|
Robert W. Williams
DEGREES
| | Ph.D. (1983) Physiology, University of California, Davis |
| | B.A. (1975) Psychobiology, University of California, Santa Cruz |
INTERESTS
| | Systems genetics, complex trait analysis, and functional genomics |
| | Control of gene expression |
| | Genetics of CNS diseases and addiction |
| | Visual system structure, function, development |
| | Advanced methods in collaborative research and data sharing |
PROFESSIONAL EXPERIENCE
| 2009-present | UT-Oak Ridge National Laboratory Governor's Chair in Computational Genomics |
| 2001-2009 | William and Dorothy Dunavant Chair of Excellence in Developmental Genetics: Department of Pediatrics (secondary appointment), University of Tennessee Health Science Center (UTHSC) |
| 2008-present | Director: UT Center for Integrative and Translational Genomics (CITG) |
| 2000-2007 | Codirector/Director: Center of Genomics and Bioinformatics, UTHSC |
| 1997-present | Professor: Department of Anatomy and Neurobiology and Center for Neuroscience, UTHSC (primary) |
| 2001-present | Member: Feinstone Center for Genomic Research, University of Memphis |
| 1992-1997 | Associate Professor: Department of Anatomy and Neurobiology and Center for Neuroscience, UTHSC |
| 1989-1992 | Assistant Professor: Department of Anatomy and Neurobiology and Center for Neuroscience, UTHSC |
| 1986-1989 | Assistant Professor: Yale University School of Medicine, Section of Neuroanatomy |
| 1985-1986 | Associate Research Scientist: Yale University School of Medicine, Section of Neuroanatomy (P. Rakic, mentor) |
| 1984-1989 | Instructor: Neuroanatomy laboratory, Yale University School of Medicine, Section of Neuroanatomy |
| 1983-1985 | Postdoctoral fellow: Yale University School of Medicine, Section of Neuroanatomy (P. Rakic, mentor) |
| 1982-1983 | Assistant Research Physiologist: University of California, Davis |
| 1982 | Instructor: University of California, Davis |
| 1979-1982 | National Institutes of Health Trainee: University of California, Davis (L.M. Chalupa, thesis advisor) |
| 1978-1981 | Teaching Assistant and Teaching Associate: Animal Physiology and Psychology, University of California, Davis |
PROFESSIONAL SOCIETIES
| | Society for Neuroscience (Chair, Neuroinformatics Committee, 2003-2008) |
| | Complex Trait Consortium (founder and director, 2001-2008) |
| | Research Society on Alcoholism (member) |
| | International Society for Computational Biology (member 2009) |
| | Association for Research in Vision and Ophthalmology (member) |
| | International Behavioural and Neural Genetics Society (president 2005) |
| | International Mammalian Genome Society (ex-member) |
| | Behavioural Neurogenetics Initiative (ex-member) |
| | IEEE (ex-member), American Society of Human Genetics (ex-member) |
GRANTS AND FELLOWSHIPS
| 2001-present | Principal Investigator: INIA: Robust Systems Genetics of Alcohol and Stress Effects on CNS, National Institutes of Health U01AA13499. TDC ~$1.68 M over 5 years (02.05.02-01.31.12) |
| 2008 | Director: State of Tennessee funds for the UT Institute for Integrative and Translational Genomics. TDC ~$1M (recurring) in 2008 budget year to UTHSC |
| 2007-2012 | Principal Investigator: Systems Genetics of the HPA, National Institutes of Health U01AA017590. TDC ~$875K over 5 years (09.30.07-9.29.12) |
| 2007-present | Coinvestigator: Modulators of Retinal Injury, National Institutes of Health R01 EY017841. TDC ~$1.0 over 5 years (10.01.07-9.31.11) |
| 2012-present | Coinvestigator: Integrated Approach to Understanding Host-Pathogen Interactions (RFP NIH NIAID DMID-AI2010100) 5 years at 5% effort (in negotiation, Gerald Byrne UTHSC PI) funding through 1/31/2019 |
| 2005-2010 | Coinvestigator: Dispersion Patterns for Retinal Neuroblasts, National Institutes of Health R01 EY0110871. TDC ~$1.0 over 5 years (07.01.05-06.30.10) |
| 2011-2013 | Genetics of Stroke. 1R21NS066166 (PI: Nowak T) NINDS, Role: consultant, collaborator (unfunded) |
| 2011-present | Memphis Research Consortium organizing member, State of Tennessee,, ~$6 million, non-recurring for Genetics and Epidemiology of Pediatric Obesity |
| 2008-2009 | Lead contract with Eli Lilly and Co, Genes that Influence Diabetic Nephropathy. (DOE NFE-08-01254, $135K subcontract to UT-Battelle, LLC) (R07-3003-263) |
| 2005-present | Coinvestigator, Mouse Biomedical Informatics Research Network (BIRN), National Institutes of Health R24 RR021760. National Center for Research Resources, TDC ~$1.0 M over 5 years (04.01.05-03.31.09) |
| 2006-2008 | Principal Investigator: Huntingtin Transcriptome Analysis, High Q Foundation, $466,800 (02-01-06 to 01-31-08) |
| 2004-present | Coinvestigator: Integrative Genetics of Cancer Susceptibility, NCI 1U01CA105417. TDC $600,000 over 5 years (04.01.04-03.31.2009, with DW Threadgill) |
| 2000-present | Principal Investigator: Informatics Center for Mouse Neurogenetics, National Institutes of Health and National Science Foundation, Human Brain Project 2P20-DA21131, 1P20-MH62009, and IBN-0003982. TDC ~$5.4 M over 5 years (9.28.00-6.30.10, 32%) |
| 2007-2011 | Associated partner: German Network for Systems Genetics (GeNeSys). Helmholtz Centre for Infection Research. No funds |
| 2007-2011 | Coinvestigator, subcontract: Gene Array Technology Center for Alcohol Research (the Rodent Gene Array Program) with Boris Tabakoff, University of Colorado Medical Center (08.01.07-07-31-11) |
| 2005-2007 | Coinvestigator: Development of Advanced Tools for Diagnosis and Triaging of Individuals Exposed to Select Pathogens, DOD/US W81XHW-05-01-0227 |
| 2005-2010 | Coinvestigator: Dispersion Patterns for Retinal Neuroblasts, NEI R01EY011087-07A1. (B Reese, PI; RW Williams, coinvestigator) |
| 2001-2006 | Principal Investigator: INIA: Genotyping Core, National Institutes of Health 1U24AA13513. TDC ~$600,000 over 5 years (01.01.02-12.30.06) |
| 2004-2007 | Consultant: Conti Center, John Csernanski PI, Jim Cheverud, PI Project 5. Genetics of Schizophrenia-Related Traits in Mice, Washington University |
| 2007-present | Consultant: Consortium for Neuropsychiatric Phenomics-Coordinating Center (R Bilder PI, UCLA) |
| 2004-2007 | External Advisory Board: P20 Exploratory Transdisciplinary Imaging Genetics Center and Function BIRN (Steve Potkin, PI, University of California, Irvine) |
| 2000-2004 | Principal Investigator: Genetic and Epigenetic Control of Eye Growth National Institutes of Health R01 EY12991. TDC $200,00 year 1, $800,000 all years (9.1.00-7.31.04, 30%) |
| 1999-2002 | Principal Investigator: Biometric and Functional Studies of the Eye and Retina, National Institutes of Health R01 EY13070. TDC $150,000 year 1, $444,381 all years (12.01.99-11.30.02, 25%) |
| 2001 | Principal Investigator: High Resolution QTL Mapping in Mice. NIHLB Mammalian Genotyping Service (7.1.01). Grant funded 350,000 genotypes. |
| 2001 | Collaborator: Sleep Patterns During Infectious Disease, NIH NL70522. TDC $225,00 year 1, $1.11M all years (9.19.01-7.31.05; Linda Toth, PI; no funded effort) |
| 2000-2005 | Eye Domain Coinvestigator: Targeted Mutagenesis of the Mouse Genome and Neural Phenotypes, NIH U01-MH61971. TDC, $2,664,000/year (D Goldowitz PI, RW Williams co-PI; funding from 7.1.00-6.30.05, RW 5%) |
| 2000 | Principal Investigator: An Advanced Intercross for Mapping Multigenic Morphometric Traits in Mice: A Community QTL Mapping Resource, NIHLB Mammalian Genotyping Service. (1.1.00) Grant funded ~190,000 genotypes. |
| 1996-2000 | Principal Investigator: Genetic Control of Neuron Populations, NIH R01 NS35485. TDC ~$733,000 all years (07.1.96 to 07.31.00, 20%) |
| 1987-2000 | Principal Investigator: Growth of Optic Nerve Fibers, NIH R01 EY06627-10. TDC, $437,500 (12.1.95 to 05.30.00) |
| 1991-1994 | Principal Investigator: Development and Clonal Structure of the Mammalian Retina, NIH R01 EY 08868-03. TDC $260,518 |
| 1992-1996 | Coinvestigator: Genetic Basis of Retinal Development, NIH R01 EY09586-03 (Dan Goldowitz, PI). TDC $505,991 (4.1.92 to 3.31.96) |
AWARDS
| | Loren D. Carlson Prize in Physiology, 1982-83 |
| | Fellow Award, Winter Conference on Brain Research, 1987 |
| | Excellence in Teaching Award, University of Tennessee, 1995 |
| | Distinguished Scientist Award, 2007, International Behavioural and Neural Genetics Society |
PATENTS
| | Tissue Analyzer: Inventors Robert W. Williams, Pasko Rakic, U.S. Patent 4,932,044; filed November 4, 1988; issued June 5, 1990. See http://www.patents.ibm.com/claims?patent_number=4932044 |
| | Method for ultra-high resolution mapping of genes and determination of genetic networks among genes underlying phenotypic traits: Inventors David W. Threadgill (Chapel Hill NC) and Robert W. Williams (Memphis TN), U.S. Patent Application (EP 1543930) filed December 1, 2000. |
| | Method for determining sensitivity to environmental toxins and susceptibility to Parkinson's disease. Inventors: Richard Smeyne (Memphis TN) and Robert W. Williams (Memphis TN). U.S. Patent Application (EP Patent 1543930). |
| | Invention Disclosure: P2P-R cooperates with the MAD2, BUB3 and p55CDC/cdc20 mitotic checkpoint-associated proteins. Inventors: Dr. Robert E. Scott and Robert W. Williams, Memphis TN |
 |  |
SYMPOSIA, CONFERENCES, CONSORTIA
| 2010 | Coorganizer: Mouse Genetics 2011, Washington DC, June 22-26 |
| 2009 | Coorganizer: 1st world-wide BXD scientific meeting (The BXD World), Braunschweig, (with Dr. Klaus Schughart). Nov 30 - Dec 1 |
| | Chair: INCF Digital Atlasing Taskforce meeting, Pilzen, Czech Republic (Sept 6, and 7) |
| 2008 | Organizer, International Neuroinformatics Congress, Stockholm, Workshop on Neurogenomics Meets Bioinformatics Meets Neuroinformatics (Sept 27-28) |
| | Chair: SfN Task Force on Metadata and Linkage (with Jack Van Horn and David Van Essen). A follow-up to the PubMed Plus leadership conference |
| | Lead organizer: INCF Workshop on Mouse and Rat Brain Atlasing Systems. March 5, UCLA |
| | Organizer: UT-ORNL-UKY Bioinformatics Summit. Mar 28-30, Lake Barkley, KY |
| 2007 | Lead organizer: Consortium for Integrative and Translational Genomics, first meeting at the Oak Ridge National Laboratory, Sept 27-28 |
| | Neurogenetics Terminology workshop leader: Neuroscience Informatics Framework sponsored workshop held at the SfN 2007 meeting. Jointly organized with Daniel Gardner |
| | Lead organizer: PubMed Plus leadership conference, sponsored by the SfN, David Van Essen (President), St. Louis, June 14-16 |
| | Lead organizer: International Neuroscience Coordinating Facility Workshop on Mouse and Rat Brain Atlasing Systems. Feb 13-14, Karolinska Institute, Stockholm |
| 2006 | Multistrain Mouse Testing Strategy Advisory Working Group, NIEHS, Research Triangle Park, July 21 (with John Pritchard) |
| | Databasing the Brain, European Union workshop, Oslo, Norway, June 25-27 |
| | Symposium honoring Dr. Lorraine Flaherty, Genomics Institute, Wadsworth Center, Albany Medical College, Albany, New York, June 19 |
| | Neurofederatie Keynote Lecture, Endo-Neuro-Psychopharmacology (ENP) annual meeting, Amsterdam, June 7 |
| | Genes Meet Behavior, a joint symposium of the International Behavioral |
| | Neuroscience Society and International Behavioural and Neural Genetics Society, Whistler, Canada, May 24 |
| | Gordon Research Conference on Genes and Behavior, Ventura, California, Feb 11-17 |
| | Blueprint LINC team member, NIH, Bethesda, March 30-31 |
| 2005 | Human Brain Project Special Interest Social, presentation, SfN annual meeting, Washington, Nov 14 |
| | German Genetics Society, Genetics of Infection, symposium presentation, Braunschweig, Germany, Sept 22 |
| | Opening lecture, 4th Annual Complex Trait Consortium (CTC) meeting, Groningen, Netherlands, June 27 |
| | Mouse Models of Human Cancers Consortium Glioblastoma Meeting, St. Louis, June 16-18 |
| | International Behavioural and Neural Genetics Society annual meeting, Sitges, Spain, June 9-13 |
| | GENSAT Gene Selection Advisory Meeting, Bethesda, June 7 |
| | High Q Foundation Meeting on Microarrays and Discovery of Therapeutic Targets for Huntington's Disease, New York, May 19 |
| | 2nd Annual Experimental Neurogenetics of the Mouse workshop, faculty member, Memphis, May 16 -24 |
| | Plenary lecture, Data Sharing in the Age of Discovery Science, Human Brain Project, NIH, Natcher Center, April 25 |
| | Collaborative Cross Organizing Committee meeting, ORNL, March 24-25 |
| | Gordon Research Conference on Quantitative Genetics and Genomics, Ventura, California, Feb 19-24 |
| | Mouse Models of Human Cancers Consortium Committee Meeting, Vanderbilt, Jan 19-21 |
