Robert W. Williams
DEGREES
|
Ph.D. (1983) Physiology, University
of California, Davis
B.A. (1975) Psychobiology, University
of California, Santa Cruz
|
INTERESTS
|
� Systems genetics, complex trait analysis, and functional genomics
� Control of gene expression � Genetics of CNS diseases and addiction
� Visual system structure, function, and development
� Advanced methods in collaborative research and data interchange |
PROFESSIONAL EXPERIENCE
2001�present |
William and Dorothy Dunavant Chair of
Excellence in Developmental Genetics:
Department of Pediatrics (2nd appointment),
University of Tennessee |
2000�present |
Codirector: Center of Genomics and Bioinformatics,
University of Tennessee |
1997�present |
Professor: Department of Anatomy and
Neurobiology and Center for Neuroscience,
University of Tennessee Health Science
Center (primary) |
2001�present |
Professor: Department of Pediatrics |
2001�present |
Member: Feinstone Center for Genomic Research,
University of Memphis |
1992�1997 |
Associate Professor: Department of Anatomy
and Neurobiology and Center for Neuroscience,
University of Tennessee |
1989�1992 |
Assistant Professor: Department of Anatomy
and Neurobiology and Center for Neuroscience,
University of Tennessee |
1986�1989 |
Assistant Professor: Yale University
School of Medicine, Section of Neuroanatomy |
1985�1986 |
Associate Research Scientist: Yale University
School of Medicine, Section of Neuroanatomy
(P. Rakic, mentor) |
1984�1989 |
Instructor, Neuroanatomy laboratory:
Yale University School of Medicine, Section
of Neuroanatomy |
1983�1985 |
Postdoctoral fellow: Yale University
School of Medicine, Section of Neuroanatomy,
(P. Rakic, mentor) |
1982�1983 |
Assistant Research Physiologist: University
of California, Davis |
1982 |
Instructor: University of California,
Davis |
1979�1982 |
National Institutes of Health Trainee:
University of California, Davis, (L.M.
Chalupa, thesis advisor) |
1978�1981 |
Teaching Assistant and Teaching Associate:
Animal Physiology and Psychology, University
of California, Davis |
Professional SOCIETIES
|
Society for Neuroscience (Chair, Neuroinformatics Committee) |
|
Complex Trait Consortium (founder and director, 2001�present) |
|
Research Society on Alcoholism (member) |
|
Association for Research in Vision and Ophthalmology (member) |
|
International Behavioural and Neural Genetics Society (president 2005) |
|
International Mammalian Genome Society (member) |
|
Behavioural Neurogenetics Initiative (member) |
|
IEEE (member) |
Grants and Fellowships
2001�present |
Principal Investigator: National Institutes
of Health. �INIA: Complex Trait Analysis
of Alcohol-Stress Interactions� U01AA13499.
TDC approx. $1.68M over 5 years (02.01.02�12.31.06). |
2001�present |
Principal Investigator: National Institutes
of Health. �INIA: Genotyping Core�
1U24AA13513. TDC ~$1.68 M over 5 years
(01.01.02�12.30.06; renewal in progress) |
2005�present |
Coinvestigator, Mouse Biomedical Informatics Research Network (BIRN), National Institutes of Health R24 RR021760. National Center for Research Resources, TDC ~$1.0 M over 5 years (04.01.05�03.31.09) |
2006�2007 |
Principal Investigator: Huntingtin Transcriptome Analysis, High Q Foundation, $466,800 over 1 year (02-01-06 to 01-31-07) |
2001�present |
Principal Investigator: INIA: Genotyping Core, National Institutes of Health 1U24AA13513. TDC ~$600,000 over 5 years (01.01.02�12.30.06) |
2004�present |
Coinvestigator: Integrative Genetics of Cancer Susceptibility, NCI 1U01CA105417. TDC $600,000 over 5 years (04.01.04�03.31.2009, with KF Manly and DW Threadgill, 2%) |
2000�present |
Principal Investigator: Informatics Center for Mouse Neurogenetics, National Institutes of Health and National Science Foundation, Human Brain Project 2P20-DA21131, 1P20-MH62009, and IBN-0003982. TDC ~$5.4 M over 5 years (7.1.00�8.30.10, 32%) |
2005�2007 |
Coinvestigator: Development of Advanced Tools for Diagnosis and Triaging Individuals Exposed to Select Pathogens, DOD/US W81XHW-05-01-0227 |
2005�2010 |
Coinvestigator: Dispersion Patterns for Retinal Neuroblasts, NEI R01EY011087-07A1. (B Reese, PI; RW Williams, coinvestigator) |
2004�present |
Consultant: Conti Center, John Csernanski PI, Jim Cheverud, PI Project 5. Genetics of Schizophrenia-Related Traits in Mice, Washington University |
2004�2007 |
External Advisory Board: P20 Exploratory Transdisciplinary Imaging Genetics Center and Function BIRN. (Steve Potkin, PI, Univ of California, Irvine) |
2000�2004 |
Principal Investigator: National Institutes
of Health. �Genetic and Epigenetic Control
of Eye Growth� R01 EY12991. TDC
$200,00 year 1, $800,000 all years (9.1.00�7.31.04,
30%). |
1999�2002 |
Principal Investigator: National Institutes
of Health. �Biometric and Functional Studies
of the Eye and Retina� R01 EY13070. TDC
$150,000 year 1, $444,381 all years (12.01.99�11.30.02
25%). |
2001 |
Principal Investigator: NIHLB Mammalian Genotyping
Service. "High Resolution QTL Mapping in
Mice" (7.1.01). Grant funds 350,000 genotypes. |
2001 |
Collaborator: National Institutes of Health.
"Sleep Patterns During Infectious Disease"
NL70522. TDC $225,00 year 1, $1.11M all years
(9.19.01�7.31.05; PI Linda Toth, no funded
effort). |
2000�present |
Eye Domain coinvestigator: National Institutes
of Health. �Targeted Mutagenesis of the
Mouse Genome and Neural Phenotypes� U01-MH61971,
TDC, $2,664,000/year (D. Goldowitz, PI, M. Jablonski,
domain PI) (funding from 7.1.00�6.30.05,
RW 5%). |
2000 |
Principal Investigator: NIHLB Mammalian Genotyping
Service. "An Advanced Intercross for Mapping
Multigenic Morphometric Traits in Mice: A Community
QTL Mapping Resource" (1.1.00). Grant funded
~190,000 genotypes. |
1996�2000 |
Principal Investigator: National Institutes
of Health. �Genetic Control of Neuron
Populations� R01 NS35485. TDC ~$733,000
all years (07.1.96 to 07.31.00, 20%). |
1987�2000 |
Principal Investigator: National Institutes
of Health. �Growth of Optic Nerve Fibers�
R01 EY06627-10. TDC, $437,500 (12.1.95 to 05.30.00). |
1991�1994 |
Principal Investigator: National Institutes
of Health. �Development and Clonal Structure
of the Mammalian Retina� R01 EY 08868�03.
TDC, $260,518 |
1992�1996 |
Co-Principal Investigator: National Institutes
of Health. �Genetic Basis of Retinal Development�
R01 EY09586-03. P.I, Dan Goldowitz, TDC, $505,991
(4.1.92 to 3.31.96). |
Awards
|
Loren D. Carlson Prize in Physiology, 1982-83 |
|
Fellow Award, Winter Conference on Brain Research, 1987 |
|
Excellence in Teaching Award, 1995 |
|
Distinguished Scientist Award, 2007, International Behavioural and Neural Genetics Society |
Patents
|
Tissue Analyzer: Inventors Robert W. Williams,
Pasko Rakic, U.S. Patent 4,932,044; filed November
4, 1988; issued June 5, 1990. See http://www.patents.ibm.com/claims?patent_number=4932044 |
|
Method for ultra-high resolution mapping of
genes and determination of genetic networks
among genes underlying phenotypic traits: Inventors
David W. Threadgill (Chapel Hill NC) and Robert
W. Williams (Memphis TN), U.S. Patent Application
(Preliminary) filed December 1, 2000. |
|
Method for determining sensitivity to environmental
toxins and susceptibility to Parkinson�s
disease. Inventors: Richard Smeyne (Memphis
TN) and Robert W. Williams (Memphis TN). U.S.
Patent Application (Preliminary), to be filed. |
|
Invention Disclosure: P2P-R cooperates with the MAD2, BUB3 and p55CDC/cdc20 mitotic checkpoint-associated proteins. Inventors: Dr. Robert E. Scott, and Robert W. Williams, Memphis TN) |
Symposia, Conferences, Committees
2007 |
Lead organizer: PubMed Plus Conference, sponsored by the SfN, David Van Essen (President), St. Louis, June 14, 16 |
2007 |
Lead organizer: International Neuroscience Coordinating Facility Workshop on Mouse and Rat Brain Atlasing Systems. Feb 13 14, Karolinska Institute, Stolkholm |
2006 |
Multistrain Mouse Testing Strategy Advisory Working Group, NIEHS, Research Triangle Park, July 21 (with John Pritchard) |
2006 |
Databasing the Brain, European Union workshop, Oslo, Norway, June 25�27 |
2006 |
Symposium honoring Dr. Lorraine Flaherty, Genomics Institute, Wadsworth Center, Albany Medical College, Albany, New York, June 19 |
2006 |
Neurofederatie Keynote Lecture, Endo-Neuro-Psychopharmacology (ENP) annual meeting, Amsterdam, June 7 |
2006 |
Genes Meet Behavior, a joint symposium of the International Behavioral
Neuroscience Society and International Behavioural and Neural Genetics Society, Whistler, Canada, May 24
|
2006 |
Gordon Research Conference on Genes and Behavior, Ventura, Feb 11�17 |
2006 |
Blueprint LINC team member, NIH, Bethesda, March 30�31 |
2005 |
Human Brain Project Special Interest Social, presentation, SfN annual meeting, Washington, Nov 14 |
2005 |
German Genetics Society, Genetics of Infection, symposium presentation, Braunschweig, Germany, Sept 22 |
2005 |
Opening lecture, 4th Annual CTC meeting, Groningen, Holland, June 27 |
2005 |
Mouse Models of Human Cancer Consortium Glioblastoma Meeting, St. Louis, June 16�18 |
2005 |
International Behavioural and Neural Genetics Society annual meeting, Sitges, Spain, June 9�13 |
2005 |
GENSAT Gene Selection Advisory Meeting, Bethesda, June 7 |
2005 |
High Q Foundation Meeting on Microarrays and Discovery of Therapeutic Targets for Huntington�s Disease, May 19, New York |
2005 |
2nd Annual Experimental Neurogenetics of the Mouse workshop, faculty member, Memphis, May 16-24 |
2005 |
Plenary lecture, Data Sharing in the Age of Discovery Science, Human Brain Project, NIH, Natcher Center, April 25 |
2005 |
Collaborative Cross Organizing Committee meeting, ORNL, March 24�25 |
2005 |
Gordon Research Conference on Quantitative Genetics and Genomics, Ventura, Feb 19�24 |
2005 |
Models of Human Cancer Consortium Committee Meeting, Vanderbilt, Jan 19�21 |
2005 |
1st International Imaging Genetics Conference, UC Irvine, Jan 17 |
2004 |
NIEHS Toxicogenomics Research Consortium meeting, Chapel Hill, Dec 6�8 |
2004 |
Mouse Resources Roundtable Conference, The Jackson Laboratory, Nov 19�21 |
2004 |
Biomedical Informatics Research Network (BIRN) Symposium speaker, Boston, Oct 13 |
2004 |
Co-organizer, 3rd Annual Complex Trait Consortium meeting, Bar Harbor, July 6�9 |
2004 |
Organizer, 10th International Summer School
on Behavioral Neurogenetics (Memphis TN, August
8�15 |
2003 |
Mouse Atlas Workshop (NIMH Office of Neuroinformatics),
Nov 18, 2003 |
2003 |
Behavior Genetics Association Symposium: Chicago
June 27 |
2003 |
Mouse Initiatives V: Genomics of Complex System
in Biomedical Research, July 31�Aug 2,
www.jax.org/courses/mi5_03.html |
2003 |
Joint Statistics Meeting symposium speaker:
San Francisco, Aug 4 to 6. |
2003 |
Society for Neuroscience Brain Information Group
member |
2003 |
Keynote: 9th International Summer School on
Behavioral Neurogenetics, Aug 6�9. Toulouse,
France |
2002 |
National Cancer Institute: Mouse Models of Human
Cancers Consortium- Roundtable, Newport Beach
CA, Dec 11�13. |
2002 |
Lecturer: NIDA Addiction Studies Workshop for
Journalist (Tuscon AZ, Dec 8) |
2003 |
Spring Brain Conference Plenary Session organizer:
Identifying Genes Controlling Brain Structure
and Behavior using Complex Trait Analysis, Sedona,
March 12�15 |
2002 |
Chair: Bioinformatics 2002, Society for
Neuroscience Short Course, Orlando FL, Nov 2 |
2002 |
Instructor: 8th International Summer School
on Behavioral Neurogenetics, Aug 5�9.
