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Robert W. Williams

Office Address:
Department of Anatomy and Neurobiology
University of Tennessee
Health Science Center
855 Monroe Avenue
Memphis  TN  38163
(901) 448-7050   FAX ...-7193
rwilliam@nb.utmem.edu
 
www.nervenet.org
www.mbl.org
www.webqtl.org
www.complextrait.org

DEGREES

Ph.D. (1983) Physiology, University of California, Davis
B.A. (1975) Psychobiology, University of California, Santa Cruz

INTERESTS

• Systems genetics, complex trait analysis, and functional genomics
• Control of gene expression
• Genetics of CNS diseases and addiction
• Visual system structure, function, and development
• Advanced methods in collaborative research and data interchange

PROFESSIONAL EXPERIENCE

2001–present William and Dorothy Dunavant Chair of Excellence in Developmental Genetics: Department of Pediatrics (2nd appointment), University of Tennessee
2000–present Codirector: Center of Genomics and Bioinformatics, University of Tennessee
1997–present Professor: Department of Anatomy and Neurobiology and Center for Neuroscience, University of Tennessee Health Science Center (primary)
2001–present Professor: Department of Pediatrics
2001–present Member: Feinstone Center for Genomic Research, University of Memphis
1992–1997 Associate Professor: Department of Anatomy and Neurobiology and Center for Neuroscience, University of Tennessee
1989–1992 Assistant Professor: Department of Anatomy and Neurobiology and Center for Neuroscience, University of Tennessee
1986–1989 Assistant Professor: Yale University School of Medicine, Section of Neuroanatomy
1985–1986 Associate Research Scientist: Yale University School of Medicine, Section of Neuroanatomy (P. Rakic, mentor)
1984–1989  Instructor, Neuroanatomy laboratory: Yale University School of Medicine, Section of Neuroanatomy
1983–1985  Postdoctoral fellow: Yale University School of Medicine, Section of Neuroanatomy, (P. Rakic, mentor)
1982–1983 Assistant Research Physiologist: University of California, Davis
1982  Instructor: University of California, Davis
1979–1982 National Institutes of Health Trainee: University of California, Davis, (L.M. Chalupa, thesis advisor)
1978–1981 Teaching Assistant and Teaching Associate: Animal Physiology and Psychology, University of California, Davis

Professional SOCIETIES

Society for Neuroscience (Chair, Neuroinformatics Committee)
Complex Trait Consortium (founder and director, 2001–present)
Research Society on Alcoholism
Association for Research in Vision and Ophthalmology
International Behavioural and Neural Genetics Society (president 2005)
International Mammalian Genome Society
Behavioural Neurogenetics Initiative (member)
IEEE

Grants and Fellowships

2001–present Principal Investigator: National Institutes of Health. “INIA: Complex Trait Analysis of Alcohol-Stress Interactions” U01AA13499. TDC approx. $1.68M over 5 years  (02.01.02–12.31.06).
2001–present Principal Investigator: National Institutes of Health. “INIA: Genotyping Core”  1U24AA13513. TDC approx. $600,000 over 5 years (01.01.02–12.30.06).
2000–present Principal Investigator: National Institutes of Health and National Science Foundation, Human Brain Project. “Informatics Center for Mouse Neurogenetics”  P20-MH62009 and IBN-0003982. TDC approx. $5.4 million over 5 years (7.1.00–6.30.05, 32%).
2000–present Principal Investigator: National Institutes of Health. “Genetic and Epigenetic Control of Eye Growth”  R01 EY12991. TDC $200,00 year 1, $800,000 all years (9.1.00–7.31.04, 30%).
1999–2002 Principal Investigator: National Institutes of Health. “Biometric and Functional Studies of the Eye and Retina” R01 EY13070. TDC $150,000 year 1, $444,381 all years  (12.01.99–11.30.02 25%).
2001 Principal Investigator: NIHLB Mammalian Genotyping Service. "High Resolution QTL Mapping in Mice" (7.1.01). Grant funds 350,000 genotypes.
2001 Collaborator: National Institutes of Health. "Sleep Patterns During Infectious Disease" NL70522. TDC $225,00 year 1, $1.11M all years (9.19.01–7.31.05; PI Linda Toth, no funded effort).
2000–present Eye Domain coinvestigator: National Institutes of Health. “Targeted Mutagenesis of the Mouse Genome and Neural Phenotypes” U01-MH61971, TDC, $2,664,000/year (D. Goldowitz, PI, M. Jablonski, domain PI) (funding from 7.1.00–6.30.05, RW 5%).
2000 Principal Investigator: NIHLB Mammalian Genotyping Service. "An Advanced Intercross for Mapping Multigenic Morphometric Traits in Mice: A Community QTL Mapping Resource" (1.1.00). Grant funded ~190,000 genotypes.
1996–2000 Principal Investigator: National Institutes of Health. “Genetic Control of Neuron Populations” R01 NS35485. TDC ~$733,000 all years (07.1.96 to 07.31.00, 20%).
1987–2000 Principal Investigator: National Institutes of Health. “Growth of Optic Nerve Fibers” R01 EY06627-10. TDC, $437,500 (12.1.95 to 05.30.00).
1991–1994 Principal Investigator: National Institutes of Health. “Development and Clonal Structure of the Mammalian Retina” R01 EY 08868–03. TDC, $260,518
1992–1996 Co-Principal Investigator: National Institutes of Health. “Genetic Basis of Retinal Development” R01 EY09586-03. P.I, Dan Goldowitz, TDC, $505,991 (4.1.92 to 3.31.96).

Awards

Loren D. Carlson Prize in Physiology, 1982-83
Fellow Award, Winter Conference on Brain Research, 1987
Excellence in Teaching Award, 1995

Patents

Tissue Analyzer: Inventors Robert W. Williams, Pasko Rakic, U.S. Patent 4,932,044; filed November 4, 1988; issued June 5, 1990. See http://www.patents.ibm.com/claims?patent_number=4932044
Method for ultra-high resolution mapping of genes and determination of genetic networks among genes underlying phenotypic traits: Inventors David W. Threadgill (Chapel Hill NC) and Robert W. Williams (Memphis TN), U.S. Patent Application (Preliminary) filed December 1, 2000.
Method for determining sensitivity to environmental toxins and susceptibility to Parkinson’s disease. Inventors: Richard Smeyne (Memphis TN) and Robert W. Williams (Memphis TN). U.S. Patent Application (Preliminary), to be filed.
Invention Disclosure: P2P-R cooperates with the MAD2, BUB3 and p55CDC/cdc20 mitotic checkpoint-associated proteins. Inventors: Dr. Robert E. Scott, and Robert W. Williams, Memphis TN)

Symposia, Conferences, Committees

2006 Multistrain Mouse Testing Strategy Advisory Working Group, NIEHS, Research Triangle Park, July 21 (with John Pritchard)
2006 Databasing the Brain, European Union workshop, Oslo, Norway, June 25–27
2006 Symposium honoring Dr. Lorraine Flaherty, Genomics Institute, Wadsworth Center, Albany Medical College, Albany, New York, June 19
2006 Neurofederatie Keynote Lecture, Endo-Neuro-Psychopharmacology (ENP) annual meeting, Amsterdam, June 7
2006 Genes Meet Behavior, a joint symposium of the International Behavioral Neuroscience Society and International Behavioural and Neural Genetics Society, Whistler, Canada, May 24
2006 Gordon Research Conference on Genes and Behavior, Ventura, Feb 11–17
2006 Blueprint LINC team member, NIH, Bethesda, March 30–31
2005 Human Brain Project Special Interest Social, presentation, SfN annual meeting, Washington, Nov 14
2005 German Genetics Society, Genetics of Infection, symposium presentation, Braunschweig, Germany, Sept 22
2005 Opening lecture, 4th Annual CTC meeting, Groningen, Holland, June 27
2005 Mouse Models of Human Cancer Consortium Glioblastoma Meeting, St. Louis, June 16–18
2005 International Behavioural and Neural Genetics Society annual meeting, Sitges, Spain, June 9–13
2005 GENSAT Gene Selection Advisory Meeting, Bethesda, June 7
2005 High Q Foundation Meeting on Microarrays and Discovery of Therapeutic Targets for Huntington’s Disease, May 19, New York
2005 2nd Annual Experimental Neurogenetics of the Mouse workshop, faculty member, Memphis, May 16-24
2005 Plenary lecture, Data Sharing in the Age of Discovery Science, Human Brain Project, NIH, Natcher Center, April 25
2005 Collaborative Cross Organizing Committee meeting, ORNL, March 24–25
2005 Gordon Research Conference on Quantitative Genetics and Genomics, Ventura, Feb 19–24
2005 Models of Human Cancer Consortium Committee Meeting, Vanderbilt, Jan 19–21
2005 1st International Imaging Genetics Conference, UC Irvine, Jan 17
2004 NIEHS Toxicogenomics Research Consortium meeting, Chapel Hill, Dec 6–8
2004 Mouse Resources Roundtable Conference, The Jackson Laboratory, Nov 19–21
2004 Biomedical Informatics Research Network (BIRN) Symposium speaker, Boston, Oct 13
2004 Co-organizer, 3rd Annual Complex Trait Consortium meeting, Bar Harbor, July 6–9
2004 Organizer, 10th International Summer School on Behavioral Neurogenetics (Memphis TN, August 8–15
2003 Mouse Atlas Workshop (NIMH Office of Neuroinformatics), Nov 18, 2003
2003 Behavior Genetics Association Symposium: Chicago June 27
2003 Mouse Initiatives V: Genomics of Complex System in Biomedical Research, July 31–Aug 2, www.jax.org/courses/mi5_03.html
2003 Joint Statistics Meeting symposium speaker: San Francisco, Aug 4 to 6.
2003 Society for Neuroscience Brain Information Group member
2003 Keynote: 9th International Summer School on Behavioral Neurogenetics, Aug 6–9. Toulouse, France
2002 National Cancer Institute: Mouse Models of Human Cancers Consortium- Roundtable, Newport Beach CA, Dec 11–13.
2002 Lecturer: NIDA Addiction Studies Workshop for Journalist (Tuscon AZ, Dec 8)
2003 Spring Brain Conference Plenary Session organizer: Identifying Genes Controlling Brain Structure and Behavior using Complex Trait Analysis, Sedona, March 12–15
2002 Chair:  Bioinformatics 2002, Society for Neuroscience Short Course, Orlando FL, Nov 2
2002 Instructor: 8th International Summer School on Behavioral Neurogenetics, Aug 5–9. Worcester MA.
2001 Chair: International Complex Trait Consortium, Edinburgh, Oct.23, 2001 and Memphis, May2.
2001 Sponsor and organizing committee: 4th Annual Meeting: International Behavioral and Neural Genetics Society, San Diego, Nov. 8–9
2001 Workshop presentation: South-East Regional Meeting of the Society of Developmental Biology, Montreat NC, May 24
2001 Invited speaker: Neuroinformatics Faces Functional Genomics symposium: Natcher Building: Bethesda MD, May 22: Tools for Collaborative Analysis of Complex Neurodevelopmental and Behavioral Traits.
2000 Invited speaker: NIAAA-sponsored QTL meeting: Washington DC (Dec 1; organized by Robert Karp)
2000 Invited participant: Human Brain Project: Neuroinformatics Satellite Symposium. New Orleans (Nov 4,; presentation by GD Rosen)
1999 Co-organizer: Symposium on QTL Mapping, Behavior Genetics Association, Vancouver, Canada, July
1999 Co-organizer and sponsor: The Molecular Biology/Molecular Genetics of the Visual System, Center for Vision Research Memphis TN (Mar 26)
1999 Participant: Gordon Research Conference in Quantitative Genetics. Ventura, CA (Feb 14–19)
1998 Course Lecturer: Short Course in Quantitative Neuroanatomy. Society for Neuroscience, Los Angeles CA
1998 Chairman: American Association of Anatomists: Experimental Biology 98: Experimental Biology: Symposium on Quantitative Neurobiology and the Human Brain Project
1996 Chairman: Mouse Chromosome 7 Committee: International Mammalian Genome Society
1998 Presentation: Chautauqua Short Course for college teachers in neuroscience
1997 Chairman: American Association of Anatomists: Experimental Biology 97: Mini-symposium on Quantitative Neurobiology
1994 Co-chairman: Mouse Chromosome 7 Committee: International Mammalian Genome Society (1994–1996)
1989 Organizer: Winter Brain Conference Workshop, “Different Strategies of Brain Development,” Co-organized with Karl Herrup. Jan. 1989
1996 Co-organizer: Symposium on Cortical Development, Center for Neuroscience, University of Tennessee, June 1996
1991 Participant: The Jackson Laboratory,  “Short Course in Medical and Experimental Mammalian Genetics ” Aug. 1991
1985 Participant: Gordon Research Conference, “Central Nervous System,” Tilton School, New Hampshire, June 1985
1983 Participant: The Neuroscience Institute, “Molecular Bases of Neuronal Development,” The Salk Institute, October 1983
1981 Participant: NATO Advanced Studies Institute, “Formation of Neuronal Connections,” Varenna, Italy, May 1981