| | 1st International Imaging Genetics Conference, UC Irvine, Jan 17 |
| 2004 | NIEHS Toxicogenomics Research Consortium meeting, Chapel Hill, Dec 6-8 |
| | Mouse Resources Roundtable Conference, The Jackson Laboratory, Nov 19-21 |
| | Biomedical Informatics Research Network (BIRN) Symposium speaker, Boston, Oct 13 |
| | Co-organizer, 3rd Annual Complex Trait Consortium meeting, Bar Harbor, July 6-9 |
| | Organizer, 10th International Summer School on Behavioral Neurogenetics, Memphis, August 8-15 |
| 2003 | Lecturer, NIDA Addiction Studies Workshop for Journalists, Tucson, Dec 8 |
| | Mouse Atlas Workshop, NIMH Office of Neuroinformatics, Nov 18 |
| | American Society of Human Genetics symposium speaker, Los Angeles, Nov 5 |
| | Oregon Health Science symposium, Portland, Oct 9 |
| | Keynote, 9th International Summer School on Behavioral Neurogenetics, Aug 6-9, Toulouse, France |
| | Joint Statistics Meeting symposium speaker, San Francisco, Aug 4-6 |
| | Mouse Initiatives V: Genomics of Complex System in Biomedical Research, July 31-Aug 2, www.jax.org/courses/mi5_03.html |
| | Behavior Genetics Association Symposium, Chicago, June 27 |
| 2002 | National Cancer Institute: Mouse Models of Human Cancers Consortium Roundtable, Newport Beach, Dec 11-13 |
| | Host and organizer, 1st Complex Trait Consortium Meeting, Memphis, May 2-4 |
| | Spring Brain Conference Plenary Session organizer: Identifying Genes Controlling Brain Structure and Behavior Using Complex Trait Analysis, Sedona, March 12-15 |
| | Chair, Bioinformatics 2002, Society for Neuroscience Short Course, Orlando, Nov 2 |
| | Instructor, 8th International Summer School on Behavioral Neurogenetics, Worcester, Aug 5-9 |
| 2001 | Chair, International Complex Trait Consortium, Edinburgh, Scotland, Oct. 23 |
| | Sponsor and organizing committee, 4th Annual Meeting, International Behavioral and Neural Genetics Society, San Diego, Nov. 8-9 |
| | Workshop presentation, South-East Regional Meeting of the Society of Developmental Biology, Montreat NC, May 24 |
| | Invited speaker, Neuroinformatics Faces Functional Genomics symposium: Tools for Collaborative Analysis of Complex Neurodevelopmental and Behavioral Traits, Natcher Building, Bethesda, May 22 |
| 2000 | NIAAA-sponsored QTL meeting, invited speaker, Washington, Dec 1 (organized by Robert Karp) |
| | Human Brain Project: Neuroinformatics Satellite Symposium, invited participant, New Orleans, Nov 4 (presentation by GD Rosen) |
| 1999 | Co-organizer, Symposium on QTL Mapping, Behavior Genetics Association, Vancouver, July 1 |
| | Co-organizer and sponsor, Molecular Biology/Molecular Genetics of the Visual System, Center for Vision Research, Memphis, Mar 26 |
| | Gordon Research Conference in Quantitative Genetics, Ventura, Feb 14-19 |
| 1998 | Lecturer, Short Course in Quantitative Neuroanatomy, Society for Neuroscience |
| | Chair, American Association of Anatomists, Experimental Biology 98: Symposium on Quantitative Neurobiology and the Human Brain Project |
| | Presentation, Chautauqua Short Course for college teachers in neuroscience |
| 1997 | Chair, American Association of Anatomists, Experimental Biology 97: Mini-symposium on Quantitative Neurobiology |
| 1996-2000 | Chair, Mouse Chromosome 7 Committee, International Mammalian Genome Society |
| 1994-1996 | Co-chair, Mouse Chromosome 7 Committee, International Mammalian Genome Society |
| 1996 | Co-organizer, Symposium on Cortical Development, Center for Neuroscience, University of Tennessee, Memphis, June |
| 1991 | Participant, The Jackson Laboratory, Short Course in Medical and Experimental Mammalian Genetics, Aug |
| 1989 | Organizer, Winter Brain Conference Workshop, Different Strategies of Brain Development, Jan (co-organizer Karl Herrup) |
| 1985 | Participant, Gordon Research Conference, Central Nervous System, Tilton School, New Hampshire, June |
| 1983 | Participant, Molecular Bases of Neuronal Development, Neuroscience Institute, Salk, La Jolla, Oct |
| 1981 | Participant, NATO Advanced Studies Institute, Formation of Neuronal Connections, Varenna, Italy, May |
VISITING SCIENTIST
| 2007-2009 | Visiting Professor, University of Utrecht (Prestige MSc Neuroscience Program hosted by Martien Kas) |
| 2006 | University of California, San Diego, March (Dr. Mark Ellisman) |
| 2000-2002 | Advisory Professor, Fudan University, Shanghai, China |
| 2000-present | Collaborator, with Profs. Tan and Gu, Nantong Medical College, Nantong, China |
| 1997 | Harvard University, Beth Israel Hospital, June (Dr. Glenn Rosen) |
| 1996 | California Institute of Technology, Aug (Drs. John Allman and Scott Fraser) |
| 1993 | The Jackson Laboratory, July (Dr. Muriel Davisson) |
SCIENTIFIC BOARDS
| 2008-present | Chairman of the Board: Varigenix Inc., Memphis TN (a biotech startup with licenses from UTHSC and JAX to commercialize BXD strains of mice) |
| 2007-present | Chair: Oversight Committee of the INCF Digital Brain Atlasing Program |
| 2006-2007 | Scientific Advisory Board, Institute Clinique de la Souris, Strasbourg, France (Prof. Johan Auwerx) |
| 2007-present | Scientific Advisory Board, Conte Center: Genes Controlling Assembly and Function of Serotonin Systems, Randy Blakely and colleagues, Vanderbilt University |
| 2002-2008 | NIAAA INIA-Stress Scientific Advisory Board |
| 2006-present | Scientific Advisory Board, National Center for Microscopy and Imaging Research (NCMIR), UCSD, Mark Ellisman and colleagues |
| 2006-2008 | US Representative and Advisory Board member, International Neuroinformatics Coordinating Facility (INCF), Stockholm, Sweden |
| 2004-2009 | Scientific Advisory Board, Portland Alcohol Research Center, VAM (PARC) Portland |
| 2004-2007 | External Advisory Board, Exploratory Transdisciplinary Imaging Genetics Center (Steven Potkin, PI, UCI) |
| 2001-2007 | Genome Explorations Inc., Memphis |
INVITED SEMINARS, WORKSHOPS, AND LECTURES (INCOMPLETE)
| 2009 | |
| | Speaker: Genetics of Neurodevelopmental Disorders: Use of New Mouse Models for High-Efficiency Translational Research. Children's Foundation Research Center seminar, Le Bonheur Hospital, Memphis, Sep 21 |
| | Presenter: Genetics of Nicotine Addiction, Lung Cancer, and COPD. GeneNetwork: a web resource to study gene functionand to evaluate candidate genes from GWAS studies. 1 hr. web seminar (hosted by J. Pollack), July 27 |
| | Speaker: International Society for Computational Biology, ISMB/ECCB, Highlights Special Session on eQTL, Stockholm, Sweden, Jun 28 |
| | Speaker: ICNF, Presentation on the Digital Brain Atlasing Program, Karolinska, Sweden, May 7 |
| | Speaker: EPFL, Lausanne, Switzerland, May 1 |
| | Speaker: International Waldenstrom's Macroglobulinemia Foundation meeting, Memphis, April 20 |
| | Speaker: Buck Institute for Age Research, Novato, CA, Apr 20 |
| | Seminar: UTHSC Molecular Sciences: A practical guide to host genetics of infectious disease using mouse reference populations, Apr 13. |
| | Seminar and workshop: University of Nebraska, Lincoln, Dept of Animal Science, Mar 30 - 31 |
| | Speaker and consultant: UCLA, Symposium on ultra high throughput biology, Feb 19 - 20 |
| | Two lectures and workshop: University of Utrecht, Rudolf Magnus Institute, Jan 5 - 9 |
| 2008 | |
| | Speaker: Departments of Psychiatry and Neurology, VCU, Richmond, Dec 2 |
| | Speaker: NIDA Workforce Development, Philadelphia, Nov 16 |
| | Speaker: Departments of Pharmacology, University of Colorado, Denver, Richmond, Nov 3 |
| | Speaker: GeneSys Inaugural Meeting, Systems genetics of brain function and disease using the GeneNetwork platform, Edinburg, Oct 1-3 |
| | Presentation: CHDI, High Q Foundation, New York and Princeton Aug 18-19 |
| | Speaker: GeNeSys 2nd Annual Meeting, Dresden Germany, Oct 24-25 |
| | Speaker and participant: Gordon Research Conference, Oxford UK, Aug 11-15 |
| | Participant: French-American Workshop on Multi-scale Modeling in Neuroscience, Bordeaux, June 8-10 |
| | Speaker: Eli Lilly and Co, May 22 |
| | Moderator: Genes, Brain, and Behavior: Symposium on Methodological considerations in the genetical genomics of complex traits, Portland OR, May 7 |
| | Speaker: Seminar, Northwestern University, Chicago, Apr 14 |
| | Speaker: Seminar and 1 day workshop leader, Dalhousie University, Department of Psychology. Halifax, Canada, Apr 4-5 |
| | Speaker: Understanding the Brain through Informatics, INCF @ Karolinska (The Neuroinformatics of Gene Expression: Collaborative Web Classes and Labs), Washington DC, Mar 7 |
| | Speaker: Universit� de Lausanne, UNIL-EPFL mini-symposium on mouse resources to map complex traits (Collaborative Web Software Systems for Integrative Genomics), Lausanne, Switzerland, Feb 26 |
| | Speaker: University of Iowa, Department of Human Genetics seminar series, Cedar Rapids, Feb 19 |
| | Speaker: University of Alabama, Birmingham, Department of Molecular Biology seminar series (Genetics of Gene Expression in Brain and Kidney: Problems and Prospects) Feb 15 |
| | Speaker: Mouse Models of Human Cancers Consortium Steering Committee satellite conference on the Collaborative Cross, Washington DC, Jan 7 |
| 2007 | |
| | Speaker: 11st Annual Meeting of GeneSys, Dresden, Germany, Dec 4-5 |
| | Co-organizer, New Directions in Data Mining: Synergies between Databases and Online Journal Publications, Society for Neuroscience workshop, San Diego, Nov 7 |
| | Speaker: California Nanosystems Institute, UCLA, Sept 18 |
| | Speaker: Riken Brain Science Institute, Tokyo, Japan, Sept 13 |
| | Speaker: Neuro2007 Special Session on International Collaborations in Neuroinformatics (Large Scale Analysis of Gene Expression in the CNS: A Rapidly Expanding Collaborative Landscape), Yokohama, Japan, Sept 10 |
| | Keynote speaker: 2nd Annual Department of Genetics Retreat, University of Alabama, Birmingham, Sept 6 |
| | Participant: International Neuroscience Coordinating Facility Workshop on Portals in Neuroinformatics, Karolinska Institute, Stockholm, Sweden, Sept 3-4 |
| | Seminar: Institute for Systems Biology, Seattle, July 31 |
| | Seminar: Allen Institute for Brain Science, Seattle, July 30 |
| | Workshop: High Q Foundation, New York, July 17-18 |
| | Seminar: Vanderbilt University, Nashville, July 2 |
| | Organizer: SfN PubMed Plus Leadership Conference, Washington University, St. Louis, June 17-19 |
| | NIDA Workshop, Addiction, Microarrays, and Gene Discovery, May 30-June 1 |
| | Seminar: University of Wageningen, Netherlands, May 24 |
| | Distinguished Investigator award presentation: IBANGS, Doorwerth, Netherlands, May 23 |
| | Seminar: Genetics of Gene Expression in the Mouse Eye, GSF, Seminars on Genome Research, Institute for the Environment and Health, Munich, Germany, May 15 |
| | Keynote lecture: 5th Annual Dean's Symposium, UTHSC College of Medicine, (Personalized, Predictive and Preventive Health Care: How the Mouse Will Make It Happen), April 13 |
| | Co-organizer: UT-UK-ORNL Bioinformatics Summit, Paris Landing, TN, April 13-15 |
| | Karolinska Institute, keynote seminar, Feb 15 |
| | Organizer: 1st International Neuroscience Coordinating Facility Workshop on Mouse and Rat Brain Digital Atlasing Systems, Karolinska Institute, Stockholm, Sweden, Feb 13-14 |
| | Scripps Florida, seminar series presentation, Jupiter, Florida, Jan 9 |
| | |
| 2006 | |
| | Panelist: Society for Scholarly Publishing: Washington DC, Nov 13 |
| | Workshop presentation: Application of Pharmacogenomics to Drug Development and Therapy, 14th ISSX Meeting, Puerto Rico, Short Course presentation, Oct 22 |
| | Speaker: IIIe cycle, Lausanne Genome Day, Lausanne, Switzerland, Oct 4-5 |
| | Speaker: Unveiling Genome-Wide DNA Variation in 15 Diverse Mouse Strains: NIEHS, Sept 26 |
| | Speaker: West Virginia University Eye Institute, seminar, Sept 20 |
| | Instructor: Route 28 Meeting Adult Neurogenesis Course, Fraueninsel, Germany, Sept 2-8 |
| | Instructor: Plant Genome Short Course, Boston, Aug 1-3 |
| | Speaker: Eli Lilly Integrative Biology Research Group, Lectures, Indianapolis, June 12-13 |
| | Speaker: Workshop on Systems Genetics, University of Utrecht, Netherlands, June 6 |
| | Speaker: ARVO mini symposium, Ft. Lauderdale, May 3 |
| | Speaker: UT-UK-ORNL Bioinformatics Summit, Lake Barkley KY, April 22 |
| | Speaker: Society for Neuroscience Chapter lecture, University of Mississippi Medical Center, April 11 |
| | Speaker: SERCEB Infectious Disease Meeting, New York City, March 26-28 |
| | Speaker: Cold Spring Harbor, Systems Biology lecture, March 25 |
| | Speaker: Illumina Corp, La Jolla, March 15 |