Worcester MA. |
2001 |
Chair: International Complex Trait Consortium,
Edinburgh, Oct.23, 2001 and Memphis, May2. |
2001 |
Sponsor and organizing committee: 4th Annual
Meeting: International Behavioral and Neural
Genetics Society, San Diego, Nov. 8�9 |
2001 |
Workshop presentation: South-East Regional Meeting
of the Society of Developmental Biology, Montreat
NC, May 24 |
2001 |
Invited speaker: Neuroinformatics Faces Functional
Genomics symposium: Natcher Building: Bethesda
MD, May 22: Tools for Collaborative Analysis
of Complex Neurodevelopmental and Behavioral
Traits. |
2000 |
Invited speaker: NIAAA-sponsored QTL meeting:
Washington DC (Dec 1; organized by Robert Karp) |
2000 |
Invited participant: Human Brain Project: Neuroinformatics
Satellite Symposium. New Orleans (Nov 4,; presentation
by GD Rosen) |
1999 |
Co-organizer: Symposium on QTL Mapping, Behavior
Genetics Association, Vancouver, Canada, July |
1999 |
Co-organizer and sponsor: The Molecular Biology/Molecular
Genetics of the Visual System, Center for Vision
Research Memphis TN (Mar 26) |
1999 |
Participant: Gordon Research Conference in Quantitative
Genetics. Ventura, CA (Feb 14�19) |
1998 |
Course Lecturer: Short Course in Quantitative
Neuroanatomy. Society for Neuroscience, Los
Angeles CA |
1998 |
Chairman: American Association of Anatomists:
Experimental Biology 98: Experimental Biology:
Symposium on Quantitative Neurobiology and the
Human Brain Project |
1996 |
Chairman: Mouse Chromosome 7 Committee: International
Mammalian Genome Society |
1998 |
Presentation: Chautauqua Short Course for college
teachers in neuroscience |
1997 |
Chairman: American Association of Anatomists:
Experimental Biology 97: Mini-symposium on Quantitative
Neurobiology |
1994 |
Co-chairman: Mouse Chromosome 7 Committee: International
Mammalian Genome Society (1994�1996) |
1989 |
Organizer: Winter Brain Conference Workshop,
�Different Strategies of Brain Development,�
Co-organized with Karl Herrup. Jan. 1989 |
1996 |
Co-organizer: Symposium on Cortical Development,
Center for Neuroscience, University of Tennessee,
June 1996 |
1991 |
Participant: The Jackson Laboratory, �Short
Course in Medical and Experimental Mammalian
Genetics � Aug. 1991 |
1985 |
Participant: Gordon Research Conference, �Central
Nervous System,� Tilton School, New Hampshire,
June 1985 |
1983 |
Participant: The Neuroscience Institute, �Molecular
Bases of Neuronal Development,� The Salk
Institute, October 1983 |
1981 |
Participant: NATO Advanced Studies Institute,
�Formation of Neuronal Connections,�
Varenna, Italy, May 1981 |
Visiting Scientist
2007-2008 |
Visiting Professor, University of Utrech (Prestige MSc Neuroscience Program (hosted by Marten Kas) |
2006 |
University of California, San Diego, March (Dr. Mark Ellisman) |
2000�2002 |
Advisory Professor, Fudan University, Shanghai |
2000�present |
Collaborator, with Profs Tan and Gu, Nantong
Medical College, |
1997 |
Harvard University, Beth Israel Hospital, Dr.
Glenn Rosen, June 1997 |
1996 |
The California Institute of Technology, Drs.
John Allman and Scott Fraser, Aug. 1996 |
1993 |
The Jackson Laboratory, Dr. Muriel Davisson,
July 1993 |
Scientific Advisory Boards
2006�2008 |
Scientific Advisory Board, Institute Clinique de la Souris, Strasbourg, France (Pierre Chambon, Johan Auwerx, and colleagues) |
2006�2007 |
US Representative and advisory board member, International Neuroinformatics Coordinating Facility |
2004�2007 |
Portland Alcohol Research Center, VAMC, Portland |
2004�2006 |
Consultant, Exploratory Transdisciplinary Imaging Genetics Center (Steven Potkin, PI, UCI) |
2001�2007 |
Genome Explorations Inc. |
Invited Seminars and Lectures (Incomplete List)
|
Organizer: PubMed Plus Conference (sponsored by the Society for Neuroscience), Washington University 2007 |
|
Organizer: 1st International Neuroscience Coordinating Facility Workshop on Mouse and Rat Brain Digital Atlasing Systems, Karolinska Institute, Stockholm, Sweden, Feb 13-14, 2007 |
|
Panelist: Society for Scholarly Publishing: Washington DC, Nov 13, 2007 |
|
Application of Pharmacogenomics to Drug Development and Therapy, 14th ISSX Meeting, Short Course presentation. Oct 22, 2006 |
|
IIIe cycle, Lausanne Genome Day, lecture, Lausanne Switzerland, Oct 4-5, 2006 |
|
Unveiling Genome-Wide DNA Variation in 15 Diverse Mouse Strains: NIEHS, lecture, Sept 26, 2006 |
|
West Virgina University Eye Institute, seminar; Sept 20, 2006 |
|
Route 28 Meeting Adult Neurogenesis Course, Fraueninsel, Germany, Sept 2�8, 2006 |
|
Instructor, Plant Genome Short Course, Boston, Aug 1�3, 2006 |
|
Eli Lilly Integrative Biology Research Group, Lectures, Indianapolis, June 12�13, 2006 |
|
Workshop on Systems Genetics, University of Utrecht, Netherlands, June 6, 2006 |
|
ARVO mini symposium speaker, Ft. Lauderdale, May 3, 2006 |
|
Bioinformatics Summit, Lake Barkley KY, April 22, 2006 |
|
Society for Neuroscience Chapter lecture, University of Mississippi Medical Center, April 11, 2006 |
|
SERCEB Infectious Disease Meeting, New York City, March 26�28, 2006 |
|
Cold Spring Harbor, Systems Biology lecture, March 25, 2006 |
|
Illumina Corp, La Jolla, March 15, 2006 |
|
Cold Spring Harbor Laboratory, weekly seminar, Feb 24, 2006 |
|
UCSB Engineering, seminar in imaging and genetics, Feb 14, 2006 |
|
University of Texas at Austin, Department of Neurobiology, Nov 28, 2005 |
|
University of Colorado, Boulder, Institute for Behavior Genetics, Oct 14, 2005 |
|
Oxford University, Wellcome Trust, July 1, 2005 |
|
Lecture, Universidad Autonoma de Barcelona, Spain, June 8, 2005 |
|
SERCEB Annual Meeting seminar, Chapel Hill, May 5, 2005 |
|
NIEHS Seminar: Systems Genetics, Research Triangle Park, May 2, 2005 |
|
VA MC Memphis Seminar, March 11, 2005 |
|
UTHSC Pathogenesis Center Chalk talk, March 2, 2005 |
|
NIDA, Molecular Anatomy: Synergy by Informatics 2, Feb 15, 2005 |
|
UTHSC Department of Pharmacology, Genetic Modulation of Transcripts, Cells, and Behavior: Or, How I learned to stop worrying and love complexity, Feb 9, 2005 |
|
St. Jude Children�s Hospital Danny Thomas Lecture Series: Genetic Variation in Transcriptional Activity, Jan 7, 2005 |
|
Vanderbilt University: Seminar in Integrative Genomics, Nov 30, 2004 |
|
Department of Neuroscience, Vrije Universiteit, Amsterdam, Aug 27, 2004 |
|
Groningen Universiteit, Department of Stem Cell Biology, Aug 26, 2004 |
|
Route 28 Conference, Fraueninsel, Germany, Aug 23, 2004 |
|
Czech National Academy of Science, Prague, Aug 20, 2004 |
|
IGBMC Illkirch, France, Aug 18, 2004 |
|
T�bingen Neurocolloquium, Germany, May 27, 2004 |
|
GBF Braunschweig, Germany, May 25, 2004 |
|
Max-Delbr�ck-Centrum, Berlin-Buch, Germany, May 24, 2004 |
|
University of Kentucky, Lexington, April 2004 |
|
MGH/MIT Harvard: Feb 25, 2004 |
|
Washington University: |
|
Yale University, Department of Genetics, Dec 16, 2003 |
|
University of Chicago, Committee on Genetics, Dec. 2, 2003 |
|
American Society of Human Genetics symposium speaker: Nov 5, 2003 |
|
Vanderbilt University, Neuroscience: Oct 22, 2003 |
|
Nathan Kline Institute: Oct 17, 2003 |
|
Oregon Health Science symposium, Oct 9, 2003 |
|
Special lecture: 9th international summer school on behavioral neurogenetics, Toulouse, Aug 5, 2003. |
|
Symposium at the Joint Statistics Meeting,,Aug 3, 2003, San Francisco |
|
Mouse Initiatives V meeting, Jackson Laboratory, Aug 1, 2003 |
|
Symposium at Behavioral Genetics Association, June 26, 2003, Chicago |
|
Purdue University: June 19, 2003 |
|
Human Brain Project, Bethesda: May 12, 2003 Natcher Center presentation: http://videocast.nih.gov/ram/brain051203.ram |
|
Pennsylvania State University: May 2, 3, 2003: Genomics Spring Fever: Complex Genetics of Brain and Behavior |
|
St Jude Children�s Research Hospital, Feb 6, 2003: Dissecting Transcriptional Networks (Affy Memphis User Group Meeting) |
|
University of Toronto, Mt. Sinai Hospital, Feb 4, 2003 |
|
University of T�bingen: Neurobiology of Vision, July 9�10, 2002 |
|
Wake Forrest University, Drug Addiction Workshop for Journalist, Dec 2002 (Tucson AZ) |
|
Wadsworth Center, Albany New York, Feb 2003 |
|
University of California, Davis, Dec 2002 |
|
University of Memphis, Sept 13, 2002 |
|
Wilmer Eye Institute, Johns Hopkins University, Aug 29, 2002. The Complex Genetics of Eye and Brain Development: Gene Network Analysis using Microarrays |
|
King�s College, London: July 7, 2002 |
|
University of Alabama, Section of Statistical Genetics, June 17, 2002 |
|
New England College of Optometry, Apr 25, 2002 |
|
University of Tennessee Health Science Center, Grand Rounds in Pediatrics, Mar 13, 2002 |
|
Southern Illinois University, School of Medicine, Mar 15, 2002 |
|
Neuroinformatics. The 35th Annual Winter Conference on Brain Research, Jan.27, 2002 |
|
New Mouse Behavioral Phenotyping Assays: Half Moon Bay CA, Dec 2001 |
|
Society for Developmental Biology, Southeast Regional Meeting, Workshop presentation, May 2001 |
|
Human Brain Project Conference, Natcher Center, NIH, May 2001 |
|
Cornell University, Department of Psychology and Dept of Neuroscience, Apr 2001 |
|
Stanford University, Apr 12, 2001 |
|
University of Alabama, Birmingham, Department of Medicine, Mar 21, 2001 |
|
MCP-Hahneman, Department of Neuroscience, Mar 14, 2001 |
|
UCLA, Neuroscience Grand Rounds, Feb 7, 2001 |
|
Shanghai Medical University (Fudan), Department of Histology and Embryology, Nov 2000 |
|
Beijing Medical University, Department of Histology and Embryology, Nov 2000 |
|
Nantong Medical College, Neuroscience Institute, Nov 2000 |
|
University of North Carolina, Chapel Hill, Department of Genetics, Oct 23, 2000 |
|
University of Tennessee, Biomedical Engineering Joint Program, Sept 14, 2000 |
|
Cold Spring Harbor, Banbury Center, August 28, 2000 |
|
University of California, Santa Barbara, Neuroscience Research Institute, May 26, 2000. Quantitative Genetics of CNS development: View from the trailhead |
|
State University of New York at Buffalo, Roswell Park Cancer Institute, May 8, 2000 |
|
Drexel University, Department of Biomedical Engineering, Nov 2, 1999 |
|
University of Michigan, Department of Genetics, Oct 5, 1999 |
|
Vanderbilt University, Vision Research Center, May 7, 1999. The genetics of brain evolution |
|
University of California, Santa Barbara, Neuroscience Research Institute, Feb 16, 1999 |
|
Case Western Reserve University, Department of Neurosciences, Cleveland OH, Jan 21, 1999 |
|
VA Medical Center, Memphis TN, Nov 20, 1998 (New Power of Forward Genetics: Analysis of Polygenic Traits that Control Disease and Development) |
|
Case Western Reserve University, Depts Ophthalmology and Genetics, Cleveland OH, Nov 18, 1998 |
|
Yale University, Department of Neuroanatomy, New Haven CT, July 1998 |
|
University of Southern California, Department of Anatomy & Neuro, June 1998 |
|
University of California, San Diego, Department of Neuroscience, June 1998 |
|