Visiting Scientist

2006 University of California, San Diego, March (Dr. Mark Ellisman)
2000–2002 Advisory Professor, Fudan University, Shanghai
2000–present Collaborator, with Profs Tan and Gu, Nantong Medical College,
1997 Harvard University, Beth Israel Hospital, Dr. Glenn Rosen, June 1997
1996 The California Institute of Technology, Drs. John Allman and Scott Fraser, Aug. 1996
1993 The Jackson Laboratory, Dr. Muriel Davisson, July 1993

Scientific Advisory Boards

2006–2008 Scientific Advisory Board, Institute Clinique de la Souris, Strasbourg, France (Pierre Chambon, Johan Auwerx, and colleagues)
2006–2007 Representative and advisory board member, International Neuroinformatics Coordinating Facility
2004–2007 Portland Alcohol Research Center, VAMC, Portland
2004–2006 Consultant, Exploratory Transdisciplinary Imaging Genetics Center (Steven Potkin, PI, UCI)
2001–2007 Genome Explorations Inc.

Invited Seminars and Lectures (Incomplete List)

Application of Pharmacogenomics to Drug Development and Therapy, 14th ISSX Meeting, Short Course presentation. Oct 22, 2006
IIIe cycle, Lausanne Genome Day, lecture, Lausanne Switzerland, Oct 4-5, 2006
Unveiling Genome-Wide DNA Variation in 15 Diverse Mouse Strains: NIEHS, lecture, Sept 26, 2006
West Virgina University Eye Institute, seminar; Sept 20, 2006
Route 28 Meeting Adult Neurogenesis Course, Fraueninsel, Germany, Sept 2–8, 2006
Instructor, Plant Genome Short Course, Boston, Aug 1–3, 2006
Eli Lilly Integrative Biology Research Group, Lectures, Indianapolis, June 12–13, 2006
Workshop on Systems Genetics, University of Utrecht, Netherlands, June 6, 2006
ARVO mini symposium speaker, Ft. Lauderdale, May 3, 2006
Bioinformatics Summit, Lake Barkley KY, April 22, 2006
Society for Neuroscience Chapter lecture, University of Mississippi Medical Center, April 11, 2006
SERCEB Infectious Disease Meeting, New York City, March 26–28, 2006
Cold Spring Harbor, Systems Biology lecture, March 25, 2006
Illumina Corp, La Jolla, March 15, 2006
Cold Spring Harbor Laboratory, weekly seminar, Feb 24, 2006
UCSB Engineering, seminar in imaging and genetics, Feb 14, 2006
University of Texas at Austin, Department of Neurobiology, Nov 28, 2005
University of Colorado, Boulder, Institute for Behavior Genetics, Oct 14, 2005
Oxford University, Wellcome Trust, July 1, 2005
Lecture, Universidad Autonoma de Barcelona, Spain, June 8, 2005
SERCEB Annual Meeting seminar, Chapel Hill, May 5, 2005
NIEHS Seminar: Systems Genetics, Research Triangle Park, May 2, 2005
VA MC Memphis Seminar, March 11, 2005
UTHSC Pathogenesis Center Chalk talk, March 2, 2005
NIDA, Molecular Anatomy: Synergy by Informatics 2, Feb 15, 2005
UTHSC Department of Pharmacology, Genetic Modulation of Transcripts, Cells, and Behavior: Or, How I learned to stop worrying and love complexity, Feb 9, 2005
St. Jude Children’s Hospital Danny Thomas Lecture Series: Genetic Variation in Transcriptional Activity, Jan 7, 2005
Vanderbilt University: Seminar in Integrative Genomics, Nov 30, 2004
Department of Neuroscience, Vrije Universiteit, Amsterdam, Aug 27, 2004
Groningen Universiteit, Department of Stem Cell Biology, Aug 26, 2004
Route 28 Conference, Fraueninsel, Germany, Aug 23, 2004
Czech National Academy of Science, Prague, Aug 20, 2004
IGBMC Illkirch, France, Aug 18, 2004
Tübingen Neurocolloquium, Germany, May 27, 2004
GBF Braunschweig, Germany, May 25, 2004
Max-Delbrück-Centrum, Berlin-Buch, Germany, May 24, 2004
University of Kentucky, Lexington, April 2004
MGH/MIT Harvard: Feb 25, 2004
Washington University:
Yale University, Department of Genetics, Dec 16, 2003
University of Chicago, Committee on Genetics, Dec. 2, 2003
American Society of Human Genetics symposium speaker: Nov 5, 2003
Vanderbilt University, Neuroscience: Oct 22, 2003
Nathan Kline Institute: Oct 17, 2003
Oregon Health Science symposium, Oct 9, 2003
Special lecture: 9th international summer school on behavioral neurogenetics, Toulouse, Aug 5, 2003.
Symposium at the Joint Statistics Meeting,,Aug 3, 2003, San Francisco
Mouse Initiatives V meeting, Jackson Laboratory, Aug 1, 2003
Symposium at Behavioral Genetics Association, June 26, 2003, Chicago
Purdue University: June 19, 2003
Human Brain Project, Bethesda: May 12, 2003 Natcher Center presentation: http://videocast.nih.gov/ram/brain051203.ram
Pennsylvania State University: May 2, 3, 2003: Genomics Spring Fever: Complex Genetics of Brain and Behavior
St Jude Children’s Research Hospital, Feb 6, 2003: Dissecting Transcriptional Networks (Affy Memphis User Group Meeting)
University of Toronto, Mt. Sinai Hospital, Feb 4, 2003
University of Tübingen: Neurobiology of Vision, July 9­10, 2002
Wake Forrest University, Drug Addiction Workshop for Journalist, Dec 2002 (Tucson AZ)
Wadsworth Center, Albany New York, Feb 2003
University of California, Davis, Dec 2002
University of Memphis, Sept 13, 2002
Wilmer Eye Institute, Johns Hopkins University, Aug 29, 2002. The Complex Genetics of Eye and Brain Development: Gene Network Analysis using Microarrays
King’s College, London: July 7, 2002
University of Alabama, Section of Statistical Genetics, June 17, 2002
New England College of Optometry, Apr 25, 2002
University of Tennessee Health Science Center, Grand Rounds in Pediatrics, Mar 13, 2002
Southern Illinois University, School of Medicine, Mar 15, 2002
Neuroinformatics. The 35th Annual Winter Conference on Brain Research, Jan.27, 2002
New Mouse Behavioral Phenotyping Assays: Half Moon Bay CA, Dec 2001
Society for Developmental Biology, Southeast Regional Meeting, Workshop presentation, May 2001
Human Brain Project Conference, Natcher Center, NIH, May 2001
Cornell University, Department of Psychology and Dept of Neuroscience, Apr 2001
Stanford University, Apr 12, 2001
University of Alabama, Birmingham, Department of Medicine, Mar 21, 2001
MCP-Hahneman, Department of Neuroscience, Mar 14, 2001
UCLA, Neuroscience Grand Rounds, Feb 7, 2001
Shanghai Medical University (Fudan), Department of Histology and Embryology, Nov 2000
Beijing Medical University, Department of Histology and Embryology, Nov 2000
Nantong Medical College, Neuroscience Institute, Nov 2000
University of North Carolina, Chapel Hill, Department of Genetics, Oct 23, 2000
University of Tennessee, Biomedical Engineering Joint Program, Sept 14, 2000
Cold Spring Harbor, Banbury Center, August 28, 2000
University of California, Santa Barbara, Neuroscience Research Institute, May 26, 2000. Quantitative Genetics of CNS development: View from the trailhead
State University of New York at Buffalo, Roswell Park Cancer Institute, May 8, 2000
Drexel University, Department of Biomedical Engineering, Nov 2, 1999
University of Michigan, Department of Genetics, Oct 5, 1999
Vanderbilt University, Vision Research Center, May 7, 1999. The genetics of brain evolution
University of California, Santa Barbara, Neuroscience Research Institute, Feb 16, 1999
Case Western Reserve University, Department of Neurosciences, Cleveland OH, Jan 21, 1999
VA Medical Center, Memphis TN, Nov 20, 1998 (New Power of Forward Genetics: Analysis of Polygenic Traits that Control Disease and Development)
Case Western Reserve University, Depts Ophthalmology and Genetics, Cleveland OH, Nov 18, 1998
Yale University, Department of Neuroanatomy, New Haven CT, July 1998
University of Southern California, Department of Anatomy & Neuro, June 1998
University of California, San Diego, Department of Neuroscience, June 1998
Mount Sinai Medical School, Department of Neuroscience, New York, NY, June 1997
Harvard University, Beth Israel Deaconess, Department of Neurology, June 1997
Pasteur Institute, Paris, France. Oct. 1996
Conference on Brain Evolution, Ithaca, NY, June 1995
California Institute of Technology, Pasadena, CA. Nov. 1995
National Cancer Institute (Steve O'Brien) Frederick, MD, June 9, 1994
The Jackson Lab Bioinformatics Group, Bar Harbor Maine, July 1993
25th Annual Meeting of the Biomedical Engineering Society, Memphis, Oct. 24, 1993
University of Utah, Department of Biology, Salt Lake City, UT, Jan. 1989
Winter Conference for Brain Research, Snowbird, Utah, Jan. 1989
University of Texas, Houston, Department of Neurobiology and Anatomy, Dec 1988
SUNY, Stony Brook, Department of Neurobiology, Oct 1988
Winter Conference for Brain Research, Vail, Colorado, Jan. 1987
Conference on the Development of the Vertebrate Retina, Ithaca, N.Y., June 1987
New York University, Department of Physiology and Neuroscience, Oct 1986
University of Rochester, Center for Visual Sciences, Rochester, N.Y., Apr 1986
Rush-Presbyterian-St. Luke's Medical Center, Chicago, Nov 1986
University of California, Davis, Department of Psychology, June 1985
Stanford University, Department of Neurobiology, June 1985
SUNY, Albany, N.Y., Department of Biological Sciences, Jan 1984

