Educational Background

Postdoctoral training 1987-1989. Neurobiology Group, University of California, San Diego. Director: Walter F. Heiligenberg, Ph.D.

Ph.D. 1983-1987 University of Colorado, Boulder. Department of Environmental, Population and Organismic Biology. Subdiscipline: Neurobiology. Dissertation title: Coordination of Rapid Escape Turning in Fishes. Thesis advisor: Robert C. Eaton.

B.A. 1975-1979 University of Colorado, Boulder. Double major: A) Molecular, Cellular and Developmental Biology and B) Biochemistry

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Associate Professor. Department of Neurobiology & Anatomy Medical College of Pennsylvania/Hahnemann University
Research Professor, School of Biomedical Engineering, Science and Health Systems, Drexel University

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Papers

Eaton, R.C., Nissanov, J. and C.M. Wieland.. 1984. Differential activation of Mauthner and non-Mauthner startle circuits in the zebrafish:  Implications for functional     substitution. J. Comp. Phys.155:813-820.

Eaton, R.C. and J. Nissanov. 1985. A review of Mauthner-initiated escape behavior and its possible role in hatching behavior in the immature zebrafish, Brachydanio rerio . Env. Biol. Fish. 12:265-279.

DiDomenico, R., Nissanov, J. and R.C. Eaton. 1988. Lateralization and adaptation of  a continuously variable central program following microlesions of a reticulospinal command neuron. Brain Res. 473:15-28.

Eaton, R.C., DiDomenico, R. and J. Nissanov. 1988. Flexible body dynamics of the goldfish C-start: implications for reticulospinal command mechanisms. J. Neurosci. 8:2758-2768

Nissanov, J. and R.C. Eaton. 1989. Reticulospinal control of rapid escape turning maneuvers in fishes. Amer. Zool. 29:103-121.

Nissanov, J., Eaton, R.C. and R. DiDomenico. 1990. The motor output of the Mauthner cell, a reticulospinal command neuron. Brain Res. 517:88-98.

Eaton, R.C., DiDomenico, R. and J. Nissanov. 1991. Role of the Mauthner cell in sensorimotor integration by the brain stem escape network. Brain Behav. Evol. 37:272-285.

Nissanov, J. and D.L. McEachron. 1991. Advances in image processing for autoradiography. J. Chem. Neuroanat. 4:329-342.

Dubin  S., J. Nissanov, S. Zietz, A. Naim A., B. Shrope, R. Morano, and R. Hanania . 1994. Bioengineering approach to non-invasive measurement of body fat percentage. Biomedical Sciences Instrumentation 30:225-232.

Nissanov, J. C. Ozturk, and D. Kozinska. 1995. Brain surface scanning using structured light. SPIE Proceedings 2598:334-341.

Nissanov, J., R.W. Tuman, L. Gruver and J. Fortunato. 1995. Automatic vessel segmentation and quantification of the rat aortic ring assay of angiogenesis.  Lab. Invest. 73:734-739.

Ozturk, C., J. Nissanov, S. Dubin, W.Y Shi, J. Nichols, R. Mark., 1995. Measurement of wound healing by image analysis. Biomedical Sciences Instrumentation 31:189-193.

Nissanov, J. 1996. Surface guided 3D alignment: A new approach to brain mapping. Scanning 18:151-152

Nissanov, J. and L. Rioux. 1996. Evaluation of commercial tritium standards:  A significant source of error in quantitative autoradiography. Microscopy and Microanalysis 1996, pp. 460-461.

Ozturk, C., J. Nissanov and S. Dubin. 1996. Generation of perfect map codes for an active stereo imaging system. Proceedings of the 22nd Annual NorthEast Bioengineering Conference 76-77.

Chaudhuri, A., Nissanov, J., Larocque, S. and L. Rioux. 1997. Dual activity maps in primate visual cortex produced by different temporal patterns of zif268 mRNA and protein expression. PNAS 94:2671-2675.

