1. Fentress JC, Stanfield BB, Cowan WM: Observation on the development of the striatum in mice and rats. Anat Embryol 1981, 163:275–298.
2. O’Kusky JR, Nasir J, Cicchetti F, Parent A, Hayden MR: Neuronal degeneration in the basal ganglia and loss of pallido-subthalamic synapses in mice with targeted disruption of the Huntington's disease gene. Brain Res 1999, 818:468–479.
3. Beckmann H, Lauer M: The human striatum in schizophrenia. II. Increased number of striatal neurons in schizophrenics. Psychiatry Res 1997, 68:99–109.
4. Heinsen H, Strik M, Bauer M, Luther K, Ulmar G, Gangnus D, Jungkunz G, Eisenmenger W, Gotz M: Cortical and striatal neurone number in Huntington's disease. Acta Neuropath (Berl) 1994, 88:320–333.
5. Braak H, Braak E: Neuronal types in the striatum of man. Cell Tissue Res 1982, 227:319–342.
6. Kemp JM, Powell TP: The structure of the caudate nucleus of the cat: light and electron microscopy. Philos Trans R Soc Lond B Biol Sci 1971, 262:383–401.
7. Wilson CJ, Groves PM: Fine structure and synaptic connections of the common spiny neuron of the rat neostriatum: a study employing intracellular inject of horseradish peroxidase. J Comp Neurol 1980, 194:599–615.
8. Kita H, Kitai ST: Glutamate decarboxylase immunoreactive neurons in rat neostriatum: their morphological types and populations. Brain Res 1988, 447:346–352.
9. Graybiel AM, Ragsdale CW, Jr.: Histochemically distinct compartments in the striatum of human, monkeys, and cat demonstrated by acetylthiocholinesterase staining. Proc Natl Acad Sci U S A 1978, 75:5723–5726.
10. Herkenham M, Nauta WJ: Afferent connections of the habenular nuclei in the rat.a horseradish peroxidase study,with a note on the fiber-of-passage problem. J Comp Neurol 1977, 173:123–146.
11. Gerfen CR: The neostriatal mosaic: compartmentalization of corticostriatal input and striatonigral output systems. Nature 1984, 311:461–464.
12. Gerfen CR: The neostriatal mosaic. I. Compartmental organization of projections from the striatum to the substantia nigra in the rat. J Comp Neurol 1985, 236:454–476.
13. Gerfen CR: The neostriatal mosaic: Multiple levels of compartmental organization. Trends Neurosci 1992, 15:133–139.
14. Reiner A, Albin RL, Anderson KD, D'Amato CJ, Penney JB, Young AB: Differential loss of striatal projection neurons in Huntington disease. Proc Natl Acad Sci U S A 1988, 85:5733–5737.
15. Sapp E, Ge P, Aizawa H, Bird E, Penney J, Young AB, Vonsattel JP, DiFiglia M: Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysis. Neuroscience 1995, 64:397–404.
16. Kosinski CM, Cha JH, Young AB, Persichetti F, MacDonald M, Gusella JF, Penney JB, Jr., Standaert DG: Huntingtin immunoreactivity in the rat neostriatum: differential accumulation in projection and interneurons. Exp Neurol 1997, 144:239–247.
17. Reddy PH, Charles V, Williams M, Miller G, Whetsell WO, Jr., Tagle DA: Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease. Philos Trans R Soc Lond B Biol Sci 1999, 354:1035–1045.
18. Anderson SA, Eisenstat DD, Shi L, Rubenstein JL: Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes. Science 1997, 278:474–476.
19. Eisenstat DD, Liu JK, Mione M, Zhong W, Yu G, Anderson SA, Ghattas I, Puelles L, Rubenstein JL: DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation. J Comp Neurol 1999, 414:217–237.
20. Sussel L, Marin O, Kimura S, Rubenstein JL: Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development 1999, 126:3359–3370.
21. Takahashi JS, Pinto LH, Vitaterna MH: Forward and reverse genetic approaches to behavior in the mouse. Science 1994, 264:1724–1733.
22. Williams RW: Mapping genes that modulate mouse brain development: A quantitative genetic approach. In: Mouse Brain Development. Edited by Goffinet A, Rakic P. pp. 21–49. Berlin: Springer; 2000.
23. Moore KJ, Nagle DL: Complex trait analysis in the mouse: The strengths, the limitations and the promise yet to come. Annu Rev Genet 2000, 34:653–686.
