CURRICULUM VITAE

 

 

Name:      Lu Lu

Address:  855 Monroe Ave. Memphis, TN 38163

Phone:     901-448-7557 (O); 901-448-7018 (Lab)

Fax:         901-448-7193 (Dept); 901-448-1716 (Lab)

Email:     lulu@nb.utmem.edu

 

EDUCATION

 

1999-2001: Post-doctoral Research Fellow, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, USA

1998-1999: Post-doctoral Research Fellow, Department of Medicine, College of Physicians & Surgeons, Columbia University, USA

1984-1987: M.S. in Histology & Embryology, Shanghai Medical University, Shanghai.

1977-1982: M.D. in Medicine, Nantong Medical College, Nantong.

 

PROFESSIONAL EXPERIENCE

 

2006-present: Associate Professor, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee

2001-2005: Assistant Professor, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, USA

2001-present: Professor (honorary), Department of Histology & Embryology, Nantong Medical College, P. R. China

1994-1998: Associate Professor, Director of Department of Histology & Embryology, Tenure review committee member of Nantong Medical College, P. R. China

1989-1994: Lecturer, Department of Histology & Embryology, Nantong Medical College, P. R. China

1987-1989: Teacher Assistant, Department of Histology & Embryology, Shanghai Medical University, P. R. China

1982-1984: Research Associate, Diving Physiology Research Institute, Shanghai, P. R. China

 

RESEARCH SUPPORT

 

2004-2009: Principal Investigator, NIAAA fund. Genetic analysis of ethanol-mediated stress reduction.

2005-2010: Coinvestigator, NIMH. Mapping Cerebellar Development in Time and Space, R01MH74460 (PI: Daniel Goldowitz), TDC ~$2.7M over 5 years (07.01.05–06.30.10)

2005-2010: Coinvestigator, NIMH. Informatics Center for Mouse Neurogenetics, P20 DA-021131-06 (Robert Williams), TDC ~$5.5M over 5 years (09.01.05–08.31.10)

2004-2009: Coinvestigator, NCI. Integrative genetics of cancer susceptibility, U01-CA105417-01 (PI: David Threadgill), TDC ~$0.84M over 5 years (04.01.04–03.31.09)

2002-2006: Co-investigator, NIAAA fund. “Complex trait analysis of alcohol-stress interaction”.

2002-2006: Co-investigator, NIAAA fund. “Genotyping core”.

1999-2001: Visiting Research Fellow with Robert W. Williams, Center for Neuroscience, University of Tennessee.

1998-2000: Principal Investigator, Jiangsu Natural Science Foundation of China. “Changes of thrombopoietin (TPO) in platelet physiology and pathology”.

1995-1998: Principal Investigator, Nantong Medical College. “Study on NGF gene expression in non-nervous tissues”.

1992-1995: Investigator, National Natural Science Foundation of China. “NGF and his receptor genes expression in animal model (rat) of Alzheimer's disease”.

1991-1993: Principal Investigator, Nantong Medical College. “In vitro study on neurotrophic factor and doparminergic neuron”.

1990-1993: Principal Investigator, National Natural Science Foundation of China. “In vitro culture and transplantation of mesencephalic dopaminergic neuron of human and rat”.

1986-1989: Investigator, National Natural Science Foundation of China. “Study of distribution and application of neuron-specific enolase in nervous and endocrine systems”.

 

AWARDS

 

1999   Award for May Day Prize of Jiangsu, P. R. China

1997   Remarkable Leader in “ Research and Technical Project Across the Century Named as 333 of Jiangsu”, P. R. China

1997   Award for May Day Special Prize of Nantong City

1996   Excellent Teacher of Universities in Jiangsu, P. R. China

1994   Outstanding Researcher of Nantong Medical College

1994-1995   Prize for the Advancement of Science Research of Nantong Medical

1991-1993   Prize for the Advancement of Science Research of Nantong Medical

 

PROFESSIONAL SOCIETY MEMBERSHIPS

 

American Association for the Advancement of Science

Research Society Alcoholism

Society for Neuroscience

Behavior Genetics Association

International mammalian genome society

International Complex Trait Consortium

International Behavioral and Neural Genetics Society (IBANGS)

 

TEACHING

 

1984-1989   Medical Histology, Shanghai Medical University

1984-1989   Medical Embryology, Shanghai Medical University

1989-1998   Medical Histology, Nantong Medical College

1989-1998   Medical Embryology, Nantong Medical College

1993-1998   Molecular Biology, Nantong Medical College

 

REVIEWER FOR

 

Journal of Pharmacology and Experimental Therapeutics

 

PATENT AND INVENTION

 

Lu L, Gu XS, Dai JJ, Lu SL, Cao Z, Zhang PY, Xu HJ, Tang XL: Liquid of brain cells activation. Bulletin of Patent Invention, 1997, 13(13):16

 

Administration

 

2001~ present: Head of genotype core for integrative Neuroscience Initiative Alcoholism (INIA)

 

ORIGINAL PAPERS

 