Mount Sinai Medical School, Department of Neuroscience, New York, NY, June 1997 |
|
Harvard University, Beth Israel Deaconess, Department of Neurology, June 1997 |
|
Pasteur Institute, Paris, France. Oct. 1996 |
|
Conference on Brain Evolution, Ithaca, NY, June 1995 |
|
California Institute of Technology, Pasadena, CA. Nov. 1995 |
|
National Cancer Institute (Steve O'Brien) Frederick, MD, June 9, 1994 |
|
The Jackson Lab Bioinformatics Group, Bar Harbor Maine, July 1993 |
|
25th Annual Meeting of the Biomedical Engineering Society, Memphis, Oct. 24, 1993 |
|
University of Utah, Department of Biology, Salt Lake City, UT, Jan. 1989 |
|
Winter Conference for Brain Research, Snowbird, Utah, Jan. 1989 |
|
University of Texas, Houston, Department of Neurobiology and Anatomy, Dec 1988 |
|
SUNY, Stony Brook, Department of Neurobiology, Oct 1988 |
|
Winter Conference for Brain Research, Vail, Colorado, Jan. 1987 |
|
Conference on the Development of the Vertebrate Retina, Ithaca, N.Y., June 1987 |
|
New York University, Department of Physiology and Neuroscience, Oct 1986 |
|
University of Rochester, Center for Visual Sciences, Rochester, N.Y., Apr 1986 |
|
Rush-Presbyterian-St. Luke's Medical Center, Chicago, Nov 1986 |
|
University of California, Davis, Department of Psychology, June 1985 |
|
Stanford University, Department of Neurobiology, June 1985 |
|
SUNY, Albany, N.Y., Department of Biological Sciences, Jan 1984 |
REVIEWER FOR
|
Anatomy
and Embryology, Behavior Genetics, Brain Behavior
and Evolution, Behavioral Brain Sciences, Cerebral
Cortex, Current Biology, Developmental Biology,
European Journal of Neuroscience, Experimental
Eye Research, Gene Expression Patterns, Genesis,
Genomics, Investigative Ophthalmology and Vision
Science, Journal of Comparative Neurology, Journal
of Heredity, Journal of Neurobiology, Journal
of Neurochemistry, Journal of Neurophysiology,
Journal of Neuroscience, Journal of Neuroscience
Methods, Molecular Vision, Nature Genetics,
Neuroscience, Optometry and Vision Research,
Proceedings of the National Academy of Science,
Science, Visual Neuroscience, Vision Research |
EDITORIAL BOARDS/COMMITEES
2005�Present |
Member: Executive Committee of the Collaborative Cross |
2006�Present |
NeuroCommons Working Group (Science Commons, Creative Commons (chaired by John Wilbanks) |
2006�Present |
Member of the NIH Blueprint Neuroinformatic Framework group (PI Dan Gardner) |
2004�2005 |
President: International Behavioural and Neural Genetics Society (executive committee from 2003�2006) |
2003�2006 |
Society for Neuroscience: Committee on Animals
in Research |
2003�2006 |
Society for Neuroscience: Committee on Animals
in Research |
2003�2006 |
Society for Neuroscience: Committee on Animals
in Research |
2003�2006 |
Society for Neuroscience: Committee on Animals
in Research |
2002�present |
Gene, Brain and Behavior: board member |
2002�present |
Neuroinformatics: board member |
2002 |
Gene Expression Patterns: board member |
2001�present |
BioMed Central Neuroscience: core reviewer
board member www.biomedcentral.com/info/biologyeditorial.asp |
2001�present |
Behavior Genetics: board member |
2000 |
Behavior Genetics: guest editor |
1995�present |
Molecular Vision: board member |
1993�present |
European Journal of Anatomy: board member |
GRANT PROPOSAL REVIEWS
2007 |
Special Emphasis Panel, NIH IRG: Conte Center: ZMH1-ERB-S-03 (Feb 26) |
2006 |
Review Member, NIH IRG: Neuroinformatics and Neuroimaging: ZRG1 MDCN-K51 S (June 21) |
2005 |
ZRG1 MDCN-K (92), Neurogenetics |
2004 |
Chair NIH ZRG1 IDM-K (04) Host Genetics of Viral Pathogenesis Mar 15, 2004 |
2004 |
21st Century Fund Review (State of Indiana) |
2004 |
Chair NIH ZRG1 IDM-K (04) Host Genetics of Viral
Pathogenesis Mar 15, 2004 |
2004 |
Chair NIH MDCN-G (55) Human Brain Project, Feb
6, 7, 2004 |
2003 |
MRC Program Review (July 2003) |
2002 |
BISTI SS-E(51) and Human Brain Project SS-E(95),
Oct 22�25, 2002 |
2002 |
MCDN Special Review panel ZRG1 SSS-P 09 S (Sept
6, 2002) |
2002 |
NEI Special Review panel ZEY1 VSN 06 R (Aug
2002) |
2002 |
Science Foundation Ireland reviewer (July 2002) |
2002 |
NIH Mammalian Genetics IRG (June 2002) |
2002-2003 |
Mammalian Genotyping Advisory Panel (Apr 2002,
2003) |
2002 |
NIH Special Review (Feb 8, 2002) |
2001 |
NIH Innovations in Biomedical Science Tech ZRG1
SSS-7 21 B (Nov 6, 2001) |
2001 |
NIH BISTI Panel Reviewer ZRG1 SSS-E01 1 (July
2001, Nov 2001) |
2001 |
NIH CSR Reviewer ZRG1FCN-3 01 BISTI (July 19,
2001) |
2001 |
NIH Special Emphasis Panel ZRG1 SSS-R (02) (July
2, 2001) |
2001 |
NIEHS Review Panel (Inbred Rodents) ES-01-05
(June 29, 2001) |
2001 |
Medical Research Council (UK) Strategic Grants
Reviewer |
2000 |
Fonds voor Weterschappelijk Onderzoek - Vlaanderen
(Belgian NIH) |
2000 |
NIH VISB Study Section Ad Hoc Member (6/00) |
2000 |
NIMH Special Emphasis Panel Reviewer (Gene Array
RFA MH-00-002, 7/00) |
2000 |
UT System-wide Advisory Panel: Biotechnology
and Biological Sciences Review (7/00) |
1999 |
NIH VISC Study Section Ad Hoc Member (2/99) |
1999 |
NIMH Center Grant Reviewer |
1999 |
NIMH Special Emphasis Panel Reviewer ZMH1 BRB-I |
1998 |
Department of Veterans Affairs: Merit Review
Consultant |
1995 |
Consultant to NIH VIS-B Study Section |
Teaching
2007 |
University of Memphis, Bioinformatics. 4 x 90 minute lectures (Feb and March)
|
2006 |
The Jackson Laboratory: Short Course in Vision Research
NSF Plant Microarray Short Course, instructor, Boston, Aug 1�3
Third Annual Experimental Neurogenetics of the Mouse workshop, Memphis, May 16�24, 2006
|
2001�present |
Course co-director: Neuroscience Seminar Series
(NS8XX): a graduate level course, 15�20
contact hours, ~15 students/year. |
2004�2006 |
Cold Spring Harbor, Systems Biology Short Course, March 23
2004�2006 Faculty, Annual Experimental Neurogenetics of the Mouse Workshop, 15�20 students/year (8 day short course at UTHSC and UM)
|
2005�present |
Course director: NIEHS Short Course on Systems Genetics (offered twice) at NIEHS main campus, Sept 7�8 |
2005�present |
NS 825: Graduate School, Developmental and Molecular Neurobiology lecturer (fall) |
2005�present |
NS212: School of Medicine, Neuroscience lecturer (fall) |
2005 |
Society for Neuroscience, Meet the Expert Series leader, Microarray analysis, SfN annual meeting, Washington, Nov 12
Memphis City Schools Middle/Secondary Science In-Service Session 15: The Human Genome, August 11 (2 sessions)
|
2001�present |
Course member and co-director: International Summer School in Behavioral Neurogenetics (Behavioral Neurogenetics Initiative). Annual course (one week, 15 to 30 grad and postdoctoral students/year) |
2001�present |
Course co-director: Neuroscience Seminar Series
(NS8XX): a graduate level course, 15�20
contact hours, ~15 students/year. |
1992�present |
Course director: Morphological Neuroscience
(NS822): a graduate level course, ~40 contact
hours, ~ 8 students/year. |
2003�present |
Lecturer: Comparative Medicine CM712, UTHSC:
Mouse Genetics (graduate level) |
2003�present |
Lecturer: Bioinformatics, University of Memphis
(graduate level) |
2000�2002 |
Lecturer and Lab: Medical Neuroanatomy (M):
~20 contact hours, Lectures in CNS development.
150 students/year. |
2002�2003 |
Short Course director: Society of Neuroscience,
Bioinformatics |
2003 |
Course co-director: Memphis Microarray Short
Course (June 4 to June 12, 2003) |
2002 |
Lecturer: NIDA Addiction Studies Workshop for
Journalist (Tuscon AZ, Dec 8) |
2002 |
Short Course director: UAB Birmingham:
Design and Analysis of Recombinant Inbred Strain
Experiments (all day course, June 18, 2002). |
1998 |
Course Lecturer: Short Course in Quantitative
Neuroanatomy. Society for Neuroscience, Los
Angeles CA |
1994�1996 |
Course director: Seminars in Neuroscience (NS821):
Graduate level. 40 contact hours, 10 to 15 students
per year |
1995 |
SGAEC Excellence in Teaching Award, University
of Tennessee (for NS822) |
1995 |
Short Course in Genetic Testing: Memphis city
schools service training for science high school
teachers (Summer 1995). 15 high school science
teachers |
1994�1995 |
Human and Mouse Genetics: City Labs program
for high school science teachers. 10 to 12 high
school science teachers |
1990�1996 |
Medical Embryology, University of Tennessee,
8 lectures on development of cardiovascular,
urogenital, and gastrointestinal systems. 8
lecture hours, ~120 first-year medical
students. |
1983�1989 |
Neuroscience-Neuroanatomy laboratory instructor,
Yale University. Team-taught first-year medical
students, roughly 20 contact hours, 25 students
per lab. |
1982 |
Course Director: Sensory Psychology, University
of California, Davis. 25 junior and senior psychology
majors. |
PERSONAL
|
Born April, 1952, Baltimore, USA. Married to
Kathryn A. Graehl (freelance editor), two sons
(15 and 20). |
Administrative
2001 � present |
Founding Director: Complex Trait Consortium |
2000 � present |
Codirector: UT Center of Excellence in Genomics
and Bioinformatics |
2002 � present |
Member, Computing and Telecommunications Committee
of the Faculty Senate (C. Russell, chair). Chair:
Research Computing subcommittee. |
2002 � present |
University of Tennessee Research Foundation
Task Force Subcommittee (T. Ballard,
chair) |
2001 � 2002 |
Section Coordinator for the Visual and Auditory
Systems research section. Center for Neuroscience |
1999 � present |
Tennessee Mouse Genome Consortium, Scientific
Steering Committee |
1999 � 2001 |
Member: Promotion and Tenure Committee, Department
of Anatomy and Neurobiology |
1999 � present |
Scientific Advisory Board: Tennessee Mouse Genome
Consortium |
1998 |
Chair: Promotion and Tenure Committee, Department
of Anatomy and Neurobiology |
1998 � present |
Member: Department of Anatomy and Neurobiology
Space and Research Committee |
1997 � present |
Member: Department of Anatomy and Neurobiology
Advisory Council |
1997 � present |
Member: University of Tennessee, Graduate Health
Sciences Electronic Thesis and Dissertation
Advisory Committee |
1997 � 1999 |
Member: Center for Neuroscience: Graduate Student
Recruitment Committee |
1990 � 1997 |
Member: University of Tennessee, Graduate Health
Science School, Policy Subcommittee |
1995 � 1997 |
Member: University of Tennessee, Graduate Health
Science School, Graduate Studies Council |
1990 � 1994 |
Member, University of Tennessee library committee
member |
1990 � 1996 |
Member: Department of Anatomy and Neurobiology:
Graduate student admissions and policy committee |
Graduate Students and Postdoctoral Fellows
Khyobeni Mozhui |
Ph.D. candidate, 2006�present (currently working toward degree) |
Dennis Rice |
Ph.D., 1996. University of Tennessee. Dr. Rice
is currently a Senior Scientist in Neurology
at Lexicon Genetics, Woodlands, Texas |
Richelle C. Strom |
Ph.D., 1999. University of Tennessee. Dr. Strom
is now a Postdoctoral Fellow with Prof. Ruben
Adler, Johns Hopkins University |
Dale Hogan, Ph.D. |
NRSA NEI Postdoctoral fellow, 1992�1996.