REVIEWER FOR

Anatomy and Embryology, Behavior Genetics, Brain Behavior and Evolution, Behavioral Brain Sciences, Cerebral Cortex, Current Biology, Developmental Biology, European Journal of Neuroscience, Experimental Eye Research, Gene Expression Patterns, Genesis, Genomics, Investigative Ophthalmology and Vision Science, Journal of Comparative Neurology, Journal of Heredity, Journal of Neurobiology, Journal of Neurochemistry, Journal of Neurophysiology, Journal of Neuroscience, Journal of Neuroscience Methods, Molecular Vision, Nature Genetics, Neuroscience, Optometry and Vision Research, Proceedings of the National Academy of Science, Science, Visual Neuroscience, Vision Research

EDITORIAL BOARDS/COMMITEES

2005–Present Member: Executive Committee of the Collaborative Cross
2006–Present NeuroCommons Working Group (Science Commons, Creative Commons (chaired by John Wilbanks)
2006–Present Member of the NIH Blueprint Neuroinformatic Framework group (PI Dan Gardner)
2004–2005 President: International Behavioural and Neural Genetics Society (executive committee from 2003–2006)
2003–2006 Society for Neuroscience: Committee on Animals in Research
2003–2006 Society for Neuroscience: Committee on Animals in Research
2003–2006 Society for Neuroscience: Committee on Animals in Research
2003–2006 Society for Neuroscience: Committee on Animals in Research
2002–present Gene, Brain and Behavior: board member
2002–present Neuroinformatics: board member
2002 Gene Expression Patterns: board member
2001–present BioMed Central  Neuroscience: core reviewer board member www.biomedcentral.com/info/biologyeditorial.asp
2001–present Behavior Genetics: board member
2000 Behavior Genetics: guest editor
1995–present Molecular Vision: board member
1993–present European Journal of Anatomy: board member

GRANT PROPOSAL REVIEWS

2006 Review Member, NIH IRG: Neuroinformatics and Neuroimaging: ZRG1 MDCN-K51 S (June 21)
2005 ZRG1 MDCN-K (92), Neurogenetics
2004 Chair NIH ZRG1 IDM-K (04) Host Genetics of Viral Pathogenesis Mar 15, 2004
2004 21st Century Fund Review (State of Indiana)
2004 Chair NIH ZRG1 IDM-K (04) Host Genetics of Viral Pathogenesis Mar 15, 2004
2004 Chair NIH MDCN-G (55) Human Brain Project, Feb 6, 7, 2004
2003 MRC Program Review (July 2003)
2002 BISTI SS-E(51) and Human Brain Project SS-E(95), Oct 22–25, 2002
2002 MCDN Special Review panel ZRG1 SSS-P 09 S (Sept 6, 2002)
2002 NEI Special Review panel ZEY1 VSN 06 R (Aug 2002)
2002 Science Foundation Ireland reviewer (July 2002)
2002 NIH Mammalian Genetics IRG (June 2002)
2002-2003 Mammalian Genotyping Advisory Panel (Apr 2002, 2003)
2002 NIH Special Review (Feb 8, 2002)
2001 NIH Innovations in Biomedical Science Tech ZRG1 SSS-7 21 B (Nov 6, 2001)
2001 NIH BISTI Panel Reviewer ZRG1 SSS-E01 1 (July 2001, Nov 2001)
2001 NIH CSR Reviewer ZRG1FCN-3 01 BISTI (July 19, 2001)
2001 NIH Special Emphasis Panel ZRG1 SSS-R (02) (July 2, 2001)
2001 NIEHS Review Panel (Inbred Rodents) ES-01-05 (June 29, 2001)
2001 Medical Research Council (UK) Strategic Grants Reviewer
2000 Fonds voor Weterschappelijk Onderzoek - Vlaanderen (Belgian NIH)
2000 NIH VISB Study Section Ad Hoc Member (6/00)
2000 NIMH Special Emphasis Panel Reviewer (Gene Array RFA MH-00-002, 7/00)
2000 UT System-wide Advisory Panel: Biotechnology and Biological Sciences Review (7/00)
1999 NIH VISC Study Section Ad Hoc Member (2/99)
1999 NIMH Center Grant Reviewer
1999 NIMH Special Emphasis Panel Reviewer ZMH1 BRB-I
1998 Department of Veterans Affairs: Merit Review Consultant
1995 Consultant to NIH VIS-B Study Section

Teaching

2006 The Jackson Laboratory: Short Course in Vision Research NSF Plant Microarray Short Course, instructor, Boston, Aug 1–3 Third Annual Experimental Neurogenetics of the Mouse workshop, Memphis, May 16–24, 2006
2001–present Course co-director: Neuroscience Seminar Series (NS8XX): a graduate level course, 15–20 contact hours, ~15 students/year.
2004–2006 Cold Spring Harbor, Systems Biology Short Course, March 23 2004–2006 Faculty, Annual Experimental Neurogenetics of the Mouse Workshop, 15–20 students/year (8 day short course at UTHSC and UM)
2005–present Course director: NIEHS Short Course on Systems Genetics (offered twice) at NIEHS main campus, Sept 7–8
2005–present NS 825: Graduate School, Developmental and Molecular Neurobiology lecturer (fall)
2005–present NS212: School of Medicine, Neuroscience lecturer (fall)
2005 Society for Neuroscience, Meet the Expert Series leader, Microarray analysis, SfN annual meeting, Washington, Nov 12 Memphis City Schools Middle/Secondary Science In-Service Session 15: The Human Genome, August 11 (2 sessions)
2001–present Course member and co-director: International Summer School in Behavioral Neurogenetics (Behavioral Neurogenetics Initiative). Annual course (one week, 15 to 30 grad and postdoctoral students/year)
2001–present Course co-director: Neuroscience Seminar Series (NS8XX): a graduate level course, 15–20 contact hours, ~15 students/year.
1992–present Course director: Morphological Neuroscience (NS822): a graduate level course, ~40 contact hours, ~ 8 students/year.
2003–present Lecturer: Comparative Medicine CM712, UTHSC: Mouse Genetics (graduate level)
2003–present Lecturer: Bioinformatics, University of Memphis (graduate level)
2000–2002 Lecturer and Lab: Medical Neuroanatomy (M): ~20 contact hours, Lectures in CNS development. 150 students/year.
2002–2003 Short Course director: Society of Neuroscience, Bioinformatics
2003 Course co-director: Memphis Microarray Short Course (June 4 to June 12, 2003)
2002 Lecturer: NIDA Addiction Studies Workshop for Journalist (Tuscon AZ, Dec 8)
2002 Short Course director:  UAB Birmingham: Design and Analysis of Recombinant Inbred Strain Experiments (all day course, June 18, 2002).
1998 Course Lecturer: Short Course in Quantitative Neuroanatomy. Society for Neuroscience, Los Angeles CA
1994–1996 Course director: Seminars in Neuroscience (NS821): Graduate level. 40 contact hours, 10 to 15 students per year
1995 SGAEC Excellence in Teaching Award, University of Tennessee (for NS822)
1995 Short Course in Genetic Testing: Memphis city schools service training for science high school teachers (Summer 1995). 15 high school science teachers
1994–1995 Human and Mouse Genetics: City Labs program for high school science teachers. 10 to 12 high school science teachers
1990–1996 Medical Embryology, University of Tennessee, 8 lectures on development of cardiovascular, urogenital, and gastrointestinal systems. 8 lecture hours,  ~120 first-year medical students.
1983–1989 Neuroscience-Neuroanatomy laboratory instructor, Yale University. Team-taught first-year medical students, roughly 20 contact hours, 25 students per lab.
1982 Course Director: Sensory Psychology, University of California, Davis. 25 junior and senior psychology majors.

PERSONAL

Born April, 1952, Baltimore, USA. Married to Kathryn A. Graehl (freelance editor), two sons (15 and 20).