  1. Wang HR, Lu L, Tang PZ, Tong BY, Gu HY: Scanning electron microscopy of the cerebellum of the newborn rat in tissue culture.  Acta Acad. Medi. Shanghai, 1986,13:455-457
  2. Lu L, Wang HR, Gu HY, Chen LL, Shen XY,Tong BY: Immuno-histochmical observation of rat cerebellar granule cells in tissue culture. Acta Acad. Medi. Shanghai, 1987,14:89-92
  3. Yang YQ, Gu HY, Lu L, Wang HR: Differentiation of neuron-specific enolasse positive cells in the rat submandibular gland.  Acta Acad. Medi. Shanghai, 1989,16:265-268
  4. Yang YQ, Lu L, Gu HY, Wang HR: The neuroendocrine cells in submandibular gland -- a preliminary observation.  Chinese J. Anatomy, 1990, 13:15-18
  5. Feng LY, Lu L, Tong BY, Zhou L, Gu HY: Improvement of method to make rat model of Parkinson' disease.  Acta Acad. Medi.  Shanghai, 1990, 17:160
  6. Tian ML, Lu L, Xu HJ, Wu YM: Viability observation of rat mesencephalic dopaminergic neurons in different nutrient solution.  Acta Acad. Medi. Nantong, 1992,12:164-165
  7. Lu L, Xu HJ, Wu YM, Tian ML: Laminin promotes growth and development of embryonic mesencephalic dopaminergic neurons in vitro. Chinese J. Neuroanatomy, 1992,8: 42-46
  8. Lu L, Xu HJ, Wu YM, Tian ML: Effects of striatal cell on morphological development of mesencephalic dopaminergic neurons in vitro. Chinese J. Anatomy, 1992,15:341-345
  9. Lu L, Xu HJ, Wu YM, Tian ML: Morphological observation of rat mesencephalic dopaminergic neurons in long-term culture. Chinese J Neuroanatomy, 1992, 8:250-254
  10. Lu L, Xu HJ, Wu YM, Tian ML: Study on MPTP toxicity for rat mesencephalic dopaminergic neurons in culture. Acta Acad. Medi. Nantong, 1994,14:127-130
  11. Lu L, Xu HJ, Wu YM, Tian ML: Protective effects of ganglioside GM1 on MPTP damaged dopaminergic neurons of rat in vitro. Chinese J. Neuroanatomy,1994, 10:33-38
  12. Li XY, Lu L: Study in fibronectin of lung cancerous tissue by immuno- histochemical method. Acta Acad. Medi. Nantong, 1994,14:135-137
  13. Gu J, Lu L: Study on affected factors of making enzyme labeled antibody detecting PAIg. Acta Acad. Medi. Nantong, 1994,14:248-249
  14. Cao Z, Lu L, Ding F, Gu J, Liu F, Ying DM, Gu XS: Purification and its application of the digoxigenin labeled human b-NGF DNA probe. Chinese J Neuroscience, 1995,2:141-144
  15. Feng JS, Xu HJ, Wu YM, Huang Z, Lu GM, Lu L: The changes of astrocytes during intracerebral transplantation.  Chinese J. Neuroanatomy, 1995,11:185-189
  16. Tian ML, Lu L, Xu HJ: Study on cholinergic neurons in vitro by histochemical method of acetylcholine. Acta Acad. Medi. Nantong, 1996,16:149-150 
  17. Chen YS, Xu HJ, Wu YM, Lu L: The effect of ganglioside GM1 on MPTP-treated mice. Chinese J. Anatomy, 1996,19:133-137
  18. Cao Z, Lu L, Ding F, Hu YQ, Gu XS: Relationship between levels of NGF mRNA and maturation and functions of testis spermatogenic cell.  Chinese J. Andrology, 1996,10:136-140
  19. Lu L, Cao Z, Ding F, Gu J, Gu XS, Wang JZ, Yu YK, Fan M: Preparation of human bNGF DNA probe labeled with digoxigenin and expression of NGF gene in mouse submandibular gland.  Chinese J. Histochemistry and Cytochemistry, 1997,6:346-351
  20. Lu L, Ding F, Cao Z, Gu J, Gu XS: Detection of NGF mRNA in submandibular gland of female mouse by in situ hybridization method. Acta Acad. Medi. Nantong, 1997,17:147-149
  21. Cao Z, Lu L, Ding F, Yao Denbin,Ying  DM, Gu XS: Preparation and application of the dig-NGF cDNA probe.  Acta Acad. Medi. Nantong, 1997,17:150-151
  22. Gu P, Gu J, Lu L: Study of anticardiolipin antibodies in rheumatoid arthritis. Acta Acad. Medi. Nantong, 1997,17:183-184
  23. Lu L, Ding F, Cao Z, Gu J, Gu XS: Sex difference of NGF gene expression in submandibular gland of mice.  Chinese J. Anatomy, 1998, 21:233-236
  24. Lu L, Ding F, Cao Z, Gu J, Gu XS, Wang JZ, Fan M: Nerve growth factor gene expression in submandibular gland of mice during postnatal development.  Acta Anatomica Sinica, 1998,29:284-288
  25. Lu L, Ding F, Cao Z, Gu J, Gu XS: The study on the NGF gene expression in epididymis of mice.  Chinese J. Family Planning, 1998,7:301-303
  26. Gu J, Lu L, Wu FY, Chen XF, Ding F, Cao Z, Gu XS: Detection of NGF gene expression in human bone marrow by in situ hybridization method.  Acta Acad. Medi. Nantong, 1998,18:147-149
  27. Lu L, Cao Z, Ding F, Gu XS, Gu J, Chen XF, Wu FY: Gene expression of nerve growth factor during development of megalocaryocytes in human bone marrow. Chinese J. Anatomy, 1999, 22:205-207
  28. Ding F, Lu L, Cao Z, Zhong QQ, Gu XS: The effects of lead poisoning on expression of nerve growth factor gene of submandibular gland in mice.  Chinese J Preventive Medicine, 1999, 33:266-268
  29. Ding F, Lu L, Cao Z, Gu XS, Wang JZ, Yu YK, Fang M: The influence of NGF mRNA in submandibular gland in mouse poisoned by lead. Modern Preventive Medicine, 1999,26:291-292