Currently a Research Associate with Mark Opp,
Department of Psychiatry and Behavior, University
of Texas Medical Branch, Galveston
Guomin Zhou, M.D., Ph.D.: Research fellow, 1997�1999.
G. Zhou is Chairman and Professor of Histology
and Embryology at Fudan University, Shanghai,
China |
Lu Lu,, M.D. |
Research fellow, 1999�2001. Dr. Lu is
an Associate Professor in Histology and Embryology
at the Medical University of Nantong, China.
He is also an Assistant Professor at the University
of Tennessee Health Science Center. |
David C. Airey, Ph.D. |
NRSA, NEI Postdoctoral
fellow, April 1999�July 2001. Dr. Airey
received his Ph.D. from Cornell University in
1999. He is currently a postdoctoral fellow
with Dr. Elaine Sanders-Bush at Vanderbilt. |
Elissa J. Chesler, Ph.D |
Research fellow, July
2002�present. |
Jeremy Perice, Ph.D. |
Research
fellow, June 2003-present |
Anand Kulkarni, M.D. |
Research fellow, Nov 1999�Nov
2000. Currently a physician in the Memphis area. |
Siming Shou, Ph.D. |
Postdoctoral
fellow, September 2001�2002. |
Emmanuel Gilissen ,Ph.D. |
Postdoctoral fellow
(1996�1997, with John Allman at Caltech).
Emmanuel is now on the faculty of paleontology,
University of the Witwassersrand, South Africa. |
Kathryn Ryder |
M.D. dissertation, Yale University School of
Medicine, 1987. Dr. Ryder is currently an assistant
professor, Department of Medicine at University
of Tennessee Health Science Center. |
Michael Borodkin |
M.D. dissertation, Yale University School of
Medicine, 1989 |
Ph.D., M.S. Committees
|
Khyobeni Mozhui Ph.D. candidate in Neuroscience, UTHSC 2006 |
|
C. J. Jeon, Ph.D. in Neuroscience, 1992 |
|
Angela R. Howe, Ph.D. in Neuroscience, 1994 |
|
Vandana Menon, Ph.D. in Physiology, 1996 |
|
Qing Tang, Ph.D. in Anatomy and Neurobiology,
June 1996 |
|
Toya H. Kimble, Ph.D. in Anatomy and Neurobiology,
Jan 2003 |
|
Loren Martin, Ph.D. candidate in Anatomy and
Neurobiology, Nov 2000 |
|
Kathryn Ryder M.D. MS in Epidemiology, UTHSC
2002 |
|
Alessandro Iannaccone M.D., MS in Epidemiology,
UTHSC 2002 |
|
F�lix V�zquez-Chona, candidate
in Anatomy and Neurobiology |
ORIGINAL PAPERS with citation analysis
A substantial number of these papers are available online at . |
1. |
Williams RW, Chalupa LM (1982) Prenatal development of retinocollicular projections in the cat: An anterograde tracer transport study. Journal of Neuroscience 2:604�622 Revised and updated text at . |
2. |
Stone, J, Rapaport DH, Williams RW, Chalupa LM (1982) Uniformity of cell distribution in the ganglion cell layer of prenatal cat retina: Implications for mechanisms of retinal development. Developmental Brain Research 2: 231�242 |
3. |
Williams RW, Bastiani MJ, Chalupa LM (1983) Loss of axons in the cat optic nerve following fetal unilateral enucleation: An electron microscopic analysis. Journal of Neuroscience 3: 133�144 |
4. |
Williams RW, Chalupa LM (1983) An analysis of axon caliber within the optic nerve of the cat: Evidence of size groupings and regional organization. Journal of Neuroscience 3: 1554�1564 |
5. |
Williams RW, Chalupa LM (1983) Development of the retinal pathway to the pretectum of the cat. Neuroscience 10: 1249�1267 |
6. |
Chalupa LM, Williams RW, Hughes MJ (1983) Visual properties of neurons in the tectorecipient zone of the cat�s lateral posterior-pulvinar complex: A comparison with the superior colliculus. Journal of Neuroscience 3: 2587�2596 |
7. |
Chalupa, LM, Williams RW (1984) Organization of the cat�s lateral geniculate nucleus following interruption of prenatal binocular competition. Human Neurobiology 3: 103�107 |
8. |
Chalupa LM, Williams RW, Henderson Z (1984) Binocular interaction in the fetal cat regulates the size of the ganglion cell population. Neuroscience 12: 1139�1146 |
9. |
Williams RW, Rakic P (1985) Dispersion of growing axons within the optic nerve of the embryonic monkey. Proceedings of the National Academy of Science USA 82: 3906�3910 |
10. |
Williams RW, Crabtree, JW, Chalupa LM, Spear PD, Kornguth SE (1985) Selectivity of antibody-mediated destruction of retinal ganglion cell axons. Brain Research 336: 57�66 |
11. |
Williams RW, Bastiani MJ, Lia B, Chalupa LM (1986) Growth cones, dying axons, and developmental fluctuations in the fiber population of the cat�s optic nerve. Journal of Comparative Neurology 246: 32�69 . |
12. |
Lia B, Williams RW, Chalupa LM (1986) Does axonal branching contribute to the overproduction of optic nerve fibers during early development of the cat�s visual system. Developmental Brain Research 25:296�301 |
13. |
Lia B, Williams RW, Chalupa LM (1987) Formation of retinal ganglion cell topography during prenatal development. Science 236:848�851 |
14. |
Williams RW, Rakic P (1988) Elimination of neurons from the lateral geniculate nucleus of rhesus monkeys during development. Journal of Comparative Neurology 272:424�436 |
15. |
Williams RW, Rakic P (1988) Three-dimensional counting: An accurate and direct method to estimate cell numbers in sectioned material. Journal of Comparative Neurology 278:344�352 |
16. |
Wikler KC, Williams RW, Rakic P (1990) Photoreceptor mosaic: Number and distribution of rods and cones in the rhesus monkey retina. Journal of Comparative Neurology:297:499�508 |
17. |
Williams RW, Borodkin M, Rakic P (1991) Growth cone distribution patterns in the optic nerve of fetal monkeys: Implications for mechanisms of axonal guidance. Journal of Neuroscience 11: 1081�1094 |
18. |
Rakic, P., Su�er I, Williams RW (1991) A novel cytoarchitectonic area induced experimentally within the primate visual cortex. Proceedings of the National Academy of Science USA 88: 2083�2087 |
19. |
Williams RW (1991) The human retina has a cone-enriched rim. Visual Neuroscience 6:403�406 |
20. |
Williams RW, Goldowitz D (1992) Structure of clonal and polyclonal cell arrays in chimeric mouse retina. Proceedings of the National Academy of Science USA 89: 1184�1188 |
21. |
Williams RW, Cavada C, Reinoso-Su�rez F (1993) Rapid evolution of the visual system: A cellular assay of the retina and dorsal lateral geniculate nucleus of the Spanish wildcat and the domestic cat. Journal of Neuroscience 13:208�228 |
22. |
Williams RW, Hogan D, Garraghty PE (1994) Target recognition and visual maps in the thalamus of achiasmatic mutant dogs. Nature 367:637�639; and see New and Views article by R.W. Guillery, Nature 367:597�598 |
23. |
Williams RW (1994) The Portable Dictionary of the Mouse Genome: A personal database for gene mapping and molecular biology. Mammalian Genome: 5:372-375. See . This short paper�s main claim to fame is that it is the earliest publication in PubMed to list a web site URL (�http://�) in the abstract. |
24. |
Brilliant MB, Williams RW, Conti C, Angel J, Holdener BC (1994) Mouse chromosome 7. Mammalian Genome 5: S104�S123 |
25. |
Dell'Osso LF, Williams RW (1995) Ocular motor abnormalities in achiasmatic mutant Belgian sheepdogs: Unyoked eye movements in a mammal. Vision Research: 35:109�116 |
26. |
Scheetz AJ, Williams RW, Dubin MW (1995) Severity of ganglion cell death during early postnatal development is modulated by neuronal activity and binocular competition. Visual Neuroscience 12:605�610 |
27. |
Hogan D, Williams RW (1995) Analysis of the retinas and optic nerves of achiasmatic Belgian sheepdogs. Journal of Comparative Neurology: 352:367�380 |
28. |
Rice DS, Williams RW, Goldowitz D (1995) Genetic control of retinal projections in inbred strains of albino mice. Journal of Comparative Neurology 354: 459�469 |
29. |
Rice DS, Williams RW, Harris B, Bailey PW, Davisson MT, Goldowitz D (1995) Mapping the Bst mutation on mouse Chromosome 16: A model for human optic atrophy. Mammalian Genome 6:546�548 |
30. |
Hogan D, Garraghty PE, Williams RW (1996) Lamination and visual topography in the lateral geniculate nucleus of normal and achiasmatic dogs. European Journal of Anatomy 1:3�11 |
31. |
Ezer AD, Williams RW, Goldowitz D (1996) Arbitrary primer PCR of dog DNA with estimates of average heterozygosity. Journal of Heredity 87:450�455 |
32. |
Goldowitz D, Rice DS, Williams RW (1996) Clonal architecture of the mouse retina. Progress in Brain Research 108: 2�15 |
33. |
Brilliant MH, Williams RW, Holdener BC, Angel JM (1996) Mouse chromosome 7. Mammalian Genome 6: S135�S150 |
34. |
Hamvas R, Trachtulec Z, Forejt J, Williams RW, Artzt K, Fischer-Lindahl K., Silver LM (1996) Mouse chromosome 17. Mammalian Genome 6: S281�S299 |
35. |
Williams RW, Strom RC, Rice DS, Goldowitz D (1996) Genetic and environmental control of retinal ganglion cell number in mice. Journal of Neuroscience 16: 7193�7205 |
36. |
Rice DS, Tang Q, Williams RW, Harris B, Davisson MT, Goldowitz D (1997) Retinal ganglion cell loss and misdirect axon growth associated with fissure defects in Bst mutant mice. Investigative Ophthalmology and Visual Science 38:2112�2124 |
37. |
Williams RW, Strom RC, Goldowitz D (1998) Natural variation in neuron number in mice is linked to a major quantitative trait locus on Chr 11. Journal of Neuroscience 18:138�146 |
38. |
Williams RW, Holdener BC, Angel JM, Oakey R, Hunter K (1998) Mouse chromosome 7. Mammalian Genome 8:S136�159. |
39. |
Strom, RC, Williams RW (1998) Cell production and cell death in the generation of normal variation in neuron number. Journal of Neuroscience 18:9948�9953 |
40. |
Dell'Osso, LF Williams RW, Jacobs JB, Erchul DM (1998) The congenital and see-saw nystagmus in the prototypical achiasma of canines: comparison to the human achiasmatic prototype. Vision Research 38:1629�1641 |
41. |
Zhou G, Williams RW (1999) Eye1 and Eye2: Gene loci that modulate eye size, lens weight, and retinal area in mouse. Investigative Ophthalmology and Visual Science 40:817�825 |
42. |
Williams RW (1999) A targeted screen to detect recessive mutations that have quantitative effects. Mammalian Genome 10:734�738 |
43. |
Zhou G, Williams RW (1999) Mouse models for the analysis of myopia: an analysis of variation in eye size of adult mice. Optometry and Vision Science: 76:408�418 . |
44. |
Williams RW, Angel JM, Holdener BC, Oakey R, Hunter K (1999) Mouse chromosome 7. Mammalian Genome 10:947 |
45. |
Dell'Osso LF, Hertle RW, Williams RW, Jacobs JB (1999) A new surgery for congenital nystagmus: effects of tenotomy on an achiasmatic canine and the role of extraocular proprioception. J Amer Acad Ped Ophthal Soc, 3:166�182 |
46. |
Toth LA, Williams RW (1999) Circadian patterns of locomotor activity in CXB recombinant inbred mice. Behavior Genetics 29:319�328 |
47. |
Toth LA, Williams RW (1999) Strain-related differences in slow wave sleep and rapid-eye-movement sleep in C57BL/6J and BALB/c mice. Behavior Genetics 29:329�337 |
48. |
Toth LA, Williams RW (1999) Circadian patterns of slow wave sleep in influenza-infected C57BL/6 and BALB/c mice: A genetic analysis using CXB recombinant inbred strains. Behavior Genetics 29:339�348 |
49. |
Rice DS, Goldowitz D, Williams RW, Hamre K, Johnson PT, Tan SS, Reese BE (1999) Extrinsic modulation of retinal ganglion cell projections: analysis of the albino mutation in pigmentation mosaic mice. Developmental Biology 216:41�56 |
50. |
Hogan D, Garraghty PE, Williams RW (1999) Asymmetric connections, duplicate layers, and reversed maps in the primary visual system. Journal of Neuroscience 19: RC38:1�6 |
51. |
Kimble TDH, Williams RW (1999) Structure of the cone photoreceptor mosaic in the retinal periphery of adult humans: Analysis as a function of age, sex, and hemifield. Anatomy and Embryology, 201:305�316 |
52. |
Dell'Osso LF, Hogan D, Jacobs JB, Williams RW (1999) Eye movements in canine hemichiasma: Does human hemichiasma exist? Neuro-ophthalmology 22:47�58 |
53. |