24. Williams RW, Rakic P: Three-dimensional counting: An accurate and direct method to estimate numbers of cells in sectioned material. J Comp Neurol 1988, 278:344–352.
25. Gundersen HJ, Bagger P, Bendtsen TF, Evans SM, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B, et al.: The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 1988, 96:857–881.
26. Anderson SA, Qiu M, Bulfone A, Eisenstat DD, Meneses J, Pedersen R, Rubenstein JL: Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons. Neuron 1997, 19:27–37.
27. Hallonet M, Hollemann T, Pieler T, Gruss P: Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system. Genes Dev 1999, 13:3106–3114.
28. Hallonet M, Hollemann T, Wehr R, Jenkins NA, Copeland NG, Pieler T, Gruss P: Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain. Development 1998, 125:2599–2610.
29. Tzeng SF, de Vellis J: Id1, Id2, and Id3 gene expression in neural cells during development. Glia 1998, 24:372–381.
30. Yoshida M, Suda Y, Matsuo I, Miyamoto N, Takeda N, Kuratani S, Aizawa S: Emx1 and Emx2 functions in development of dorsal telencephalon. Development 1997, 124:101–111.
31. Haggard EA: Intraclass correlation and the analysis of variance. New York: Dryden Press; 1958.
32. Dains K, Hitzemann B, Hitzemann R: Genetics, neuroleptic response and the organization of cholinergic neurons in the mouse striatum. J Pharmacol Exp Ther 1996, 279:1430–1438.
33. Wimer RE, Wimer CC, Vaughn JE, Barber RP, Balvanz BA, Chernow CR: The genetic organization of neuron number in the granule cell layer of the area dentata in house mice. Brain Res 1978, 157:105–122.
34. Wimer RE, Wimer CC: A geneticist's map of the mouse brain. In: Genetics of the Brain. Edited by Lieblich I. pp. 395–420: Elsevier; 1982.
35. Wimer RE, Wimer CC, Alameddine L: On the development of strain and sex differences in granule cell number in the area dentata of house mice. Dev Brain Res 1988, 42:191–197.
36. Abusaad I, MacKay D, Zhao J, Stanford P, Collier DA, Everall IP: Stereological estimation of the total number of neurons in the murine hippocampus using the optical disector. J Comp Neurol 1999, 408:560–566.
37. Kachele DL, Lasiter PS: Murine strain differences in taste responsivity and organization of the rostral nucleus of the solitary tract. Brain Res Bull 1990, 24:239–247.
38. Wee BE, Clemens LG: Characteristics of the spinal nucleus of the bulbocavernosus are influenced by genotype in the house mouse. Brain Res 1987, 424:305–310.
39. Williams RW, Strom RC, Rice DS, Goldowitz D: Genetic and environmental control of variation in retinal ganglion cell number in mice. J Neurosci 1996, 16:7193–7205.
40. Williams RW, Strom RC, Goldowitz D: Natural variation in neuron number in mice is linked to a major quantitative trait locus on Chr 11. J Neurosci 1998, 18:138–146.
41. Lu L, Airey DC, Williams RW: Complex trait analysis of the hippocampus: Mapping and biometric analysis of two novel gene loci with specific effects on hippocampal structure in mice. J Neurosci In Press.
42. Usui H, Falk JD, Dopazo A, de Lecea L, Erlander MG, Sutcliffe JG: Isolation of clones of rat striatum-specific mRNAs by directional tag PCR subtraction. J Neurosci 1994, 14:4915–4926.
43. Rikke BA, Johnson TE: Towards the cloning of genes underlying murine QTLs. Mamm Genome 1998, 9:963–968.
44. Rubinsztein DC, Leggo J, Chiano M, Dodge A, Norbury G, Rosser E, Craufurd D: Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease. Proc Natl Acad Sci U S A 1997, 94:3872–3876.
45. Chergui K, Bouron A, Normand E, Mulle C: Functional GluR6 kainate receptors in the striatum: indirect downregulation of synaptic transmission. J Neurosci 2000, 20:2175–2182.
46. Stumpo DJ, Bock CB, Tuttle JS, Blackshear PJ: MARCKS deficiency in mice leads to abnormal brain development and perinatal death. Proc Natl Acad Sci U S A 1995, 92:944–948.