Administrative

2001 – present Director: Complex Trait Consortium
2000 – present Codirector: UT Center of Excellence in Genomics and Bioinformatics
2002 – present Member, Computing and Telecommunications Committee of the Faculty Senate (C. Russell, chair). Chair: Research Computing subcommittee.
2002 – present University of Tennessee Research Foundation Task Force Subcommittee   (T. Ballard, chair)
2001 – 2002 Section Coordinator for the Visual and Auditory Systems research section. Center for Neuroscience
1999 – present Tennessee Mouse Genome Consortium, Scientific Steering Committee
1999  – 2001 Member: Promotion and Tenure Committee, Department of Anatomy and Neurobiology
1999 – present Scientific Advisory Board: Tennessee Mouse Genome Consortium
1998 Chair: Promotion and Tenure Committee, Department of Anatomy and Neurobiology
1998 – present Member: Department of Anatomy and Neurobiology Space and Research Committee
1997 – present Member: Department of Anatomy and Neurobiology Advisory Council
1997 – present Member: University of Tennessee, Graduate Health Sciences Electronic Thesis and Dissertation Advisory Committee
1997 – 1999 Member: Center for Neuroscience: Graduate Student Recruitment Committee
1990 – 1997 Member: University of Tennessee, Graduate Health Science School, Policy Subcommittee
1995 – 1997 Member: University of Tennessee, Graduate Health Science School, Graduate Studies Council
1990 – 1994 Member, University of Tennessee library committee member
1990 – 1996 Member: Department of Anatomy and Neurobiology: Graduate student admissions and policy committee

Graduate Students and Postdoctoral Fellows

Khyobeni Mozhui Ph.D. candidate, 2006–present (currently working toward degree)
Dennis Rice Ph.D., 1996. University of Tennessee. Dr. Rice is currently a Senior Scientist in Neurology at Lexicon Genetics, Woodlands, Texas
Richelle C. Strom Ph.D., 1999. University of Tennessee. Dr. Strom is now a Postdoctoral Fellow with Prof. Ruben Adler, Johns Hopkins University
Dale Hogan, Ph.D. NRSA NEI Postdoctoral fellow, 1992–1996. Currently a Research Associate with Mark Opp, Department of Psychiatry and Behavior, University of Texas Medical Branch, Galveston
Guomin Zhou, M.D., Ph.D.: Research fellow, 1997–1999. G. Zhou is Chairman and Professor of Histology and Embryology at Fudan University, Shanghai, China
Lu Lu,, M.D. Research fellow, 1999–2001. Dr. Lu is an Associate Professor in Histology and Embryology at the Medical University of Nantong, China. He is also an Assistant Professor at the University of Tennessee Health Science Center.
David C. Airey, Ph.D. NRSA, NEI Postdoctoral fellow, April 1999–July 2001. Dr. Airey received his Ph.D. from Cornell University in 1999. He is currently a postdoctoral fellow with Dr. Elaine Sanders-Bush at Vanderbilt.
Elissa J. Chesler, Ph.D Research fellow, July 2002–present.
Jeremy Perice, Ph.D. Research fellow, June 2003-present
Anand Kulkarni, M.D. Research fellow, Nov 1999–Nov 2000. Currently a physician in the Memphis area.
Siming Shou, Ph.D. Postdoctoral fellow, September 2001–2002.
Emmanuel Gilissen ,Ph.D. Postdoctoral fellow (1996–1997, with John Allman at Caltech). Emmanuel is now on the faculty of paleontology, University of the Witwassersrand, South Africa.
Kathryn Ryder M.D. dissertation, Yale University School of Medicine, 1987. Dr. Ryder is currently an assistant professor, Department of Medicine at University of Tennessee Health Science Center.
Michael Borodkin M.D. dissertation, Yale University School of Medicine, 1989

Ph.D., M.S. Committees

Khyobeni Mozhui Ph.D. candidate in Neuroscience, UTHSC 2006
C. J. Jeon, Ph.D. in Neuroscience, 1992
Angela R. Howe, Ph.D. in Neuroscience, 1994
Vandana Menon, Ph.D. in Physiology, 1996
Qing Tang, Ph.D. in Anatomy and Neurobiology, June 1996
Toya H. Kimble, Ph.D. in Anatomy and Neurobiology, Jan 2003
Loren Martin, Ph.D. candidate in Anatomy and Neurobiology, Nov 2000
Kathryn Ryder M.D. MS in Epidemiology, UTHSC 2002
Alessandro Iannaccone M.D., MS in Epidemiology, UTHSC 2002
Félix Vázquez-Chona, candidate in Anatomy and Neurobiology