Angel JM, Williams RW (2000) Mouse chromosome 7. Mammalian Genome 11: 948�949 |
54. |
Williams RW, Lu L, Kulkarni A, Zhou G, Airey DC (2001) Genetic dissection of the olfactory bulbs of mice: QTLs on chromosomes 4, 6, 11, and 17 modulate bulb size. Behavior Genetics, 31:61�77 |
55. |
Cook MN, Williams RW, Flaherty L (2001) Anxiety-related behaviors in the elevated zero maze are affected by genetic factors and retinal degeneration. Behavioral Neuroscience, 115:468�476 |
56. |
Lu L, Airey DC, Williams RW (2001) Complex trait analysis of the mouse hippocampus: Mapping and biometric analysis of two novel gene loci that modulate hippocampal size. Journal of Neuroscience, 21:3503�3514 |
57. |
Rosen GD, Williams RW (2001) Complex trait analysis of the mouse striatum: Independent QTLs modulate volume and neuron number. Biomed Central Neuroscience 2:5 |
58. |
Airey DC ,Lu L, Williams RW (2001). Genetic control of the mouse cerebellum: identification of quantitative trait loci modulating size and architecture. Journal of Neuroscience, 21:5099�5109 |
59. |
Hardy CL, Lu L, Nguyen P, Woodland DL, Williams RW, Blackman MA (2001) Identification of quantitative trait loci controlling activation of TRBV4 CD8+ T cells during murine ?-herpes virus-induced infectious mononucleosis Immunogenetics, 53: 395�400 |
60. |
Williams RW, Gu J, Qi S, Lu L (2001) The genetic structure of recombinant inbred mice: High-resolution consensus maps for complex trait analysis. Genome Biology 2:46.1�46.18 |
61. |
Zhou G, Strom RC, Giguere V, Williams RW (2001) Modulation of retinal cell populations and eye size in retinoic acid receptor knockout mice. Molecular Vision, 7, |
|
62. Hsu, HC, Mountz JD, Williams RW, Shelton BJ, Yang P, Matsuki Y, Xu X, Zhang HG, Geiger H, van Zant G (2002) Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11. Mech Ageing Dev,123:1145�1158 |
|
63. Geisert Jr EE, Williams RW, Geisert G, Maecker HT, Deng J, Levy S (2002) Increased brain size and glial cell number in CD81-null mice. Journal of Comparative Neurology, 453:22�32 |
|
64. Airey DW, Lu L, Shou S, Williams RW (2002) Genetic sources of individual differences in cerebellum. The Cerebellum 1:233�240 |
|
65. Hitzemann R, Hitzemann B, Rivera S, Gatley J, Thanos P, Lu L, Shou S, Williams RW (2002) Dopamine D2 receptor binding, Drd2 expression and the number of dopamine neurons in the BXD recombinant inbred series: genetic relationships to alcohol and other drug associated phenotypes. Alcoholism: Clinical and Experimental Research 27:1�11 |
|
66. Grizzle WE, Mountz JD, Yang PA, Xu X, Sun S, Van Zant GE, Williams RW, Hsu HC, Zhang HG (2002) BXD recombinant inbred mice represent a novel T-cell mediated immune response tumor model. International Journal of Cancer 101:270�279 |
|
67. Cook R, Lu L, Gu J, Williams RW, Smeyne RJ (2003) Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. Molecular Brain Research 110:279�288 |
|
68. Hsu HC, Zhang HG, Li L, Yi N, Yang PA, Wu Q, Zhou J, Sun S, Xu X, Yang X, Lu L, Van Zant G, Williams RW, Allison DB, Mountz JD (2003) Age-related thymic involution in C57BL/6J X DBA/2J recombinant inbred mice maps to mouse chromosome 9. Genes and Immunity 4:402�410 |
|
69. Hitzemann R, Malmanger B, Reed C, Lawler M, Hitzemann B, Coulombe S, Buck K, Rademacher B, Walter N, Polyakov Y, Sikela J, Williams RW, Flint J, Talbot C (2003) A strategy for integration of QTL, gene expression, and sequence analyses. Mammalian Genome 14: 733�747 |
|
70. Schaeffel F, Burkhardt E, Howland HC, Williams RW (2004) Measurement of refractive state and deprivation myopia in two strains of mice. Optometry and Vision Science, 81:99�110 |
|
71. Peirce J, Chesler EJ, Williams RW, Lu L (2003) Genetic architecture of the mouse hippocampus: identification of gene loci with regional effects. Genes, Brain and Behavior 2:238�252 |
|
72. Wang J, Williams RW, Manly KF (2003) WebQTL: Web-based complex trait analysis. Neuroinformatics 1:299�308. |
|
73. Pollock GS, Robichon R, Boyd KA, Kerkel KA, Kramer M, Lyles J, Ambalavanar R, Khan A, Kaplan DR, Williams RW, Frost DO (2003) TRKB receptor signaling regulates dynamics of developmental retinal ganglion cell death but not final number. Journal of Neuroscience 23: 10137�10145 |
|
74. Rosen GD, La Porte NT, Diechtiareff B, Pung, CJ, Nissanov J, Gustafson C, Bertrand L, Gefen S, Fan Y, Tretiak OJ, Manly KF, Parks MR, Williams AG, Connolly MT, Capra JA, Williams RW (2003) Informatics center for mouse genomics: the dissection of complex traits of the nervous system. Neuroinformatics, 1:327�342 |
|
75. Chesler EJ, Wang J, Lu L, Qu Y, Manly KF, Williams RW (2003) Genetic correlates of gene expression in recombinant inbred strains: a relational model system to explore neurobehavioral phenotypes. Neuroinformatics 1: 343�357 |
|
76. Seecharan DJ, Kulkarni AL, Lu L, Rosen GD, Williams RW (2003) Genetic control of interconnected neuronal populations in the mouse primary visual system. Journal of Neuroscience, 23:11178�11188 |
|
77. Williams AG, Williams RW (2004) GenomeMixer: A complex genetic cross simulator. Bioinformatics 20:2488-2490 |
|
78. Peirce J, Lu L, Gu J, Silver LM, Williams RW (2004) A new set of BXD recombinant inbred lines from advanced intercross populations in mice. BMC Genetics 5:7 |
|
79. Williams RW, Bennett B, Lu L, Gu J, DeFries JC, Carosone-Link P, Rikke B, Belknap JK, Johnson TE (2004) Genetic structure of the LXS panel of recombinant inbred mouse strains. Mammalian Genome 15:637-647 |
|
80. Schauwecker PE, Williams RW, Santos JB (2004) Genetic control of seizure-induced cell death susceptibility in mice. Journal of Comparative Neurology 477:96-107 |
|
81. Ponomarev I, Schafer GL, Blednov YA, Williams RW, Iyer VR, Harris A (2004) Convergent analysis of cDNA and short oligomer microarrays, mouse null mutant, and bioinformatics resources to study complex traits. Genes, Brains and Behavior 3:360-368 |
|
82. Tan XL, Zhou Y, Cai KF, Shao YX, Zhu SX, Lu L, Williams RW, Gu XS (2004) Identification of QTLs for weight and cross-sectional area on cervical enlargement of spinal cord in mice. Yi Chuan Xue Bao 31:801-806 |
|
83. Jablonski MM, Lu L, Wang, XF, Chesler EJ, Carps E, Qi S. Gu J, Williams RW (2004) The ldis1 lens mutation in RIIIS/J mice maps to chromosome 8 near cadherin 1. Molecular Vision 10:577��587 |
|
84. Simon P, Schott K, Williams RW, Schaeffel F (2004) Post-translational regulation of the immediate early gene EGR1 by light in the mouse retina. European Journal of Neuroscience 20:3371-3377 |
|
85. Scott RE, White-Grindley E, Ruley HE, Chesler EJ, Williams RW (2005) P2P-R expression is genetically coregulated with components of the translation machinery with PUM2, a translational repressor that associates with the P2P-R mRNA. Journal of Cellular Physiology 204:99-105 |
|
86. Baldwin NE, Chesler EJ, Kirov S, Langston MA, Snoddy JR, Williams RW, Zhang B (2005) Computational, integrative and comparative methods for the elucidation of genetic co-expression networks. Journal of Biomedicine and Biotechnology 2:172-180 |
|
87. Mountz JD, Yang PA, Wu Q, Zhou J, Tousson A, Fitgerald A, Allen J, Wang X, Cartner S, Grizzle WE, Yi N, Lu L, Williams RW, and Hsu H-C (2005) Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in BXD2 recombinant inbred strain of mice. Scandinavian Journal of Immunology 61:128�138 |
|
88. Chesler EJ, Lu L, Shou S, Qu Y, Gu J, Wang J, Hsu HC, Mountz JD, Baldwin N, Langston MA, Threadgill DW, Manly KF, Williams RW (2005) Genetic dissection of gene expression reveals polygenic networks modulating brain structure and function. Nature Genetics 37:233-242 |
|
89. Bystrykh L, Weersing E, Dontje B, Sutton S, Pletcher MT, Wiltshire T, Su AI, Vellenga E, Wang J, Manly KF, Lu L, Chesler EJ, Alberts R, Jansen RC, Williams RW, Cooke M, de Haan G (2005) Uncovering regulatory pathways affecting hematopoietic stem cell function using �genetical genomics� Nature Genetics 37:225-232 |
|
90. Kerns RT, Ravindranathan A, Hassan S, Cage MP, York T, Williams RW, Miles MF (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. Journal of Neuroscience 25:2255-2265 |
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91. Carlborg �, De Koning D-J, Chesler EJ, Manly KM, Williams RW, Haley CS (2005) Methodological aspects of the genetic dissection of gene expression. Bioinformatics 21:2383�2393 |
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92. Manly KF, Wang J, Williams RW (2005) Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression. Genome Biology 6:R27.1-27.10 |
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93. Zou F, Gelfond JA, Airey DC, Lu L, Manly KF, Williams RW, Threadgill DW (2005) Quantitative trait locus analysis using recombinant inbred intercrosses (RIX): theoretical and empirical considerations. Genetics 170:1299-1311 |
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94. Tsaih, SW, Lu L, Airey DC, Williams RW, Churchill GA (2005) Quantitative trait mapping in a diallel cross of recombinant inbred lines. Mammalian Genome 16:344�355 |
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95. Li HQ, Lu L, Manly KF, Wang J, Zhou M, Williams RW, Cui Y (2005) Inferring gene transcriptional modulatory relations: a genetical genomics approach. Human Molecular Genetics 14:119�1125 |
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96. Jablonski MM, Wang, XF, Lu L, Miller DR, Rinchik EM, Williams RW, Goldowitz, D (2005) The Tennessee Mouse Genome Consortium: identification of novel ocular mutants. Visual Neuroscience 22:595-604 |
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97. Jablonski MM, Dalke C, Wang XF, Lu L, Manly K, Pretsch W, Pardue M, Rinchik, Williams RW, Goldowitz D, Graw J (2005) An ENU-induced mutation in Rs1h causes disruption of retinal structure and function. Molecular Vision 11:596�581 |
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98. Vazquez-Chona FR, Khan AN, Chan CK, Moore AN, Dash PK, Rosario Hernandez R, Lu L, Chesler EJ, Manly KF, Williams RW, Geisert Jr EE (2005) Genetic networks controlling retinal injury. Molecular Vision 11:958-970 |
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99. Li CX, Wei X, Lu L, Peirce JL, Williams RW, Waters RS (2005) Genetic analysis of barrel field size in the first somatosensory area (SI) in inbred and recombinant inbred strains of mice. Somatosensory and Motor Research 22:141�150 |
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100. Kempermann G, Chesler EJ, Lu L, Williams RW, Gage FH (2006) Natural variation and genetic covariance in adult hippocampal neurogenesis. Proceedings of the National Academy of Science USA 103:780-785 |
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101. Lan H, Chen M, Byers JE, Yandell BS, Stapleton DS, Mata CM, Mui TK, Flowers MT, Schueler KL, Manly KF, Williams RW, Kendziorski, CM, Attie AD (2006) Combined expression trait correlations and expression quantitative trait locus mapping. PLoS Genetics 2:51-61 |
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102. Li H, Chen H, Bao L, Manly KF, Chesler EJ, Lu L, Wang J, Zhou M, Williams RW, Cui Y (2006) Integrative genetic analysis of transcription modules: towards filling the gap between genetic loci and inherited traits. Human Molecular Genetics 15:481-492 |
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103. Bao L, Wei L, Peirce JL, Homayouni R, Li H, Zhou M, Chen H, Lu L, Williams RW, Pfeffer LM, Goldowitz D, Cui Y (2006) Combining gene expression QTL mapping and phenotype spectrum analysis to uncover gene regulatory relations. Mammalian Genome 17:575-583 |
