and Vision Science 45:2457–2462

38. Chesler EJ, Lu L, Wang J, Williams RW, Manly KF (2004) WebQTL: Rapid exploratory analysis of gene expression and genetic networks for brain and behavior. Nature Neuroscience 7:485–486

39. Chesler EJ, Williams RW (2004) Brain gene expression: genomics and genetics. In: DNA Arrays in Neurobiology (ed. Miles M) Academic Press, International Review of Neurobiology 60:59–95

40. The Complex Trait Consortium: Churchill GA, ... Williams RW and many coauthors (2004) The collaborative cross: a community resource for the genetic analysis of complex traits. Nature Genetics 36: 1-5

41. de Haan G, Williams RW (2005) A genetic and genomic approach to identify longevity genes in mice. Mechanisms of Aging and Development 126:133–138

42. Johnson DK, Rinchik EM, Moustaid-Moussa N, Miller DR, Williams RW, Michaud EJ, Jablonski MM, Goldowitz D (2005) Phenotype screening for genetically-determined age-onset disorders and increased longevity in ENU-mutagenized mice. AGE 27:75–90

43. Matthews DB, Bhave SV, Belknap JK, Brittinham C, Chesler EJ, Hitzemann RJ, Hoffmann PL, LuL, McWeeney S, Miles MF, Tabakoff B, Williams RW(2005) Complex genetics of interactions of alcohol and CNS function and behavior. Alcoholism: Clinical and Experimental Research 29:1706–1719

44. Williams RW (2006) Genomics and dyslexia: Bridging the gap (2006) In: The Dyslexic Brain: New Pathways in Neuroscience Discovery, Rosen GD, ed. Lawrence Erlbaum Associates, pp. 167–190

45. Williams RW (2006) Animal models in biomedical research: ethics, challenges, and opportunities. In: Principles of molecular medicine, 2nd ed. Runge MS, Patterson C eds, Chapter 8, Humana Press, Totowa, New Jersey, pp. 53–60

46. Williams RW (2006) Expression genetics and the phenotype revolution. Mammalian Genome 17:496–502

47. Peirce JL, Williams RW (2006) Expression and brain structure: black boxes between genes and behaviors. Neurobehavioral Genetics: Methods and Applications, 2nd ed (Jones B, Mormede P, eds). Taylor and Francis, Boca Raton

48. Chesler EJ, Bystrykh L, Cooke M, de Haan G, Manly KF, Williams RW (2006) Normalization procedures and detection of linkage signal in genetical-genomics experiments. Reply to RBH Williams et al., Nature Genetics 38:856–858

49. Miles M, Williams RW (2007) Meta-analysis for microarray studies of the genetics of complex traits. Trends in Biotechnology 25:45–47

50. Shifman S, Tzenova Bell J, Copley RR, Taylor MS, Mott R, Flint J, Williams RW (2007) Evidence of a large-scale functional organization of mammalian chromosomes; Authors’ reply. PLoS Biol 5:e128

51. Hsu HC, Lu L, Yi N, Van Zant G, Williams RW, Mountz JD (2007) Quantitative trait locus (QTL) mapping in aging systems. In: Methods in Molecular Biology (Biological Aging: Methods and Protocols), Tollefsbol TO, ed. Chapter 23, Humana Press, Totowa, New Jersey, Vol 371, pp 321–348

52. Morahan G. Williams RW (2007) Systems genetics: the next generation in genetics research? Novartis Foundation Symp 281:181–188

53. Rosen GD, Chesler EJ, Manly KF, Williams RW (2007) An informatics approach to systems neurogenetics. Neuroinformatics, ed. Crasto CJ, Humana Press, New York. Methods in Molecular Biology 401:287-303

54. Boline J, Hawrylycz M, Williams RW (2007) 1st INCF workshop on mouse and rat digital atlasing systems. http://precedings.nature.com/documents/1046/version/1 http://www.incf.org/med/incf_report_digitalatlasing_070915.pdf%20

55. Chalupa LM, Williams RW (2008) Eye, Retina, and Visual System of the Mouse (2008) MIT Press. 754 pp

56. Geisert EE, Williams RW (2008) The mouse eye transcriptome: cellular signatures, molecular networks, and candidate genes for human disease. In Eye, Retina, and Visual System of the Mouse, Chalupa LM, Williams RW, eds. MIT Press, pp 659–674.