ORIGINAL PAPERS with citation analysis

After some of these papers I have included a citations count. A paper‘s impact factor is the number of citations divided by years since publication. To provide some context, papers published in Science and Nature are cited an average of 5 times a year over a 15 year period. Journal of Neuroscience articles are typically cited 4.4 times a year, Journal of Comparative Neurology articles, 3.7 times a year (see The Scientist, Feb. 2, 1998, p. 11). A substantial number of these papers are available online at <www.nervenet.org>.
1. Williams RW, Chalupa LM (1982) Prenatal development of retinocollicular projections in the cat: An anterograde tracer transport study.  Journal of Neuroscience 2: 604–622. Citations = 1983:5, 85:7, 86:13, 87:11, 88:10, 89:9, 90:7, 91:5, 92:2, 93:10, 94:2, 95:4, 96:2 (14 year total = 87). Revised and updated text at <http://nervenet.org/papers/SC1982.html>.
2. Stone, J, Rapaport DH, Williams RW, Chalupa LM (1982) Uniformity of cell distribution in the ganglion cell layer of prenatal cat retina: Implications for mechanisms of retinal development.  Developmental Brain Research 2: 231–242. Citations = 1983:12, 84:8, 85:12, 86:11, 87:14, 88:9, 89:9, 90:3, 91:2, 92:2, 93:2, 94:1, 95:1, 96:3 (total = 89; 84 in first decade).
3. Williams RW, Bastiani MJ, Chalupa LM (1983) Loss of axons in the cat optic nerve following fetal unilateral enucleation: An electron microscopic analysis.  Journal of Neuroscience 3: 133–144. Citations = 1983:7, 84:10, 85:12, 86:19, 87:12, 88:7, 89:3, 90:2, 91:3, 93:3, 94:2, 95:3, 96:4 (total = 87, 78 in first decade).
4. Williams RW, Chalupa LM (1983) An analysis of axon caliber within the optic nerve of the cat: Evidence of size groupings and regional organization.  Journal of Neuroscience 3: 1554–1564. Citations = 1984:1, 85:8, 86:8, 87:5, 88:2, 89:4, 90:3, 91:0, 92:1, 93:4, 94:4, 95:6, 96:2 (total = 46, 38 in first decade).
5. Williams RW, Chalupa LM (1983) Development of the retinal pathway to the pretectum of the cat.  Neuroscience 10: 1249–1267. Citations = 1984:2, 85:4, 86:4, 87:5, 88:3, 89:2, 90:0, 91:4, 92:2, 93:1, 94:1, 95:0, 96:0 (total = 28, 27 in first decade).
6. Chalupa LM, Williams RW, Hughes MJ (1983) Visual properties of neurons in the tectorecipient zone of the cat’s lateral posterior-pulvinar complex: A comparison with the superior colliculus.  Journal of Neuroscience 3: 2587–2596. Citations = 1984:1, 85:1, 86:3, 87:5, 88:5, 89:5, 90:3, 91:5, 92:0, 93:3, 94:1, 95:1, 96:1 (total = 39; 36 in first decade).
7. Chalupa, LM, Williams RW (1984) Organization of the cat’s lateral geniculate nucleus following interruption of prenatal binocular competition.  Human Neurobiology 3: 103–107. Citations = 1985:4, 86:7, 87:0, 88:5, 89:4, 90:2, 91:0, 92:3, 93:5, 94:2, 95:2, 96:2 (total = 36, 32 in first decade).
8. Chalupa LM, Williams RW, Henderson Z (1984) Binocular interaction in the fetal cat regulates the size of the ganglion cell population.  Neuroscience 12: 1139–1146. Citations = 1985:5, 86:7, 87:5, 88:8, 89:4, 90:1, 91:0, 92:1, 93:5, 94:1, 95:6, 96:1 (total = 44, 43 in first decade). <nervenet.org/papers/SC1982.html>
9. Williams RW, Rakic P (1985) Dispersion of growing axons within the optic nerve of the embryonic monkey.  Proceedings of the National Academy of Science USA 82: 3906–3910. Citations = 1986:9, 87:9, 88:8, 89:4, 90:4, 91:3, 92:4, 93:2, 94:2, 95:4, 96:6 (total = 55; 55 in first decade). <nervenet.org/papers/dispersion85.html>
10. Williams RW, Crabtree, JW, Chalupa LM, Spear PD, Kornguth SE (1985) Selectivity of antibody-mediated destruction of retinal ganglion cell axons.  Brain Research 336: 57–66. Citations through 1996: total = 6.
11. Williams RW, Bastiani MJ, Lia B, Chalupa LM (1986) Growth cones, dying axons, and developmental fluctuations in the fiber population of the cat’s optic nerve.  Journal of Comparative Neurology 246: 32–69. Citations 1987:18, 88:22, 89:17, 90:19, 91:11, 92:8, 93:11, 94:10, 95:10, 96:7 (total = 133). <nervenet.org/papers/Cat86.html>.
12. Lia B, Williams RW, Chalupa LM (1986) Does axonal branching contribute to the overproduction of optic nerve fibers during early development of the cat’s visual system.  Developmental Brain Research 25:296–301. Citations through 1996: total = 14.
13. Lia B, Williams RW, Chalupa LM (1987) Formation of retinal ganglion cell topography during prenatal development. Science 236:848–851. Citations 1987:1, 88:7, 89:10, 90:2, 91:5, 92:7, 93:1, 94:0, 95:2, 96:2 (total = 37).
14. Williams RW, Rakic P (1988) Elimination of neurons from the lateral geniculate nucleus of rhesus monkeys during development. Journal of Comparative Neurology 272:424–436. Citations = 1989:4, 90:11, 91:5, 92:7, 93:9, 94:5, 95:3, 96:12 (total = 56). <nervenet.org/papers/RHESUS_LGN.html>
15. Williams RW, Rakic P (1988) Three-dimensional counting: An accurate and direct method to estimate cell numbers in sectioned material. Journal of  Comparative Neurology 278:344–352. Citations = 1989:4, 90:9, 91:6, 92:7, 93:9, 94:4, 95:3, 96:12 (total = 64). <nervenet.org/papers/3DCounting.html>
16. Wikler KC, Williams RW, Rakic P (1990) Photoreceptor mosaic: Number and distribution of rods and cones in the rhesus monkey retina. Journal of Comparative Neurology:297:499–508. Citations = 1991:6, 92:5, 93:1, 94:4, 95:5, 96:10 (total = 31).
17. Williams RW, Borodkin M, Rakic P (1991) Growth cone distribution patterns in the optic nerve of fetal monkeys: Implications for mechanisms of axonal guidance. Journal of Neuroscience 11: 1081–1094. Citations = 1992:4, 93:4, 94:3, 95:7, 96:6 (total = 24). <nervenet.org/papers/GC91.html>
18. Rakic, P., Suñer I, Williams RW (1991) A novel cytoarchitectonic area induced experimentally within the primate visual cortex. Proceedings of the National Academy of Science USA 88: 2083–2087. Citations = 1992:8, 93:3, 94:7, 95:8, 96:7 (total = 33).
19. Williams RW (1991) The human retina has a cone-enriched rim. Visual Neuroscience 6:403–406. Citations = 1992:?, 93:2, 94:1, 95:3, 96:3 (total = 9).
20. Williams RW, Goldowitz D (1992) Structure of clonal and polyclonal cell arrays in chimeric mouse retina. Proceedings of the National Academy of Science USA  89: 1184–1188. Citations = 19923:5, 94:3, 95:8, 96:5 (total = 21).
21. Williams RW, Cavada C, Reinoso-Suárez F (1993) Rapid evolution of the visual system: A cellular assay of the retina and dorsal lateral geniculate nucleus of the Spanish wildcat and the domestic cat. Journal of Neuroscience 13:208–228. Citations = 1994:2, 95:7, 96:6 (total = 15). <nervenet.org /papers/wildcat.html>
22. Williams RW, Hogan D, Garraghty PE (1994) Target recognition and visual maps in the thalamus of achiasmatic mutant dogs. Nature  367:637–639; and see New and Views article by R.W. Guillery, Nature 367:597–598. Citations = 1994:2, 95:6, 96:5 (total = 13). <nervenet.org/papers/DOGLGNNature.html>
23. Williams RW (1994) The Portable Dictionary of the Mouse Genome: A personal database for gene mapping and molecular biology. Mammalian Genome: 5:372-375. Citations total = 5. See <nervenet.org/main/ dictionary.html>
24. Brilliant MB, Williams RW, Conti C, Angel J, Holdener BC (1994) Mouse chromosome 7. Mammalian Genome 5: S104–S123. Citations = 1995:1, 96:18 (total = 19).
25. Dell'Osso LF, Williams RW (1995) Ocular motor abnormalities in achiasmatic mutant Belgian sheepdogs: Unyoked eye movements in a mammal. Vision Research: 35:109–116. Citations 1996 = 2, 97 =  (total = 2).
26. Scheetz AJ, Williams RW, Dubin MW (1995) Severity of ganglion cell death during early postnatal development is modulated by neuronal activity and binocular competition. Visual Neuroscience 12:605–610. Citations 1996 = 0, 97 =  (total = 0).
27. Hogan D, Williams RW (1995) Analysis of the retinas and optic nerves of achiasmatic Belgian sheepdogs. Journal of Comparative Neurology: 352:367–380.
28. Rice DS, Williams RW, Goldowitz D (1995) Genetic control of retinal projections in inbred strains of albino mice. Journal of Comparative Neurology 354: 459–469. Citations 1996 = 4, 97 =  (total = 4).
29. Rice DS, Williams RW, Harris B, Bailey PW, Davisson MT, Goldowitz D (1995) Mapping the Bst mutation on mouse Chromosome 16: A model for human optic atrophy. Mammalian Genome 6:546–548. Citations 1996 = 1, 97 =  (total = 1). <nervenet.org/papers/Bst2.html>.
30. Hogan D, Garraghty PE, Williams RW (1996) Lamination and visual topography in the lateral geniculate nucleus of normal and achiasmatic dogs. European Journal of Anatomy 1:3–11.
31. Ezer AD, Williams RW, Goldowitz D (1996) Arbitrary primer PCR of dog DNA with estimates of average heterozygosity. Journal of Heredity 87:450–455.
32. Goldowitz D, Rice DS, Williams RW (1996) Clonal architecture of the mouse retina. Progress in Brain Research 108: 2–15.
33. Brilliant MH, Williams RW, Holdener BC, Angel JM (1996) Mouse chromosome 7. Mammalian Genome  6: S135–S150.
34. Hamvas R, Trachtulec Z, Forejt J, Williams RW, Artzt K, Fischer-Lindahl K., Silver LM  (1996) Mouse chromosome 17. Mammalian Genome 6: S281–S299.
35. Williams RW, Strom RC, Rice DS, Goldowitz D  (1996) Genetic and environmental control of retinal ganglion cell number in mice. Journal of Neuroscience 16: 7193–7205. <www.jneurosci.org/cgi/content/full /16/22/7193>
36. Rice DS, Tang Q, Williams RW, Harris B, Davisson MT, Goldowitz D (1997) Retinal ganglion cell loss and misdirect axon growth associated with fissure defects in Bst mutant mice. Investigative Ophthalmology and Visual Science 38:2112–2124.
37. Williams RW, Strom RC, Goldowitz D (1998) Natural variation in neuron number in mice is linked to a major quantitative trait locus on Chr 11. Journal of Neuroscience 18:138–146. <www.jneurosci.org/cgi/content/ab stract/18/1/138> <www.informatics.jax.org/bin/fetch_expt?13547 /TEXT>
38. Williams RW, Holdener BC, Angel JM, Oakey R, Hunter K (1998) Mouse chromosome 7. Mammalian Genome 8:S136–159. <www.informatics.jax.org/bin/ccr/index?year=1998>
39. Strom, RC, Williams RW (1998) Cell production and cell death in the generation of normal variation in neuron number. Journal of Neuroscience 18:9948–9953. <www.jneurosci.org/cgi/content/abstract/18/23/ 9948>