  30. Williams RW, Airey DC, Kulkarni A, Zhou GM, Lu L: Genetic dissection of olfactory bulbs of mice: QTLs on four chromosomes modulate bulb size. Behavioral Genetics, 2001, 133:61-77
  31. Lu L, Airey DC, Williams RW: Complex trait analysis of the hippocampus: Mapping and biometric analysis of two novel gene loci with specific effects on hippocampal structure in mice. Journal of Neuroscience, 2001, 21:3503-3514
  32. Airey DC, Lu L, Williams RW: Genetic control of the mouse cerebellum: identification of quantitative trait loci modulating size and architecture. Journal of Neuroscience, 2001, 21:5099-5109
  33. Hardy CL, Lu L, Nguyen P, Woodland DL, Williams RW, Blackman MA: Identification of quantitative trait loci controlling activation of TRBV4 CD8+ T cells during murine herpes virus-induced infectious mononucleosis. Immunogenetics, 2001, 53: 395-400
  34. Williams RW, Gu J, Qi SH, and Lu L: The genetic structure of recombinant inbred mice: High-resolution consensus maps for complex trait analysis. Genome Biology 2001, 2(11): research 0046.1-0046.18
  35. Lu L, Mei DF, Gustain DE, Zwas D, Homma S, Yi GH, Wang J: Exercise training normalized altered calcium handling proteins during development of heart failure. J Appl Physiology 2002, 92:1524-1530.
  36. Gu J, Lu L, Xu HR, Chen XF: Plasma thrombopoietin levels in patients with aplastic anaemia and idiopathic thrombocytopenic purpura. Chinese J. Medicine 2002, 115(7):983-987
  37. Airey DC, Lu L, Shou SS, Williams RW: Genetic sources of individual differences in the cerebellum. The Cerebellum, 2002, 1:233-240.
  38. Lu L, Cook R, Gu J, Williams RW, Smeyne RJ: Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. Molecular Brain Research 2003, 110(2): 279-88.
  39. Hitzemann R, Hitzemann B, Rivera S, Gatley J, Thanos P, Lu L, Shou S, and Williams R: Dopamine D2 receptor binding, Drd2 expression and the number of dopamine neurons in the BXD recombinant inbred series: genetic relationships to alcohol and other drug associated phenotypes. Alcoholism: Clinical and Experimental Research 2003; 27(1):1-11
  40. Peirce J, Chesler EC, Williams RW, Lu L: Genetic architecture of the mouse hippocampus: Identification of gene loci with regional effects. Genes, Brain and Behavior, 2003,2:238-252.
  41. Chesler EJ, Wang J, Lu L, Qu Y, Manly KF, Williams RW: Genetic Correlates of gene expression in recombinant inbred strains: a relational model system to explore neurobehavioral phenotypes. Neuroinformatic 2003; 1(4): 343-357.
  42. Abiola O, …, Lu L, …, Zou F: The nature and identification of quantitative trait loci: a community’s view. Nature Genetics 2003;4:911-916.
  43. Hsu HC, Zhang HG, Li L, Yi N, Yang PA, Wu Q, Zhou J, Sun S, Xu X, Yang X, Lu L, Van Zant G, Williams RW, Allison DB, Mountz JD: Age-related thymic involution in C57BL/6J X DBA/2J recombinant inbred mice maps to mouse chromosomes 9 and 10. Genes and Immunity, 2003, 4(6): 402-410.
  44. Seecharan DJ, Kulkarni AL, Lu L, Rosen GD, Williams RW: Genetic control of interconnected neuronal populations in the mouse primary visual system. Journal of Neuroscience, 2003, 23: 11178-11188.
  45. Churchill GA,…., Lu L, … Zou F: The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics 2004, 36(11):1133-7
  46. Williams RW, Bennett B, Lu L, Gu J, DeFries JC, Carosone-Link PJ, Rikke BA, Belknap JK and Johnson TE: Genetic Structure of the LXS Panel of Recombinant Inbred Mouse Strains: A Powerful Resource for Complex Trait Analysis. Mammalian Genome, 2004, 15(8):637-647.
  47. Lu L, Peirce JL, Gu J, Silver LM, Williams RW: A new set of BXD recombinant inbred lines from advanced intercross populations in mice. BMC Genetics 2004, 5(1):7
  48. Jablonski MM, Lu L, Wang XF, Chesler EJ, Carps E, Qi SH, Gu J, Williams RW: The ldis1 lens mutation in RIIIS/J mice maps to chromosome 8 near cadherin 1. Molecular Vision 2004, 10:577-87
  49. Tan XL, Zhou Y, Cai KF, Shao YX, Zhu SX, Lu L, Williams RW, Gu XS: Identification of QTLs for weight and cross-sectional area on cervical enlargement of spinal cord in mice. Yi Chuan Xue Bao. 2004 Aug;31(8):801-6.
  50. Chesler EJ, Lu L, Wang J, Williams RW, Manly KF: WebQTL: Rapid Exploratory Analysis of Gene Expression and Genetic Networks for Brain and Behavior. Nature Neuroscience, 2004, 7(5): 485-486.
  51. Lu L, Chesler EL, Shou S, Qu Y, Gu J, Wang J, Hsu H, Mountz JD, Baldwin N, Langston MA, Hogenesch JB, Threadgill DW, Manly KF, Williams RW: Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nature Genetics 2005, 37(3):233-42.
  52. Bystrykh L, Weersing E, Dontje B, Sutton S, Pletcher MT, Wiltshire T, Su AI, Vellenga E, Wang J, Manly KF, Lu L, Chesler EJ, Alberts R, Jansen RC, Williams RW, Cooke MP, de Haan G: Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nature Genetics 2005, 37(3):225-32.