57. Kotb M, Fathey N, Aziz R, Rowe S, Williams RW, Lu L (2008) Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections. Novartis Found Symp 293:156-65; discussion165-7, 181-3 (PMID: 18972751)

58. Morahan G, Peeva V, Munish M, Williams R (2008) Systems genetics can provide new insights in to immune regulation and autoimmunity. Journal of Autoimmunity 31:233-236

59. Williams RW, Lu L (2008) Integrative genetic analysis of alcohol dependence using the GeneNetwork web resources. In Pathways to Alcohol Dependence: Alcohol Research & Health 31:275-277

60. Beiter T, Reich E, Williams RW, Simon P (2009) Antisense transcription: a critical look in both directions. Cellular and Molecular Life Sciences 66:94-112

61. Badea A, Johnson GA, Williams RW (2009) Genetic dissection of the mouse CNS using magnetic resonance microscopy. Current Opinion in Neurology 22:379-86 (PMC2734144)

62. Williams RW (2009) Herding cats: the sociology of data integration. Frontiers in Neuroscience 3:151-154 PMCID: PMC2751652

63. Williams RW (2010) Headlong into a genomics singularity. Frontiers in Neuroscience 4:25 (PMC2858621)

64. Houtkooper RH, Williams RW, Auwerx J (2010) Metabolic networks of longevity. Cell 142:9-14

65. Williams RW (2011) Mammalian genetics: recombinant inbred strain. Brenner’s Online Encyclopedia of Genetics 2 ed. Maloy S. Hughes K, Elsevier Inc.

66. Williams RW (2012) Genetic and genomic web resources for research on alcohol use and abuse. Alcohol Research, Current Reviews 34: 378–380 in press.

67. Williams RW, Norohna A (2012) A watershed year for an update on the genetics of alcoholism. Alcohol Research, Current Reviews 34:263

68. Mozhui K, Williams RW (2012) Multidimentional databases of model organisms. In OMICs in Neuroscience, G Coppola, ed., in press

69. Williams RW, Mulligan MK (2012) Genetic and molecular network analysis of behavior. International Review of Neurobiology: Bioinformatics of Behavior, M Haendel, EJ. Chesler. Elsevier

Research Web Sites

1. www.genenetwork.org, GeneNetwork (GN) and WebQTL were created by Manly KF, JT Wang, and RW Williams in 2001, initially as part of a Human Brain Project. GN and a number of specialized code modules (GenomeGraph, SNP Browser, QTL Reaper) are being developed by RW Williams and colleagues (2001-present). GeneNetwork is a major genomics resource site that receives ~12,000 hits per day and ~ 1200 hosts per week (see http://www.genenetwork.org/webqtllog/). GN has reciprocal links with UCSC’s Genome Browser, NCBI, The Allen Brain Atlas, NEIBank, and The BIRN MBAT project. A full mirror site of GN is maintained at the Helmholtz Zentrum für Infektionsforschung in Germany (http://genesys.helmholtz-hzi.de/search.html). Approximately 30 publications referenced GeneNetwork and WebQTL in 2007 (see http://www.genenetwork.org/reference.html).

2. www.nervenet.org. Nervenet was initiated by RW Williams, January 1994. It is one of the oldest neuroscience web sites and now serves as the Williams lab portal. It predecessor, mickey.utmem.edu originally housed the Portable Dictionary of the Mouse Genome. The earliest “http” reference in a PubMed abstract is associated with this portal: see http://www.ncbi.nlm.nih.gov/pubmed/8043953

3. www.mbl.org. The Mouse Brain Library was initiated by Williams RW, Rosen GD, Williams, A.G., May 1997. The Mouse Brain Library and the Internet Atlas of the Mouse Brain have been in continuous operation since May 1997. This is a growing and well-used Internet database with histological image data for over 2000 mouse brains imaged at low, intermediate, and high resolution. It includes several stereotaxic atlases of the brains of mice. The MBL was included in ISI Current Web Contents (CC Connect TM) starting in Jan 2001. The site was reviewed by Kaiser J (2000) in Science. Mouse Brain Library: Netwatch Images selection. Science 289:211.

4. www.complextrait.org. The main web site for the Complex Trait Consortium. Founded in 2002 by RW Williams and colleagues. The site is housed in the Williams lab.