McEachron, D.L., Nissanov J., and O. Tretiak. 1997. Region-specific tritium enrichment, and not differential b-absorption, is the major cause of 'quenching' in film autoradiography. Phys. Biol. Med. 42:1121-1132

Kozinska, D., Tretiak, O.J, Nissanov, J., and C. Ozturk. 1997. Multidimensional alignment using the Euclidean distance transform. Graphical Models & Image Processing 59:373-387.

Tretiak, O. and J. Nissanov. 1997. Neurocartography: Geometry and biology of the central nervous system. Microscopy and Microanalysis 3(supp 2): 295-296.

Cohen, F.S., Yang, Z., Huang, Z. and J. Nissanov.  1998. Automatic matching of homologous histological sections. IEEE Trans. Biomed. Eng. 45:642-649.

Morano, R.A., Ozturk, C., Conn, R., Dubin, S., Zietz and J. Nissanov. 1998. Structured light using pseudo-random codes. PAMI 20:322-327.

Rioux, L., J. Joyce and J. Nissanov. 1998.  Altered number of (125I)BH-substance P binding sites in  schizophrenia. Prog. Neuro-Psychopharm. & Biol. Psychiatry 22:1295-1299

Shumsky, J.S., Wu, Y, Murphy, E.H., Nissanov, J. and D.R. Grayson. 1998. Prenatal cocaine exposure does not affect selected GABA_A receptor subunit mRNA expression in rabbit visual cortex. Annal New York Academy of Sciences. 846:371-375

Dougherty, D.A., Nissanov, J. and G.R. Gindi. 1999. Construction details of an autoradiographic-based rat brain phantom for emission tomography. IEEE Proceeding Medical Imaging Conference 1998.

Komisaruk, B.R., Rosenblatt, J.S., Barona, M.L., Chinapen, S., Nissanov, J., O'Bannon, R.T. and M.C.R. Del Cerro. 2000. Combined c-fos and ¹⁴C-2-deoxyglucose method to differentiate site-specific excitation from disinhibition: Analysis of maternal behavior in the rat. Brain Res. 859:262-272

Nguyen C, Nissanov J, Ozturk C, Nuveen M, Tuncay OC. 2000. Three-dimensional imaging of the craniofacial complex. Clin Orthod Res 3:46-50

Mitchell,T.W., Nissanov, J., Han, L-Y, Mufson, E., Schneider, J.A., Cochran, E.J, Bennett, DA, Lee, V.M.-Y, Trojanowski, J Q., Arnold S.E.. In Press. Novel method to quanitfy neuropil threads in brains from elders with/without cognitive impairment. J. Histochem Cytochem

Nissanov, J., Bertrand, L., and O. Tretiak. In Press. Cryosectioning Distortion reduction using tape support.  Microsc. Res. Tech.
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Software

Nissanov, J. 1987. Knowal.. Boulder, CO.

Finegold, E. Nissanov, J. and O. Tretiak. 1990. DUMAS, v2.1. Autoradiographic Image Processing Center, a Biomedical Technology Resource. Philadelphia, PA.

Reed, C., Nissanov, J. and O. Tretiak. 1992. Brain for Macintosh, v 1.0. Autoradiographic Image Processing Center, a Biomedical Technology Resource. Philadelphia, PA.

Gustafson, C., Nissanov, J. and O. Tretiak. 1993. Brain for Macintosh, v 1.1.3. Autoradiographic Image Processing Center, a Biomedical Technology Resource. Philadelphia, PA.

Gustafson, C., Nissanov, J. and O. Tretiak. 1993. Brain for Macintosh, v 1.2. Autoradiographic Image Processing Center, a Biomedical Technology Resource. Philadelphia, PA.

Gustafson, C., Nissanov, J. and O. Tretiak. 1994. Brain for Macintosh, v 1.3. Autoradiographic Image Processing Center, a Biomedical Technology Resource. Philadelphia, PA.

Nissanov, J. 1994. Vessels, v 1.2.8. Digital Vision, Incorporated. Philadelphia, PA.

Gustafson, C., Nissanov, J. and O. Tretiak. 1995. Brain for Macintosh, v 1.4. Computer Vision Center for Vertebrate Brain Mapping, a Biomedical Technology Resource. Philadelphia, PA.