| | Speaker: Cold Spring Harbor Laboratory, weekly seminar, Feb 24 |
| | Speaker: UCSB Engineering, seminar in imaging and genetics, Santa Barbara, Feb 14 |
| 2005 | |
| | University of Texas at Austin, Department of Neurobiology, Nov 28 |
| | University of Colorado, Boulder, Institute for Behavior Genetics, Oct 14 |
| | Oxford University, Wellcome Trust, July 1 |
| | Lecture, Universidad Autonoma de Barcelona, Spain, June 8 |
| | SERCEB Annual Meeting seminar, Chapel Hill, May 5 |
| | NIEHS Seminar: Systems Genetics, Research Triangle Park, May 2 |
| | VA MC Memphis Seminar, March 11 |
| | UTHSC Pathogenesis Center Chalk talk, March 2 |
| | NIDA, Molecular Anatomy: Synergy by Informatics 2, Feb 15 |
| | UTHSC Department of Pharmacology, Genetic Modulation of Transcripts, Cells, and Behavior: Or, How I learned to stop worrying and love complexity, Feb 9 |
| | St. Jude Children's Hospital Danny Thomas Lecture Series: Genetic Variation in Transcriptional Activity, Jan 7 |
| 2004 | |
| | Vanderbilt University: Seminar in Integrative Genomics, Nov 30 |
| | Department of Neuroscience, Vrije Universiteit, Amsterdam, Aug 27 |
| | Groningen Universiteit, Department of Stem Cell Biology, Aug 26 |
| | Route 28 Conference, Fraueninsel, Germany, Aug 23 |
| | Czech National Academy of Science, Prague, Aug 20 |
| | IGBMC Illkirch, France, Aug 18 |
| | T�bingen Neurocolloquium, Germany, May 27 |
| | GBF Braunschweig, Germany, May 25 |
| | Max-Delbr�ck-Centrum, Berlin-Buch, Germany, May 24 |
| | University of Kentucky, Lexington, April |
| | MGH/MIT Harvard, Feb 25 |
| 2003 | |
| | Yale University, Department of Genetics, Dec 16 |
| | University of Chicago, Committee on Genetics, Dec 2 |
| | Department of Neuroscience, Vanderbilt University, Nashville, Oct 22 |
| | Nathan Kline Institute, New York, Oct 17 |
| | Special lecture: 9th international summer school on behavioral neurogenetics, Toulouse, Aug 5 |
| | Mouse Initiatives V meeting, Jackson Laboratory, Aug 1 |
| | Purdue University, June 19 |
| | Human Brain Project, Bethesda, Natcher Center, http://videocast.nih.gov/ram/brain051203.ram May 12 |
| | Pennsylvania State University, Genomics Spring Fever: Complex Genetics of Brain and Behavior, May 2, 3 |
| | Wadsworth Center, Albany, New York, Feb 2003 |
| | St Jude Children's Research Hospital: Dissecting Transcriptional Networks (Affymetrix Memphis User Group Meeting), Feb 6 |
| | University of Toronto, Mt. Sinai Hospital, Feb 4 |
| 2002 | |
| | Wake Forest University, Drug Addiction Workshop for Journalists, Tucson, Dec |
| | Department of Physiology, University of California, Davis, Dec |
| | University of Memphis, Sept 13 |
| | Wilmer Eye Institute, Johns Hopkins University, The Complex Genetics of Eye and Brain Development: Gene Network Analysis Using Microarrays, Aug 29 |
| | University of T�bingen, Neurobiology of Vision, Germany, July 9-10 |
| | King's College, London, July 7 |
| | University of Alabama, Section of Statistical Genetics, June 17 |
| | New England College of Optometry, Boston, Apr 25 |
| | Southern Illinois University, School of Medicine, Mar 15 |
| | University of Tennessee Health Science Center, Grand Rounds in Pediatrics, Mar 13 |
| | Neuroinformatics, 35th Annual Winter Conference on Brain Research, Jan 27 |
| 2001 | |
| | New Mouse Behavioral Phenotyping Assays: Half Moon Bay CA, Dec |
| | Society for Developmental Biology, Southeast Regional Meeting, Workshop presentation, May |
| | Human Brain Project Conference, NIH, Natcher Center, May |
| | Cornell University, Departments of Psychology and Neuroscience, Apr |
| | Stanford University, Apr 12 |
| | University of Alabama, Birmingham, Department of Medicine, Mar 21 |
| | MCP-Hahneman, Department of Neuroscience, Mar 14 |
| | UCLA, Neuroscience Grand Rounds, Feb 7 |
| 2000 | |
| | Shanghai Medical University (Fudan), Department of Histology and Embryology, Nov |
| | Beijing Medical University, Department of Histology and Embryology, Nov |
| | Nantong Medical College, Neuroscience Institute, Nov |
| | University of North Carolina, Chapel Hill, Department of Genetics, Oct 23 |
| | University of Tennessee, Biomedical Engineering Joint Program, Sept 14 |
| | Cold Spring Harbor, Banbury Center, August 28 |
| | UCSB Neuroscience Research Institute, Quantitative Genetics of CNS Development: View from the Trailhead, Santa Barbara, May 26 |
| | State University of New York at Buffalo, Roswell Park Cancer Institute, May 8 |
| 1999 and earlier | |
| | Drexel University, Department of Biomedical Engineering, Nov 2, 1999 |
| | University of Michigan, Department of Genetics, Oct 5, 1999 |
| | Vanderbilt University, Vision Research Center: The genetics of brain evolution, Nashville, May 7, 1999 |
| | UCSB Neuroscience Research Institute, Santa Barbara, Feb 16, 1999 |
| | Case Western Reserve University, Department of Neurosciences, Cleveland, Jan 21, 1999 |
| | VA Medical Center, New Power of Forward Genetics: Analysis of Polygenic Traits that Control Disease and Development, Memphis, Nov 20, 1998 |
| | Case Western Reserve University, Depts. of Ophthalmology and Genetics, Cleveland, Nov 18, 1998 |
| | Yale University, Department of Neuroanatomy, New Haven, July 1998 |
| | University of Southern California, Department of Anatomy & Neurobiology, June 1998 |
| | UCSD Department of Neuroscience, San Diego, June 1998 |
| | Pasteur Institute, Paris, France, Oct 1997 |
| | Mount Sinai Medical School, Department of Neuroscience, New York, NY, June 1997 |
| | Harvard University, Beth Israel Deaconess, Department of Neurology, June 1997 |
| | California Institute of Technology, Pasadena, Nov. 1995 |
| | Conference on Brain Evolution, Ithaca, New York, June 1995 |
| | National Cancer Institute (Steve O'Brien), Frederick, Maryland, June 9, 1995 |
| | The Jackson Lab Bioinformatics Group, Bar Harbor Maine, July 1993 |
| | 25th Annual Meeting of the Biomedical Engineering Society, Memphis, Oct 24, 1993 |
| | University of Utah, Department of Biology, Salt Lake City, Jan. 1989 |
| | Winter Conference for Brain Research, Snowbird, Utah, Jan. 1989 |
| | University of Texas, Houston, Department of Neurobiology and Anatomy, Dec 1988 |
| | SUNY, Stony Brook, Department of Neurobiology, Oct 1988 |
| | Winter Conference for Brain Research, Vail, Colorado, Jan 1987 |
| | Conference on the Development of the Vertebrate Retina, Ithaca, New York, June 1987 |
| | New York University, Department of Physiology and Neuroscience, New York, Oct 1986 |
| | University of Rochester, Center for Visual Sciences, Rochester, New York, Apr 1986 |
| | Rush-Presbyterian-St. Luke's Medical Center, Chicago, Nov 1986 |
| | University of California, Davis, Department of Psychology, June 1985 |
| | Stanford University, Department of Neurobiology, June 1985 |
| | SUNY Department of Biological Sciences, Albany, New York, Jan 1984 |
REVIEWER FOR
| | Anatomy and Embryology, Behavior Genetics, Brain Behavior and Evolution, Behavioral Brain Sciences, Cerebral Cortex, Current Biology, Developmental Biology, European Journal of Neuroscience, Experimental Eye Research, Gene Expression Patterns, Genesis, Genomics, Investigative Ophthalmology and Vision Science, Journal of Comparative Neurology, Journal of Heredity, Journal of Neurobiology, Journal of Neurochemistry, Journal of Neurophysiology, Journal of Neuroscience, Journal of Neuroscience Methods, Molecular Vision, Nature Genetics, Neuroscience, Optometry and Vision Research, Proceedings of the National Academy of Science, Science, Visual Neuroscience, Vision Research |
EDITORIAL BOARDS/COMMITEES
| 2008-present | Editor-in-Chief: Frontiers in Neurogenomics |
| 2007-2010 | Editorial advisory board: Alcohol Research & Health (NIAAA) |
| 2007-present | Associate editor: Frontiers in Neuroinformatics (CRC Press) |
| 2005-2008 | Member: Executive Committee of the Collaborative Cross |
| 2006-2008 | NeuroCommons Working Group (Science Commons, Creative Commons); chaired by John Wilbanks |
| 2006-2008 | US Representative and member of the Executive Committee of the International Neuroinformatics Coordinating Facility (INCF, Stockholm) |
| 2006-2008 | Advisory board member of the NIH Blueprint Neuroinformatic Framework group (PI Dan Gardner) |
| 2004-2005 | President: International Behavioural and Neural Genetics Society (executive committee from 2003-2006) |
| 2004-present | Chair (2004-2008) and member: Neuroinformatics Committee, Society for Neuroscience |
| 2004-2005 | Member: International Mouse Resource Centers Roundtable |
| 2004-present | Elected Member: International Committee on Standardized Genetic Nomenclature for Mice |
| 2003-2005 | Member: Committee on Animals in Research, Society for Neuroscience |
| 2004-2005 | Member: Science Educator Award Selection Committee, SfN |
| 2006-present | Journal of Biomedical Discovery and Collaboration (www.j-biomed-discovery.com) |
| 2005-present | Alcohol: editorial board member |
| 2002-present | Genes, Brain and Behavior: editorial board member |
| 2002-present | Neuroinformatics: editorial board member |
| 2002 | Gene Expression Patterns: board member |
| 2001-present | BioMed Central Neuroscience: core reviewer board member www.biomedcentral.com/info/biologyeditorial.asp |
| 2001-present | Behavior Genetics: editorial board member |
| 2000 | Behavior Genetics: guest editor |
| 1995-present | Molecular Vision: board member |
| 1993-present | European Journal of Anatomy: board member |
GRANT PROPOSAL REVIEWS
| 2008-2011 | Chair, Molecular Neurogenetics (MNG) Study Section |
| 2009 | Review for NWO: Netherlands Organisation for Scientific Research (TOP-Chemistry in relation to biological and medical sciences 2008) |
| 2007 | Chair, MDCN-K(51) Special Emphasis Panel, NIH IRG: Neuroinformatics and Neuroimaging, July 18-19 |
| 2007 | Special Emphasis, NIH IRG: Conte Center: ZMH1-ERB-S-03, Feb 26 |
| 2006 | Review Member, NIH IRG: Neuroinformatics and Neuroimaging: ZRG1 MDCN-K51 S, June 21 |
| 2005 | ZRG1 MDCN-K (92), Neurogenetics |
| 2004 | Chair NIH ZRG1 IDM-K (04) Genetics of Viral Pathogenesis, Mar 15 |
| 2004-2005 | Chair and member NIH MDCN-G (55) Human Brain Project |
| 2004 | American Institute of Biological Sciences: Disease Prevention & Epidemiology review panel, USAMRMC |
| 2003 | MRC Program Review, July 2003 |
| 2002 | BISTI SS-E(51) and Human Brain Project SS-E(95), Oct 22-25 |
| 2002 | MCDN Special Review panel ZRG1 SSS-P 09 S, Sept 6 |
| 2002 | NEI Special Review panel ZEY1 VSN 06 R, Aug |
| 2002 | Science Foundation Ireland reviewer, July |
| 2002 | NIH Mammalian Genetics IRG, June 2002 |
| 2002-2004 | Mammalian Genotyping Advisory Panel, Apr 2002, 2003, 2004 |
| 2002 | NIH Special Review, Feb 8 |
| 2001 | NIH Innovations in Biomedical Science Tech ZRG1 SSS-7 21B, Nov 6 |
| 2001 | NIH BISTI Panel Reviewer ZRG1 SSS-E01, July 1, Nov |
| 2001 | NIH CSR Reviewer ZRG1FCN-3 01 BISTI, July 19 |
| 2001 | NIH Special Emphasis Panel ZRG1 SSS-R (02), July 2 |
| 2001 | NIEHS Review Panel (Inbred Rodents) ES-01-05, June 29 |
| 2001 | Medical Research Council (UK) Strategic Grants Reviewer |
| 2000 | Fonds voor Weterschappelijk Onderzoek - Vlaanderen (Belgian NIH) |
| 2000 | NIH VISB Study Section Ad Hoc Member, June |
| 2000 | NIMH Special Emphasis Panel Reviewer (Gene Array RFA MH-00-002, July |
| 2000 | UT System-wide Advisory Panel: Biotechnology and Biological Sciences Review, July |
| 1999 | NIH VISC Study Section Ad Hoc Member, Feb |
| 1999 | NIMH Center Grant Reviewer |
| 1999 | NIMH Special Emphasis Panel Reviewer ZMH1 BRB-I |
| 1998 | Department of Veterans Affairs: Merit Review Consultant |
| 1995 | Consultant to NIH VIS-B Study Section |
TEACHING
| 2008 | UTHSC, Behavioral Neuroscience (ANAT 821), graduate student seminar in neurogenetics |
| 2007 | University of Memphis, Bioinformatics. Four 90-minute lectures (Feb and March) |
| 2006 | The Jackson Laboratory: Short Course in Vision Research |
| | NSF Plant Microarray Short Course, instructor, Boston, Aug 1-3 |
| | Third Annual Experimental Neurogenetics of the Mouse workshop, Memphis, May 16-24 |
| | Cold Spring Harbor, Systems Biology Short Course, March 23 |
| 2004-2006 | Faculty, Annual Experimental Neurogenetics of the Mouse Workshop, 15-20 students/year (8-day short course at UTHSC and the University of Memphis) |
| 2005-present | Course director: NIEHS Short Course on Systems Genetics (offered twice) at NIEHS main campus, Sept 7-8 |
| 2005-present | NS 825: Graduate School, Developmental and Molecular Neurobiology lecturer (fall) |
| 2005-present | NS212: School of Medicine, Neuroscience lecturer (fall) |