40. Dell'Osso, LF Williams RW, Jacobs JB, Erchul DM (1998) The congenital and see-saw nystagmus in the prototypical achiasma of canines: comparison to the human achiasmatic prototype. Vision Research 38:1629–1641.
41. Zhou G, Williams RW (1999) Eye1 and Eye2: Gene loci that modulate eye size, lens weight, and retinal area in mouse. Investigative Ophthalmology and Visual Science 40:817–825. <nervenet.org/papers/Eye1.html>.
42. Williams RW (1999) A targeted screen to detect recessive mutations that have quantitative effects. Mammalian Genome 10:734–738.  <nervenet.org/papers/consomic.html>
43. Zhou G, Williams RW  (1999) Mouse models for the analysis of myopia: an analysis of variation in eye size of adult mice. Optometry and Vision Science: 76:408–418. <nervenet.org/papers/OVSMyopia.html>.
44. Williams RW, Angel JM, Holdener BC, Oakey R, Hunter K (1999) Mouse chromosome 7. Mammalian Genome 10:947 <www.informatics.jax.org/bin/ccr/index?year=1999>.
45. Dell'Osso LF, Hertle RW, Williams RW, Jacobs JB (1999) A new surgery for congenital nystagmus: effects of tenotomy on an achiasmatic canine and the role of extraocular proprioception. J Amer Acad Ped Ophthal Soc, 3:166–182.
46. Toth LA, Williams RW (1999) Circadian patterns of locomotor activity in CXB recombinant inbred mice. Behavior Genetics 29:319–328.
47. Toth LA, Williams RW (1999) Strain-related differences in slow wave sleep and rapid-eye-movement sleep in C57BL/6J and BALB/c mice.  Behavior Genetics 29:329–337.
48. Toth LA, Williams RW (1999) Circadian patterns of slow wave sleep in influenza-infected C57BL/6 and BALB/c mice: A genetic analysis using CXB recombinant inbred strains. Behavior Genetics 29:339–348.
49. Rice DS, Goldowitz D, Williams RW, Hamre K, Johnson PT, Tan SS, Reese BE (1999) Extrinsic modulation of retinal ganglion cell projections: analysis of the albino mutation in pigmentation mosaic mice. Developmental Biology 216:41–56. Online: <www.idealibrary.com/links/artid/dbio.1999.9467>
50. Hogan D, Garraghty PE, Williams RW (1999) Asymmetric connections, duplicate layers, and reversed maps in the primary visual system. Journal of Neuroscience 19: RC38:1–6 . www.jneurosci.org/cgi/content/full/3657
51. Kimble TDH, Williams RW  (1999) Structure of the cone photoreceptor mosaic in the retinal periphery of adult humans: Analysis as a function of age, sex, and hemifield. Anatomy and Embryology, 201:305–316.
52. Dell'Osso LF, Hogan D, Jacobs JB, Williams RW (1999) Eye movements in canine hemichiasma: Does human hemichiasma exist? Neuro-ophthalmology 22:47–58.
53. Angel JM, Williams RW (2000) Mouse chromosome 7. Mammalian Genome 11: 948–949.
54. Williams RW, Lu L, Kulkarni A, Zhou G, Airey DC (2001) Genetic dissection of the olfactory bulbs of mice: QTLs on chromosomes 4, 6, 11, and 17 modulate bulb size. Behavior Genetics, 31:61–77. <nervenet.org/papers/OB/OB2000.html>
55. Cook MN, Williams RW, Flaherty L (2001) Anxiety-related behaviors in the elevated zero maze are affected by genetic factors and retinal degeneration. Behavioral Neuroscience, 115:468–476.
56. Lu L, Airey DC, Williams RW (2001) Complex trait analysis of the mouse hippocampus: Mapping and biometric analysis of two novel gene loci that modulate hippocampal size. Journal of Neuroscience, 21:3503–3514. <nervenet.org/papers/hipp1.html>
57. Rosen GD, Williams RW (2001) Complex trait analysis of the mouse striatum: Independent QTLs modulate volume and neuron number. Biomed Central Neuroscience  2:5 <http://www.biomedcentral.com/1471-2202/2/5>
58. Airey DC ,Lu L, Williams RW (2001). Genetic control of the mouse cerebellum: identification of quantitative trait loci modulating size and architecture. Journal of Neuroscience, 21:5099–5109. <nervenet.org/papers/cerebellum2000.html>
59. Hardy CL, Lu L, Nguyen P, Woodland DL, Williams RW, Blackman MA (2001) Identification of quantitative trait loci controlling activation of TRBV4 CD8+ T cells during murine g-herpes virus-induced infectious mononucleosis. Immunogenetics, 53: 395–400.
60. Williams RW, Gu J, Qi S, Lu L (2001) The genetic structure of recombinant inbred mice: High-resolution consensus maps for complex trait analysis.  Genome Biology 2:46.1–46.18 <http://genomebiology.com/2001/2/11/research/0046/>
61. Hsu, HC, Mountz JD, Williams RW, Shelton BJ, Yang P, Matsuki Y, Xu X, Zhang HG, Geiger H, van Zant G (2002) Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11.  Mech Ageing Dev,123:1145–1158.
62. Zhou G, Strom RC, Giguere V, Williams RW (2001) Modulation of retinal cell populations and eye size in retinoic acid receptor knockout mice. Molecular Vision, 7, www.molvis.org/molvis/v7/a36/
63. Geisert Jr EE, Williams RW, Geisert G, Maecker HT, Deng J, Levy S (2002) Increased brain size and glial cell number in CD81-null mice.  Journal of Comparative Neurology, 453:22–32.
64. Airey DW, Lu L, Shou S, Williams RW (2002) Genetic sources of individual differences in cerebellum. The Cerebellum 1:233–240.
65. Hitzemann R, Hitzemann B, Rivera S, Gatley J, Thanos P, Lu L, Shou S, Williams RW (2002) Dopamine D2 receptor binding, Drd2 expression and the number of dopamine neurons in the BXD recombinant inbred series: genetic relationships to alcohol and other drug associated phenotypes. Alcoholism: Clinical and Experimental Research 27:1–11.
66. Grizzle WE, Mountz JD, Yang PA, Xu X, Sun S, Van Zant GE, Williams RW, Hsu HC, Zhang HG (2002) BXD recombinant inbred mice represent a novel T-cell mediated immune response tumor model. International Journal of Cancer 101:270–279.
67. Cook R, Lu L, Gu J, Williams RW, Smeyne RJ (2003) Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. Molecular Brain Research 110:279–288.
68. Hsu HC, Zhang HG, Li L, Mullinax C, Yang PA, Wu Q, Wu Y, Sun S, Renda J, Xu X, Yang X, Lu L, Van Zant G, Williams RW, Allison DB, Mountz JD (2003) Age-related thymic involution in C57BL/6J X DBA/2J recombinant inbred mice fits a negative exponential regression model and maps to mouse chromosome 9.  Genes and Immunity In press.
69. Hitzemann R, Malmanger B, Reed C, Lawler M, Hitzemann B, Coulombe S, Buck K, Rademacher B, Walter N, Polyakov Y, Sikela J, Williams RW, Flint J, Talbot C (2003) A strategy for integration of QTL, gene expression, and sequence analyses Mammalian Genome, 733–747.
70. Schaeffel F, Burkhardt E, Howland HC, Williams RW (2003) Measurement of refractive state and deprivation myopia in two strains of mice. Optometry and Vision Science, XX:XXX–XXX.
71. Peirce J, Chesler EJ, Williams RW, Lu L (2003) Genetic architecture of the mouse hippocampus: identification of gene loci with regional effects. Genes, Brain and Behavior 2:238–252.
72. Wang J, Williams RW,  Manly KF (2002) WebQTL: Web-based complex trait analysis. Neuroinformatics 1:299–308.
73. Pollock GS, Robichon R, Boyd KA, Kerkel KA, Kramer M, Lyles J, Ambalavanar R, Khan A, Kaplan DR, Williams RW, Frost DO (2003) TRKB receptor signaling regulates dynamics of developmental retinal ganglion cell death but not final number. Journal of Neuroscience,23: 10137–10145.
74. Rosen GD, La Porte NT, Diechtiareff B, Pung, CJ, Nissanov J, Gustafson C, Bertrand L, Gefen S, Fan Y, Tretiak OJ, Manly KF, Parks MR, Williams AG, Connolly MT, Capra JA, Williams RW (2003) Informatics center for mouse genomics: the dissection of complex traits of the nervous system. Neuroinformatics, 1:327–342.
75. Chesler EJ, Wang J, Lu L, Qu Y, Manly KF, Williams RW (2003) Genetic correlates of gene expression in recombinant inbred strains: a relational model system to explore neurobehavioral phenotypes. Neuroinformatics, 1: 343–357.
76. Seecharan DJ, Kulkarni AL, Lu L, Rosen GD, Williams RW (2003) Genetic control of interconnected neuronal populations in the mouse primary visual system. Journal of Neuroscience, 23:11178–11188.
77. Santos JB, Williams RW, Schauwecker PE (2003) Genetic control of seizure-induced cell death susceptibility in mice. in review.
78. Chesler EJ, Lu L, Shou S, Qu Y, Wang J, Hsu HC, Mountz JD, Manly KF, Threadgill DW, Williams RW. Massively parallel analysis of mouse brain gene transcription regulation and transcription networks. Submitted Aug 22, 2003.
79. Williams AG, Williams RW (2003) GenomeMixer; A complex genetic cross simulator. Bioinformatics, In press.
80. Peirce J, Lu L, J. Gu , Silver LM, Williams RW (2004) A new set of  BXD recombinant inbred lines from advanced intercross populations. BMC Genetics. In press.
81. Williams RW, Bennett B, Lu L, Gu J, DeFries JC, Carosone-Link P, Rikke B, Belknap JK, Johsnon TE (2004) Genetic structure of the LXS panel of recombinant inbred mouse strains. Mammalian Genome. In press.
82. Baldwin NE, Chesler EJ, Krov S, Langsteon MA, Snoddy JR, Williams RW, Zhang B (2004) Computational, integrative and comparative methods for the elucidation of gene regulatory networks. Workshop on Algorithms in Bioinformatics (WABI 2004) Bergen Norway. www.ii.uib.no/algo2004
83. Schauwecker PE, Williams RW, Santos JB (2004) Genetic control of seizure-induced cell death susceptibility in mice. Journal of Comparative Neurology 477:96-107
84. Ponomarev I, Schafer GL, Blednov YA, Williams RW, Iyer VR, Harris A (2004) Convergent analysis of cDNA and short oligomer microarrays, mouse null mutant, and bioinformatics resources to study complex traits. Genes, Brains and Behavior 3:360-368
85. Tan XL, Zhou Y, Cai KF, Shao YX, Zhu SX, Lu L, Williams RW, Gu XS (2004) Identification of QTLs for weight and cross-sectional area on cervical enlargement of spinal cord in mice. Yi Chuan Xue Bao 31:801-806
86. Jablonski MM, Lu L, Wang, XF, Chesler EJ, Carps E, Qi S. Gu J, Williams RW (2004) The ldis1 lens mutation in RIIIS/J mice maps to chromosome 8 near cadherin 1. Molecular Vision 10:577–¬587
87. Simon P, Schott K, Williams RW, Schaeffel F (2004) Post-translational regulation of the immediate early gene EGR1 by light in the mouse retina. European Journal of Neuroscience 20:3371-3377
88. Scott RE, White-Grindley E, Ruley HE, Chesler EJ, Williams RW (2005) P2P-R expression is genetically coregulated with components of the translation machinery with PUM2, a translational repressor that associates with the P2P-R mRNA. Journal of Cellular Physiology 204:99-105