  53. Mountz JD, Yang PA, Wu Q, Zhou J, Tousson A, Fitgerald A, Allen J, Wang X, Cartner S, Grizzle WE, Yi N, Lu L, Williams RW, and Hsu HC: Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in BXD2 recombinant inbred strain of mice.  Scandanavian Journal of Immunology 2005,61(2):128-38.
  54. Zou F, Gelfond J, Airey DC, Lu L, Manly KF, Williams RW, and Threadgill DW: Extending the power of quantitative trait locus analysis using recombinant inbred lines through recombinant inbred intercrosses (RIX): theoretical and empirical considerations. Genetics, 2005, 170(3):
  55. Li HQ, Lu L, Manly KF, Wang J, Zhou M, Williams RW, Cui Y: Inferring gene transcriptional modulatory relations: a genetical genomics approach. Human Molecular Genetics, 2005, 14(9): 1119-1125.
  56. Tsaih, SW, Lu L, Airey DC, Williams RW, Churchill GA: Quantitative trait mapping in a diallel cross of recombinant inbred lines. Mammalian Genome, 2005, 16:344-355
  57. Jablonski MM, Dalke C, Wang XF, Lu L, Manly K, Pretsch W, Pardue M, Rinchik, Williams RW, Goldowitz D, Graw J: An ENU-induced mutation in Rs1h causes disruption of retinal structure and function. Molecular Vision, 2005,11:569-81.
  58. Matthews DB, Bhave SV, Belknap JK, Brittingham C, Chesler EJ, Hitzemann RJ, Hoffmann PL, Lu L, McWeeney S, Miles MF, Tabakoff B, Williams RW: Complex Genetics of Interactions of Alcohol and CNS Function and Behavior. Alcohol Clin Exp Res, 2005 Sep;29(9):1706-1719
  59. Bennett B, Carosone-Link PJ, Lu L, Chesler EJ, Johnson TE: Genetics of body weight in the LXS recombinant inbred mouse strains. Mammalian Genome, 2005 Oct 16(10):764-74
  60. Vazquez-Chona FR, Khan AN, Chan CK, Moore AN, Dash PK, Rosario Hernandez R, Lu L, Chesler EJ, Manly KF, Williams RW, Geisert Jr EE: Genetic networks controlling retinal injury. Molecular Vision, 2005, 11:958-970.
  61. Li CX, Wei X, Lu L, Peirce JL, Williams RW, Waters RS: Genetic Analysis of Barrel Field Size in the First Somatosensory Area (SI) in Inbred and Recombinant Inbred Strains of Mice. Somatosensory and Motor Research, 2005, 22:141-150.
  62. Jablonski MM, Wang XF, Lu L, Miller DR, Rinchik EM, Williams RW, Goldowitz D: The Tennessee Mouse Genome Consortium: Identification of Ocular Mutants. Visual Neuroscience, 2005, 22(5):595-604
  63. Kempermann G, Chesler EJ, Lu L, Lein E, Nathanson J, Williams RW, Gage FH: Natural variation and genetic covariance in adult hippocampal neurogenesis. Proc Natl Acad Sci USA, 2006, 103(3):780-5
  64. Li HQ, Chen H, Bao L, Manly KF, Chesler EJ, Lu L, Wang J, Zhou M, Williams RW, Cui Y: Integrative Genetic Analysis of Transcription Modules: Towards Filling the Gap between Genetic Loci and Inherited Traits. Human Molecular Genetics, 2006,15(3):481-92
  65. Bao L, Wei L. Peirce JL, Homayouni R, Li H, Zhou M, Chen H, Lu L, Williams RW, Pfeffer LM, Goldowitz D, Cui Y: Combining gene expression QTL mapping and phenotypic spectrum analysis to uncover gene regulatory relations. Mammalian Genome, 2006, 17(6):575-583.
  66. Peirce JL, Li H, Wang J, Manly KF, Hitzemann RJ, Belknap JK, Rosen GD, Sutter TR, Williams RW, Lu L: How replicable are mRNA expression QTLs? Mammalian Genome, 2006, 17(6):643-656.
  67. Bao L, Zhou M, Ligang Wu, Lu L, Goldowitz D, Williams RW, Cui Y: PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits. Nucleic Acids Research, 2006 (in press)
  68. Martin M, Dong H, Vallera D, Lee D, Lu L, Williams RW, Rosen GD, Cheverud J, Csernansky J: Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice. Genes, Brain and Behavior, 2006, (in press)
  69. Dong H, Martin M, Colvin J, Ali Z, Borek J, Wang L, Lu L, Williams RW, Rosen GD, Csernansky JG, Cheverud J: Quantitative trait loci linked to thalamic and cortical gray matter volumes in BXD recombinant inbred mice: implications for the genetics of schizophrenia. Biological Psychiatry, 2006 (in press)
  70. Miyairi I, Lu L, Tatireddigari A, Madi, OS, Belland RJ, Williams RW, Byrne GI: Recombinant inbred mice facilitate rapid identification of p47GTPases conferring resistance to Chlamydial infection. 2006 (in review)
  71. Carneiro AM, Airey DC, Zhu C, Lu L, Blakely R: Murine SERT polymorphism associated with anatomical and behavioral traits linked to depression. Science, 2006 (in review)
  72. Peirce JL, Broman KW, Lu L, Chesler EJ, Zhou G, Airey DC, Birmingham AE, Williams RW: A permutation method for quantitative analysis of expanded advanced intercross populations. BMC Genetics 2006 (in review)
  73. Peirce JL, Broman KW, Lu L, Williams RW: A simple method for combining QTL maps multiple crosses and experimental designs. BMC Genetics 2006 (in review)