| 2005* | Society for Neuroscience, Meet the Expert Series leader, Microarray analysis, SfN annual meeting, Washington, Nov 12 |
| | Memphis City Schools Middle/Secondary Science In-Service Session 15: The Human Genome, August 11 (2 sessions) |
| 2001-present | Course member and co-director: International Summer School in Behavioral Neurogenetics (Behavioral Neurogenetics Initiative). Annual course (one week, 15 to 30 grad and postdoctoral students/year) |
| 2001-2003 | Course co-director: Neuroscience Seminar Series (NS8): a graduate level course, 15-20 contact hours, ~15 students/year. |
| 1992-2003 | Course director: Morphological Neuroscience (NS822): a graduate level course, ~40 contact hours, ~ 8 students/year. |
| 2003-2004 | Lecturer: Comparative Medicine CM712, UTHSC: Mouse Genetics (graduate level) |
| 2003-present | Lecturer: Bioinformatics, University of Memphis (graduate level) |
| 2000-2002 | Lecturer and Lab: Medical Neuroanatomy (M): ~20 contact hours, Lectures in CNS development. 150 students/year. |
| 2002-2003 | Short Course director: Society of Neuroscience, Bioinformatics |
| 2003 | Course co-director: Memphis Microarray Short Course, June 4-12 |
| 2002 | Lecturer: NIDA Addiction Studies Workshop for Journalists, Tucson, Dec 8 |
| 2002 | Short Course director: UAB Birmingham: Design and Analysis of Recombinant Inbred Strain Experiments, all day course, June 18 |
| 1998 | Course Lecturer: Short Course in Quantitative Neuroanatomy, Society for Neuroscience, Los Angeles |
| 1994-1996 | Course director: Seminars in Neuroscience (NS821): Graduate level. 40 contact hours, 10 to 15 students per year |
| 1995 | SGAEC Excellence in Teaching Award, University of Tennessee (for NS822) |
| 1995 | Short Course in Genetic Testing: Memphis city schools service training for science high school teachers. 15 high school science teachers. |
| 1994-1995 | Human and Mouse Genetics: City Labs program for high school science teachers. 10 to 12 high school science teachers. |
| 1990-1996 | Medical Embryology, University of Tennessee, 8 lectures on development of cardiovascular, urogenital, and gastrointestinal systems. 8 lecture hours, ~120 first-year medical students. |
| 1983-1989 | Neuroscience-Neuroanatomy laboratory instructor, Yale University. Team-taught first-year medical students, roughly 20 contact hours, 25 students per lab. |
| 1982 | Course Director: Sensory Psychology, University of California, Davis. 25 junior and senior psychology majors. |
ADMINISTRATIVE
| 2001 - present | Founding Director: Complex Trait Consortium |
| 2007 - present | Scientific Director: Center for Integrative and Translational Genomics, UTHSC |
| 2000 - 2008 | Director (2007-2008) and codirector: UT Center of Excellence in Genomics and Bioinformatics |
| 2003 - present | Member: Health Science Center Information Technology Committee |
| 2004 - present | Member: Biomedical Informatics Research Network (Mouse BIRN) |
| 2001 - present | The Center for Vision Research, UTHSC |
| 2005 - 2006 | Member: Search Committee; Executive Dean of UT Medical Colleges |
| 2002 | University of Tennessee Research Foundation Task Force Subcommittee (T. Ballard, chair) |
| 2001 - 2002 | Section Coordinator for the Visual and Auditory Systems research section, Center for Neuroscience, UTHSC |
| 2002 - 2004 | Member: Computing and Telecommunications Committee of the UTHSC Faculty Senate (C. Russell, chair). Chair: Research Computing subcommittee, UTHSC |
| 1999 - present | Tennessee Mouse Genome Consortium, Scientific Steering Committee |
| 1999 - 2001 | Member: Promotion and Tenure Committee, Department of Anatomy and Neurobiology, UTHSC |
| 1999 - present | Scientific Advisory Board: Tennessee Mouse Genome Consortium |
| 1998 | Chair: Promotion and Tenure Committee, Department of Anatomy and Neurobiology, UTHSC |
| 1998 - present | Member: Department of Anatomy and Neurobiology Space and Research Committee, UTHSC |
| 1997 - present | Member: Department of Anatomy and Neurobiology Advisory Council, UTHSC |
| 1997 - present | Member: Graduate Health Sciences Electronic Thesis and Dissertation Advisory Committee, UTHSC |
| 1997 - 1999 | Member: Center for Neuroscience: Graduate Student Recruitment Committee, UTHSC |
| 1990 - 1997 | Member: University of Tennessee, Graduate Health Science School, Policy Subcommittee |
| 1995 - 1997 | Member: University of Tennessee, Graduate Health Science School, Graduate Studies Council |
| 1990 - 1994 | Member, University of Tennessee library committee member |
| 1990 - 1996 | Member: Department of Anatomy and Neurobiology: Graduate student admissions and policy committee |
GRADUATE STUDENTS, POSTDOCTORAL FELLOWS, ADVISEES
| Megan Mulligan, Ph.D. | Postdoctoral fellow (May 2009 - present) |
| Khyobeni Mozhui | Ph.D. in 2009 (Now a postdoctoral fellow with RWW) |
| Daniel Ciobanu, Ph.D. | Postdoctoral fellow with RWW from 2007-Jan 2009. Now Assistant Professor, University of Nebraska, Lincoln |
| Collin Hovinga, Pharm.D. | K12 CTSI-sponsored research mentor. Collin is currently an assistant professor in Clinical Pharmacy and Pediatrics at UTHSC (2008-2010) |
| Jasgit (Jesse) C. Sachdev M.D. | K12 CTSI-sponsored research mentor. Jesse is an assistant professor in the Department of Medicine at UTHSC (2008-2010) |
| Manjunatha N. Jagalur | Ph.D. candidate, computer science. Primary mentor is Dr. David Kulp at University of Massachusetts, Amherst. My role is as a joint Ph.D. advisor. |
| Richelle C. Strom | Ph.D. in 1999, University of Tennessee. Postdoctoral Fellow with Prof. Ruben Adler, Johns Hopkins University |
| Dennis S. Rice | Ph.D. in 1996, University of Tennessee. Director of Ophthalmology at Lexicon Pharmaceuticals, The Woodlands, TX |
| Dale Hogan, Ph.D. | NRSA NEI Postdoctoral fellow, 1992-1996; Research Associate with Mark Opp, Department of Psychiatry and Behavior, University of Texas Medical Branch, Galveston |
| Guomin Zhou, M.D., Ph.D. | Research fellow, 1997-1999; Chairman and Professor of Histology and Embryology, Fudan University, Shanghai, China |
| Lu Lu, M.D. | Research fellow, 1999-2001; Associate Professor, UTHSC; Professor in Histology and Embryology, Medical University of Nantong, China |
| David C. Airey, Ph.D. | NRSA, NEI Postdoctoral fellow, April 1999-July 2001; Assistant Professor, Vanderbilt University |
| Elissa J. Chesler, Ph.D. | Research fellow, July 2002-2005; staff scientist at Oak Ridge National Laboratory, Director, Systems Genetics Group |
| Jeremy Peirce, Ph.D. | Research fellow, June 2003-2006; staff scientist at Illumina Inc. Author of Attention-Deficit/Hyperactivity Disorder (2008) by Chelsea House Publishers |
| Anand Kulkarni, M.D. | Research fellow, Nov 1999-Nov 2000; pathologist, UTHSC |
| Siming Shou, Ph.D. | Postdoctoral fellow, September 2001-2002 |
| E. Gilissen, Ph.D. | Postdoctoral fellow (1996-1997, with John Allman at Caltech); faculty Ph.D. of paleontology, University of the Witwassersrand, South Africa |
| Kathryn Ryder | M.D. Dissertation, Yale University School of Medicine, 1987; associate professor, Department of Medicine, UTHSC |
| Michael Borodkin | M.D. dissertation, Yale University School of Medicine, 1989 |
Ph.D. and M.S. COMMITTEES
| Khyobeni Mozhui | Ph.D. in Neuroscience, UTHSC, May 2009 |
| Rick Laughlin | Ph.D. candidate, UCLA 2008 |
| Nourtan Adeltawab | Ph.D. candidate, UTHSC 2008 |
| C. J. Jeon | Ph.D. in Neuroscience, UTHSC 1992 |
| Angela R. Howe | Ph.D. in Neuroscience, UTHSC 1994 |
| Vandana Menon | Ph.D. in Physiology, UTHSC 1996 |
| Qing Tang | Ph.D. in Anatomy and Neurobiology, UTHSC June 1996 |
| Loren Martin | Ph.D. in Anatomy and Neurobiology, UTHSC Nov 2000 |
| Toya H. Kimble | Ph.D. in Anatomy and Neurobiology, UTHSC Jan 2003 |
| Félix Vázquez-Chona | Ph.D. in Anatomy and Neurobiology, UTHSC 2006 |
| Kathryn Ryder, M.D. | M.S. in Epidemiology, UTHSC 2002 |
| A. Iannaccone, M.D. | M.S. in Epidemiology, UTHSC 2002 |
A substantial number of these papers are available online at www.nervenet.org.
| 1 | Williams RW, Chalupa LM (1982) Prenatal development of retinocollicular projections in the cat: An anterograde tracer transport study. |
| 2 | Stone, J, Rapaport DH, Williams RW, Chalupa LM (1982) Uniformity of cell distribution in the ganglion cell layer of prenatal cat retina: Implications for mechanisms of retinal development. |
| 3 | Williams RW, Bastiani MJ, Chalupa LM (1983) Loss of axons in the cat optic nerve following fetal unilateral enucleation: An electron microscopic analysis. |
| 4 | Williams RW, Chalupa LM (1983) An analysis of axon caliber within the optic nerve of the cat: Evidence of size groupings and regional organization. Journal of Neuroscience 3: 1554-1564 |
| 5 | Williams RW, Chalupa LM (1983) Development of the retinal pathway to the pretectum of the cat. |
| 6 | Chalupa LM, Williams RW, Hughes MJ (1983) Visual properties of neurons in the tectorecipient zone of the cat's lateral posterior-pulvinar complex: A comparison with the superior colliculus. |
| 7 | Chalupa, LM, Williams RW (1984) Organization of the cat's lateral geniculate nucleus following interruption of prenatal binocular competition. Human Neurobiology 3: 103-107 |
| 8 | Chalupa LM, Williams RW, Henderson Z (1984) Binocular interaction in the fetal cat regulates the size of the ganglion cell population. |
| 9 | Williams RW, Rakic P (1985) Dispersion of growing axons within the optic nerve of the embryonic monkey. |
| 10 | Williams RW, Crabtree, JW, Chalupa LM, Spear PD, Kornguth SE (1985) Selectivity of antibody-mediated destruction of retinal ganglion cell axons. |
| 11 | Williams RW, Bastiani MJ, Lia B, Chalupa LM (1986) Growth cones, dying axons, and developmental fluctuations in the fiber population of the cat's optic nerve. |
| 12 | Lia B, Williams RW, Chalupa LM (1986) Does axonal branching contribute to the overproduction of optic nerve fibers during early development of the cat's visual system. |
| 13 | Lia B, Williams RW, Chalupa LM (1987) Formation of retinal ganglion cell topography during prenatal development. Science 236:848-851 |
| 14 | Williams RW, Rakic P (1988) Elimination of neurons from the lateral geniculate nucleus of rhesus monkeys during development. Journal of Comparative Neurology 272:424-436 |
| 15 | Williams RW, Rakic P (1988) Three-dimensional counting: An accurate and direct method to estimate cell numbers in sectioned material. Journal of |
| 16 | Wikler KC, Williams RW, Rakic P (1990) Photoreceptor mosaic: Number and distribution of rods and cones in the rhesus monkey retina. Journal of Comparative Neurology:297:499-508 |
| 17 | Williams RW, Borodkin M, Rakic P (1991) Growth cone distribution patterns in the optic nerve of fetal monkeys: Implications for mechanisms of axonal guidance. Journal of Neuroscience 11: 1081-1094 |
| 18 | Rakic, P., Su-er I, Williams RW (1991) A novel cytoarchitectonic area induced experimentally within the primate visual cortex. Proceedings of the National Academy of Science USA 88: 2083-2087 |
| 19 | Williams RW (1991) The human retina has a cone-enriched rim. Visual Neuroscience 6:403-406 |
| 20 | Williams RW, Goldowitz D (1992) Structure of clonal and polyclonal cell arrays in chimeric mouse retina. Proceedings of the National Academy of Science USA |
| 21 | Williams RW, Cavada C, Reinoso-Su�rez F (1993) Rapid evolution of the visual system: A cellular assay of the retina and dorsal lateral geniculate nucleus of the Spanish wildcat and the domestic cat. Journal of Neuroscience 13:208-228 |
| 22 | Williams RW, Hogan D, Garraghty PE (1994) Target recognition and visual maps in the thalamus of achiasmatic mutant dogs. Nature |
| 23 | Williams RW (1994) The Portable Dictionary of the Mouse Genome: A personal database for gene mapping and molecular biology. Mammalian Genome: 5:372-375. See . This short paper's main claim to fame is that it is the earliest publication in PubMed to list a web site URL ("http://") in the abstract. |
| 24 | Brilliant MB, Williams RW, Conti C, Angel J, Holdener BC (1994) Mouse chromosome 7. Mammalian Genome 5: S104-S123 |
| 25 | Dell'Osso LF, Williams RW (1995) Ocular motor abnormalities in achiasmatic mutant Belgian sheepdogs: Unyoked eye movements in a mammal. Vision Research: 35:109-116 |
| 26 | Scheetz AJ, Williams RW, Dubin MW (1995) Severity of ganglion cell death during early postnatal development is modulated by neuronal activity and binocular competition. Visual Neuroscience 12:605-610 |
| 27 | Hogan D, Williams RW (1995) Analysis of the retinas and optic nerves of achiasmatic Belgian sheepdogs. Journal of Comparative Neurology: 352:367-380 |