REVIEWS, LETTERS, BOOK CHAPTERS

1. Chalupa LM., Williams RW (1984) Prenatal development and reorganization in the visual system of the cat. In Development of Visual Pathways in Mammals. Stone J, Dreher B, Rapaport DH (eds)  Alan R Liss Inc,  New York, pp 89–102. Citations total through 1996 = 25. Full text <nervenet.org/papers/CatRev84.html>.
2. Chalupa LM, Williams RW (1985) Formation of retinal projections in the cat. In Advances in Neuronal and Behavioral Development. vol 1. (Aslin RN, ed): Norwood, New Jersey: Ablex Publishing, pp 1–32. Citations total through 1996 = 5.
3. Williams RW, Herrup K (1988) The control of neuron number. Annual Review of Neuroscience 11: 423–453. Citations = 1988:3, 89:12, 90:14, 91:20, 22:14, 93:21, 94:11, 95:11, 96:12 (total = 118). Full text <nervenet.org/papers/NUMBER_REV_1988.html>.
4. Williams RW. Goldowitz D (1992) Lineage versus environment in embryonic retina: A revisionist perspective. Trends in Neuroscience. 15:368–373. Also see: Williams RW, Goldowitz D (1993) Lineage versus environment in embryonic retina: Letters to the editor. Trends in Neuroscience. 16:96–98. Citations = 1993:6, 94:5, 95:11, 96:4 (total = 25). Full text <nervenet.org/papers/TINS_1992.html>.
5. Williams RW (1990) The primary visual system does not care about Previc’s near-far dichotomy. Why not?  Behavioral and Brain Sciences: 13: 557.
6. Williams RW (1992) A very rare congenital eye movement disorder in Belgian sheepdogs. National Belgian Newsletter: 44:75.
7. Williams RW, Strom RC, Zhou G, Yan Z (1998) Genetic dissection of retinal development. Seminars in Cell and Developmental Biology 9:249–255. <nervenet.org/papers/retinarev.html>.
8. Williams RW (1998) Neuroscience meets quantitative genetics: Using morphometric data to map genes that modulate CNS architecture. Short Course in Quantitative Neuroanatomy (Morrison J, and Hof P, eds) pp 66-78. Full text <nervenet.org/papers/ShortCourse98.html>
9. Toth LA, Williams RW (1998). Genetic analysis of complex quantitative traits using inbred mice. Sleep Research Society Bulletin 4:50–56.
10. Williams RW (2000). Mapping genes that modulate mouse brain development: a quantitative genetic approach. In: Mouse brain development (Goffinet AF, Rakic P, eds). Springer, New York, pp 21–49. <nervenet.org/papers/brainrev99.html>
11. Belknap JK, Crabbe JC, Phillips TJ, Hitzemann R, Buck KJ, Williams RW (2001) Quantitative trait loci and genome-wide mutagenesis: two phenotype-driven approaches to the dissection of complex murine traits. Behavior Genetics 31: 5–15.
12. Mountz JD, van Zant G, Zhang H, Grizzle WE, Ahmed R, Williams RW, Hsu HC (2001) Genetic dissection of age-related changes in immune function in mice.  Scandinavian Journal of Immunology, 54:10–20.
13. Airey DC, Williams RW. (2002) Quantitative genetic perspectives. Commentary to Finlay BL, Darlington RB, and Nicastro N (2002) Developmental structure in brain evolution. Behavioral and Brain Sciences 24: 279–280.
14. Hunter K, Williams RW (2002) Quantitative trait locus analysis in cancer research. ILAR J 43: 80–88.
15. Threadgill, Hunter K, Williams RW (2002) Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort. Mammalian Genome 13:175–178.
16. Williams RW, Dubnau J, Enoch MA, Flaherty L, Sluyter F, Gannon KS, Maxson SC, Riedl CAL,  Williams KD, Holmes A, Bolivar VJ,  Crusio WE (2002) Hot topics in behavioral and neural genetics. Gene, Brain and Behavior 1: 1–10.
17. Williams RW, Glueck SB (2002) New views of gene expression in the brain: Focus on “Gene expression tomography.” Physiological Genomics, 8:79.
18. Williams RW (2002) Everyday bioinformatics: map, microarrays and beyond. Bioinformatics 2002, a Society for Neuroscience Short Course (Williams RW, Goldowitz D, eds), Society for Neuroscience, pp. 1–10.
19. Dell’Osso LF, Williams RW, Jacobs JB, Hertle RW, FitzGibbon EJ, Thompson MA, Yang D (2002) Novel surgery for mystagus: initial trial results.  Res to Prevent Blindness 16: 56–57.
20. Williams RW, Flaherty L, Threadgill DW (2003) The math of making mutant mice. Genes, Brain and Behavior 2:191–200.
21. Williams RW, Moody SA (2003) Developmental and genetic control of cell number in the retina. In: The Visual Neurosciences, eds. Chalupa LM , Werner JS. MIT Press. Pp 65–78.
22. Williams RW, Broman KW, Cheverud JM, Churchill GA, Hitzemann RW, Hunter K, Mountz JD, Pomp P, Reeves RH, Schalkwyk LC, Threadgill DW (2002) A collaborative cross for high-precision complex trait analysis. 1st Workshop Report of the Complex Trait Consortium: Sept 2002. http://www.complextrait.org/Workshop1.pdf
23. von Bartheld CS, Williams RW (2003) Measurement of differential shrinkage or compression in the z-axis of tissue sections. Current Protocols in Neuroscience Unit 11.11–1.11.29 Suppl 24.
24. von Bartheld CS, Williams RW (2003) Calibration of counting methods by a limited and simple 3-D reconstruction of serial sections. Current Protocols in Neuroscience Unit 11.11–1.11.29 Suppl 24.
25. Williams RW, von Bartheld CS, Rosen GD (2003) Counting cells in sectioned material—3D counting, the optical disector, and Abercrombie’s two-section comparison method. Current Protocols in Neuroscience Unit 1.11.1–1.11.29 Suppl 24.
26. Rosen GD, Williams RW (2003) Celloidin embedding and cresyl violet staining. Current Protocols in Neuroscience Unit 11.11–1.11.29 Suppl 24.
27. Rosen GD, Williams RW (2003) Estimation of regional volume from serial sections using point counting and Cavalieri’s rule. Current Protocols in Neuroscience Unit 1.11.
28. Williams RW, Rosen GD (2003) Providing researchers access to tissue banks. American Laboratory, in press.
29. Gardner D, Toga AW, Ascoli GA, Beatty J, Brinkley AF, Dale AM, Fox PT, Gardner EP, George JS, Goddard N, Harris KM, Herskovits EH, Hines M, Jacobs GA, Jacobs RE, Jones EG, Kennedy DN, Kimberg DY, Mazziotta JC, Miller P, Mori S, Mountain DC, Reiss AL, Rosen GD, Rottenberg DA, Shepherd GM, Smalheiser NR, Smith KP, Strachan T, Van Essen DC, Williams RW, Song STC (2003) Toward effective and rewarding data sharing. Neuroinformatics, in press.
30. Schaeffel F, Simon P, Feldkaemper M, Ohngemach S, Williams RW (2003) Molecular biology of myopia. Clinical and Experimental Optometry, 86: 295–307.
31. The Complex Trait Consortium: Flaherty L, Abiola, O., Angel, J. M., Avner, P., Bachmanov, A. A.,  Belknap, J. K., Bennett, B., Blankenhorn, E. P.,  Blizard, D. A., Bolivar, V.,  Brockmann, G. A., Buck , K. J., Bureau, J-F., Casley, W. L., Chesler E. J., Cheverud, J. M., Churchill, G. A., Cook, M.,  Crabbe, J. C., Crusio, W. E., Darvasi, A., de Haan, G., Demant, P., Doerge, R. W., Elliott, R. W., Farber, C. R., Flint, J.,Gershenfeld, H., Gibson, J. P., Gu, W., Himmelbauer, H.,  Hitzemann, R., Hsu, H.-C., Hunter, K., Iraqi, F., Jansen, R. C., Johnson, T. E.,  Jones, B. C., Kempermann, G., Lammert, F., Lu, L., Manly, K. F., Matthews, D. B., Medrano, J. F.,  Mehrabian, M., Mittleman, G., Mock, B. A., Mogil, J. S., Montagutelli, X., Morahan, G.,  Mountz , J. D., Nagase, H., Nowakowski , R. S., O'Hara, B. F., Osadchuk, A. V., Paigen, B., Palmer, A. A., Peirce, J. L., Pomp, D., Rosemann,  M., Rosen, G. D.,  Schalkwyk, L. C., Seltzer,  Z., Settle, S., Shimomura, K., Shou, S., Sikela, J. M., Siracusa, L. D., Spearow, J. L., Teuscher, C., Threadgill DW, Toth LA, Toye AA., Vadasz C. Van Zant, G.,Wakeland, E., Williams RW, Zhang, H-G., Zou, F.  The nature and identification of quantitative trait loci: a community’s view. Nature Genetics Reviews 4: 911–916.
32. Nissanov J, Williams RW (2003) Mouse neuroinformatic public resources. An invitation to end-users. Neuroinformatics 1: 297–298.
33. Williams RW (2003) A neuroscientist’s guide to genomic resources. In: The Bioinformatics of Brains: From genes and proteins to behavior (Williams RW, ed) pp. 1–8. Washington, DC: Society for Neuroscience.
34. Williams RW (2003) WebQTL: a tour of transcriptional networks. In: The Bioinformatics of Brains: From genes and proteins to behavior (Williams RW, ed) pp. 51–59. Washington, DC: Society for Neuroscience.
35. Williams RW (2003) Managing your lab data flux: getting beyond Excel (Williams RW, ed) pp. 83–92. Washington, DC: Society for Neuroscience.
36. Zareparsi S, Hero A, Zack DJ, Williams RW, Swaroop A (2004) Seeing the unseen: microarray-based gene expression profiling in vision. Investigative Ophthalmology and Vision Science, in press.
37. Chesler EJ, Lu L, Wang J, Williams RW, Manly KF (2004) WebQTL: Rapid exploratory analysis of gene expression and genetic networks for brain and behavior. Nature Neuroscience, 7:3–4.

Web Sites

1. Williams RW (1994) The Portable Dictionary of the Mouse Genome. An electronic dictionary of gene loci with map, phenotype, and strain distribution data. <http://nervenet.org> January 1994–present.
2. Williams RW, Rosen GD, Williams, A. G. (1997) The Mouse Brain Library and the Internet Atlas of the Mouse Brain at <www.mbl.org> May 1997–present.  This is an Internet database of over 800 brains imaged at high resolution. It includes a stereotaxic atlas of the brain of strain C57BL/6J.  As of Jan. 2001, www.nervenet.mbl.mbl.html is included in ISI Current Web Contents (CC Connect TM). Reviewed in: Kaiser J (2000) Mouse Brain Library: Netwatch Images selection. Science 289:211.
3. Williams RW, Cruz B, Connolly M; Capra JA (1999) iScope. A motorized microscope that can be controlled on the WWW. <zoom.utmem.edu > Aug 1999–present.
4. Wang JT, Williams RW, Manly KF (2002-present) WebQTL  Project. A system for rapidly analyzing transcriptional networks. http://webqtl.roswellpark.org/search.html  and http://headmaster.utmem.edu

RECENT ABSTRACTS (from 1999 onward only)