 

ABSTRACTS OF INTERNATIONAL MEETING

 

  1. Lu L, Xu HJ, Wu YM, Tian ML: Effects of laminin, gangliside GM1, and 1-Methyl-4-phonyl-1,2,3,6-tetrahydropyridine (MPTP) on growth and development of mesencephalic dopamenergic neurons in vitro. The 2nd International Conference on Anatomical Sciences, Beijing China, October 12-15,1992
  2. Wu YM, Lu L, Xu HJ, Tian ML: Effects of laminin on growth and development of mesencephalic dopamenergic neurons in vitro and in vivo. The 2nd International Conference on Anatomical Sciences, Beijing, China, October 12-15, 1992
  3. Lu L, Cao Z, Gu J, Ding F, Gu XS: Expression of the nerve growth factor gene in submandibular gland, testis and bone marrow. The 10th International Congress on Histochemistry and Cytochemistry, Kyoto, Japan, August 18-23, 1996
  4. Lu L, Airey DC, Gillissen E, Zhou GM, Williams RW: New murine hippocampus-specific QTL maps to distal Chr 1. The 13th International Mouse Genome Conference. Philadelphia, USA, October 31-November 3, 1999
  5. Airey DC, Lu L, Strom R, Gillissen E, Zhou GM, Williams RW: Cerebellum-specific QTLs in the mouse brain. The 13th International Mouse Genome Conference, Philadelphia, USA, October 31-November 3, 1999
  6. Lu L, Airey DC, Williams RW: Complex trait analysis of the mouse hippocampus. The 30th Neuroscience Meeting, New Orleans, USA, November 4-9, 2000
  7. Airey DC, Lu L, Williams RW: Gene loci for mouse cerebellum and internal granule layer size. The 30th Neuroscience Meeting, New Orleans, USA, November 4-9, 2000
  8. Williams RW, Kulkarni A, L Jones, Zhou GM, Airey DC, Lu L: Growth of the olfactory bulbs is modulated by QTLs on chromosomes 4,6,11 and 17. The 30th Neuroscience Meeting, New Orleans, USA, November 4-9, 2000
  9. Ding F, Cao Z, Lu L, Gu XS: Effects of lead exposure on transcription of nerve growth factor mRNA and cell growth of the submandibular gland of mice. The 30th Neuroscience Meeting, New Orleans, USA, November 4-9, 2000
  10. Rosen GD, Williams AG, Capra JA, Connolly MT, Cruz B, Lu L, Airay DC, Kulkarni A, Williams RW: The mouse brain library. The 14th International Mouse Genome Conference, Narita, Japan, November 6-10, 2000
  11. Williams RW, Threadgill DW, Airey DC, Gu J, Lu L: RIX Mapping: A demonstration using CXB RIX hybrids to map QTLs modulating brain weight in mice. The 31th Neuroscience Meeting, San Diego, USA, November 10-15, 2001.
  12. Threadgill DW, Airey DC, Lu L, Manly K, Williams RW: Recombinant inbred intercross mapping: a new approach to extend the power of existing mouse resources. The 15th International Mouse Genome Conference, Edinburgh, Scotland, October 21-24, 2001.
  13. Shou S, Lu L, Williams RW: Transcriptome chromosome maps: a novel resource for complex trait analysis of the mouse CNS. The 4th Annual Meeting of the International Behavioural and Neural Genetics Society, San Diego, USA, November 8-10, 2001
  14. Williams RW, Threadgill DW, Manly KF, Rosen GD, Shou S, Airey DC, Gu J, Lu L: Integrated complex trait analysis of brain and behavior in mouse: near-term prospects for high-resolution QTL mapping using large RI and RIX sets. The 4th Annual Meeting of the International Behavioural and Neural Genetics Society, San Diego, USA, November 8-10, 2001
  15. Lu L, Airey DC, Rosen GD, Williams RW: Gemetic dissection of the mouse hippocampus: Mapping quatitative trait loci with selective and regional effects. International conference on neuroregeneration (ICN), Nantong, China, September 21-24, 2001
  16. Williams RW, Lu L, Wang XF, Qi S, Gu J, Jablonski MM: Mapping and initial characterization of a spontaneous mutation affecting lens development in RIIIS/J inbred mice. The ARVO 2002 Annual Meeting, Ft Lauderdale, Florida, USA, May 4 - 9, 2002
  17. Watson R, Koratkar R, Lu L, Gu J, Finegan AA, Margan JL, Guz J, Williams RW, Siracusa LD: Expansion of the BXH RI series: derivation and characterization of three new BXH recombinant inbred lines and one new BXH recombinant congenic line. Abst Amer Assoc Cancer Res 2002.
  18. Peirce JL, Lu L, Zhou G, Silver LM, and Williams RW: Generation and Characterization of Highly Recombinant Inbred Lines from an Advanced Intercross. 1st Annual Complex Trait Consortium (CTC) Meeting, Memphis, USA, May 15-17, 2002.
  19. Hsu HC, Huang-Ge Zhang HG, Li L, Mullinax C, Lu L, Zant GV, Williams RW, Allison DB, Mountz JD: Age-related Thymic Involution in C57BL/6J X DBA/2J Recombinant Inbred Mice Fits A Negative Exponential Regression Model and Maps to Mouse Chromosome 9. 1st Annual Complex Trait Consortium (CTC) Meeting, Memphis, USA, May 15-17, 2002.