| 28 | Rice DS, Williams RW, Goldowitz D (1995) Genetic control of retinal projections in inbred strains of albino mice. Journal of Comparative Neurology 354: 459-469 |
| 29 | Rice DS, Williams RW, Harris B, Bailey PW, Davisson MT, Goldowitz D (1995) Mapping the Bst mutation on mouse Chromosome 16: A model for human optic atrophy. Mammalian Genome 6:546-548 |
| 30 | Hogan D, Garraghty PE, Williams RW (1996) Lamination and visual topography in the lateral geniculate nucleus of normal and achiasmatic dogs. European Journal of Anatomy 1:3-11 |
| 31 | Ezer AD, Williams RW, Goldowitz D (1996) Arbitrary primer PCR of dog DNA with estimates of average heterozygosity. Journal of Heredity 87:450-455 |
| 32 | Goldowitz D, Rice DS, Williams RW (1996) Clonal architecture of the mouse retina. Progress in Brain Research 108: 2-15 |
| 33 | Brilliant MH, Williams RW, Holdener BC, Angel JM (1996) Mouse chromosome 7. Mammalian Genome |
| 34 | Hamvas R, Trachtulec Z, Forejt J, Williams RW, Artzt K, Fischer-Lindahl K., Silver LM |
| 35 | Williams RW, Strom RC, Rice DS, Goldowitz D |
| 36 | Rice DS, Tang Q, Williams RW, Harris B, Davisson MT, Goldowitz D (1997) Retinal ganglion cell loss and misdirect axon growth associated with fissure defects in Bst mutant mice. Investigative Ophthalmology and Visual Science 38:2112-2124 |
| 37 | Williams RW, Strom RC, Goldowitz D (1998) Natural variation in neuron number in mice is linked to a major quantitative trait locus on Chr 11. Journal of Neuroscience 18:138-146 |
| 38 | Williams RW, Holdener BC, Angel JM, Oakey R, Hunter K (1998) Mouse chromosome 7. Mammalian Genome 8:S136-159. |
| 39 | Strom, RC, Williams RW (1998) Cell production and cell death in the generation of normal variation in neuron number. Journal of Neuroscience 18:9948-9953 |
| 40 | Dell'Osso, LF Williams RW, Jacobs JB, Erchul DM (1998) The congenital and see-saw nystagmus in the prototypical achiasma of canines: comparison to the human achiasmatic prototype. Vision Research 38:1629-1641 |
| 41 | Zhou G, Williams RW (1999) Eye1 and Eye2: Gene loci that modulate eye size, lens weight, and retinal area in mouse. Investigative Ophthalmology and Visual Science 40:817-825 |
| 42 | Williams RW (1999) A targeted screen to detect recessive mutations that have quantitative effects. Mammalian Genome 10:734-738 |
| 43 | Zhou G, Williams RW |
| 44 | Williams RW, Angel JM, Holdener BC, Oakey R, Hunter K (1999) Mouse chromosome 7. Mammalian Genome 10:947 |
| 45 | Dell'Osso LF, Hertle RW, Williams RW, Jacobs JB (1999) A new surgery for congenital nystagmus: effects of tenotomy on an achiasmatic canine and the role of extraocular proprioception. J Amer Acad Ped Ophthal Soc, 3:166-182 |
| 46 | Toth LA, Williams RW (1999) Circadian patterns of locomotor activity in CXB recombinant inbred mice. Behavior Genetics 29:319-328 |
| 47 | Toth LA, Williams RW (1999) Strain-related differences in slow wave sleep and rapid-eye-movement sleep in C57BL/6J and BALB/c mice. |
| 48 | Toth LA, Williams RW (1999) Circadian patterns of slow wave sleep in influenza-infected C57BL/6 and BALB/c mice: A genetic analysis using CXB recombinant inbred strains. Behavior Genetics 29:339-348 |
| 49 | Rice DS, Goldowitz D, Williams RW, Hamre K, Johnson PT, Tan SS, Reese BE (1999) Extrinsic modulation of retinal ganglion cell projections: analysis of the albino mutation in pigmentation mosaic mice. Developmental Biology 216:41-56 |
| 50 | Hogan D, Garraghty PE, Williams RW (1999) Asymmetric connections, duplicate layers, and reversed maps in the primary visual system. Journal of Neuroscience 19: RC38:1-6 |
| 51 | Kimble TDH, Williams RW |
| 52 | Dell'Osso LF, Hogan D, Jacobs JB, Williams RW (1999) Eye movements in canine hemichiasma: Does human hemichiasma exist? Neuro-ophthalmology 22:47-58 |
| 53 | Angel JM, Williams RW (2000) Mouse chromosome 7. Mammalian Genome 11: 948-949 |
| 54 | Williams RW, Lu L, Kulkarni A, Zhou G, Airey DC (2001) Genetic dissection of the olfactory bulbs of mice: QTLs on chromosomes 4, 6, 11, and 17 modulate bulb size. Behavior Genetics, 31:61-77 |
| 55 | Cook MN, Williams RW, Flaherty L (2001) Anxiety-related behaviors in the elevated zero maze are affected by genetic factors and retinal degeneration. Behavioral Neuroscience, 115:468-476 |
| 56 | Lu L, Airey DC, Williams RW (2001) Complex trait analysis of the mouse hippocampus: Mapping and biometric analysis of two novel gene loci that modulate hippocampal size. Journal of Neuroscience, 21:3503-3514 |
| 57 | Rosen GD, Williams RW (2001) Complex trait analysis of the mouse striatum: Independent QTLs modulate volume and neuron number. Biomed Central Neuroscience 2:5 |
| 58 | Airey DC ,Lu L, Williams RW (2001). Genetic control of the mouse cerebellum: identification of quantitative trait loci modulating size and architecture. Journal of Neuroscience, 21:5099-5109 |
| 59 | Hardy CL, Lu L, Nguyen P, Woodland DL, Williams RW, Blackman MA (2001) Identification of quantitative trait loci controlling activation of TRBV4 CD8+ T cells during murine g-herpes virus-induced infectious mononucleosis Immunogenetics, 53: 395-400 |
| 60 | Williams RW, Gu J, Qi S, Lu L (2001) The genetic structure of recombinant inbred mice: High-resolution consensus maps for complex trait analysis. |
| 61 | Zhou G, Strom RC, Giguere V, Williams RW (2001) Modulation of retinal cell populations and eye size in retinoic acid receptor knockout mice. Molecular Vision, 7, |
| 62 | Hsu, HC, Mountz JD, Williams RW, Shelton BJ, Yang P, Matsuki Y, Xu X, Zhang HG, Geiger H, van Zant G (2002) Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11. |
| 63 | Geisert Jr EE, Williams RW, Geisert G, Maecker HT, Deng J, Levy S (2002) Increased brain size and glial cell number in CD81-null mice. |
| 64 | Airey DW, Lu L, Shou S, Williams RW (2002) Genetic sources of individual differences in cerebellum. The Cerebellum 1:233-240 |
| 65 | Hitzemann R, Hitzemann B, Rivera S, Gatley J, Thanos P, Lu L, Shou S, Williams RW (2002) Dopamine D2 receptor binding, Drd2 expression and the number of dopamine neurons in the BXD recombinant inbred series: genetic relationships to alcohol and other drug associated phenotypes. Alcoholism: Clinical and Experimental Research 27:1-11 |
| 66 | Grizzle WE, Mountz JD, Yang PA, Xu X, Sun S, Van Zant GE, Williams RW, Hsu HC, Zhang HG (2002) BXD recombinant inbred mice represent a novel T-cell mediated immune response tumor model. International Journal of Cancer 101:270-279 |
| 67 | Cook R, Lu L, Gu J, Williams RW, Smeyne RJ (2003) Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. Molecular Brain Research 110:279-288 |
| 68 | Hsu HC, Zhang HG, Li L, Yi N, Yang PA, Wu Q, Zhou J, Sun S, Xu X, Yang X, Lu L, Van Zant G, Williams RW, Allison DB, Mountz JD (2003) Age-related thymic involution in C57BL/6J X DBA/2J recombinant inbred mice maps to mouse chromosome 9. |
| 69 | Hitzemann R, Malmanger B, Reed C, Lawler M, Hitzemann B, Coulombe S, Buck K, Rademacher B, Walter N, Polyakov Y, Sikela J, Williams RW, Flint J, Talbot C (2003) A strategy for integration of QTL, gene expression, and sequence analyses. Mammalian Genome 14: 733-747 |
| 70 | Schaeffel F, Burkhardt E, Howland HC, Williams RW (2004) Measurement of refractive state and deprivation myopia in two strains of mice. Optometry and Vision Science, 81:99-110 |
| 71 | Peirce J, Chesler EJ, Williams RW, Lu L (2003) Genetic architecture of the mouse hippocampus: identification of gene loci with regional effects. Genes, Brain and Behavior 2:238-252 |
| 72 | Wang J, Williams RW, Manly KF (2003) WebQTL: Web-based complex trait analysis. Neuroinformatics 1:299-308 |
| 73 | Pollock GS, Robichon R, Boyd KA, Kerkel KA, Kramer M, Lyles J, Ambalavanar R, Khan A, Kaplan DR, Williams RW, Frost DO (2003) TRKB receptor signaling regulates dynamics of developmental retinal ganglion cell death but not final number. Journal of Neuroscience 23: 10137-10145 |
| 74 | Rosen GD, La Porte NT, Diechtiareff B, Pung, CJ, Nissanov J, Gustafson C, Bertrand L, Gefen S, Fan Y, Tretiak OJ, Manly KF, Parks MR, Williams AG, Connolly MT, Capra JA, Williams RW (2003) Informatics center for mouse genomics: the dissection of complex traits of the nervous system. Neuroinformatics, 1:327-342 |
| 75 | Chesler EJ, Wang J, Lu L, Qu Y, Manly KF, Williams RW (2003) Genetic correlates of gene expression in recombinant inbred strains: a relational model system to explore neurobehavioral phenotypes. Neuroinformatics 1: 343-357 |
| 76 | Seecharan DJ, Kulkarni AL, Lu L, Rosen GD, Williams RW (2003) Genetic control of interconnected neuronal populations in the mouse primary visual system. Journal of Neuroscience 23:11178-11188 |
| 77 | Williams AG, Williams RW (2004) GenomeMixer: A complex genetic cross simulator. Bioinformatics 20:2488-2490 |
| 78 | Peirce J, Lu L, Gu J, Silver LM, Williams RW (2004) A new set of BXD recombinant inbred lines from advanced intercross populations in mice. BMC Genetics 5:7 |
| 79 | Williams RW, Bennett B, Lu L, Gu J, DeFries JC, Carosone-Link P, Rikke B, Belknap JK, Johnson TE (2004) Genetic structure of the LXS panel of recombinant inbred mouse strains. Mammalian Genome 15:637-647 |
| 80 | Schauwecker PE, Williams RW, Santos JB (2004) Genetic control of seizure-induced cell death susceptibility in mice. Journal of Comparative Neurology 477:96-107 |
| 81 | Ponomarev I, Schafer GL, Blednov YA, Williams RW, Iyer VR, Harris A (2004) Convergent analysis of cDNA and short oligomer microarrays, mouse null mutant, and bioinformatics resources to study complex traits. Genes, Brains and Behavior 3:360-368 |
| 82 | Tan XL, Zhou Y, Cai KF, Shao YX, Zhu SX, Lu L, Williams RW, Gu XS (2004) Identification of QTLs for weight and cross-sectional area on cervical enlargement of spinal cord in mice. Yi Chuan Xue Bao 31:801-806 |
| 83 | Jablonski MM, Lu L, Wang, XF, Chesler EJ, Carps E, Qi S. Gu J, Williams RW (2004) The ldis1 lens mutation in RIIIS/J mice maps to chromosome 8 near cadherin 1. Molecular Vision 10:577- 587 |
| 84 | Simon P, Schott K, Williams RW, Schaeffel F (2004) Post-translational regulation of the immediate early gene EGR1 by light in the mouse retina. European Journal of Neuroscience 20:3371-3377 |
| 85 | Scott RE, White-Grindley E, Ruley HE, Chesler EJ, Williams RW (2005) P2P-R expression is genetically coregulated with components of the translation machinery with PUM2, a translational repressor that associates with the P2P-R mRNA. Journal of Cellular Physiology 204:99-105 |
| 86 | Baldwin NE, Chesler EJ, Kirov S, Langston MA, Snoddy JR, Williams RW, Zhang B (2005) Computational, integrative and comparative methods for the elucidation of genetic co-expression networks. Journal of Biomedicine and Biotechnology 2:172-180 |
| 87 | Mountz JD, Yang PA, Wu Q, Zhou J, Tousson A, Fitgerald A, Allen J, Wang X, Cartner S, Grizzle WE, Yi N, Lu L, Williams RW, and Hsu H-C (2005) Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in BXD2 recombinant inbred strain of mice. Scandinavian Journal of Immunology 61:128-138 |
| 88 | Chesler EJ, Lu L, Shou S, Qu Y, Gu J, Wang J, Hsu HC, Mountz JD, Baldwin N, Langston MA, Threadgill DW, Manly KF, Williams RW (2005) Genetic dissection of gene expression reveals polygenic networks modulating brain structure and function. Nature Genetics 37:233-242 |
| 89 | Bystrykh L, Weersing E, Dontje B, Sutton S, Pletcher MT, Wiltshire T, Su AI, Vellenga E, Wang J, Manly KF, Lu L, Chesler EJ, Alberts R, Jansen RC, Williams RW, Cooke M, de Haan G (2005) Uncovering regulatory pathways affecting hematopoietic stem cell function using "genetical genomics" Nature Genetics 37:225-232 |
| 90 | Kerns RT, Ravindranathan A, Hassan S, Cage MP, York T, Williams RW, Miles MF (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. Journal of Neuroscience 25:2255-2265 |
| 91 | Carlborg �, De Koning D-J, Chesler EJ, Manly KM, Williams RW, Haley CS (2005) Methodological aspects of the genetic dissection of gene expression. Bioinformatics 21:2383-2393 |
| 92 | Manly KF, Wang J, Williams RW (2005) Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression. Genome Biology 6:R27.1-27.10 |
| 93 | Zou F, Gelfond JA, Airey DC, Lu L, Manly KF, Williams RW, Threadgill DW (2005) Quantitative trait locus analysis using recombinant inbred intercrosses (RIX): theoretical and empirical considerations. Genetics 170:1299-1311 |
| 94 | Tsaih, SW, Lu L, Airey DC, Williams RW, Churchill GA (2005) Quantitative trait mapping in a diallel cross of recombinant inbred lines. Mammalian Genome 16:344-355 |