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104. Radcliffe RA, Lee MJ, Williams RW (2006) Prediction of cis-QTLs in a pair of inbred mouse strains with the use of expression and haplotype data from public databases. Mammalian Genome 17:643-642 |
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105. Peirce JL, Lu L, Li H, Wang J, Manly KF, Hitzemann RJ, Belknap JK, Rosen GD, Williams RW (2006) How replicable are mRNA expression QTLs. Mammalian Genome 17:643-642 |
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106. Aliesky HA, Pichurin PN, Chen CR, Williams RW, Rapoport B, McLachlan SM (2006) Probing the genetic basis for thyrotropin receptor antibodies and hyperthyroidism in immunized CXB recombinant inbred mice. Endocrinology 147:2789�2800 |
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107. Martin M, Dong H, Vallera D, Lee D, Lu L, Williams RW, Rosen GD, Cheverud J, Csernansky J (2006) Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice. Genes, Brain and Behavior 5:614�623 |
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108. Shifman S,Bell JT, Copley RR, Taylor M, Williams RW, Mott R, Flint J (2006) A high resolution single nucleotide polymorphism genetic map of the mouse genome. PLoS Biology 4:2227-2237 |
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109. Mozhui K, Hamre KM, Holmes A, Lu L, Williams RW (2007) Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Behavior Genetics 37:223�243 |
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110. Bao L, Zhou M, Wu L, Lu L, Goldowitz D, Williams RW, Cui Y (2007) PolymiRTS database: linking polymorphisms in microRNA target sites with complex traits. Nucleic Acids Res (database issue): D51-4 |
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111. Gatti D, Maki A, Chesler EJ, Kosyk O, Kirova R, Lu L, Manly KF, Qu Y, Williams RW, Perkins A, Langston ME, Threadgill DW, Rusyn I (2007) Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology in press |
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112. Bao L, Peirce JL, Lu L, Zhou M, Li H, Goldowitz D, Williams RW, Cui Y (2007) An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes. Human Molecular Genetics in press |
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113. Dong H, Martin M, Colvin J, Ali Z, Wang L, Lu L, Williams RW, Rosen GD, Csernansky JG, Cheverud JM (2007) Quantitative trait loci linked to thalamic and cortical gray matter volumes in BXD recombinant inbred mice: implications for the genetics of schizophrenia. Heredity in press |
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114. Miyairi I, Tatireddigari A, Madi, OS, Belland RJ, Williams RW, Byrne GI (2007) Recombinant inbred mice facilitate rapid identification of p47GTPases conferring resistance to Chlamydial infection. in submission |
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115. Yang RJ, Mozhui K, Karlsson RM, Cameron HA, Williams RW, Holmes A (2007) Genetically-driven variation in mouse basolateral amygdala volume predicts differences in fear learning and stress-reactivity. in revision |
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116. Bug W, Wong WW, Gustafson C, Johnson GA, Martone ME, Price DL, Rosen GD, Williams RW, Zaslavsky, Nissanov J (2007) Brain atlasing tool interoperation: NeuroTerrain-Smart Atlas synergistic visualization and analysis environment. IEEE EMBS Conference on Neural Engineering, submitted |
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117. Pardue MT, Fernandes A, Yin H, Faulkner AE, Schaeffel F, Williams RW, Iuvone PM (2007) High susceptibility to experimental myopia in a mouse model with ON pathway defect. Invest Ophthalmol Vis Sci, submitted |
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118. Aziz, R, Kanal R, Abdeltawab NF, Rowe SL, Su Y, Carrigan D, Nooh MM, Attia RR, Brannen C, Gardner LA, Lu L, Williams RW, Kotb M (2007) Susceptibility to severe streptococcal sepsis: a mouse reference population to study genetic and environmental factors. Gene and Immunity, submitted |
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119. Bhave SV, Hornbaker C, Phang TL, Saba L, Lapadat R, Kechris K, Gaydos J, McGoldrick D, Dolbey A, Leach S, Soriano B, Ellington A, Ellington E, Jones K, Mangion J, Belknap JK, Williams RW, Hunter LE, Hoffman PL, Tabakoff B (2007) The Colorado INIA informatics website: Tools for the analysis of complex traits. BMC Genetics, in submission |
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120. Yang J, Zhu J, Williams RW (2007) Mapping the genetic architecture of complex traits in experimental populations. Bioinformatics, in press |
REVIEWS, LETTERS, BOOK CHAPTERS
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1. Chalupa LM, Williams RW (1984) Prenatal development and reorganization in the visual system of the cat. In Development of Visual Pathways in Mammals. Stone J, Dreher B, Rapaport DH (eds) Alan R Liss Inc, New York, pp 89�102. Full text |
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2. Chalupa LM, Williams RW (1985) Formation of retinal projections in the cat. In Advances in Neuronal and Behavioral Development. vol 1 (Aslin RN, ed): Norwood, New Jersey: Ablex Publishing, pp 1�32 |
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3. Williams RW, Herrup K (1988) The control of neuron number. Annual Review of Neuroscience 11:423�453 . |
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4. Williams RW. Goldowitz D (1992) Lineage versus environment in embryonic retina: A revisionist perspective. Trends in Neuroscience 15:368�373 |
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5. Williams RW, Goldowitz D (1993) Lineage versus environment in embryonic retina: Letters to the editor. Trends in Neuroscience 16:96�98 |
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6. Williams RW (1990) The primary visual system does not care about Previc�s near-far dichotomy. Why not? Behavioral and Brain Sciences: 13:557 |
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7. Williams RW (1992) A very rare congenital eye movement disorder in Belgian sheepdogs. National Belgian Newsletter 44:75 |
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8. Williams RW, Strom RC, Zhou G, Yan Z (1998) Genetic dissection of retinal development. Seminars in Cell and Developmental Biology 9:249�255 |
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9. Williams RW (1998) Neuroscience meets quantitative genetics: Using morphometric data to map genes that modulate CNS architecture. Short Course in Quantitative Neuroanatomy (Morrison J, and Hof P, eds) pp 66-78 |
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10. Toth LA, Williams RW (1998). Genetic analysis of complex quantitative traits using inbred mice. Sleep Research Society Bulletin 4:50�56 |
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11. Williams RW (2000). Mapping genes that modulate mouse brain development: a quantitative genetic approach. In: Mouse brain development (Goffinet AF, Rakic P, eds). Springer, New York, pp 21�49 |
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12. Belknap JK, Crabbe JC, Phillips TJ, Hitzemann R, Buck KJ, Williams RW (2001) Quantitative trait loci and genome-wide mutagenesis: two phenotype-driven approaches to the dissection of complex murine traits. Behavior Genetics 31:5�15 |
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13. Mountz JD, van Zant G, Zhang H, Grizzle WE, Ahmed R, Williams RW, Hsu HC (2001) Genetic dissection of age-related changes in immune function in mice. Scandinavian Journal of Immunology 54:10�20 |
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14. Airey DC, Williams RW. (2002) Quantitative genetic perspectives. Commentary to Finlay BL, Darlington RB, and Nicastro N (2002) Developmental structure in brain evolution. Behavioral and Brain Sciences 24:279�280 |
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15. Hunter K, Williams RW (2002) Quantitative trait locus analysis in cancer research. ILAR J 43:80�88 |
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16. Threadgill, Hunter K, Williams RW (2002) Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort. Mammalian Genome 13:175�178 |
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17. Williams RW, Dubnau J, Enoch MA, Flaherty L, Sluyter F, Gannon KS, Maxson SC, Riedl CAL, Williams KD, Holmes A, Bolivar VJ, Crusio WE (2002) Hot topics in behavioral and neural genetics. Gene, Brain and Behavior 1:1�10 |
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18. Williams RW, Glueck SB (2002) New views of gene expression in the brain: Focus on �Gene expression tomography.� Physiological Genomics 8:79 |
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19. Williams RW (2002) Everyday bioinformatics: map, microarrays and beyond. Bioinformatics 2002, a Society for Neuroscience Short Course (Williams RW, Goldowitz D, eds), Society for Neuroscience, pp. 1�10 |
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20. Dell�Osso LF, Williams RW, Jacobs JB, Hertle RW, FitzGibbon EJ, Thompson MA, Yang D (2002) Novel surgery for nystagmus: initial trial results. Research to Prevent Blindness 16: 56�57 |
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21. Williams RW, Flaherty L, Threadgill DW (2003) The math of making mutant mice. Genes, Brain and Behavior 2:191�200 |
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22. Williams RW, Moody SA (2003) Developmental and genetic control of cell number in the retina. In: The Visual Neurosciences, eds. Chalupa LM , Werner JS. MIT Press. pp 65�78 |
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23. Williams RW, Broman KW, Cheverud JM, Churchill GA, Hitzemann RW, Hunter K, Mountz JD, Pomp P, Reeves RH, Schalkwyk LC, Threadgill DW (2002) A collaborative cross for high-precision complex trait analysis. 1st Workshop Report of the Complex Trait Consortium: Sept 2002. http://www.complextrait.org/Workshop1.pdf |
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24. von Bartheld CS, Williams RW (2003) Measurement of differential shrinkage or compression in the z-axis of tissue sections. Current Protocols in Neuroscience Unit 11.11�1.11.29 Suppl 24 |
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25. von Bartheld CS, Williams RW (2003) Calibration of counting methods by a limited and simple 3-D reconstruction of serial sections. Current Protocols in Neuroscience Unit 11.11�1.11.29 Suppl 24 |
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26. Williams RW, von Bartheld CS, Rosen GD (2003) Counting cells in sectioned material�3D counting, the optical disector, and Abercrombie�s two-section comparison method. Current Protocols in Neuroscience Unit 1.11.1�1.11.29 Suppl 24 |
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27. Rosen GD, Williams RW (2003) Celloidin embedding and cresyl violet staining. Current Protocols in Neuroscience Unit 11.11�1.11.29 Suppl 24 |
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28. Rosen GD, Williams RW (2003) Estimation of regional volume from serial sections using point counting and Cavalieri�s rule. Current Protocols in Neuroscience Unit 1.11 |
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29. Williams RW, Rosen GD (2003) Providing researchers access to tissue banks. American Laboratory |
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30. Gardner D, Toga AW, Ascoli GA, Beatty J, Brinkley AF, Dale AM, Fox PT, Gardner EP, George JS, Goddard N, Harris KM, Herskovits EH, Hines M, Jacobs GA, Jacobs RE, Jones EG, Kennedy DN, Kimberg DY, Mazziotta JC, Miller P, Mori S, Mountain DC, Reiss AL, Rosen GD, Rottenberg DA, Shepherd GM, Smalheiser NR, Smith KP, Strachan T, Van Essen DC, Williams RW, Song STC (2003) Toward effective and rewarding data sharing. Neuroinformatics, 1:288�295 |