47. Blackshear PJ, Silver J, Nairn AC, Sulik KK, Squier MV, Stumpo DJ, Tuttle JS: Widespread neuronal extopia associated with secondary defects in cerebrocortical chondroitin sulfate proteoglycans and basal lamina in MARCKS-deficient mice. Exp Neurol 1997, 145:46–61.
48. McNamara RK, Lenox RH: Distribution of the protein kinase C substrates MARCKS and MRP in the postnatal developing rat brain. J Comp Neurol 1998, 397:337–356.
49. Bertuzzi S, Hindges R, Mui SH, O'Leary DD, Lemke G: The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain. Genes Dev 1999, 13:3092–3105.
50. Kohtz JD, Baker DP, Corte G, Fishell G: Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog. Development 1998, 125:5079–5089.
51. Zamenhof S, Guthrie D, van Marthens E: Neonatal rats with outstanding values of brain and body parameters. Life Sci 1976, 18:1391–1396.
52. Zamenhof S, Marthens Ev, Grauel L: DNA (cell number) in neonatal brain: second generation (F2) alteration by maternal (F0) dietary protein restriction. Science 1971, 172:850–851.
53. Pakkenberg B, Gundersen HJG: Neocortical neuron number in humans: Effect of sex and age. J Comp Neurol 1997, 384:312–320.
54. Galaburda AM, Corsiglia J, Rosen GD, Sherman GF: Planum temporale asymmetry: Reappraisal since Geschwind and Levitsky. Neuropsychologia 1987, 25:853–868.
55. Rosen GD, Sherman GF, Galaburda AM: Ontogenesis of neocortical asymmetry: A (3H)thymidine study. Neuroscience 1991, 41:779–790.
56. Strom RC: Genetic analysis of variation in neuron number. Memphis: University of Tennessee; 1999.
57. Airey DC, Lu L, Strom R, Gilissen EI, Zhou GM, Williams RW: Cerebellum-specific QTLs in the mouse brain. In: Int Mamm Genome Conf; 1999. E9.
58. Taylor BA: Recombinant inbred strains. In: Genetic Variants and Strains of the Laboratory Mouse. Edited by Lyon ML, Searle AG, 2nd ed. pp. 773–796. Oxford: Oxford University Press; 1989.
59. Sherman GF, Galaburda AM, Behan PO, Rosen GD: Neuroanatomical anomalies in autoimmune mice. Acta Neuropathol (Berl) 1987, 74:239–242.
60. Rosen GD, Harry JD: Brain volume estimation from serial section measurements: A comparison of methodologies. J Neurosci Meth 1990, 35:115–124.
61. Herman AE, Galaburda AM, Fitch HR, Carter AR, Rosen GD: Cerebral microgyria, thalamic cell size and auditory temporal processing in male and female rats. Cereb Cortex 1997, 7:453–464.
62. Rosen GD, Herman AE, Galaburda AM: Sex differences in the effects of early neocortical injury on neuronal size distribution of the medial geniculate nucleus in the rat are mediated by perinatal gonadal steroids. Cereb Cortex 1999, 9:27–34.
63. Laird PW, Zijderveld A, Linders K, Rudnicki MA, Jaenisch R, Berns A: Simplified mammalian DNA isolation procedure. Nucleic Acids Res 1991, 19:4293.
64. Love JM, Knight AM, McAleer MA, Todd JA: Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellites. Nucleic Acids Res 1990, 18:4123–4130.
65. Dietrich W, Katz H, Lincoln SE, Shin H-S, Friedman J, Dracopoli NC, Lander ES: A genetic map of the mouse suitable for typing intraspecific crosses. Genetics 1992, 131:423–447.
66. Zhou G, Williams RW: Eye1 and Eye2: gene loci that modulate eye size, lens weight, and retinal area in the mouse. Invest Ophthalmol Vis Sci 1999, 40:817–825.
67. Manly KF, Olson JM: Overview of QTL mapping software and introduction to map manager QT. Mamm Genome 1999, 10:327–334.
68. Haley CS, Knott SA, Elsen JM: Mapping quantitative trait loci in crosses between outbred lines using least squares. Genetics 1994, 136:1195–1207.
69. Churchill GA, Doerge RW: Empirical threshold values for quantitative trait mapping. Genetics 1994, 138:963–971.
70. Darvasi A, Soller M: A simple method to calculate resolving power and confidence interval of QTL map location. Behav Genet 1997, 27:125–132.