| 95 | Li HQ, Lu L, Manly KF, Wang J, Zhou M, Williams RW, Cui Y (2005) Inferring gene transcriptional modulatory relations: a genetical genomics approach. Human Molecular Genetics 14:119-1125 |
| 96 | Jablonski MM, Wang, XF, Lu L, Miller DR, Rinchik EM, Williams RW, Goldowitz, D (2005) The Tennessee Mouse Genome Consortium: identification of novel ocular mutants. Visual Neuroscience 22:595-604 |
| 97 | Jablonski MM, Dalke C, Wang XF, Lu L, Manly K, Pretsch W, Pardue M, Rinchik, Williams RW, Goldowitz D, Graw J (2005) An ENU-induced mutation in Rs1h causes disruption of retinal structure and function. Molecular Vision 11:596-581 |
| 98 | Vazquez-Chona FR, Khan AN, Chan CK, Moore AN, Dash PK, Rosario Hernandez R, Lu L, Chesler EJ, Manly KF, Williams RW, Geisert Jr EE (2005) Genetic networks controlling retinal injury. Molecular Vision 11:958-970 |
| 99 | Li CX, Wei X, Lu L, Peirce JL, Williams RW, Waters RS (2005) Genetic analysis of barrel field size in the first somatosensory area (SI) in inbred and recombinant inbred strains of mice. Somatosensory and Motor Research 22:141-150 |
| 2006 | |
| 100 | Kempermann G, Chesler EJ, Lu L, Williams RW, Gage FH (2006) Natural variation and genetic covariance in adult hippocampal neurogenesis. Proceedings of the National Academy of Science USA 103:780-785 |
| 101 | Lan H, Chen M, Byers JE, Yandell BS, Stapleton DS, Mata CM, Mui TK, Flowers MT, Schueler KL, Manly KF, Williams RW, Kendziorski, CM, Attie AD (2006) Combined expression trait correlations and expression quantitative trait locus mapping. PLoS Genetics 2:51-61 |
| 102 | Li H, Chen H, Bao L, Manly KF, Chesler EJ, Lu L, Wang J, Zhou M, Williams RW, Cui Y (2006) Integrative genetic analysis of transcription modules: towards filling the gap between genetic loci and inherited traits. Human Molecular Genetics 15:481-492 |
| 103 | Martin M, Dong H, Vallera D, Lee D, Lu L, Williams RW, Rosen GD, Cheverud J, Csernansky J (2006) Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice. Genes, Brain and Behavior 5:614-623 |
| 104 | Bao L, Wei L, Peirce JL, Homayouni R, Li H, Zhou M, Chen H, Lu L, Williams RW, Pfeffer LM, Goldowitz D, Cui Y (2006) Combining gene expression QTL mapping and phenotype spectrum analysis to uncover gene regulatory relations. Mammalian Genome 17:575-583 |
| 105 | Radcliffe RA, Lee MJ, Williams RW (2006) Prediction of cis-QTLs in a pair of inbred mouse strains with the use of expression and haplotype data from public databases. Mammalian Genome 17:643-642 |
| 106 | Peirce JL, Lu L, Li H, Wang J, Manly KF, Hitzemann RJ, Belknap JK, Rosen GD, Goodwin S, Sutter TR, Williams RW (2006) How replicable are mRNA expression QTLs. Mammalian Genome 17:643-642 |
| 107 | Aliesky HA, Pichurin PN, Chen CR, Williams RW, Rapoport B, McLachlan SM (2006) Probing the genetic basis for thyrotropin receptor antibodies and hyperthyroidism in immunized CXB recombinant inbred mice. Endocrinology 147:2789-2800 |
| 108 | Shifman S, Bell JT, Copley RR, Taylor M, Williams RW, Mott R, Flint J (2006) A high resolution single nucleotide polymorphism genetic map of the mouse genome. PLoS Biology 4:2227-2237 |
| 2007 | |
| 109 | Aziz, R, Kanal R, Abdeltawab NF, Rowe SL, Su Y, Carrigan D, Nooh MM, Attia RR, Brannen C, Gardner LA, Lu L, Williams RW, Kotb M (2007) Susceptibility to severe streptococcal sepsis: a mouse reference population to study genetic and environmental factors. Gene and Immunity 8:404-415 |
| 110 | Bao L, Peirce JL, Lu L, Zhou M, Li H, Goldowitz D, Williams RW, Cui Y (2007) An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes. Human Molecular Genetics 16:1381-1390 |
| 111 | Bao L, Zhou M, Wu L, Lu L, Goldowitz D, Williams RW, Cui Y (2007) PolymiRTS database: linking polymorphisms in microRNA target sites with complex traits. Nucleic Acids Res (database issue): D51-54 |
| 112 | Bhave SV, Hornbaker C, Phang TL, Saba L, Lapadat R, Kechris K, Gaydos J, McGoldrick D, Dolbey A, Leach S, Soriano B, Ellington A, Ellington E, Jones K, Mangion J, Belknap JK, Williams RW, Hunter LE, Hoffman PL, Tabakoff B (2007) The PhenoGen Informatics website: tools for the analysis of complex traits. BMC Genetics 8:59 |
| 113 | Dong H, Martin M, Colvin J, Ali Z, Wang L, Lu L, Williams RW, Rosen GD, Csernansky JG, Cheverud JM (2007) Quantitative trait loci linked to thalamic and cortical gray matter volumes in BXD recombinant inbred mice: implications for the genetics of schizophrenia. Heredity 99:62-69 |
| 114 | Gatti D, Maki A, Chesler EJ, Kosyk O, Kirova R, Lu L, Manly KF, Qu Y, Williams RW, Perkins A, Langston ME, Threadgill DW, Rusyn I (2007) Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology 46:548-557 |
| 115 | Miyairi I, Tatireddigari A, Mahdi OS, Belland RJ, Lu L, Williams RW, Byrne GI (2007) The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia |
| 116 | Mozhui K, Hamre KM, Holmes A, Lu L, Williams RW (2007) Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Behavior Genetics 37:223-243 |
| 117 | Peirce JL, Broman KW, Lu L, Williams RW (2007) A simple method for combining genetic mapping data from multiple crosses and experimental designs. PLoS One 2:e1036 |
| 118 | V�zquez-Chona F, Lu L, Williams RW, Geisert EE (2007) Genetic influences on retinal gene expression and wound healing. |
| 119 | Yang J, Zhu J, Williams RW (2007) Mapping the genetic architecture of complex traits in experimental populations. Bioinformatics 23:1527-1536 |
| 2008 | |
| 120 | Abdeltawab NF, Aziz RK, Kansal R, Rowe SL, Su Y, Gardner L, Brannen C, Nooh MM, Attia RR, Abdelsamed HA, Taylor WL, Williams RW, Kotb M (2008) An unbiased systems genetics approach to mapping genetic loci modulating susceptibility to severe streptococcal sepsis. PLoS Pathogens 4:e1000042 |
| 121 | Bug W, Wong WW, Gustafson C, Johnson GA, Martone ME, Price DL, Rosen GD, Williams RW, Zaslavsky, Nissanov J (2008) Brain atlasing tool interoperation: NeuroTerrain-Smart Atlas synergistic visualization and analysis environment. IEEE EMBS Conference on Neural Engineering in press |
| 122 | Chesler EJ, Miller DR, Branstetter L, Galloway L, Jackson B, Philip Vm, Voy B, Culiat CT, Threadgill DW, Williams RW, Churchill GA, Johnson DK, Manly KF (2008) The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics. Mammalian Genome 19:382-389 |
| 123 | Crawford, NPS, Walker RC, Officewala JS, Lukes L, Williams RW, Hunter KW (2008) The diasporin pathway: a tumor progression-related network that predicts breast cancer survival. Clinical and Experimental Metastasis 25:357-369 |
| 124 | Danciger M, Ogando D, Yang H, Matthes MT, Yu H, Ahern K, Yasumura D, Williams RW, LaVail MM (2008) Genetic modifiers of retinal degeneration in the rd3 mouse. Investigative Ophthalmology and Visual Science 49:2863-2869 |
| 125 | Druka A, Potokina E, Luo Z, Bonar N, Druka I, Zhang, L, Marshall DF, Steffenson BJ, Close TJ, Wise RP, Kleinhofs A, Williams RW, Kearsey MJ, Waugh R (2008) Exploiting regulatory variation to identify genes and loci underlying quantitative resistance to the wheat stem rust pathogen Puccinia graminis f. sp. tritici in barley. Theoretical and Applied Genetics 117:261-272 |
| 126 | Druka A, Druka I, Centeno AG, Li H, Sun Z, Thomas WTB, Bonar N, Steffenson BJ, Ullrich SE, Kleinhofs A, Wise RP, Close TJ, Potokina E, Luo Z, Wagner C, Schweizer GF, Marshall DF, Kearsey MJ, Williams RW, Waugh R (2008) Towards systems genetic analyses in barley: Integration of phenotypic, expression and genotype data into GeneNetwork. Manuscript. BMC Genetics 9:73 |
| 127 | Gardner D, Akil H, Ascoli AG, Bowden DM, Bug W, Donohue DE, Goldberg DH, Grafstein B, Grethe JS, Gupta A, Halavi M, Kennedy DN, Marenco L, Marton ME, Miller P, Muller HM, Robert A, Shepherd GM, Sternberg PW, Van Essen DC, Williams RW (2008) The Neuroscience Information Framework: a data and knowledge environment for neuroscience. Neuroinformatics 6:149-160 |
| 128 | Hsu H-C, Yang PA, Wu Q, Myers R, Wang J, Guentert T, Chen J, Yi J, Tousson A, Stanus AL, Le TVL, Lorenz RG, Xu H, Kolls HK, Carter RH, Chaplin DD, Williams RW, Mountz JD (2008) Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nature Immunology 9:166-175 |
| 129 | Jan TA, Lu L, Li CX, Williams RW, Waters RS (2008) Genetic analysis of posterior medial barrel subfield (PMBSF) size in somatosensory cortex (SI) in recombinant inbred strains of mice. BMC Neuroscience 9:3 |
| 130 | Lu L, Wei L, Peirce JL, Wang X, Zhou J, Homayouni R, Williams RW, Airey DC (2008) Using gene expression databases for classical trait QTL candidate gene discovery in the BXD recombinant inbred genetic reference population: mouse forebrain weight. BMC Neuroscience 9:444 |
| 131 | McLachlan SM, Aliesky H. Pichurin PN, Chen CR, Williams RW, Rapoport B (2008) Shared and unique susceptibility genes for Graves' disease induced by thyrotropin receptor adenovirus immunization in BXH and CXB recombinant inbred mice. Endocrinology 149:2001-2009 |
| 132 | Mozhui K, Ciobanu DC, Schikorski T, Wang X, Lu L, Williams RW (2008) Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression. PLoS Genetics 4:e1000260 |
| 133 | Mulligan MK, Ponomarev I, Boehm SL, Owen JA, Levin PS, Berman AE, Blednov YA, Crabbe JC, Williams RW, Miles MF, Bergeson SE (2008) Alcohol trait and transcriptional genomic analysis of C57BL/6J substrain. Genes, Brain & Behavior 7:677-689 |
| 134 | Pardue MT, Faulkner AE, Fernandes A, Yin H, Schaeffel F, Williams RW, Pozdeyev N, Iuvone PM (2008) High susceptibility to experimental myopia in a mouse model with a retinal on pathway defect. Investigative Ophthalmology and Visual Science 49:706-712 |
| 135 | Peirce JL, Broman KW, Lu L, Chesler EJ, Zhou G, Airey DC, Birmingham AE, Williams RW (2008) Genome reshuffling for advanced intercross permutation (GRAIP): A permutation method for quantitative advanced intercross population analysis. PLoS One 3:e1977 |
| 136 | Reiner DJ, Jan TA, Boughter JD, Li CX, Lu L, Williams RW, Waters RS (2008) Genetic analysis of tongue size and taste papillae number and size in recombinant inbred strains of mice. Chemical Senses 33:693-707 |
| 137 | Yang RJ, Mozhui K, Karlsson RM, Cameron HA, Williams RW, Holmes A (2008) Variation in mouse basolateral amygdala volume is associated with differences in stress reactivity and fear learning. Neuropsychopharmacology 33:2595-2604 |
| 2009 | |
| 138 | Badea A, Johnson GA, Williams RW (2009) Genetic dissection of the mouse brain using high-field magnetic resonance microscopy. Neuroimaging 45:1067-79 (PMID: 19349225) |
| 139 | Badea A, Johnson GA, Williams RW (2009) Genetic dissection of the mouse CNS using magnetic resonance microscopy. |
| 140 | Boon ACM, deBeauchamp J, Hollmann A, Luke J, Kotb M, Rowe S, Finkelstein D, Neale G, Lu L, Williams RW, Webby RJ (2009) Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. Journal of Virology in press |
| 141 | Brigman JL, Mathur P, Lu L, Williams RW, Holmes A (2009) Genetic relationship between anxiety- and fear-related behaviors in BXD recombinant inbred mice. Behavioral Pharmacology 20:204-209 |
| 142 | Davies MN, Lawn S, Whatley S, Fernandes C, Williams RW, Schalkwyk LC (2009) Is blood a reasonable surrogate for brain in gene expression studies? Frontiers in Neurogenomics 1: 2 |
| 143 | Gaglani SM, Lu L, Williams RW, Rosen GD (2009) The genetic control of neocortex volume and covariation with patterns of gene expression in mice. BMC Neuroscience 10:44 (PMID: 19426526) |
| 144 | Geisert EE Jr, Lu L, Freeman-Anderson NE, Templeton JP, Nassr M, Wang X, Gu W, Jiao Y, Williams RW (2009) Gene expression in the mouse eye: an on-line resource for genetics using 103 strains of mice. Molecular Vision in press |
| 145 | Koutnikova H, Markku L, Lu L, Combe R, Paananen J, Kuulasmaa T, Kuusisto J, Höring H, Hansen T, Pedersen,O, Smith U, Hanefel M, Williams RW, Auwerx J (2009) Identification of UBP1 as a critical blood pressure determinant. PLoS Genetics 5:e1000591 |
| 146 | Lionikas A, Carlborg O, Lu L, Peirce JL, Williams RW, Yu F, Vogler GP, McClearn GE, Blizard DA (2009) Genomic analysis of variation in hindlimb musculature of mice from the C57BL/6J and DBA/2J lineage, Journal of Heredity in press |
| 147 | Overall RW, Kempermann G, Peirce J, Lu L, Goldowitz D, Gage FH, Goodwin S, Smit G, Airey DC, Rosen GD, Schalkwyk LC, Sutter TR, Nowakowski R, Whatley S, Williams RW (2009) Systems genetics of the hippocampal transcriptome in 99 mouse strains. Frontiers in Neurogenomics 1:3 |
| 148 | Rosen GL, Pung C, Owens C, Caplow J, Kim H, Lu L, Williams RW (2009) Genetic modulation of striatal volume in BXD recombinant inbred mice. Genes, Brain & Behavior 8:296-308 (PMID:19191878) |