  20. Lu L, Gu J, Qi SH, Airey DC, Rosen GD, Peirce J, Robert W. Williams RW, Zhou G: Analysis of a tenth generation advanced intercross and a new set of ~45 derivative BXD recombinant inbred strains. 1st Annual Complex Trait Consortium (CTC) Meeting, Memphis, USA, May 15-17, 2002.
  21. Threadgill D, Airey DC, Lu L, Manly KF, Williams RW: Genetic control of stochastic variation revealed by recombinant inbred intercross (RIX) mapping. 1st Annual Complex Trait Consortium (CTC) Meeting, Memphis, USA, May 15-17, 2002.
  22. Williams RW, Shou S, Lu L, Qu Y, Wang J, Manly K, Chesler E, Hsu HC, Mountz J, Threadgill D: Genomic Analysis of Transcriptional Networks: Combining Microarrays with Complex Trait Analysis. 1st Annual Complex Trait Consortium (CTC) Meeting, Memphis, USA, May 15-17, 2002.
  23. Lu L, Shou S, Qu YH, Manly K, Chesler E, Hsu HC, Mountz J, Threadgill D, Williams RW: Genomic Analysis of Transcriptional Networks: Combining Microarrays with Complex Trait Analysis. 2002 Southeast Regional Meeting of the Society for Developmental Biology, Gatlinburg, Tennessee, May 29-31,2002
  24. Shou S, Lu L, Qu Y, Jensen P, Williams RW (2002) High transcriptional diversity and complexity among mouse brain regions. The 32th Neuroscience Meeting, Orlando, USA, November 2-7 2002.
  25. Williams RW, Shou S, Qu YH, , Chesler E, Manly K, Wang J, Hsu HC, Mountz J, Threadgill D, Lu L: Massively parallel mapping of transcriptional networks. The 32th Neuroscience Meeting, Orlando, USA, November 2-7 2002.
  26. Tong Y, Deaton J, Lu L, Williams RW, Goldowitz D: Mapping of the hippocampal lamination defect gene, HLD, in the mouse. The 32th Neuroscience Meeting, Orlando, USA, November 2-7 2002.
  27. Lu L, Airey DC, Gu J, Zhou GM, Williams RW; Genetic architecture of the mouse hippocampus: Confirmation of gene loci with advanced intercross progeny. The 32th Neuroscience Meeting, Orlando, USA, November 2-7 2002.
  28. Smeyne RJ, Tharp R, Smeyne M, Lu L, Williams RW: Identification of quantitative trait loci for susceptibility to MPTP in an animal model of Parkinsons disease. The 32th Neuroscience Meeting, Orlando, USA, November 2-7 2002.
  29. Chesler EJ, Shou S, Qu Y, Yang X, Lu L, Williams RW: Microarray analysis of sex differences in the mouse CNS transcriptome. The 32th Neuroscience Meeting, Orlando, USA, November 2-7 2002.
  30. Jabblonski MM, Wang XF, Lu L, Goldowitz D, Willliams RW, Tennessee Mouse Genome Consortium: Regional mutagenesis of the mouse genome: Ocular phenotypes. The 32th Neuroscience Meeting, Orlando, USA, November 2-7 2002.
  31. Williams RW, Manly KF, Shou S, Chesler EJ, Hsu HC, Mountz J, Threadgill DW, Lu L: Massively parallel complex trait analysis of transcriptional activity in mouse brain. The 16th International Mouse Genome Conference, San Antonio, Texas, November 17-20, 2002.
  32. Lu L, Gu J, Threadgill D, Williams R: Complex trait analysis of mice hippocampus using CXB RIX mapping method. The 16th International Mouse Genome Conference, San Antonio, Texas, November 17-20, 2002.
  33. Manly KF, Wang J, Shou S. Qu Y, Chesler E, Lu L, Hsu HC, Mountz JD, Threadgill D, Williams RW (2002) QTL mapping with microarray expression data. The 16th International Mouse Genome Conference, San Antonio, Texas, November 17-20, 2002.
  34. Williams RW, Lu L, Qu YH, Wang JT, Chesler EJ, Hsu HC, Mountz JD, Threadgill DW, Manly KF: Brain Transcriptional Control Networks. Fourteenth Annual Spring Brain Conference, Radisson Poco Diablo Resort in Sedona, Arizona, USA, March 12-15, 2003.
  35. Geisert EE, Vazquez-Chona F, Lu L, Chesler EJ, Williams RW: The control of gene expression following injury in the rat retina: QTL and PCA. The ARVO 2003 Annual Meeting, Ft Lauderdale, Florida, USA, May 4 - 9, 2003.
  36. Williams RW, Xu JL, Zhai HT, Lu L: Complex trait analysis of mouse retinal horizontal cell number. The ARVO 2003 Annual Meeting, Ft Lauderdale, Florida, USA, May 4 - 9, 2003.
  37. Jablonski MM, Wang XF, Lu L, Pardue M, Iannaccone A, Goldowitz D, William RW: Regional Mutagenesis of the Mouse Genome: An Update of Ocular Phenotypes. The ARVO 2003 Annual Meeting, Ft Lauderdale, Florida, USA, May 4 - 9, 2003.
  38. Chesler EJ, Wang JT, Lu L, Peirce JL, Manly KF, Williams RW: Web-based QTL mapping and genetic correlation analysis of gene expression and alcohol-related traits in BXD strains. Research Society for Alcoholism 26th Annual meeting, Ft Lauderdale, Florida, USA, June 21-25, 2003.