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31. Schaeffel F, Simon P, Feldkaemper M, Ohngemach S, Williams RW (2003) Molecular biology of myopia. Clinical and Experimental Optometry, 86: 295�307 |
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32. The Complex Trait Consortium: Flaherty L, Abiola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett BB, Blankenhorn EP, Blizard DA., Bolivar V, Brockmann GA, Buck KJ, Bureau J-F, Casley, WL, Chesler EJ, Cheverud JM, Churchill GA, Cook M, Crabbe JC, Crusio WE, Darvasi A, de Haan G, Demant P, Doerge RW, Elliott RW, Farber CR, Flint J, Gershenfeld H, Gibson JP, Gu W, Himmelbauer H, Hitzemann R, Hsu H-C, Hunter K, Iraqi F, Jansen RC, Johnson TE, Jones BC, Kempermann G, Lammert F, Lu L, Manly KF, Matthews DB, Medrano JF, Mehrabian M, Mittleman G, Mock BA, Mogil JS, Montagutelli, X, Morahan G, Mountz JD, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Paigen B, Palmer AA, Peirce JL., Pomp D, Rosemann M, Rosen GD, Schalkwyk LC, Seltzer Z, Settle S, Shimomura K, Shou S, Sikela JM, Siracusa LD, Spearow JL, Teuscher C, Threadgill DW, Toth LA, Toye AA., Vadasz C, Van Zant G, Wakeland E, Williams RW, Zhang H-G, Zou F (2003) The nature and identification of quantitative trait loci: a community�s view. Nature Genetics Reviews 4: 911�916 |
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33. Nissanov J, Williams RW (2003) Mouse neuroinformatic public resources. An invitation to end-users. Neuroinformatics 1:297�298 |
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34. Williams RW (2003) A neuroscientist�s guide to genomic resources. In: The Bioinformatics of Brains: From genes and proteins to behavior (Williams RW, ed) pp. 1�8. Washington, DC: Society for Neuroscience |
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35. Williams RW (2003) WebQTL: a tour of transcriptional networks. In: The Bioinformatics of Brains: From genes and proteins to behavior (Williams RW, ed) pp. 51�59. Washington, DC: Society for Neuroscience |
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36. Williams RW (2003) Managing your lab data flux: getting beyond Excel (Williams RW, ed) pp. 83�92. Washington, DC: Society for Neuroscience |
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37. Zareparsi S, Hero A, Zack DJ, Williams RW, Swaroop A (2004) Seeing the unseen: microarray-based gene expression profiling in vision. Investigative Ophthalmology and Vision Science 45:2457-2462 |
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38. Chesler EJ, Lu L, Wang J, Williams RW, Manly KF (2004) WebQTL: Rapid exploratory analysis of gene expression and genetic networks for brain and behavior. Nature Neuroscience 7:485�486 |
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39. Chesler EJ, Williams RW (2004) Brain gene expression: genomics and genetics. In: DNA Arrays in Neurobiology (ed. Miles M) Academic Press, International Review of Neurobiology 60:59-95 |
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40. The Complex Trait Consortium: Churchill GA, ... Williams RW and many coauthors (2004) The collaborative cross: a community resource for the genetic analysis of complex traits. Nature Genetics 36: 1-5 |
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41. de Haan G, Williams RW (2005) A genetic and genomic approach to identify longevity genes in mice. Mechanisms of Aging and Development 126:133�138 |
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42. Johnson DK, Rinchik EM, Moustaid-Moussa N, Miller DR, Williams RW, Michaud EJ, Jablonski MM, Goldowitz D (2005) Phenotype screening for genetically-determined age-onset disorders and increased longevity in ENU-mutagenized mice. AGE 27:75-90 |
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43. Matthews DB, Bhave SV, Belknap JK, Brittinham C, Chesler EJ, Hitzemann RJ, Hoffmann PL, Lu L, McWeeney S, Miles MF, Tabakoff B, Williams RW (2005) Complex genetics of interactions of alcohol and CNS function and behavior. Alcoholism: Clinical and Experimental Research 29:1706�1719 |
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44. Williams RW (2006) Genomics and dyslexia: Bridging the gap (2006) In: The Dyslexic Brain: New Pathways in Neuroscience Discovery, Rosen GD, ed. Lawrence Erlbaum Associates, pp. 167-190 |
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45. Williams RW (2006) Animal models in biomedical research: ethics, challenges, and opportunities. In: Principles of molecular medicine, 2nd ed. Runge MS, Patterson C eds, Chapter 8, Humana Press, Totowa, New Jersey, pp. 53�60 |
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46. Hsu HC, Lu L, Yi N, Van Zant G, Williams RW, Mountz JD (2006) Quantitative trait locus (QTL) mapping in aging systems. In: Methods in Molecular Biology (Biological Aging: Methods and Protocols), Tollefsbol TO, ed. Chapter 23, Humana Press, Totowa, New Jersey, pp XX-XX |
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47. Williams RW (2006) Expression genetics and the phenotype revolution. Mammalian Genome 17:496-502 |
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48. Peirce JL, Williams RW (2006) Expression and brain structure: black boxes between genes and behaviors. Neurobehavioral Genetics: Methods and Applications, 2nd ed (Jones B, Mormede P, eds). Taylor and Francis, Boca Raton |
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49. Chesler EJ, Bystrykh L, Cooke M, de Haan G, Manly KF, Williams RW (2006) Normalization procedures and detection of linkage signal in genetical-genomics experiments. Reply to RBH Williams et al., Nature Genetics 38:856-858 |
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50. Miles M, Williams RW (2006) Meta-analysis for microarray studies on genetics of complex traits. Trends in Biotechnology, in press |
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51. Eye, Retina, and Visual System of the Mouse (2008) Chalupa LM, Williams RW, eds. MIT Press. Approximately 60 chapters, in progress |
Research Web Sites
1. |
www.nervenet.org Initiated by RW Williams, January 1994. The Portable Dictionary of the Mouse Genome. An electronic dictionary of gene loci with map, phenotype, and strain distribution data. http://nervenet.org January 1994�1999. |
2. |
www.mbl.org Initiated by Williams RW, Rosen GD, Williams, A.G., May 1997. The Mouse Brain Library and the Internet Atlas of the Mouse Brain have been in continuous operation since May 1997. This is a still a growing and well used Internet database with image data for over 2000 mouse brains imaged at low, intermediate, and high resolution. It includes several stereotaxic atlases of the brains of mice. The MBL was included in ISI Current Web Contents (CC Connect TM) starting in Jan 2001. the site was review by Kaiser J (2000) in Science. Mouse Brain Library: Netwatch Images selection. Science 289:211. |
3. |
iscope.nervenet.org Initiated by Williams RW, Cruz B, Connolly M; Capra JA (1999) iScope. A software suite for telemicroscopy. www.mbl.org Aug 1999�present. |
4. |
www.genenetwork.org Initiated by Manly KF, JT Wang, and RW Williams (2001-present) The GeneNetwork and WebQTL Projects. A system for rapidly analyzing transcriptional networks. This is a major genetics resource site with over 100,000 hits per week. |
RECENT ABSTRACTS (from 1999 onward only)
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Williams RW (1999) Mapping QTLs that modify
the architecture of the mouse brain: a prelude
to behavioral analyses. Behavior Genetics Society
Abstracts 29: XX. |
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Williams RW, Zhou G (1999) Genetic control of
eye size: A novel quantitative genetic approach.
Invest. Ophthalmol Vis Sci Suppl 40: S964. |
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Toth LA, Williams RW (1999) A quantitative trait
locus for slow-wave sleep in influenza-infected
CXB recombinant inbred mice. World Fed Sleep
Res Soc. |
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Airey DC, Lu L, Strom R, Zhou G, Gilissen E,
Williams RW (1999) Cerebellum-specific QTLs
in the mouse brain. Int Mouse Genome Conf 13:E9. |
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Lu L, Airey DC, Zhou G, Williams RW (1999) New
murine hippocampus-specific QTL maps to distal
Chr 1. Int Mouse Genome Conf 13:E44. |
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Williams RW, Kulkarni AL, Jones L,
Zhou G, Airey DC, Lu L (2000) Growth of the
olfactory bulbs is modulated by QTLs on chromosomes
4, 6, 11, and 17. Neuroscience Abstracts
26: 1088. |
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Rosen GD, Williams RW (2000) Stereological and
quantitative genetic analysis of the mouse caudate
nucleus. Neuroscience Abstracts 26: 311. |
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Kulkarni AL, Airey DC, Williams RW (2000)
Genetic architecture of the mouse retinogeniculate
system: a QTL analysis of numerical matching.
Neuroscience Abstracts 26: 1087. |
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Airey DC, Lu L, Williams RW (2000) Gene loci
for mouse cerebellum and internal granule layer
size. Neuroscience Abstracts 26: 1087. |
|
Lu L Airey DC, Williams RW (2000) Complex trait
analysis of the mouse hippocampus. Neuroscience
Abstracts 26: 1087. |
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Tharp R, Williams RW, Smeyne RJ (2000) Complex
trait analysis of susceptibility to MPTP-induced
Parkinsonism. Neuroscience Abstracts 26:
1286. |
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Rosen GD, Williams AG, Capra JA, Connolly MT,
Cruz B, Lu L, Airey DC, Kulkarni A, Williams
RW (2000) The Mouse Brain Library @ www.mbl.org.
Int Mouse Genome Conference 14: 166. www.nervenet.org/papers/MBLabst2000.html |
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Williams RW, Zhou G (2001) Development of genetic
models for myopia research: high resolution
mapping of a new set of loci that control eye
size in mice. Invest Ophthal Vis Sci Suppl 42:S
652. |
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Manly KF and Williams RW (2001) WEBQTL�WWW
services for mapping quantitative trait loci.
Mouse Initiatives III. www.jax.org/courses/documents/mouse_init_0801.html |
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Li L, Lu L, Williams RW, Waters RS (2001) Quantitative
analysis of the barrel field in somatosensory
cortex (S1) of inbred mice. Neuroscience Abstracts
27: 394.3. |
|
Lu L, Airey DC, Williams RW, 2001. Genetic architecture
of the mouse hippocampus: identification of
gene loci with regional effects. Neuroscience
Abstracts 27: 587.2. |
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Goldowitz D, Rinchik E, Johnson D, Goss K, Snoddy
J, Ferkin M, Matthews D, Mittleman G, Hamre
K, Jablonski M, Williams R, and members of the
Tennessee Mouse Genome Consortium (2001) Regional
mutagenesis of the mouse genome and neural phenotypes:
Year1 Progress Report. Neuroscience Abstracts
27: 881.7. |
|
Wolfe C, Williams RW, Goldowitz D (2001) Genetic
determinants of neurogenesis in adult mice.
Neuroscience Abstracts 27: 587.1. |
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Williams RW, Threadgill DW, Airey DC, Gu J,
Lu L (2001) RIX mapping: A demonstration using
CXB RIX hybrids to map QTLs modulating brain
weight in mice. Neuroscience Abstracts 27:
587.3. |
|
Threadgill DW, Airey DC, Lu L, Manly K, Williams
RW (2001) Recombinant inbred intercross mapping:
a new approach to extend the power of existing
mouse resources. Int Mouse Genome
Conf 15:50. |
|
Manly K, Williams RW (2001) WEBQTL�WWW
service for mapping quantitative trait loci.