| 149 | Star K, Qi H, Lu L, Williams RW, Böttinger E (2009) Multiple quantitative trait loci affect podocyte and non-podocyte glomerular cell numbers in mice. Journal of the American Society of Nephrology in press |
| 150 | Templeton JP, Nassr M, Vazques-Chona, Freeman-Anderson NE, Orr WE, Williams RW, Geisert EE (2009) Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush. BMC Neuroscience 10:90 |
| 151 | Whitney IE, Raven M, Ciobanu DC, Williams RW, Reese BE (2009) Multiple genes on chromosome 7 regulate dopaminergic amacrine cell number in the mouse retina. Investigative Ophthalmology and Visual Science 50:1996-2003 |
| 152 | Ciobanu DC, Lu L, Mozhui K, Wang X, Morris JA, Taylor WL, Dietz K, Simon P, Williams RW (2009) Detection, validation, and downstream analysis of allelic variation in gene expression. Genetics in press |
| 153 | Peidis P Giannakouros T, Burow ME, Williams RW, Scott RE (2009) Systems genetics analyses predict a transcription role for P2P-R: molecular confirmation that P2P-R is a transcriptional co-represssor. BMC Systems Biology, in press |
| 154 | Mozhui K, Karlsson RM, Kash TL, Ihne J, Norcross M, Patel S, Farrell MR, Hill EE, Martin KP, Camp M, Fitzgerald P, Ciobanu DC, Sprengel R, Mishina M, Wellman CL, Winder DG, Williams RW, Holmes A (2009) Genetically-driven variation in behavioral responses to stress is associated with divergent glutamate plasticity. in submission (Sept 9, 2009) |
| 155 | Li Z, Wolfe C, Lu L, Williams RW, Hayes NL, Nowakowski RS, Goldowitz D (2009) Genetic influences on neural proliferation in the rostral migratory stream in the adult mouse brain. European Journal of Neuroscience in submission |
|
| Legend: Illustration of the embryonic mammalian visual system in the style of da Vinci (by RWW1985) |
REVIEWS, LETTERS, BOOK CHAPTERS
| 1 | Chalupa LM, Williams RW (1984) Prenatal development and reorganization in the visual system of the cat. In Development of Visual Pathways in Mammals. Stone J, Dreher B, Rapaport DH (eds) Alan R Liss Inc, New York, pp 89-102. Full text |
| 2 | Chalupa LM, Williams RW (1985) Formation of retinal projections in the cat. In Advances in Neuronal and Behavioral Development. vol 1 (Aslin RN, ed): Norwood, New Jersey: Ablex Publishing, pp 1-32 |
| 3 | Williams RW, Herrup K (1988) The control of neuron number. Annual Review of Neuroscience 11:423-453 . |
| 4 | Williams RW. Goldowitz D (1992) Lineage versus environment in embryonic retina: A revisionist perspective. Trends in Neuroscience 15:368-373 |
| 5 | Williams RW, Goldowitz D (1993) Lineage versus environment in embryonic retina: Letters to the editor. Trends in Neuroscience 16:96-98 |
| 6 | Williams RW (1990) The primary visual system does not care about Previc's near-far dichotomy. Why not? Behavioral and Brain Sciences: 13:557 |
| 7 | Williams RW (1992) A very rare congenital eye movement disorder in Belgian sheepdogs. National Belgian Newsletter 44:75 |
| 8 | Williams RW, Strom RC, Zhou G, Yan Z (1998) Genetic dissection of retinal development. Seminars in Cell and Developmental Biology 9:249-255 |
| 9 | Williams RW (1998) Neuroscience meets quantitative genetics: Using morphometric data to map genes that modulate CNS architecture. Short Course in Quantitative Neuroanatomy (Morrison J, and Hof P, eds) pp 66-78 |
| 10 | Toth LA, Williams RW (1998). Genetic analysis of complex quantitative traits using inbred mice. Sleep Research Society Bulletin 4:50-56 |
| 11 | Williams RW (2000). Mapping genes that modulate mouse brain development: a quantitative genetic approach. In: Mouse brain development (Goffinet AF, Rakic P, eds). Springer, New York, pp 21-49 |
| 12 | Belknap JK, Crabbe JC, Phillips TJ, Hitzemann R, Buck KJ, Williams RW (2001) Quantitative trait loci and genome-wide mutagenesis: two phenotype-driven approaches to the dissection of complex murine traits. Behavior Genetics 31:5-15 |
| 13 | Mountz JD, van Zant G, Zhang H, Grizzle WE, Ahmed R, Williams RW, Hsu HC (2001) Genetic dissection of age-related changes in immune function in mice. Scandinavian Journal of Immunology 54:10-20 |
| 14 | Airey DC, Williams RW. (2002) Quantitative genetic perspectives. Commentary to Finlay BL, Darlington RB, and Nicastro N (2002) Developmental structure in brain evolution. Behavioral and Brain Sciences 24:279-280 |
| 15 | Hunter K, Williams RW (2002) Quantitative trait locus analysis in cancer research. ILAR J 43:80-88 |
| 16 | Threadgill, Hunter K, Williams RW (2002) Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort. Mammalian Genome 13:175-178 |
| 17 | Williams RW, Dubnau J, Enoch MA, Flaherty L, Sluyter F, Gannon KS, Maxson SC, Riedl CAL, Williams KD, Holmes A, Bolivar VJ, Crusio WE (2002) Hot topics in behavioral and neural genetics. Gene, Brain and Behavior 1:1-10 |
| 18 | Williams RW, Glueck SB (2002) New views of gene expression in the brain: Focus on "Gene expression tomography.' Physiological Genomics 8:79 |
| 19 | Williams RW (2002) Everyday bioinformatics: map, microarrays and beyond. Bioinformatics 2002, a Society for Neuroscience Short Course (Williams RW, Goldowitz D, eds), Society for Neuroscience, pp. 1-10 |
| 20 | Dell'Osso LF, Williams RW, Jacobs JB, Hertle RW, FitzGibbon EJ, Thompson MA, Yang D (2002) Novel surgery for nystagmus: initial trial results. Research to Prevent Blindness 16: 56-57 |
| 21 | Williams RW, Flaherty L, Threadgill DW (2003) The math of making mutant mice. Genes, Brain and Behavior 2:191-200 |
| 22 | Williams RW, Moody SA (2003) Developmental and genetic control of cell number in the retina. In: The Visual Neurosciences, eds. Chalupa LM , Werner JS. MIT Press. pp 65-78 |
| 23 | Williams RW, Broman KW, Cheverud JM, Churchill GA, Hitzemann RW, Hunter K, Mountz JD, Pomp P, Reeves RH, Schalkwyk LC, Threadgill DW (2002) A collaborative cross for high-precision complex trait analysis. 1st Workshop Report of the Complex Trait Consortium: Sept 2002. http://www.complextrait.org/Workshop1.pdf |
| 24 | von Bartheld CS, Williams RW (2003) Measurement of differential shrinkage or compression in the z-axis of tissue sections. Current Protocols in Neuroscience Unit 11.11-1.11.29 Suppl 24 |
| 25 | von Bartheld CS, Williams RW (2003) Calibration of counting methods by a limited and simple 3-D reconstruction of serial sections. Current Protocols in Neuroscience Unit 11.11-1.11.29 Suppl 24 |
| 26 | Williams RW, von Bartheld CS, Rosen GD (2003) Counting cells in sectioned material-3D counting, the optical disector, and Abercrombie's two-section comparison method. Current Protocols in Neuroscience Unit 1.11.1-1.11.29 Suppl 24 |
| 27 | Rosen GD, Williams RW (2003) Celloidin embedding and cresyl violet staining. Current Protocols in Neuroscience Unit 11.11-1.11.29 Suppl 24 |
| 28 | Rosen GD, Williams RW (2003) Estimation of regional volume from serial sections using point counting and Cavalieri's rule. Current Protocols in Neuroscience Unit 1.11 |
| 29 | Williams RW, Rosen GD (2003) Providing researchers access to tissue banks. American Laboratory |
| 30 | Gardner D, Toga AW, Ascoli GA, Beatty J, Brinkley AF, Dale AM, Fox PT, Gardner EP, George JS, Goddard N, Harris KM, Herskovits EH, Hines M, Jacobs GA, Jacobs RE, Jones EG, Kennedy DN, Kimberg DY, Mazziotta JC, Miller P, Mori S, Mountain DC, Reiss AL, Rosen GD, Rottenberg DA, Shepherd GM, Smalheiser NR, Smith KP, Strachan T, Van Essen DC, Williams RW, Song STC (2003) Toward effective and rewarding data sharing. Neuroinformatics, 1:288-295 |
| 31 | Schaeffel F, Simon P, Feldkaemper M, Ohngemach S, Williams RW (2003) Molecular biology of myopia. Clinical and Experimental Optometry, 86: 295-307 |
| 32 | The Complex Trait Consortium: Flaherty L, Abiola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett BB, Blankenhorn EP, Blizard DA., Bolivar V, Brockmann GA, Buck KJ, Bureau J-F, Casley, WL, Chesler EJ, Cheverud JM, Churchill GA, Cook M, Crabbe JC, Crusio WE, Darvasi A, de Haan G, Demant P, Doerge RW, Elliott RW, Farber CR, Flint J, Gershenfeld H, Gibson JP, Gu W, Himmelbauer H, Hitzemann R, Hsu H-C, Hunter K, Iraqi F, Jansen RC, Johnson TE, Jones BC, Kempermann G, Lammert F, Lu L, Manly KF, Matthews DB, Medrano JF, Mehrabian M, Mittleman G, Mock BA, Mogil JS, Montagutelli, X, Morahan G, Mountz JD, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Paigen B, Palmer AA, Peirce JL., Pomp D, Rosemann M, Rosen GD, Schalkwyk LC, Seltzer Z, Settle S, Shimomura K, Shou S, Sikela JM, Siracusa LD, Spearow JL, Teuscher C, Threadgill DW, Toth LA, Toye AA., Vadasz C, Van Zant G, Wakeland E, Williams RW, Zhang H-G, Zou F (2003) The nature and identification of quantitative trait loci: a community's view. Nature Genetics Reviews 4: 911-916 |
| 33 | Nissanov J, Williams RW (2003) Mouse neuroinformatic public resources. An invitation to end-users. Neuroinformatics 1:297-298 |
| 34 | Williams RW (2003) A neuroscientist's guide to genomic resources. In: The Bioinformatics of Brains: From genes and proteins to behavior (Williams RW, ed) pp. 1-8. Washington, DC: Society for Neuroscience |
| 35 | Williams RW (2003) WebQTL: a tour of transcriptional networks. In: The Bioinformatics of Brains: From genes and proteins to behavior (Williams RW, ed) pp. 51-59. Washington, DC: Society for Neuroscience |
| 36 | Williams RW (2003) Managing your lab data flux: getting beyond Excel (Williams RW, ed) pp. 83-92. Washington, DC: Society for Neuroscience |
| 37 | Zareparsi S, Hero A, Zack DJ, Williams RW, Swaroop A (2004) Seeing the unseen: microarray-based gene expression profiling in vision. Investigative Ophthalmology and Vision Science 45:2457-2462 |
| 38 | Chesler EJ, Lu L, Wang J, Williams RW, Manly KF (2004) WebQTL: Rapid exploratory analysis of gene expression and genetic networks for brain and behavior. Nature Neuroscience 7:485-486 |
| 39 | Chesler EJ, Williams RW (2004) Brain gene expression: genomics and genetics. In: DNA Arrays in Neurobiology (ed. Miles M) Academic Press, International Review of Neurobiology 60:59-95 |
| 40 | The Complex Trait Consortium: Churchill GA, ... Williams RW and many coauthors (2004) The collaborative cross: a community resource for the genetic analysis of complex traits. Nature Genetics 36: 1-5 |
| 41 | de Haan G, Williams RW (2005) A genetic and genomic approach to identify longevity genes in mice. Mechanisms of Aging and Development 126:133-138 |
| 42 | Johnson DK, Rinchik EM, Moustaid-Moussa N, Miller DR, Williams RW, Michaud EJ, Jablonski MM, Goldowitz D (2005) Phenotype screening for genetically-determined age-onset disorders and increased longevity in ENU-mutagenized mice. AGE 27:75-90 |
| 43 | Matthews DB, Bhave SV, Belknap JK, Brittinham C, Chesler EJ, Hitzemann RJ, Hoffmann PL, Lu L, McWeeney S, Miles MF, Tabakoff B, Williams RW (2005) Complex genetics of interactions of alcohol and CNS function and behavior. Alcoholism: Clinical and Experimental Research 29:1706-1719 |
| 44 | Williams RW (2006) Genomics and dyslexia: Bridging the gap (2006) In: The Dyslexic Brain: New Pathways in Neuroscience Discovery, Rosen GD, ed. Lawrence Erlbaum Associates, pp. 167-190 |
| 45 | Williams RW (2006) Animal models in biomedical research: ethics, challenges, and opportunities. In: Principles of molecular medicine, 2nd ed. Runge MS, Patterson C eds, Chapter 8, Humana Press, Totowa, New Jersey, pp. 53-60 |
| 46 | Williams RW (2006) Expression genetics and the phenotype revolution. Mammalian Genome 17:496-502 |
| 47 | Peirce JL, Williams RW (2006) Expression and brain structure: black boxes between genes and behaviors. Neurobehavioral Genetics: Methods and Applications, 2nd ed (Jones B, Mormede P, eds). Taylor and Francis, Boca Raton |
| 48 | Chesler EJ, Bystrykh L, Cooke M, de Haan G, Manly KF, Williams RW (2006) Normalization procedures and detection of linkage signal in genetical-genomics experiments. Reply to RBH Williams et al., Nature Genetics 38:856-858 |
| 49 | Miles M, Williams RW (2007) Meta-analysis for microarray studies on genetics of complex traits. Trends in Biotechnology 25:45-47 |
| 50 | Shifman S, Tzenova Bell J, Copley RR, Taylor MS, Mott R, Flint J, Williams RW (2007) Evidence of a large-scale functional organization of mammalian chromosomes; Authors' reply. PLoS Biol 5:e128 |
| 51 | Hsu HC, Lu L, Yi N, Van Zant G, Williams RW, Mountz JD (2007) Quantitative trait locus (QTL) mapping in aging systems. In: Methods in Molecular Biology (Biological Aging: Methods and Protocols), Tollefsbol TO, ed. Chapter 23, Humana Press, Totowa, New Jersey, Vol 371, pp 321-348 |