  39. De Koning DJ, Carlborg O, Williams RW, Lu L, Haley C (2003) Epistatic QTL for gene expression in mice: potential for BXD expression data. The 2nd Annual Complex Trait Consortium (CTC) Meeting, Oxford, UK, July 1-3, 2003.
  40. Chesler EJ, Wang JT, Lu L, Qu, Y, Manly K, 1Williams RW: Genetic correlations and associative networks for CNS transcript abundance and neurobehavioral phenotypes in a recombinant inbred mapping panel. The 2nd Annual Complex Trait Consortium (CTC) Meeting, Oxford, UK, July 1-3, 2003
  41. Chesler, E.J., Wang, J., Lu, L., Peirce, J.L., Qu, Y., Manly, K.F., Williams, R.W., (2003) Web-based QTL mapping and genetic correlation analysis of gene expression and alcohol-related traits in BXD strains. Alc. Clin. Exp Res. Supplement 27(5):125A.
  42. Lu L, Chesler EJ, Chen H, Li Y, Cui Y, Sharp BM, Wang JT, Manly K, Williams RW: Genomic Analysis of Gene Interaction In Mice Forebrain. The 2nd Annual Complex Trait Consortium (CTC) Meeting, Oxford, UK, July 1-3, 2003
  43. Osadchuk AV, Airey DC, Lu L, Threadgill DW, Williams RW: A novel approach to genetically dissect complex quantitative traits using a diallel cross of recombinant inbred strains. The 2nd Annual Complex Trait Consortium (CTC) Meeting, Oxford, UK, July 1-3, 2003
  44. Lu. L, Cui Y, Chesler EJ, Chen H, Li Y, Sharp BM, Williams RW: Genetic dissection of transcriptional regulatory networks in mouse forebrain. The 33th Neuroscience Meeting, New Orleans, USA, November 8-12 2003.
  45. Chesler EJ, Wang JT, Lu L, Qu, Y, Manly K, 1Williams RW: Gene expression associative networks and genetic correlations of CNS transcript abundance with neuro-behavioral phenotypes in a recombinant inbred mapping panel. The 33th Neuroscience Meeting, New Orleans, USA, November 8-12 2003.
  46. Kempermann G, Chesler EJ, Lu. L, Williams RW, Gage FG: Search for key gene loci associated with the baseline regulation of adult hippocampal neurogenesis. The 33th Neuroscience Meeting, New Orleans, USA, November 8-12 2003.
  47. Matthews DB, Lu L, Chesler EJ, Mittleman G, Williams RW: Identification of two QTLs on chromosome 16 modulating vocalization to mild foot shock in mice. The 33th Neuroscience Meeting, New Orleans, USA, November 8-12 2003.
  48. Boughter JD, Jr., John SJ, Williams RW, and Lu L: Genetic Control of Lick Rate in Mice. The 26th Annual Meeting of the Association for Chemoreception Sciences. Sarasota, FL, USA, April 21-25, 2004.
  49. Chesler EJ, Wang JT, Lu L, Qu, Y, Manly K, 1Williams RW: WebQTL: A resource for analysis of gene expression variation and the genetic dissection of alcohol related phenotypes. The 27th Annual Scientific Meeting of the Research Society on Alcoholism, Westin Bayshore Resort and Marina Vancouver, Canada, June 26-30, 2004.
  50. Osadchuk AV, Airey DC, Lu L, Threadgill DW, Williams RW: A new look at the genetic dissection of complex quantitative traits in the extended RIX diallel cross: multilocus approach. The 3rd Annual Complex Trait Consortium (CTC) Meeting, Bar Harbor, ME, USA July 6-9, 2004
  51. Chesler EJ, Baldwin NE, Zhang B, Kirov S, Wang J, Lu L, Snoddy JR, Langston MA, Manly KF, Williams RW: Genetic analysis of gene expression in mouse CNS reveals major pleiotropic and polygenic control of synaptic machinery. The 18th International Mouse Genome Conference, Seattle, USA, October 18-21, 2004
  52. Jablonski MM, Wang XF, Lu L, Williams RW, Goldowitz D: The Tennessee Mouse Genome Consortium: An update of ocular phenotypes. The 34th Neuroscience Meeting, San Diego, USA, October 23-27, 2004
  53. Chesler EJ, Lu L, Langston MA, Manly KF, Williams RW: Transcriptome - QTL analysis of correlated CNS transcripts using WEBQTL reveals major genetic variation in synaptic vesicle related gene expression. The 34th Neuroscience Meeting, San Diego, USA, October 23-27, 2004
  54. Geisert EE, Khan AN, Chesler EJ, Manly KF, Williams RW, Lu L, Vazquez-Chona F: Master regulators of glia cell reactivity. The 34th Neuroscience Meeting, San Diego, USA, October 23-27, 2004
  55. Jablonski MM, Wang X, Lu L, Manly K, Rinchik E, Pardue M, Williams RW, Goldowtiz D: Characterization of a new mutant mouse model with an aberrant retinal phenotype: 44TNJ (tmgc1) from the Tennessee Mouse Genome Consortium. The ARVO 2005 Annual Meeting, Ft Lauderdale, Florida, USA, May 1 - 5, 2005.