Gustafson, C., Nissanov, J. and O. Tretiak. 1997. Brain for Macintosh, v 2.0. Computer Vision Center for Vertebrate Brain Mapping, a Biomedical Technology Resource. Philadelphia, PA.

Gustafson, C., Nissanov, J. and O. Tretiak. 1998. Brain for Macintosh, v 3.0. Computer Vision Center for Vertebrate Brain Mapping, a Biomedical Technology Resource. Philadelphia, PA.

Atlases

Nissanov, J. and L. Bertrand. 1998. 2D Digital Atlas of the Adult Rat Brain. Computer Vision Center for Vertebrate Brain Mapping, a NIH Biomedical Technology Resource, Drexel University.

Nissanov, J. and L. Bertrand. 1998. 3D Anatomy of the Rat Brain: A 42 micron Isotropic Atlas, V 1. Computer Vision Center for Vertebrate Brain Mapping, a NIH Biomedical Technology Resource, Drexel University.
 

Technical Reports

Lo, C-C, J. Nissanov and O. Tretiak. 1996. Section Thickness Determination and Evaluation of a New Gray Value Normalization Technique for Brain Reconstruction. Imaging & Computer Vision Center Technical Report. 01-15-1996.

Nissanov, J. Brain 2.0 Laboratory Manual. Imaging & Computer Vision Center #02-27-1997

Nissanov, J. 1998. Brain 3.0: Exercise Manual. Imaging & Computer Vision Center #03-31-1998.

Patent

Sinclair, S.H., Nissanov, J., and A. Gupta. 12/31/96. Method and Apparatus for Central Visual Field Mapping and Optimization of Image Presentation Based Upon Mapped Parameters. Patent # 5589897

Abstracts

Nissanov, J., Eaton, R.C. and C.M. Wieland. 1984. A role for non-Mauthner escape circuits in larval zebrafish:  Implications for functional substitution in lesioned and normal animals.  Soc. Neurosci. Abs.

Nissanov, J. , Eaton, R.C. and  R. DiDomenico. 1986. Parallel activation within a reticulospinal command system. Soc. Neurosci. Abs. 12:109.6

Eaton, R.C., DiDomenico, R. and J. Nissanov. 1988. A kinematic comparison of Mauthner and non-Mauthner C-starts in goldfish. Soc. Neurosci. Abs. 14:128.12

Heiligenberg, W., Kawasaki, M. and J. Nissanov. 1988. Suppression of the electric organ discharge by desynchronization of pacemaker neurons in the electric fish Hypopomous. Soc. Neurosci. Abs. 14:86.6

Van Horne, S.M., Eaton, R.C, Fetcho, J.R. and J. Nissanov. 1988. What difference does it make having a Mauthner axon?  Soc. Neurosci. Abs. 14:128.13

Nissanov, J., Bhasin, S., Feingold, E., Thein, S.M. and O.J. Tretiak. 1990. Automatic alignment and subtraction of digital images.  In Vitro/In Vivo autoradiography and correlative imaging Abst. Chapel Hill, NC.

Nissanov, J., Cohen, C., Patel, P., McEachron, D.L., Tretiak, O.J. and S. Mani. 1990. An algorithm for  automated grain counting. In Vitro/In Vivo autoradiography and correlative imaging Abst. Chapel Hill, NC.

Nissanov, J., Waks, A., McEachron, D.L., Gallistel, C.R. and O.J. Tretiak. 1990. Automated delineation of neuroanatomical structures. Soc. Neurosci. Abs. 16:29.1

Nissanov, J., Mani, S. and O.J. Tretiak. 1991. Automatic grain counting.  Soc. Neurosci. Abs. 17:590.8

Nissanov, J., Xiao, J., and S. Sinclair. 1991. Automatic segmentation of fundus images: Extraction of blood  vessels. 5th Ann. Microcirculation Conf. Abst.