5. www.ibangs.org. The main web site for the International Behavioural and Neural Genetics Society. This site was initiated by Dr. Wim Crucio. It was rebuilt most recently by Arthur Centeno and RW Williams. The site is housed in the Williams lab.

6. <iscope.nervenet.org> Initiated by Williams RW, Cruz B, Connolly M; Capra JA (1999) iScope. A software suite for telemicroscopy. <www.mbl.org > Aug 1999–2005. As of 2006, this project and web site has been retired.

News and Coverage

New York Times. Blakeslee S (1993) Evolution of tabby cat mapped in brain study. Tuesday January 12, Section B5.

Il Corriere Della Sera (Milan newspaper). Simion L (1993) Al micio si e rimpicciolito il cervello. Jan 31 issue.

Discover Magazine. Oliwenstein L (1993, May issue) Brain Donors. Discover 14:18.

Nature. Guillery RW (1994) No crossing at the crossing. A New and Views article. Nature 367:597–598 (This review considers a paper by Williams et al. 1994.)

Human Genome News. Mansfield BK (1994) Mouse gene data files available from UT Memphis. Human Genome News, May 1994.

Science. Takahashi JS (1994) Forward and reserve genetic approaches to behavior in the mouse. Science 264: 1724–1733. (This review contains a brief description of the Portable Dictionary of the Mouse Genome.)

Science. Kaiser J (2000) Mouse Brain Library: Netwatch Images selection. Science 289:211.

Commercial Appeal (Memphis newspaper). July 9, 2001. Front page photo of Abigail Haynes working in R. Williams laboratory (by Lance Murphey).

Memphis Business Journal. Jan 15–21, 2002. Vol. 24 No. X. RW cited in article on Genome Explorations.

Commercial Appeal. May 15, 2002: World’s scientists sniff trail of complex traits. RW cited in article as organizer. Page A11.

Apple Computer, Inc. Providing Broad Access to Tissue Banks: on the Science & Technology site at http://www.apple.com/scitech/appletech/dv/utic/ (posted 2002)

AAAS News Release. Feb 17, 2003 by Monica Amarelo. iScope, you scope, we all scope a mouse brain

DataDescription Inc. Which gene influences what? Data Desk aids in gene mapping: DataDescription Inc., by Holly M. Bailey, July 2003, http://www.datadesk.com/company/profiles/williams.shtml

Bio IT World. June 15, 2003 issue. Building a better mouse database. http://www.bio-itworld.com/archive/061503/mouse_sidebar_2646.html and see http://www.bio-itworld.com/archive/061503/mouse.html

Science (2003) Geneticists Dream of 1001 Complex Mice. Science 301:456–457 by GretchenVogel

Bio-IT World (2004) Mouse Brains — FileMaker & Excel by Mike Nelson

Memphis Business Journal. Aug 12–18, 2005, by Scott Shepard. Mouse engineer: Williams leads project to revolutionize genomics research

BIRNing Issues: Biomedical Informatics Research Network: August 2005. “Williams helps integrate diverse mouse data.” www.nbirn.net/Publications/Newsletter/ pp 5-6

Memphis Business Journal. July 7–13, 2006, pp. 9–10 by Scott Shepard. Focus on Biotech. Biotech debate: Share or covet knowledge. pp. 9-10. This article includes an interview with RWW. “The key concept is to recognize the areas of science and areas of industry that we all regard as pre-competitive.”

Time Magazine (Jan 2007) “What the Mouse Brain Tells Us,” by Alice Park. Jan 29, 2007, p. 93.

Neuroscience Gateway (Feb 2007) Pump up the volume. Genes associated with basolateral amygdala morphology are involved in neuronal development. Feb doi:10.1038/aba1717 http://www.neuroscience-gateway.org/2007/070215/full/aba1717.shtml [An article about a paper by Mozhui, Hamre, Holmes, Lu, and Williams on loci modulating volume of the amygdala.]

Snow, D (April 2008) The Million Dollar Mouse: a statewide consortium provides a model of collaboration and research. Business TN, www.businesstn.com/pub/5_4/features/8506-1.html

Memphis Business Journal, April 24, 2012: University of Tennessee research awarded $2.1 M NIH grant, http://www.bizjournals.com/memphis/news/2012/04/25/ut-researcher-awarded-21m-nih-grant.html?ana=e_du_pub&s=article_du&ed=2012-04-25