| 52 | Morahan G. Williams RW (2007) Systems genetics: the next generation in genetics research? Novartis Foundation Symp 281:181-188 |
| 53 | Rosen GD, Chesler EJ, Manly KF, Williams RW (2007) An informatics approach to systems neurogenetics. Neuroinformatics, ed. Crasto CJ, Humana Press, New York. Methods in Molecular Biology 401:287-303 |
| 54 | Boline J, Hawrylycz M, Williams RW (2007) 1st INCF workshop on mouse and rat digital atlasing systems. http://precedings.nature.com/documents/1046/version/1 http://www.incf.org/med/incf_report_digitalatlasing_070915.pdf%20 |
| 55 | Eye, Retina, and Visual System of the Mouse (2008) Chalupa LM, Williams RW, eds. MIT Press. 754 pp |
| 56 | Geisert EE, Williams RW (2008) The mouse eye transcriptome: cellular signatures, molecular networks, and candidate genes for human disease. In Eye, Retina, and Visual System of the Mouse (2008) Chalupa LM, Williams RW, eds. MIT Press, pp 659-674. |
| 57 | Kotb M, Fathey N, Aziz R, Rowe S, Williams RW, Lu L (2008) Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections. Novartis Found Symp 293:156-65; discussion165-7, 181-3 |
| 58 | Morahan G, Peeva V, Munish M, Williams R (2008) Systems genetics can provide new insights in to immune regulation and autoimmunity. Journal of Autoimmunity 31:233-236. |
| 59 | Williams RW, Lu L (2008) Integrative genetic analysis of alcohol dependence using the GeneNetwork web resources. In Pathways to Alcohol Dependence: Alcohol Research & Health 31:275-277 |
| 60 | Beiter T, Reich E, Williams RW, Simon P (2009) Antisense transcription: a critical look in both directions. Cellular and Molecular Life Sciences 66:94-112 |
| 61 | Badea A, Johnson GA, Williams RW (2009) Genetic dissection of the mouse CNS using magnetic resonance microscopy. Current Opinion in Neurology in press |
| 62 | Williams RW (2009) Herding cats: the sociology of data integration. Frontiers in Neuroscience in press |
| 63 | Williams RW (2009) Headlong into a genomics singularity. in press |
RESEARCH WEB SITES
| 1. | www.genenetwork.org, GeneNetwork (GN) and WebQTL were created by Manly KF, JT Wang, and RW Williams in 2001, initially as part of a Human Brain Project. GN and a number of specialized code modules (GenomeGraph, SNP Browser, QTL Reaper) are being developed by RW Williams and colleagues (2001-present). GeneNetwork is a major genomics resource site that receives ~12,000 hits per day and ~ 1200 hosts per week (see http://www.genenetwork.org/webqtllog/). GN has reciprocal links with UCSC's Genome Browser, NCBI, The Allen Brain Atlas, NEIBank, and The BIRN MBAT project. A full mirror site of GN is maintained at the Helmholtz Zentrum fur Infektionsforschung in Germany (http://genesys.helmholtz-hzi.de/search.html). Approximately 30 publications referenced GeneNetwork and WebQTL in 2007 (see http://www.genenetwork.org/reference.html). |
| 2. | www.nervenet.org. Nervenet was initiated by RW Williams, January 1994. It is one of the oldest neuroscience web sites and now serves as the Williams lab portal. It predecessor, mickey.uthsc.edu originally housed the Portable Dictionary of the Mouse Genome. The earliest "http" reference in a PubMed abstract is associated with this portal: see http://www.ncbi.nlm.nih.gov/pubmed/8043953 |
| 3. | www.mbl.org. The Mouse Brain Library was initiated by Williams RW, Rosen GD, Williams, A.G., May 1997. The Mouse Brain Library and the Internet Atlas of the Mouse Brain have been in continuous operation since May 1997. This is a growing and well-used Internet database with histological image data for over 2000 mouse brains imaged at low, intermediate, and high resolution. It includes several stereotaxic atlases of the brains of mice. The MBL was included in ISI Current Web Contents (CC Connect TM) starting in Jan 2001. The site was reviewed by Kaiser J (2000) in Science. Mouse Brain Library: Netwatch Images selection. Science 289:211. |
| 4. | www.complextrait.org. The main web site for the Complex Trait Consortium. Founded in 2002 by RW Williams and colleagues. The site is housed in the Williams lab. |
| 5. | www.ibangs.org. The main web site for the International Behavioural and Neural Genetics Society. This site was initiated by Dr. Wim Crucio. It was rebuilt most recently by Arthur Centeno and RW Williams. The site is housed in the Williams lab. |
| 6. | (iscope.nervenet.org) Initiated by Williams RW, Cruz B, Connolly M; Capra JA (1999) iScope. A software suite for telemicroscopy. (www.mbl.org) Aug 1999-2005. As of 2006, this project and web stie has been retired. |
NEWS AND COVERAGE
| New York Times. Blakeslee S (1993) Evolution of tabby cat mapped in brain study. Tuesday January 12, Section B5. |
| Il Corriere Della Sera (Milan newspaper). Simion L (1993) Al micio si e rimpicciolito il cervello. Jan 31 issue. |
| Discover Magazine. Oliwenstein L (1993, May issue) Brain Donors. Discover 14:18. |
| Nature. Guillery RW (1994) No crossing at the crossing. A New and Views article. Nature 367:597-598 (This review considers a paper by Williams et al. 1994.) |
| Human Genome News. Mansfield BK (1994) Mouse gene data files available from UT Memphis. Human Genome News, May 1994. |
| Science. Takahashi JS (1994) Forward and reserve genetic approaches to behavior in the mouse. Science 264: 1724-1733. (This review contains a brief description of the Portable Dictionary of the Mouse Genome.) |
| Science. Kaiser J (2000) Mouse Brain Library: Netwatch Images selection. Science 289:211. |
| Commercial Appeal (Memphis newspaper). July 9, 2001. Front page photo of Abigail Haynes working in R. Williams laboratory (by Lance Murphey). |
| Memphis Business Journal. Jan 15-21, 2002. Vol. 24 No. X. RW cited in article on Genome Explorations. |
| Commercial Appeal. May 15, 2002: World's scientists sniff trail of complex traits. RW cited in article as organizer. Page A11. |
| Apple Computer, Inc. Providing Broad Access to Tissue Banks: on the Science & Technology site at http://www.apple.com/scitech/appletech/dv/utic/ (posted 2002) |
| AAAS News Release. Feb 17, 2003 by Monica Amarelo. iScope, you scope, we all scope a mouse brain |
| DataDescription Inc. Which gene influences what? Data Desk aids in gene mapping: DataDescription Inc., by Holly M. Bailey, July 2003, http://www.datadesk.com/company/profiles/williams.shtml |
| Bio IT World. June 15, 2003 issue. Building a better mouse database. http://www.bio-itworld.com/archive/061503/mouse_sidebar_2646.html and see http://www.bio-itworld.com/archive/061503/mouse.html |
| Science (2003) Geneticists Dream of 1001 Complex Mice. Science 301:456-457 by GretchenVogel |
| Bio-IT World (2004) Mouse Brains - FileMaker & Excel by Mike Nelson |
| Memphis Business Journal. Aug 12-18, 2005, by Scott Shepard. Mouse engineer: Williams leads project to revolutionize genomics research |
| BIRNing Issues: Biomedical Informatics Research Network: August 2005. "Williams helps integrate diverse mouse data." www.nbirn.net/Publications/Newsletter/ pp 5-6 |
| Memphis Business Journal. July 7-13, 2006, pp. 9-10 by Scott Shepard. Focus on Biotech. Biotech debate: Share or covet knowledge. pp. 9-10. This article includes an interview with RWW. "The key concept is to recognize the areas of science and areas of industry that we all regard as pre-competitive." |
| Time Magazine (Jan 2007) What the Mouse Brain Tells Us?, by Alice Park. Jan 29, 2007, p. 93. |
| Neuroscience Gateway (Feb 2007) Pump up the volume. Genes associated with basolateral amygdala morphology are involved in neuronal development. Feb doi:10.1038/aba1717 http://www.neuroscience-gateway.org/2007/070215/full/aba1717.shtml [An article about a paper by Mozhui, Hamre, Holmes, Lu, and Williams on loci modulating volume of the amygdala.] |
| Snow, D (April 2008) The Million Dollar Mouse: a statewide consortium provides a model of collaboration and research. Business TN, www.businesstn.com/pub/5_4/features/8506-1.html |
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Synopsis: Robert (Rob) W. Williams received a BA in neuroscience from UC Santa Cruz (1975) and a Ph.D. in physiology at UC Davis with Leo M Chalupa (1983). He did postdoctoral work in developmental neurobiology at Yale with Pasko Rakic and moved to the University of Tennessee in 1989. He is a professor in the Department of Anatomy and Neurobiology, Director of the Center for Translational Genomics, and holds the Dunavant professorship in developmental genetics in the Department of Pediatrics. Williams is a past president of the Society for Behavioural and Neural Genetics Society and founding director of the Complex Trait Consortium (www.complextrait.org). He is a member of the International Committee on Standardized Genetic Nomenclature for Mice and Chair of the Society for Neuroscience Neuroinformatics Committee. He is editor-in-chief of Frontiers in Neurogenomics, and he serves on the editorial boards of Genes, Brain & Behavior, Neuroinformatics, Alcohol, Molecular Vision, European Journal of Anatomy, Alcohol, BiomedCentral Neuroscience, the Journal of Biomedical Discovery and Collaboration, and Behavior Genetics. One of Williams' more notable recent contributions is in the field of systems biology. He and his research group have built GeneNetwork (www.genenetwork.org), an online resource and data analysis toolset that is used widely by the systems genetics community.
Abstract on science: Mendelian genetics is the study of single gene variants associated with specific trait variants. Systems genetics is the analysis of many gene variants and networks of interacting traits. Neuroscience is a perfect field in which to apply systems genetics. However, it is difficult to acquire large numbers of related traits for populations of humans in an experimentally controlled setting (e.g., gene expression in hippocampus following exercise). In the case of mice, it is not so difficult; we have acquired and curated hundreds of thousands of micro-traits (mRNA expression levels) for a panel of up to 100 highly diverse lines of mice that model some of the complexity of human populations. The genetic covariance among these traits and transcripts provides remarkable insights into molecular and higher order phenotypes, up to and including behavioral variation and disease susceptibility.
Abstract on models: A Paradigm Shift in Mouse Genetics: Merging Reductionist and Holistic Approaches to Model Pervasive Diseases in Human Populations
The analysis of human disease has profited enormously from systematic application of reductionist methods. But as we learn more about disease susceptibility, we realize that final outcomes are due to complex interactions among systems that are essentially irreducible. How do we model and test such complexity and take into account the major role played by genetic variation and environmental perturbations such as changes in diet, stress level, and exercise? We need experimental systems with tightly controlled genomes and environments, but with a level of genetic complexity that faithfully mirrors human populations. This is now possible using Genetic Reference Populations of mice and rats. These new resources promise to revolutionize our ability to deliver personalized and predictive health care to humans. In this talk I will review how Reference Populations are being used to study brain function, aging and disease.
Abstract for neuroscience talk. Systems Neurogenetics and Genetic Control of Expression in the Mouse Brain
Many neuroscientists are interested in understanding complex networks of molecules and cellular processes that modulate structural and behavioral variation in the brain. Over the past several years our team has produced unique tissue and transcriptome resources and companion on-line analytic and stereological tools as part of the Mouse Brain Library (www.mbl.org) and GeneNetwork (www.genenetwork.org). This set of neuroinformatics resources is now being used by neuroscientists and geneticists to systematically study the complex genetics of the mammalian brain in terms of development, architecture, function, and pathology. In this presentation I will review these online resources, and demonstrate how they can be used to elucidate functions of gene networks that modulate variation in both the hippocampus and striatum by exploiting mutliscale data generated using a panel of 100 diverse strains of mice.
Video presentation:
University of Tennessee, Memphis. November 2009.
University of Nebraska, Lincoln. March 2009. Windows Media Player required.
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