Nissanov, J., Xiao, J., and S. Sinclair. 1992. Toward an automated screening device for diabetic retinopathy. Arvo Ann. Meet. Abst. 33:3363

Mandel, J.M., Salmenson, B.D., Nissanov, J. and S. Sinclair. 1993. Digital image processing techniques for characterization of progressive retinal pigment epithelial changes in age-related macular degeneration. Arvo Ann. Meet. Abst. 34:2262

Nissanov, J., S. Bhasin, G. Gregorious, D. McEachron, R. Paz, L. Rioux, and O.J. Tretiak. 1993. Probability rat brain atlases: a tool for interpreting fused neuroanatomical maps. Soc. Neurosci. Abs. 19:545.5

Nissanov, J. and S. Sinclair. 1993. Automatic screening of diabetic retinopathy. Am  Acad Opthal Abst

Nissanov, J., R.W. Tuman, L. Gruver and J. Fortunato. 1993. Automatic vessel segmentation and quantification of the rat aortic ring assay of angiogenesis. New Cancer Strategies:  Angiogenesis and Angiogenesis Antagonists. Oct 18-19 Philadelphia, PA

Chinapen, S., Nissanov, J. and B.R. Komisaruk. 1994. Densitometric analysis of the immunocytochemical labeling of fos in the nucleus of the solitary tract induced by vaginocervical stimulation. Soc. Neurosci. Abs. 20:298.2

Hopkins, T.B., Nissanov, J., Gupta, A. and S.H. Sinclair. 1994. New concepts in testing and correcting macular visual distortion. Arvo Ann. Meet. Abst.

Hopkins, T.B., Nissanov, J., Gupta, A. and S.H. Sinclair. 1994. New concepts in testing and measuring macular visual distortion. Amer. Acad. Ophthalm.

Liu, D.M., D.L. Ross, J. Nissanov and P.J. Hand. 1994. Neocortical and thalamic plasticity following neonatal deafferentation in rats. Soc. Neurosci. Abs. 20:566.18

Chaudhuri, A., Larocque, S., Nissanov, J., Rioux, L. and A. Goldszal. 1995. Different temporal patterns of immediate-early gene mRNA and protein expression allow multiple labeling strategies in visual cortex of monkey. Soc. Neurosci. Abs. 21:689.10

Cohen, F.S., Yang, Z., Nissanov, J., Huang, Z. and D.L. McEachron. 1995. Computer matching homologous histological sections. Soc. Neurosci. Abs. 21:427.7

Nissanov, J., Ozturk, C. and D. Kozinska. 1995. Mapping the surface of intact frozen brains using a structured light based 3D scanner.  Soc. Neurosci. Abs. 21:427.10

Chaudhuri, A. and J. Nissanov. 1996. Multiple activity maps of primate visual cortex produced by sustained and transient expression of the immediate-early genes zif268 and c-fos. Soc. Neurosci. Abs. 22:632.16

Kozinska, D., J. Nissanov, O. Tretiak and C. Ozturk. 1996. Surface guided reconstruction of 3D volume from histological material. Soc. Neurosci. Abs. 22:493.2

Nissanov, J., D. Kozinska, C. Gustafson and O. Tretiak. 1996. Construction of a 42 micron 3D rat brain atlas from nissl stained sectional material. Soc. Neurosci. Abs. 22:267.9

Rioux, L, J. Nissanov and A. Chaudhuri. 1996. Activity associated expression of Zif268 in the rat whisker barrel field. Soc. Neurosci. Abs. 22:48.1.

Nissanov, J, S. Madi and S. Vinitski. 1997. Distance-based subset alignment of MR images. RSNA #1603

Nissanov, J., D. Sun, S. Madi and S. Vinitski. 1997.Subset matching and alignment of MR Images. 4th European Conference on Engineering and Medicine (Warsaw, Poland, May 25-28, 1997)

Ozturk, C., E. Schmutz, J. Nissanov. 1997. Decoding D-dimensional Perfect Maps. American Mathematical Society, MD 4/12/1997 Meeting.

Wu, Y., J.S. Shumsky, E.H. Murphy, J. Nissanov, A. OíBrien-Jenkins and D.R. Grayson. 1997. Differential Effects of prenatal cocaine exposure on selected subunit mRNAs of the GABAA Receptor. Soc. Neurosci Abs. 23:49.2

Chinapen, S, Barcona, M. L., OíBannon, R.T., Rosenblatt, J.S. Nissanov, J. Komisaruk, B.R., and M.C. Del Cerro. 1998. Combined C-fos/[14C]-2-DG analysis of maternal behavior in rat. Soc. Neurosci. Abst.