  56. Hsu HC, Lu L, Yi N, Williams RW, and Mountz JD: Production of autoantibodies and urinary proteins in autoimmune BXD2 mice mapped to mouse chromosomes 2 and 4. Arthritis Research Conference 2005
  57. Chesler EJ, Lu L, Wang JT, Langston MA, Manly KF, Williams RW: Genetic analysis of gene transcription in genetic reference populations and relations to complex phenotypes. 2005 Cold Spring Harbor laboratory meeting on systems biology: Global regulation of gene expression, Cold Spring Harbor, NY, USA, March 17 - 20, 2005
  58. Chesler EJ, Lu L, Wang JT, Manly KF, Williams RW: WebQTL: An Internet resource for the integrative genetic analysis of gene expression and pain related phenotypes. The 24 annual scientific meeting of American pain society, Boston, MA, USA, March 30 – April 2, 2005
  59. Dong H, Martin M, Colvin J, Ali Z, Wang L, Lu L, Williams RW, Rosen GD, John G. Csernansky JG, Cheverud J: Four Quantitative Trait Loci for Thalamic Volume in BXD Recombinant Inbred Mice. 2005 International Conference of Schizophrenia Research, Savannah, GA, USA April 2 to 6, 2005
  60. Martin M, Dong H, Vallera D, Meltzer M, Lu L, Williams RW, Rosen GD, John G. Csernansky JG, Cheverud J: Quantitative Trait Loci for Ventral Hippocampal Volume in BXD Recombinant Inbred Mice. International Conference of Schizophrenia Research, Savannah, GA, USA April 2 to 6, 2005
  61. Peirce JL, Bennett B, Chesler EJ, Williams RW Lu L: Genetic analysis of ethanol-related traits and gene expression in the LXS hippocampus. . The 35th Neuroscience Meeting, Washington DC, USA, November 12-16, 2005
  62. Chesler EJ, Scharff JA, Pitts SM, Lu L, Wang J, Manly KF, Langston MA, Williams RW: Systems genetics of central nervous system from genes to phenotypes. The 35th Neuroscience Meeting, Washington DC, USA, November 12-16, 2005
  63. Dong H, Martin M, Colvin J, Ali Z, Wang L, Lu L, Williams RW, Rosen GD, John G. Csernansky JG, Cheverud J: Volumes in BXD Recombinant Inbred Mice: Implications for Schizophrenia. The 35th Neuroscience Meeting, Washington DC, USA, November 12-16, 2005
  64. Martin M, Dong H, Vallera D, Meltzer M, Lu L, Williams RW, Rosen GD, John G. Csernansky JG, Cheverud J: Independent Quantitative Trait Loci Influence Ventral and Dorsal Hippocampal Volume in Recombinant, Inbred Strains of Mice. The 35th Neuroscience Meeting, Washington DC, USA, November 12-16, 2005
  65. Williams RW, Peirce JL, Wang J, Manly KF, Chesler EL, Cui Y, Lu L: Systematic Genetics of gene expression and the use of reference populations to integrate across biological scales. 2006 Cold Spring Harbor laboratory meeting on systems biology: Global regulation of gene expression, Cold Spring Harbor, NY, USA, March 23 - 26, 2006
  66. Williams RW, Haik BG, Jiao Y, Gu W, Lu L, Geisert EE: A Systematic Genetic Approach to Define Expression Networks in Eye and Their Relations to Structure and Function. The ARVO 2006 Annual Meeting, Ft Lauderdale, Florida, USA, April 30 - May 4, 2006.
  67. Kempermann G, Overall R, Peirce JL, Lu L, Goldowitz D, Gage FH, Goodwin S, Smit G, Airey D, Rosen G, Schalkwyk L, Sutter T, Nowakowski R, Watley S, Williams RW: Hippocampal Gene Networks in BXD Mice. The 5th Annual Complex Trait Consortium (CTC) Meeting, Chapel Hill, North Carolina, May 6-10, 2006
  68. Peirce JL, Li H, Wang J, Manly KF, Hitzemann RJ, Belknap JK, Rosen GD, Sutter T, Goodwin S, Williams RW, Lu L: How replicable are mRNA expression QTLs? The 5th Annual Complex Trait Consortium (CTC) Meeting, Chapel Hill, North Carolina, May 6-10, 2006
  69. Boughter JD Jr, Baird JP, St. John SJ, Williams RW, Lu L, Heck D: Genetic basis of Lick Rate and Lick Microstructure in Mice. The 8th ANNUAL MEETING OF IBANGS, Vancouver, Canada, May 19-22, 2006
  70. Yang RJ, Mozhui K, Lu L, Williams RW, Holmes A: Identifying genetic factors controlling amygdala morphology and emotion-related phenotypes in BXD recombinant inbred mice. IBNS 15th Annual Meeting, Whistler, Canada, May 23-28, 2006
  71. Peirce JL, Putman HA, Miles MF, Parker CC, Bennett B, Li H, Wang J, Manly KF, Hitzemann RJ, Belknap JK, Rosen GD, Chesler EJ, Williams RW, Lu L: Genetic association of gene expression with alcohol penotypes. The 29thAnnual Scientific Meeting of the Research Society on Alcoholism, Marriott Waterfront Hotel, Baltimore, Maryland, June 23-29, 2006
  72. Jan TA, Reiner DJ, Peirce JL, Li CX, Boughter JD, Lu L, Williams RW, Waters RS: Genetic analysis of tongue size and tongue weight in recombinant inbred strains of mice. Am Chem Senses 28, 2006

 

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