Williams RW (1999) Mapping QTLs that modify the architecture of the mouse brain: a prelude to behavioral analyses. Behavior Genetics Society Abstracts 29: XX.
Williams RW, Zhou G (1999) Genetic control of eye size: A novel quantitative genetic approach. Invest. Ophthalmol Vis Sci Suppl 40: S964.
Toth LA, Williams RW (1999) A quantitative trait locus for slow-wave sleep in influenza-infected CXB recombinant inbred mice. World Fed Sleep Res Soc.
Airey DC, Lu L, Strom R, Zhou G, Gilissen E, Williams RW (1999) Cerebellum-specific QTLs in the mouse brain. Int Mouse Genome Conf 13:E9.
Lu L, Airey DC, Zhou G, Williams RW (1999) New murine hippocampus-specific QTL maps to distal Chr 1. Int Mouse Genome Conf 13:E44.
Williams RW, Kulkarni  AL, Jones L,  Zhou G, Airey DC, Lu L (2000) Growth of the olfactory bulbs is modulated by QTLs on chromosomes 4, 6, 11, and 17.  Neuroscience Abstracts 26: 1088.
Rosen GD, Williams RW (2000) Stereological and quantitative genetic analysis of the mouse caudate nucleus.  Neuroscience Abstracts 26: 311.
Kulkarni  AL, Airey DC, Williams RW (2000) Genetic architecture of the mouse retinogeniculate system: a QTL analysis of numerical matching.  Neuroscience Abstracts 26: 1087.
Airey DC, Lu L, Williams RW (2000) Gene loci for mouse cerebellum and internal granule layer size.  Neuroscience Abstracts 26: 1087.
Lu L Airey DC, Williams RW (2000) Complex trait analysis of the mouse hippocampus.  Neuroscience Abstracts 26: 1087.
Tharp R, Williams RW, Smeyne RJ (2000) Complex trait analysis of susceptibility to MPTP-induced Parkinsonism.  Neuroscience Abstracts 26: 1286.
Rosen GD, Williams AG, Capra JA, Connolly MT, Cruz B, Lu L, Airey DC, Kulkarni A, Williams RW (2000) The Mouse Brain Library @ www.mbl.org. Int Mouse Genome Conference 14: 166. www.nervenet.org/papers/MBLabst2000.html
Williams RW, Zhou G (2001) Development of genetic models for myopia research: high resolution mapping of a new set of loci that control eye size in mice. Invest Ophthal Vis Sci Suppl 42:S 652.
Manly KF and Williams RW (2001) WEBQTL—WWW services for mapping quantitative trait loci. Mouse Initiatives III. www.jax.org/courses/documents/mouse_init_0801.html
Li L, Lu L, Williams RW, Waters RS (2001) Quantitative analysis of the barrel field in somatosensory cortex (S1) of inbred mice. Neuroscience Abstracts 27: 394.3.
Lu L, Airey DC, Williams RW, 2001. Genetic architecture of the mouse hippocampus: identification of gene loci with regional effects. Neuroscience Abstracts 27:  587.2.
Goldowitz D, Rinchik E, Johnson D, Goss K, Snoddy J, Ferkin M, Matthews D, Mittleman G, Hamre K, Jablonski M, Williams R, and members of the Tennessee Mouse Genome Consortium (2001) Regional mutagenesis of the mouse genome and neural phenotypes: Year1 Progress Report. Neuroscience Abstracts 27: 881.7.
Wolfe C, Williams RW, Goldowitz D (2001) Genetic determinants of neurogenesis in adult mice. Neuroscience Abstracts 27: 587.1.
Williams RW, Threadgill DW, Airey DC, Gu J, Lu L (2001) RIX mapping: A demonstration using CXB RIX hybrids to map QTLs modulating brain weight in mice. Neuroscience Abstracts 27:  587.3.
Threadgill DW, Airey DC, Lu L, Manly K, Williams RW (2001) Recombinant inbred intercross mapping: a new approach to extend the power of existing mouse resources.   Int Mouse Genome Conf 15:50.
Manly K, Williams RW (2001)  WEBQTL—WWW service for mapping quantitative trait loci.  Int Mouse Genome Conf 15:74.
Shou S, Lu L, Williams RW (2001) Transcriptome chromosome maps: a novel resource for complex trait analysis of the mouse CNS. Internat Behav Neural Genet Soc Abst 4:54.
Williams RW, Threadgill DW, Manly KF, Rosen GD, Shou S, Airey DC, Gu J, Lu L (2001) Integrated complex trait analysis of brain and behavior in mouse: near-term prospects for high-resolution QTL mapping using large RI and RIX sets. Internat Behav Neural Genet Soc Abst 4:62
Williams RW, Lu L, Wang XF, Qi S, Gu J, Jablonski MM (2002) Mapping and initial characterization of a spontaneous mutation affecting lens development in RIIIS/J inbred mice. Invest Ophthalmol Vis Sci Suppl 43: S XX.
Bennett B, Johnson TE, Williams RW (2002) A new panel of recombinant inbred strains from ILS and ISS. Res Soc Alcoh meeting.XX: XXX.
Watson R, Koratkar R, Lu L, Gu J, Fineegan AA, Margan JL, Guz J, Williams RW, Siracusa LD (2002) Expansion of the BXH RI series: derivation and characterization of three new BXH recombinant inbred lines and one new BXH recombinant congenic line. Abst Amer Assoc Cancer Res  XX: XXX.
Erin L. Manning EL, True JM, Henckaerts E, Snoech H, Geiger H, de Haan G, Lu L, Williams RW, Van Zant G (2002) Genetic regulation of hematopoietic stem cell telomere length in mice. Int Soc Exp Hematol Abst XX: XXX
Williams RW, Shou S, Lu L, Qu Y, Wang J,  Manly K, Chesler EJ, Hsu HC, Mountz J, Threadgill D (2002) Genomic analysis of transcriptional networks: combining microarrays with complex trait analysis. Int Complex Trait Consortium Conf 1: http://www.complextrait.org/ctcsche/start.html
Bennett B, Johnson TE, Williams RW (2002) A new panel of recombinant inbred strains from ILS and ISS.  Int Complex Trait Consortium Conf 1: http://www.complextrait.org/ctcsche/start.html
Chesler EJ, Rodriguez-Zas SL, Williams RW, Mogil JS (2002) “In Silico” mapping of complex traits in inbred mice?   Int Complex Trait Consortium Conf 1: http://www.complextrait.org/ctcsche/start.html
Manly K, Meer JM, Wang J, Williams RW (2002) QTX and WebQTL: software for analysis of complex traits.  Int Complex Trait Consortium Conf 1: http://www.complextrait.org/ctcsche/start.html
Hsu HC, Zhang HG, Li L, Mullinax CL, Lu L, VanZant G, Williams RW, Allison DB, Mountz JD (2002) Age-related thymic involution in C57BL/6J X DBA/2J recombinant inbred mice fits a negative exponential regression model and maps to mouse chromosome 9.  Int Complex Trait Consortium Conf 1: http://www.complextrait.org/ctcsche/start.html
Grizzle WE, Mountz JD, Yang PA, Xu X, Sun S, Van Zant GE, Williams RW, Hsu HC, Zhang HG (2002) Recombinant inbred mice represent a novel T-cell mediated immune response tumor model.  Int Complex Trait Consortium Conf 1: http://www.complextrait.org/ctcsche/start.html
Jablonski MM, Wang XF, Lu L, Goldowitz D, Williams RW (2002) Regional mutagenesis of the mouse genome: ocular phenotypes. Soc. Neurosci Abst.
Williams RW, Shou S, Lu L, Qu Y, Manly KF, Wang J, Chesler E, Hsu HC, Mountz J, Threadgill DW (2002) Massively parallel QTL mapping of microarray data reveals mouse forebrain transcriptional networks. Soc. Neurosci Abst.
Williams RW, Manly KF, Shou S, Chesler E, Hsu HC, Mountz J, Wang J, Threadgill DW, Lu L (2002) Massively parallel complex trait analysis of transcriptional activity in mouse brain. International Mouse Genome Conference 16: 46
Lu L, Gu J, Threadgill D, Williams R (2002) Complex trait analysis of mice hippocampus using CXB RIX mapping method. International Mouse Genome Conference 16:88.
Manly KF, Wang J, Shou S. Qu Y, Chesler E, Lu L, Hsu HC, Mountz JD, Threadgill D, Williams RW (2002) QTL mapping with microarray expression data. International Mouse Genome Conference 16: 88.
Hitzemann R, Williams R, Reed C (2002) The integration of functional genomics and QTL analysis. International Mouse Genome Conference 16: 122.
Goldowitz D, Rinchik E, Johnson d, Goss K, Hamre K, Matthews D, Ferkin M, Mittleman G, Montine T, Jablonsky M, Williams R, Snoddy J, Miller D (2002) Regional mutagenesis of the mouse genome and neural phenotypes. International Mouse Genome Conference 16:120.
Chesler EJ, Rodrigues-Zas Sl, Williams RW, Mogil JS (2002) Extension and evaluation of “in silico” mapping of complex traits. International Mouse Genome Conference 16:39.
Chesler EJ, Wang J, Lu L, Manly KF Williams RW (2003) Genetic correlations of gene expression with neurobehavioral traits in a recombinant inbred mapping panel. Int. Behav Neurosci.
Hsu HC, Li L, Yi N, Zhang, HG, Yang PA, Wu Q, Zhou J, Lu L, Allison AB, Williams RW, Mountz JD  (2003) Genomic analysis of age-related thymic involution. Am Assoc Immunol.
Chesler EJ…. Williams RW (2003) Web-based QTL mapping and genetic correlation analysis of gene expression and alcohol-related traits in BXD strains. Res Soc Alcohol
Williams RW, Xu J, Zhai H, Lu L (2003) Complex trait analysis of retinal horizontal cell number. ARVO Abst 5576.
Geisert EE…. Williams RW (2003) The control of gene expression following injury in the rat retina; QTL and PCA.  ARVO  Abst 3594.
Bystrykh L, Weersing E, DontjeB, Vellenga E, Wang J, Manly KL, Williams RW, Cooke M, de Haan G (2003) Genetical genomics to identify gene pathways regulating hematopoietic stem cells. CTC 2.
Osadchuk AV, Airey DC, Lu L, Threadgill DW, Williams RW (2003) A novel approach to genetically dissection complex quantitative traits using the RIX diallel cross of recombinant inbred strains. CTC 2.
Manly KF, Wang J, Williams RW (2003) WebQTL; Complex trait analysis beyond QTL mapping. CTC 2.
De Koning DJ, Carlborg O, Williams RW, Lu L, Haley C (2003) Epistatic QTL for gene expression in mice: potential for BXD expression data. CTC 2.
Chesler EJ, Wang J, Lu L, Manly KF, Williams RW (2003) Genetic correlations and associative networks for CNS transcript abundance and neurobehavioral phenotypes in a recombinant inbred mapping panel. CTC 2.
Chesler EJ, Wang J, Lu L, Peirce JL, Qu S, Manly KF, Williams RW (2003) Web-based QTL mapping and genetic correlation analysis of gene expression and alcohol-related traits in BXD strains. Alcoholism Clin Exp Res  27:P 125A
Fernandes A, Yin H, Byron B, Iuvone PM, Schaeffel F, Williams RW, Pardue MT (2004) Effects of form deprivation on eye size and refraction in C57BL/6J mice. IOVS
Pardue MT, Yin H, Irving B, Schaeffel F, Williams RW, Fernandes A (2004) The refractive state of a mouse model of clinical disease associated with high myopia. IOVS
Aronow B, Jegga A, Kong S, Williams S, Hutton J, Ebert C, Gupta A, Chesler EJ, Lu L, Shou S, Qu Y, Wang J, Manly KL, Williams RW, Threadgill DW (2004) Discovering transcriptional regulatory networks by correlationg quantitative trait loci that modify tissue specific gene expressison with the occurrence of phylogenetically conversed cis element clusters.
Boughter J, St. John S, Williams RW, Lu L (2004) Genetic control of  lick rate in mice. Association for Chemoreception Sciences.

News and Coverage

Blakeslee S (1993) Evolution of tabby cat mapped in brain study. The New York Times, Tuesday January 12 issue, Section B5.
Simion L (1993) Al micio si e rimpicciolito il cervello. Il Corriere Della Sera (Milan newspaper) Jan 31 issue.
Oliwenstein L (1993, May issue) Brain Donors. Discover 14:18.
Guillery RW (1994) No crossing at the crossing. A New and Views article. Nature 367:597–598 (this review considers a paper by Williams et al. 1994).
Mansfield BK (1994) Mouse gene data files available from U.T. Memphis. Human Genome News, May 1994.
Takahashi JS (1994) Forward and reserve genetic approaches to behavior in the mouse. Science 264: 1724-1733. This review contains a brief description of the Portable Dictionary of the Mouse Genome (pp. 1728-1729)
Kaiser J (2000) Mouse Brain Library: Netwatch Images selection. Science 289:211.
Memphis Commercial Appeal: July 9, 2001. Front page photo of Abigail Haynes working in R. Williams laboratory (by Lance Murphey).
Memphis Business Journal: June15–21, 2001. Vol. 23 No. 7. Photograph of Dr. Michael Dockter in R. Williams laboratory (by Alan Howell).
Memphis Business Journal: Jan 15–21, 2002. Vol. 24 No. X. RW cited in article on Genome Explorations.
Commercial Appeal: May 15, 2002: World’s scientists sniff trail of complex traits. RW cited in article as organizer. Page A11.
Providing Broad Access to Tissue Banks: on the Science & Technology site at Apple Inc. http://www.apple.com/scitech/appletech/dv/utic/  (posted 2002)
iScope, You scope, We all scope a mouse brain: AAAS News Release, Feb 17, 2003  by Monica Amarelo.
Which Gene Influences What? Data Desk Aids in Gene Mapping: DataDescription Inc.,  by Holly M. Bailey, July , 2003, http://www.datadesk.com/company/profiles/williams.shtml
Building a Better Mouse Database. Bio IT World June 15, 2003 issue. http://www.bio-itworld.com/archive/061503/mouse_sidebar_2646.html  and see http://www.bio-itworld.com/archive/061503/mouse.html
Vogel, G (2003) Geneticist Dream of 1001 Complex Mice.  Science 301:456–457.
Mouse Brains — FileMaker & Excel  by Mike Nelson for Bio-IT World


   





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