Komisaruk, B.R., Mosier, K.M., Criminale, C., Liu, W-C., Zaborszky, L., Whipple, B., Nisanov, J., and A.J. Kalnin. 1998. Functional mapping of human lower brainstem cranial nerve nuclei using fMRI. 4th International Conference on Functional Mapping of the Human Brain.

Komisaruk, B.R., Mosier, K.M., Criminale, C., Liu, W-C., Zaborszky, L., Whipple, B., Nisanov, J., and A.J. Kalnin. 1998. Functional mapping of human lower brainstem cranial nerve nuclei: an fMRI analysis. Soc. Neurosci. Abst

Madi, S., Vinitski, S. and J. Nissanov. 1998. Bold signal change with apnea. Soc. Neurosci. Abst. 24:168.5.

Nissanov, J. 1998. A rat standard coordinate system for use in cognitive studies. Cognitive Neurosciense Society Abst.

Nissanov, J, Bertrand, L and O. Tretiak. 1998. A standard brain coordinate system for the rat. Soc. Neurosci. Abst. 24:786.5.

Shumsky, J.S., Pietras, M.R., Murphy, E.H., Grayson, D.R. and J. Nissanov. 1998. High accuracy particle counter for analysis of low magnification in situ hybridization micrographs. Soc. Neurosci. Abst 24:423.14

Davis, K.L., Libon, D.J., Nissanov, J., Skalina, S., Lamar, M., & Chute, D.L. 1999. Neuropsychological assessment and volumetric magnetic resonsance imaging of the corpus callosum in dementia. National Academy of Neuropsychology conference in November (in San Antonio, TX)

Komisaruk, B.R., Mosier, K.M., Criminale, C., Liu, W-C., Zaborszky, L., Whipple, B., Nisanov, J., and A.J. Kalnin. 1999. Functional MRI of human pons, medulla and cervical spinal cord. Soc. Neurosci. Abst. 25:51.10

Madi, S., Vinitski, S., Flanders, A. and J. Nissanov. 1999. Functional imaging of the human spinal cord. ISMRM 1999 Philadelphia

Mishizen, A., Sheffield, R., Nissanov, J. & Armstrong, D.M. 1999. N-methyl-D-aspartate mRNA expression in the hippocampus of normal elderly and patients with Alzheimerís disease pathology. Soc. Neurosci. Abst. 25:338.3

Mitchell, TW, Nissanov, J, Han, L-Y, Lee, VM-Y, Trojanowski, JQ, Mufson, E, Schneider, J, Bennett, DA and SE Arnold. 1999. Correlation of neurofibrillary tangles and neuropil thread burden in patients with mild cognitive impairment. Soc. Neurosci. Abst 25:19.1.

Reed, CL, Nissanov, J., Bertrand, L and EJ Gallaher. 1999. Computerized 3-D Mouse Brain Atlas. Soc. Neurosci. Abst. 25:823.1

Tofighi, M.R., Daryoush, A.S., & J. Nissanov. 1999. Fixture design issues for complex permitivity measurement of biological tissues up to MMW frequencies. General Assembly of the International Union of Radio Science 16.

Falke, E.A., Mitchell, T.W., Nissanov, J. and S.E. Arnold. 2000. Quantitative analysis of subicular MAP2-immunoreactive dentritic arbor loss in Alzheimerís Disease. Soc. Neurosci. Abst. 26:764.8

Mitchell, T.W., Nissanov, J., Han, L-Y, Lee, V.M.-Y, Trojanowski, J.Q., Mufson, E.J., Schneider, J.A., Cochran, E.J., Bennett, D.A. and S.E. Arnold. 2000. Tau pathology in the ventromedial temporal lobe in aging and cognitive impairment. Soc. Neurosci. Abst. 26: 679.11.

Shumsky, J.S., Baynard, M.D., and J. Nissanov. 2000. Dissociation of vigilance states during performance in a sustained attention procedure. Soc. Neurosci. Abst. 26:837.4