Int Mouse Genome Conf 15:74. |
|
Shou S, Lu L, Williams RW (2001) Transcriptome
chromosome maps: a novel resource for complex
trait analysis of the mouse CNS. Internat Behav
Neural Genet Soc Abst 4:54. |
|
Williams RW, Threadgill DW, Manly KF, Rosen
GD, Shou S, Airey DC, Gu J, Lu L (2001) Integrated
complex trait analysis of brain and behavior
in mouse: near-term prospects for high-resolution
QTL mapping using large RI and RIX sets. Internat
Behav Neural Genet Soc Abst 4:62 |
|
Williams RW, Lu L, Wang XF, Qi S, Gu J, Jablonski
MM (2002) Mapping and initial characterization
of a spontaneous mutation affecting lens development
in RIIIS/J inbred mice. Invest Ophthalmol Vis
Sci Suppl 43: S XX. |
|
Bennett B, Johnson TE, Williams RW (2002) A
new panel of recombinant inbred strains from
ILS and ISS. Res Soc Alcoh meeting.XX: XXX. |
|
Watson R, Koratkar R, Lu L, Gu J, Fineegan AA,
Margan JL, Guz J, Williams RW, Siracusa LD (2002)
Expansion of the BXH RI series: derivation and
characterization of three new BXH recombinant
inbred lines and one new BXH recombinant congenic
line. Abst Amer Assoc Cancer Res XX: XXX. |
|
Erin L. Manning EL, True JM, Henckaerts E, Snoech
H, Geiger H, de Haan G, Lu L, Williams RW, Van
Zant G (2002) Genetic regulation of hematopoietic
stem cell telomere length in mice. Int Soc Exp
Hematol Abst XX: XXX |
|
Williams RW, Shou S, Lu L, Qu Y, Wang J,
Manly K, Chesler EJ, Hsu HC, Mountz J, Threadgill
D (2002) Genomic analysis of transcriptional
networks: combining microarrays with complex
trait analysis. Int Complex Trait Consortium
Conf 1: http://www.complextrait.org/ctcsche/start.html |
|
Bennett B, Johnson TE, Williams RW (2002) A
new panel of recombinant inbred strains from
ILS and ISS. Int Complex Trait Consortium
Conf 1: http://www.complextrait.org/ctcsche/start.html |
|
Chesler EJ, Rodriguez-Zas SL, Williams RW, Mogil
JS (2002) �In Silico� mapping of
complex traits in inbred mice? Int
Complex Trait Consortium Conf 1: http://www.complextrait.org/ctcsche/start.html |
|
Manly K, Meer JM, Wang J, Williams RW (2002)
QTX and WebQTL: software for analysis of complex
traits. Int Complex Trait Consortium Conf
1: http://www.complextrait.org/ctcsche/start.html |
|
Hsu HC, Zhang HG, Li L, Mullinax CL, Lu L, VanZant
G, Williams RW, Allison DB, Mountz JD (2002)
Age-related thymic involution in C57BL/6J X
DBA/2J recombinant inbred mice fits a negative
exponential regression model and maps to mouse
chromosome 9. Int Complex Trait Consortium
Conf 1: http://www.complextrait.org/ctcsche/start.html |
|
Grizzle WE, Mountz JD, Yang PA, Xu X, Sun S,
Van Zant GE, Williams RW, Hsu HC, Zhang HG (2002)
Recombinant inbred mice represent a novel T-cell
mediated immune response tumor model. Int
Complex Trait Consortium Conf 1: http://www.complextrait.org/ctcsche/start.html |
|
Jablonski MM, Wang XF, Lu L, Goldowitz D, Williams
RW (2002) Regional mutagenesis of the mouse
genome: ocular phenotypes. Soc. Neurosci Abst. |
|
Williams RW, Shou S, Lu L, Qu Y, Manly KF, Wang
J, Chesler E, Hsu HC, Mountz J, Threadgill DW
(2002) Massively parallel QTL mapping of microarray
data reveals mouse forebrain transcriptional
networks. Soc. Neurosci Abst. |
|
Williams RW, Manly KF, Shou S, Chesler E, Hsu
HC, Mountz J, Wang J, Threadgill DW, Lu L (2002)
Massively parallel complex trait analysis of
transcriptional activity in mouse brain. International
Mouse Genome Conference 16: 46 |
|
Lu L, Gu J, Threadgill D, Williams R (2002)
Complex trait analysis of mice hippocampus using
CXB RIX mapping method. International Mouse
Genome Conference 16:88. |
|
Manly KF, Wang J, Shou S. Qu Y, Chesler E, Lu
L, Hsu HC, Mountz JD, Threadgill D, Williams
RW (2002) QTL mapping with microarray expression
data. International Mouse Genome Conference
16: 88. |
|
Hitzemann R, Williams R, Reed C (2002) The integration
of functional genomics and QTL analysis. International
Mouse Genome Conference 16: 122. |
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Goldowitz D, Rinchik E, Johnson d, Goss K, Hamre
K, Matthews D, Ferkin M, Mittleman G, Montine
T, Jablonsky M, Williams R, Snoddy J, Miller
D (2002) Regional mutagenesis of the mouse genome
and neural phenotypes. International Mouse Genome
Conference 16:120. |
|
Chesler EJ, Rodrigues-Zas Sl, Williams RW, Mogil
JS (2002) Extension and evaluation of �in
silico� mapping of complex traits. International
Mouse Genome Conference 16:39. |
|
Chesler EJ, Wang J, Lu L, Manly KF Williams
RW (2003) Genetic correlations of gene expression
with neurobehavioral traits in a recombinant
inbred mapping panel. Int. Behav Neurosci. |
|
Hsu HC, Li L, Yi N, Zhang, HG, Yang PA, Wu Q,
Zhou J, Lu L, Allison AB, Williams RW, Mountz
JD (2003) Genomic analysis of age-related
thymic involution. Am Assoc Immunol. |
|
Chesler EJ�. Williams RW (2003) Web-based
QTL mapping and genetic correlation analysis
of gene expression and alcohol-related traits
in BXD strains. Res Soc Alcohol |
|
Williams RW, Xu J, Zhai H, Lu L (2003) Complex
trait analysis of retinal horizontal cell number.
ARVO Abst 5576. |
|
Geisert EE�. Williams RW (2003) The control
of gene expression following injury in the rat
retina; QTL and PCA. ARVO Abst 3594. |
|
Bystrykh L, Weersing E, DontjeB, Vellenga E,
Wang J, Manly KL, Williams RW, Cooke M, de Haan
G (2003) Genetical genomics to identify gene
pathways regulating hematopoietic stem cells.
CTC 2. |
|
Osadchuk AV, Airey DC, Lu L, Threadgill DW,
Williams RW (2003) A novel approach to genetically
dissection complex quantitative traits using
the RIX diallel cross of recombinant inbred
strains. CTC 2. |
|
Manly KF, Wang J, Williams RW (2003) WebQTL;
Complex trait analysis beyond QTL mapping. CTC
2. |
|
De Koning DJ, Carlborg O, Williams RW, Lu L,
Haley C (2003) Epistatic QTL for gene expression
in mice: potential for BXD expression data.
CTC 2. |
|
Chesler EJ, Wang J, Lu L, Manly KF, Williams
RW (2003) Genetic correlations and associative
networks for CNS transcript abundance and neurobehavioral
phenotypes in a recombinant inbred mapping panel.
CTC 2. |
|
Chesler EJ, Wang J, Lu L, Peirce JL, Qu S, Manly
KF, Williams RW (2003) Web-based QTL mapping
and genetic correlation analysis of gene expression
and alcohol-related traits in BXD strains. Alcoholism
Clin Exp Res 27:P 125A |
|
Fernandes A, Yin H, Byron B, Iuvone PM, Schaeffel
F, Williams RW, Pardue MT (2004) Effects of
form deprivation on eye size and refraction
in C57BL/6J mice. IOVS |
|
Pardue MT, Yin H, Irving B, Schaeffel F, Williams
RW, Fernandes A (2004) The refractive state
of a mouse model of clinical disease associated
with high myopia. IOVS |
|
Aronow B, Jegga A, Kong S, Williams S, Hutton
J, Ebert C, Gupta A, Chesler EJ, Lu L, Shou
S, Qu Y, Wang J, Manly KL, Williams RW, Threadgill
DW (2004) Discovering transcriptional regulatory
networks by correlationg quantitative trait
loci that modify tissue specific gene expressison
with the occurrence of phylogenetically conversed
cis element clusters. |
|
Boughter J, St. John S, Williams RW, Lu L (2004)
Genetic control of lick rate in mice.
Association for Chemoreception Sciences. |
News and Coverage
|
New York Times. Blakeslee S (1993) Evolution of tabby cat mapped in brain study. Tuesday January 12, Section B5. |
|
Il Corriere Della Sera (Milan newspaper). Simion L (1993) Al micio si e rimpicciolito il cervello. Jan 31 issue. |
|
Discover Magazine. Oliwenstein L (1993, May issue) Brain Donors. Discover 14:18. |
|
Guillery RW (1994) No crossing at the crossing.
A New and Views article. Nature 367:597�598
(this review considers a paper by Williams et
al. 1994). |
|
Human Genome News. Mansfield BK (1994) Mouse gene data files available from UT Memphis. Human Genome News, May 1994. |
|
Science. Takahashi JS (1994) Forward and reserve genetic
approaches to behavior in the mouse. Science
264: 1724-1733. This review contains a brief
description of the Portable Dictionary of the
Mouse Genome (pp. 1728-1729) |
|
Science. Kaiser J (2000) Mouse Brain Library: Netwatch
Images selection. Science 289:211. |
|
Memphis Commercial Appeal: July 9, 2001. Front
page photo of Abigail Haynes working in R. Williams
laboratory (by Lance Murphey). |
|
Memphis Business Journal: June15�21, 2001.
Vol. 23 No. 7. Photograph of Dr. Michael Dockter
in R. Williams laboratory (by Alan Howell). |
|
Memphis Business Journal: Jan 15�21, 2002.
Vol. 24 No. X. RW cited in article on Genome
Explorations. |
|
Commercial Appeal: May 15, 2002: World�s
scientists sniff trail of complex traits. RW
cited in article as organizer. Page A11. |
|
Apple Computer, Inc. Providing Broad Access to Tissue Banks: on the
Science & Technology site at Apple Inc.
http://www.apple.com/scitech/appletech/dv/utic/
(posted 2002) |
|
iScope, You scope, We all scope a mouse brain:
AAAS News Release, Feb 17, 2003 by Monica
Amarelo. |
|
Which Gene Influences What? Data Desk Aids in
Gene Mapping: DataDescription Inc., by
Holly M. Bailey, July , 2003, http://www.datadesk.com/company/profiles/williams.shtml |
|
Building a Better Mouse Database. Bio IT World
June 15, 2003 issue. http://www.bio-itworld.com/archive/061503/mouse_sidebar_2646.html
and see http://www.bio-itworld.com/archive/061503/mouse.html |
|
Vogel, G (2003) Geneticist Dream of 1001 Complex
Mice. Science 301:456�457. |
|
Mouse Brains � FileMaker & Excel
by Mike Nelson for Bio-IT World |
|
Bio IT World. June 15, 2003 issue. Building a better mouse database. http://www.bio-itworld.com/archive/061503/mouse_sidebar_2646.html and see http://www.bio-itworld.com/archive/061503/mouse.html |
|
Science (2003) Geneticists Dream of 1001 Complex Mice. Science 301:456�457 by GretchenVogel |
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Bio-IT World (2004) Mouse Brains � FileMaker & Excel by Mike Nelson |
|
Memphis Business Journal. Aug 12�18, 2005, by Scott Shepard. Mouse engineer: Williams leads project to revolutionize genomics research |
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BIRNing issues: Biomedical Informatics Research Network: August 2005. �Williams helps integrate diverse mouse data.� www.nbirn.net/Publications/Newsletter/ pp 5-6 |
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Memphis Business Journal. July 7�13, 2006, pp. 9�10 by Scott Shepard. Focus on Biotech. Biotech debate: Share or covet knowledge. pp. 9-10. This article includes an interview with RWW. �The key concept is to recognize the areas of science and areas of industry that we all regard as pre-competitive.� |
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Time Magazine. What the Mouse Brain Tells Us, by Alice Park. Jan 29, 2007 Issue. P 93. |
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